DGIdb - QUINAPRIL Drug Record

QUINAPRIL chembl:CHEMBL1592 Approved

Alternate Names:

C09AA06
CI-906
QUINAPRIL
QUINAPRILUM
rxcui:35208
pubchem.compound:54892
chemidplus:85441-61-8
drugbank:00881
chembl:CHEMBL1592

Drug Info:

Drug Class	antihypertensive agents
Year of Approval	1991
FDA Approval	approved
Drug Class	Small Molecule
Drug Indications	antihypertensive agent
Drug Categories	agents causing angioedema
Drug Categories	agents causing hyperkalemia
Drug Categories	antihypertensive agents indicated for hypertension
Drug Categories	heterocyclic compounds, fused-ring
Drug Categories	oat3/slc22a8 substrates
Drug Categories	tetrahydroisoquinolines

(3 More Sources)

Publications:

Watanabe et al., 2003, Comparative effects of angiotensin II receptor blockade (candesartan) with angiotensin-converting enzyme inhibitor (quinapril) in rats with dilated cardiomyopathy., J. Cardiovasc. Pharmacol.
Toyofyuku et al., 2002, Influence of angiotensinogen M253T gene polymorphism and an angiotensin converting enzyme inhibitor on restenosis after percutaneous coronary intervention., Atherosclerosis
Song et al., 2002, Clinical pharmacokinetics and selective pharmacodynamics of new angiotensin converting enzyme inhibitors: an update., Clin Pharmacokinet
Culy et al., 2002, Quinapril: a further update of its pharmacology and therapeutic use in cardiovascular disorders., Drugs
Klutchko et al., 1986, Synthesis of novel angiotensin converting enzyme inhibitor quinapril and related compounds. A divergence of structure-activity relationships for non-sulfhydryl and sulfhydryl types., J. Med. Chem.
Potaczek DP et al., 2005, The angiotensin-converting enzyme gene insertion/deletion polymorphism and effects of quinapril and atorvastatin on haemostatic parameters in patients with coronary artery disease., Thromb Haemost
Chen et al., 2002, TTD: Therapeutic Target Database., Nucleic Acids Res.
Díez et al., 1997, Quinapril inhibits c-Myc expression and normalizes smooth muscle cell proliferation in spontaneously hypertensive rats., Am. J. Hypertens.

QUINAPRIL AGT

Interaction Score: 4.46

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
12693379 11849656

Sources:
NCI PharmGKB
QUINAPRIL ACE

Interaction Score: 2.67

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Trial Name quinapril hydrochloride,Accupril

Novel drug target Established target

PMIDs:
11929321 11817979 3020249 16116691 11752352

Sources:
TEND PharmGKB TdgClinicalTrial TTD DrugBank
QUINAPRIL MYC

Interaction Score: 0.9

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
9370386

Sources:
NCI

DrugBank: DB00881

Version: 5.1.7

Alternate Names:

QUINAPRIL DrugBank Drug Name

85441-61-8 CAS Number

Accupril Drug Brand

Drug Info:

Drug Type small molecule

Drug Groups approved

Drug Groups investigational

Publications:

Song et al., 2002, Clinical pharmacokinetics and selective pharmacodynamics of new angiotensin converting enzyme inhibitors: an update., Clin Pharmacokinet

Culy et al., 2002, Quinapril: a further update of its pharmacology and therapeutic use in cardiovascular disorders., Drugs

Klutchko et al., 1986, Synthesis of novel angiotensin converting enzyme inhibitor quinapril and related compounds. A divergence of structure-activity relationships for non-sulfhydryl and sulfhydryl types., J. Med. Chem.

TEND: QUINAPRIL
- Version: 01-August-2011
Alternate Names:

QUINAPRIL Primary Drug Name

Drug Info:

Year of Approval 1991

Drug Class antihypertensive agents

Publications:
TdgClinicalTrial: QUINAPRIL
- Version: January-2014
Alternate Names:

Drug Info:

Drug Indications antihypertensive agent

Drug Class Small Molecule

FDA Approval approved

Publications:

NCI: QUINAPRIL

Version: 14-September-2017

Alternate Names:

C29398 NCI drug code

Drug Info:

Publications:

Watanabe et al., 2003, Comparative effects of angiotensin II receptor blockade (candesartan) with angiotensin-converting enzyme inhibitor (quinapril) in rats with dilated cardiomyopathy., J. Cardiovasc. Pharmacol.

Toyofyuku et al., 2002, Influence of angiotensinogen M253T gene polymorphism and an angiotensin converting enzyme inhibitor on restenosis after percutaneous coronary intervention., Atherosclerosis

Díez et al., 1997, Quinapril inhibits c-Myc expression and normalizes smooth muscle cell proliferation in spontaneously hypertensive rats., Am. J. Hypertens.

PharmGKB: quinapril

Version: 18-August-2020

Alternate Names:

Drug Info:

Publications:

Toyofyuku et al., 2002, Influence of angiotensinogen M253T gene polymorphism and an angiotensin converting enzyme inhibitor on restenosis after percutaneous coronary intervention., Atherosclerosis

Potaczek DP et al., 2005, The angiotensin-converting enzyme gene insertion/deletion polymorphism and effects of quinapril and atorvastatin on haemostatic parameters in patients with coronary artery disease., Thromb Haemost

TTD: Quinapril
- Version: 2020.06.01
Alternate Names:

D0I7SZ TTD Drug ID

Drug Info:

Publications:
ChemblDrugs: chembl:CHEMBL1592
- Version: ChEMBL_27
Alternate Names:

Drug Info:

Publications:

Trial Name	quinapril hydrochloride,Accupril
Novel drug target	Established target

QUINAPRIL	DrugBank Drug Name
85441-61-8	CAS Number
Accupril	Drug Brand

Drug Type	small molecule
Drug Groups	approved
Drug Groups	investigational

QUINAPRIL Drug Record

QUINAPRIL chembl:CHEMBL1592 Approved

Alternate Names:

Drug Info:

Publications:

QUINAPRIL AGT

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 12693379 11849656

Sources: NCI PharmGKB

QUINAPRIL ACE

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Trial Name quinapril hydrochloride,Accupril Novel drug target Established target

PMIDs: 11929321 11817979 3020249 16116691 11752352

Sources: TEND PharmGKB TdgClinicalTrial TTD DrugBank

QUINAPRIL MYC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 9370386

Sources: NCI

DrugBank: DB00881

Alternate Names: QUINAPRIL DrugBank Drug Name 85441-61-8 CAS Number Accupril Drug Brand

Drug Info: Drug Type small molecule Drug Groups approved Drug Groups investigational

TEND: QUINAPRIL

Alternate Names: QUINAPRIL Primary Drug Name

Drug Info: Year of Approval 1991 Drug Class antihypertensive agents

Publications:

TdgClinicalTrial: QUINAPRIL

Alternate Names:

Drug Info: Drug Indications antihypertensive agent Drug Class Small Molecule FDA Approval approved

Publications:

NCI: QUINAPRIL

Alternate Names: C29398 NCI drug code

Drug Info:

PharmGKB: quinapril

Alternate Names:

Drug Info:

TTD: Quinapril

Alternate Names: D0I7SZ TTD Drug ID

Drug Info:

Publications:

ChemblDrugs: chembl:CHEMBL1592

Alternate Names:

Drug Info:

Publications:

Interaction Types & Directionality:

n/a

PMIDs:
12693379 11849656

Sources:
NCI PharmGKB

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Trial Name quinapril hydrochloride,Accupril

Novel drug target Established target

PMIDs:
11929321 11817979 3020249 16116691 11752352

Sources:
TEND PharmGKB TdgClinicalTrial TTD DrugBank

Interaction Types & Directionality:

n/a

PMIDs:
9370386

Sources:
NCI

Alternate Names:

QUINAPRIL DrugBank Drug Name

85441-61-8 CAS Number

Accupril Drug Brand

Drug Info:

Drug Type small molecule

Drug Groups approved

Drug Groups investigational

Alternate Names:

QUINAPRIL Primary Drug Name

Drug Info:

Year of Approval 1991

Drug Class antihypertensive agents

Drug Info:

Drug Indications antihypertensive agent

Drug Class Small Molecule

FDA Approval approved

Alternate Names:

C29398 NCI drug code

Alternate Names:

D0I7SZ TTD Drug ID