DGIdb - QUINIDINE Drug Record

QUINIDINE chembl:CHEMBL1294 Approved

Alternate Names:

QUINIDINE
Β-QUININE
ALPHA-(6-METHOXY-4-QUINOLYL)-5-VINYL-2-QUINUCLIDINEMETHANOL
CONQUININE
CHINIDIN
(S)-(6-METHOXYQUINOLIN-4-YL)((2R,5R)-5-VINYLQUINUCLIDIN-2-YL)METHANOL
6-METHOXY-ALPHA-(5-VINYL-2-QUINUCLIDINYL)-4-QUINOLINEMETHANOL
BETA-QUININE
(R)-(6-METHOXYQUINOLIN-4-YL)((3S,4R,7S)-3-VINYLQUINUCLIDIN-7-YL)METHANOL
(+)-QUINIDINE
(8R,9S)-QUINIDINE
QUINIDINE HYDROCHLORIDE
(S)-(6-METHOXY-QUINOLIN-4-YL)-((2R,5R)-5-VINYL-1-AZA-BICYCLO[2.2.2]OCT-2-YL)-METHANOL
PITAYINE
QUINIDEX®
6-METHOXY-Α-(5-VINYL-2-QUINUCLIDINYL)-4-QUINOLINEMETHANOL
QUINAGLUTE®
(S)-[(4S,5R,7R)-5-ETHENYL-1-AZABICYCLO[2.2.2]OCTAN-7-YL]-(6-METHOXYQUINOLIN-4-YL)METHANOL
CONCHININ
(S)-(6-METHOXY-4-QUINOLYL)-[(2R,4S,5R)-5-VINYLQUINUCLIDIN-2-YL]METHANOL
CIN-QUIN
(S)-(6-METHOXY-4-QUINOLYL)-[(2R,4S,5R)-5-VINYL-2-QUINUCLIDINYL]METHANOL
CHINIDINUM
QUINIDINA
Α-(6-METHOXY-4-QUINOLYL)-5-VINYL-2-QUINUCLIDINEMETHANOL
chembl:CHEMBL1294
drugbank:00908
chemidplus:56-54-2
rxcui:9068
pubchem.compound:441074

Drug Info:

FDA Approval	Approved before 1982
Drug Class	small molecule
Drug Indications	Anti-Arrhythmia Agents
Drug Class	anti-arrhythmia agents
Year of Approval	approved before 1982

(3 More Sources)

Publications:

Sakatis MZ et al., 2012, Preclinical strategy to reduce clinical hepatotoxicity using in vitro bioactivation data for >200 compounds., Chem Res Toxicol
Ponte-Sucre A et al., 2009, Structure-activity relationship and studies on the molecular mechanism of leishmanicidal N,C-coupled arylisoquinolinium salts., J Med Chem
Napolitano et al., 2006, Brugada syndrome., Orphanet J Rare Dis
Tella et al., 1998, Monoamine transporter and sodium channel mechanisms in the rapid pressor response to cocaine., Pharmacol. Biochem. Behav.
Ohgo et al., 2007, Acute and chronic management in patients with Brugada syndrome associated with electrical storm of ventricular fibrillation., Heart Rhythm
Stokoe et al., 2007, Effects of flecainide and quinidine on arrhythmogenic properties of Scn5a+/Delta murine hearts modelling long QT syndrome 3., J. Physiol. (Lond.)
Sheets et al., 2010, Sodium channel molecular conformations and antiarrhythmic drug affinity., Trends Cardiovasc. Med.
Itoh et al., 2005, A novel missense mutation in the SCN5A gene associated with Brugada syndrome bidirectionally affecting blocking actions of antiarrhythmic drugs., J. Cardiovasc. Electrophysiol.
Chen et al., 2002, TTD: Therapeutic Target Database., Nucleic Acids Res.
Grant, 2005, Electrophysiological basis and genetics of Brugada syndrome., J. Cardiovasc. Electrophysiol.
Mickisch et al., 1991, Transgenic mice that express the human multidrug-resistance gene in bone marrow enable a rapid identification of agents that reverse drug resistance., Proc. Natl. Acad. Sci. U.S.A.
McPate MJ et al., 2006, Disopyramide is an effective inhibitor of mutant HERG K+ channels involved in variant 1 short QT syndrome., J Mol Cell Cardiol
Wolpert et al., 2005, Further insights into the effect of quinidine in short QT syndrome caused by a mutation in HERG., J. Cardiovasc. Electrophysiol.
Po et al., 1999, Modulation of HERG potassium channels by extracellular magnesium and quinidine., J. Cardiovasc. Pharmacol.
Lin et al., A mechanism for the potential proarrhythmic effect of acidosis, bradycardia, and hypokalemia on the blockade of human ether-a-go-go-related gene (HERG) channels., Am J Ther
Guérard et al., Selective block of IKs plays a significant role in MAP triangulation induced by IKr block in isolated rabbit heart., J Pharmacol Toxicol Methods
Dong et al., 2004, Acidification alters antiarrhythmic drug blockade of the ether-a-go-go-related Gene (HERG) Channels., Basic Clin. Pharmacol. Toxicol.
Lin et al., 2005, The influence of extracellular acidosis on the effect of IKr blockers., J. Cardiovasc. Pharmacol. Ther.
Rendic S et al., 1997, Human cytochrome P450 enzymes: a status report summarizing their reactions, substrates, inducers, and inhibitors., Drug Metab Rev
Ngui JS et al., 2001, In vitro stimulation of warfarin metabolism by quinidine: increases in the formation of 4'- and 10-hydroxywarfarin., Drug Metab Dispos
Tu et al., 1996, Inhibitory effects of quinidine and quinine on liver microsome oxidation enzymes in man and rat., Zhongguo Yao Li Xue Bao

QUINIDINE CYP3A7

Interaction Score: 1.24

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
9863152

Sources:
NCI
QUINIDINE KCNE1

Interaction Score: 1.24

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
PharmGKB
QUINIDINE SCN5A

Interaction Score: 0.8

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Novel drug target Established target

Trial Name -

PMIDs:
16972995 9476974 17556186 17023504 20685573 15877619 11752352 16138883

Sources:
TdgClinicalTrial TEND PharmGKB
QUINIDINE KCNH2

Interaction Score: 0.17

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

PMIDs:
16842817 15673388 10028924 16041196 18582585 15125690 15821840

Sources:
DTC PharmGKB
QUINIDINE ABCB1

Interaction Score: 0.08

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
1671173

Sources:
NCI PharmGKB
QUINIDINE CYP2C9

Interaction Score: 0.04

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
22931300 19117415

Sources:
DTC
QUINIDINE CYP3A4

Interaction Score: 0.04

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
19117415 22931300 9187528 11353757

Sources:
DTC PharmGKB
QUINIDINE CYP2C19

Interaction Score: 0.03

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
19117415

Sources:
DTC
QUINIDINE CYP1A2

Interaction Score: 0.02

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
22931300

Sources:
DTC
QUINIDINE CYP2D6

Interaction Score: 0.02

Interaction Types & Directionality:

n/a

Interaction Info:

Combination therapy Dextromethorphan,Quinidine

PMIDs:
None found

Sources:
PharmGKB FDA

TEND: QUINIDINE
- Version: 01-August-2011
Alternate Names:

Drug Info:

Year of Approval approved before 1982

Drug Class anti-arrhythmia agents

Publications:
TdgClinicalTrial: QUINIDINE
- Version: January-2014
Alternate Names:

Drug Info:

Drug Indications Anti-Arrhythmia Agents

Drug Class small molecule

FDA Approval Approved before 1982

Publications:

DTC: QUINIDINE

Version: 02-September-2020

Alternate Names:

CHEMBL1294 ChEMBL Drug ID

Drug Info:

Publications:

Sakatis MZ et al., 2012, Preclinical strategy to reduce clinical hepatotoxicity using in vitro bioactivation data for >200 compounds., Chem Res Toxicol

Ponte-Sucre A et al., 2009, Structure-activity relationship and studies on the molecular mechanism of leishmanicidal N,C-coupled arylisoquinolinium salts., J Med Chem

NCI: QUINIDINE

Version: 14-September-2017

Alternate Names:

C793 NCI drug code

Drug Info:

Publications:

Mickisch et al., 1991, Transgenic mice that express the human multidrug-resistance gene in bone marrow enable a rapid identification of agents that reverse drug resistance., Proc. Natl. Acad. Sci. U.S.A.

Tu et al., 1996, Inhibitory effects of quinidine and quinine on liver microsome oxidation enzymes in man and rat., Zhongguo Yao Li Xue Bao

PharmGKB: quinidine

Version: 18-August-2020

Alternate Names:

Drug Info:

Publications:

McPate MJ et al., 2006, Disopyramide is an effective inhibitor of mutant HERG K+ channels involved in variant 1 short QT syndrome., J Mol Cell Cardiol

Ngui JS et al., 2001, In vitro stimulation of warfarin metabolism by quinidine: increases in the formation of 4'- and 10-hydroxywarfarin., Drug Metab Dispos

Rendic S et al., 1997, Human cytochrome P450 enzymes: a status report summarizing their reactions, substrates, inducers, and inhibitors., Drug Metab Rev

ChemblDrugs: chembl:CHEMBL1294
- Version: ChEMBL_27
Alternate Names:

Drug Info:

Publications:
FDA: Quinidine
- Version: 04-September-2020
Alternate Names:

Drug Info:

Publications:

Novel drug target	Established target
Trial Name	-

QUINIDINE Drug Record

QUINIDINE chembl:CHEMBL1294 Approved

Alternate Names:

Drug Info:

Publications:

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 9863152

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: PharmGKB

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Novel drug target Established target Trial Name -

PMIDs: 16972995 9476974 17556186 17023504 20685573 15877619 11752352 16138883

Sources: TdgClinicalTrial TEND PharmGKB

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info:

PMIDs: 16842817 15673388 10028924 16041196 18582585 15125690 15821840

Sources: DTC PharmGKB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 1671173

Sources: NCI PharmGKB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 22931300 19117415

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 19117415 22931300 9187528 11353757

Sources: DTC PharmGKB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 19117415

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 22931300

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info: Combination therapy Dextromethorphan,Quinidine

PMIDs: None found

Sources: PharmGKB FDA

TEND: QUINIDINE

Alternate Names:

Drug Info: Year of Approval approved before 1982 Drug Class anti-arrhythmia agents

Publications:

TdgClinicalTrial: QUINIDINE

Alternate Names:

Drug Info: Drug Indications Anti-Arrhythmia Agents Drug Class small molecule FDA Approval Approved before 1982

Publications:

DTC: QUINIDINE

Alternate Names: CHEMBL1294 ChEMBL Drug ID

Drug Info:

NCI: QUINIDINE

Alternate Names: C793 NCI drug code

Drug Info:

PharmGKB: quinidine

Alternate Names:

Drug Info:

ChemblDrugs: chembl:CHEMBL1294

Alternate Names:

Drug Info:

Publications:

FDA: Quinidine

Alternate Names:

Drug Info:

Publications:

Interaction Types & Directionality:

n/a

PMIDs:
9863152

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
PharmGKB

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Novel drug target Established target

Trial Name -

PMIDs:
16972995 9476974 17556186 17023504 20685573 15877619 11752352 16138883

Sources:
TdgClinicalTrial TEND PharmGKB

Interaction Types & Directionality:

inhibitor (inhibitory)

PMIDs:
16842817 15673388 10028924 16041196 18582585 15125690 15821840

Sources:
DTC PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
1671173

Sources:
NCI PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
22931300 19117415

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
19117415 22931300 9187528 11353757

Sources:
DTC PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
19117415

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
22931300

Sources:
DTC

Interaction Types & Directionality:

n/a

Interaction Info:

Combination therapy Dextromethorphan,Quinidine

PMIDs:
None found

Sources:
PharmGKB FDA

Drug Info:

Year of Approval approved before 1982

Drug Class anti-arrhythmia agents

Drug Info:

Drug Indications Anti-Arrhythmia Agents

Drug Class small molecule

FDA Approval Approved before 1982

Alternate Names:

CHEMBL1294 ChEMBL Drug ID

Alternate Names:

C793 NCI drug code