DGIdb - QUETIAPINE Drug Record

QUETIAPINE chembl:CHEMBL716 Approved

Alternate Names:

ZALURON XL
PSYQUET XL
SEROQUEL XL
MINTRELEQ XL
QUETIAPINE
BIQUELLE XL
EBESQUE XL
SEOTIAPIM XL
SONDATE XL
BRANCICO XL
TENPROLIDE XL
SEROQUEL
ATROLAK XL
2-[2-(4-DIBENZO[B,F][1,4]THIAZEPIN-11-YL-1-PIPERAZINYL)ETHOXY]ETHANOL
ZM-204636
QUETIAPINE FUMARATE
ICI 204636
SEROQUEL®
2-[2-(4-{2-THIA-9-AZATRICYCLO[9.4.0.0^{3,8}]PENTADECA-1(11),3(8),4,6,9,12,14-HEPTAEN-10-YL}PIPERAZIN-1-YL)ETHOXY]ETHAN-1-OL
ZD5077
QUETIAPINE HEMIFUMARATE
QUETIAPINUM
QUETIAPINA
rxcui:51272
pubchem.compound:5002
drugbank:01224
chembl:CHEMBL716
chemidplus:111974-69-7

Drug Info:

Year of Approval	1997
Drug Class	antipsychotic agents
Drug Class	Small Molecule
Drug Indications	antipsychotic agent,antidepressant
FDA Approval	approved

(2 More Sources)

Publications:

Thümmler S et al., 2018, Pharmacoresistant Severe Mental Health Disorders in Children and Adolescents: Functional Abnormalities of Cytochrome P450 2D6., Front Psychiatry
Stephan PL et al., 2006, Adverse drug reactions following nonresponse in a depressed patient with CYP2D6 deficiency and low CYP 3A4/5 activity., Pharmacopsychiatry
Nasrallah, 2008, Atypical antipsychotic-induced metabolic side effects: insights from receptor-binding profiles., Mol. Psychiatry
Cabaleiro T et al., 2015, Pharmacogenetics of quetiapine in healthy volunteers: association with pharmacokinetics, pharmacodynamics, and adverse effects., Int Clin Psychopharmacol
Vernaleken I et al., 2010, Dopamine D2/3 receptor occupancy by quetiapine in striatal and extrastriatal areas., Int J Neuropsychopharmacol
Bressan RA et al., 2003, Optimizing limbic selective D2/D3 receptor occupancy by risperidone: a [123I]-epidepride SPET study., J Clin Psychopharmacol
Tresadern G et al., 2011, Molecular properties affecting fast dissociation from the D2 receptor., Bioorg Med Chem
Richelson et al., 2000, Binding of antipsychotic drugs to human brain receptors focus on newer generation compounds., Life Sci.
Seeman, 2002, Atypical antipsychotics: mechanism of action., Can J Psychiatry
Chen et al., 2002, TTD: Therapeutic Target Database., Nucleic Acids Res.
Kapur et al., 2000, A positron emission tomography study of quetiapine in schizophrenia: a preliminary finding of an antipsychotic effect with only transiently high dopamine D2 receptor occupancy., Arch. Gen. Psychiatry
Tauscher J et al., 2004, Equivalent occupancy of dopamine D1 and D2 receptors with clozapine: differentiation from other atypical antipsychotics., Am J Psychiatry
Moallem N et al., 2012, Quetiapine improves response inhibition in alcohol dependent patients: a placebo-controlled pilot study., Pharmacol Biochem Behav
López-Rodríguez R et al., 2013, Pharmacodynamic genetic variants related to antipsychotic adverse reactions in healthy volunteers., Pharmacogenomics
McIntyre et al., 2007, A preclinical and clinical rationale for quetiapine in mood syndromes., Expert Opin Pharmacother
Goldstein, 1999, Quetiapine fumarate (Seroquel): a new atypical antipsychotic., Drugs Today
Yatham et al., 2005, Atypical antipsychotics in bipolar depression: potential mechanisms of action., J Clin Psychiatry
Kim KA et al., 2014, Influence of ABCB1 and CYP3A5 genetic polymorphisms on the pharmacokinetics of quetiapine in healthy volunteers., Pharmacogenet Genomics
Zanger UM et al., 2008, Functional pharmacogenetics/genomics of human cytochromes P450 involved in drug biotransformation., Anal Bioanal Chem
Nurmi EL et al., 2013, Moderation of antipsychotic-induced weight gain by energy balance gene variants in the RUPP autism network risperidone studies., Transl Psychiatry
Monteleone P et al., 2010, Endocannabinoid Pro129Thr FAAH functional polymorphism but not 1359G/A CNR1 polymorphism is associated with antipsychotic-induced weight gain., J Clin Psychopharmacol
Tiwari AK et al., 2010, A common polymorphism in the cannabinoid receptor 1 (CNR1) gene is associated with antipsychotic-induced weight gain in Schizophrenia., Neuropsychopharmacology
Wood et al., 2006, Pharmacological profile of antipsychotics at monoamine receptors: atypicality beyond 5-HT2A receptor blockade., CNS Neurol Disord Drug Targets
Ichikawa et al., 2002, Atypical antipsychotic drugs, quetiapine, iloperidone, and melperone, preferentially increase dopamine and acetylcholine release in rat medial prefrontal cortex: role of 5-HT1A receptor agonism., Brain Res.
Crisafulli C et al., 2012, Case-control association study for 10 genes in patients with schizophrenia: influence of 5HTR1A variation rs10042486 on schizophrenia and response to antipsychotics., Eur Arch Psychiatry Clin Neurosci
Vázquez-Bourgon J et al., 2010, Serotonin transporter polymorphisms and early response to antipsychotic treatment in first episode of psychosis., Psychiatry Res
Xu Q et al., 2016, Association studies of genomic variants with treatment response to risperidone, clozapine, quetiapine and chlorpromazine in the Chinese Han population., Pharmacogenomics J
Drago A et al., 2014, Genome-wide association study supports the role of the immunological system and of the neurodevelopmental processes in response to haloperidol treatment., Pharmacogenet Genomics
Opgen-Rhein C et al., 2010, Association of HTR2C, but not LEP or INSIG2, genes with antipsychotic-induced weight gain in a German sample., Pharmacogenomics
Porcelli S et al., 2016, PDE7B, NMBR and EPM2A Variants and Schizophrenia: A Case-Control and Pharmacogenetics Study., Neuropsychobiology
Zhang JP et al., 2016, Pharmacogenetic Associations of Antipsychotic Drug-Related Weight Gain: A Systematic Review and Meta-analysis., Schizophr Bull
Czerwensky F et al., 2013, MC4R rs489693: a clinical risk factor for second generation antipsychotic-related weight gain?, Int J Neuropsychopharmacol
Malhotra AK et al., 2012, Association between common variants near the melanocortin 4 receptor gene and severe antipsychotic drug-induced weight gain., Arch Gen Psychiatry
Delacrétaz A et al., 2017, Association of variants in SH2B1 and RABEP1 with worsening of low-density lipoprotein and glucose parameters in patients treated with psychotropic drugs., Gene

QUETIAPINE MIR582

Interaction Score: 2.29

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
PharmGKB
QUETIAPINE EIF2AK4

Interaction Score: 0.76

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
24751813

Sources:
PharmGKB
QUETIAPINE MC4R

Interaction Score: 0.72

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
27217270 23920449 23799528 22566560

Sources:
PharmGKB
QUETIAPINE EPM2A

Interaction Score: 0.65

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
27092952

Sources:
PharmGKB
QUETIAPINE RABEP1

Interaction Score: 0.51

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
28694205

Sources:
PharmGKB
QUETIAPINE SH2B1

Interaction Score: 0.51

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
28694205

Sources:
PharmGKB
QUETIAPINE HTR1A

Interaction Score: 0.33

Interaction Types & Directionality:

partial agonist (activating)

agonist (activating)

antagonist (inhibitory)

Interaction Info:

PMIDs:
17563257 11132243 16918396 17848919 12445705 22120873

Sources:
TEND PharmGKB
QUETIAPINE CNR1

Interaction Score: 0.29

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
23799528 20631561 20107430

Sources:
PharmGKB
QUETIAPINE HTR2C

Interaction Score: 0.27

Interaction Types & Directionality:

ligand

antagonist (inhibitory)

Interaction Info:

Trial Name Seroquel

Novel drug target Established target

PMIDs:
11132243 17848919 20504252

Sources:
TdgClinicalTrial TEND PharmGKB
QUETIAPINE HTR2B

Interaction Score: 0.27

Interaction Types & Directionality:

n/a

Interaction Info:

Novel drug target Established target

Trial Name Seroquel

PMIDs:
None found

Sources:
TdgClinicalTrial TEND
QUETIAPINE FAAH

Interaction Score: 0.22

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
20631561

Sources:
PharmGKB
QUETIAPINE DRD3

Interaction Score: 0.18

Interaction Types & Directionality:

ligand

antagonist (inhibitory)

Interaction Info:

PMIDs:
17848919 25025989 20392299 12544369

Sources:
PharmGKB
QUETIAPINE HTR2A

Interaction Score: 0.16

Interaction Types & Directionality:

agonist (activating)

antagonist (inhibitory)

Interaction Info:

Trial Name Seroquel

Novel drug target Established target

PMIDs:
17563257 11132243 12973385 17848919 16038601

Sources:
TdgClinicalTrial TEND
QUETIAPINE COMT

Interaction Score: 0.14

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
26282453

Sources:
PharmGKB
QUETIAPINE DRD2

Interaction Score: 0.14

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Trial Name Seroquel

Novel drug target Established target

PMIDs:
21421319 11132243 11873706 17848919 11752352 10839333

Sources:
DTC TdgClinicalTrial TEND TTD
QUETIAPINE SLC6A4

Interaction Score: 0.13

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
23859574 20031235

Sources:
PharmGKB
QUETIAPINE GRIN2B

Interaction Score: 0.12

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
23859574

Sources:
PharmGKB
QUETIAPINE ADRA1B

Interaction Score: 0.11

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

PMIDs:
11132243 17848919

Sources:
TEND
QUETIAPINE PDE4D

Interaction Score: 0.08

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
PharmGKB
QUETIAPINE CYP3A5

Interaction Score: 0.07

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
24240480 18695978

Sources:
PharmGKB
QUETIAPINE DRD1

Interaction Score: 0.06

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

PMIDs:
17848919 15337652 22037407

Sources:
TEND
QUETIAPINE HRH1

Interaction Score: 0.05

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

PMIDs:
11132243 17848919

Sources:
TEND
QUETIAPINE RGS4

Interaction Score: 0.02

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
PharmGKB
QUETIAPINE CYP2D6

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
29472872 16871470

Sources:
PharmGKB
QUETIAPINE CYP2C19

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
25025989

Sources:
PharmGKB
QUETIAPINE CYP1A2

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
25025989

Sources:
PharmGKB
QUETIAPINE CYP3A4

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC PharmGKB

TEND: QUETIAPINE
- Version: 01-August-2011
Alternate Names:

QUETIAPINE Primary Drug Name

Drug Info:

Year of Approval 1997

Drug Class antipsychotic agents

Publications:
TdgClinicalTrial: QUETIAPINE
- Version: January-2014
Alternate Names:

Drug Info:

FDA Approval approved

Drug Indications antipsychotic agent,antidepressant

Drug Class Small Molecule

Publications:
DTC: QUETIAPINE
- Version: 02-September-2020
Alternate Names:

CHEMBL716 ChEMBL Drug ID

Drug Info:

Publications:

Tresadern G et al., 2011, Molecular properties affecting fast dissociation from the D2 receptor., Bioorg Med Chem

PharmGKB: quetiapine

Version: 18-August-2020

Alternate Names:

Drug Info:

Publications:

Cabaleiro T et al., 2015, Pharmacogenetics of quetiapine in healthy volunteers: association with pharmacokinetics, pharmacodynamics, and adverse effects., Int Clin Psychopharmacol

Drago A et al., 2014, Genome-wide association study supports the role of the immunological system and of the neurodevelopmental processes in response to haloperidol treatment., Pharmacogenet Genomics

Monteleone P et al., 2010, Endocannabinoid Pro129Thr FAAH functional polymorphism but not 1359G/A CNR1 polymorphism is associated with antipsychotic-induced weight gain., J Clin Psychopharmacol

TTD: Quetiapine
- Version: 2020.06.01
Alternate Names:

D0H7KF TTD Drug ID

Drug Info:

Publications:
ChemblDrugs: chembl:CHEMBL716
- Version: ChEMBL_27
Alternate Names:

Drug Info:

Publications:

partial agonist (activating)
agonist (activating)
antagonist (inhibitory)

ligand
antagonist (inhibitory)

Trial Name	Seroquel
Novel drug target	Established target

Novel drug target	Established target
Trial Name	Seroquel

QUETIAPINE Drug Record

QUETIAPINE chembl:CHEMBL716 Approved

Alternate Names:

Drug Info:

Publications:

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: PharmGKB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 24751813

Sources: PharmGKB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 27217270 23920449 23799528 22566560

Sources: PharmGKB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 27092952

Sources: PharmGKB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 28694205

Sources: PharmGKB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 28694205

Sources: PharmGKB

Interaction Types & Directionality: partial agonist (activating) agonist (activating) antagonist (inhibitory)

Interaction Info:

PMIDs: 17563257 11132243 16918396 17848919 12445705 22120873

Sources: TEND PharmGKB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 23799528 20631561 20107430

Sources: PharmGKB

Interaction Types & Directionality: ligand antagonist (inhibitory)

Interaction Info: Trial Name Seroquel Novel drug target Established target

PMIDs: 11132243 17848919 20504252

Sources: TdgClinicalTrial TEND PharmGKB

Interaction Types & Directionality: n/a

Interaction Info: Novel drug target Established target Trial Name Seroquel

PMIDs: None found

Sources: TdgClinicalTrial TEND

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 20631561

Sources: PharmGKB

Interaction Types & Directionality: ligand antagonist (inhibitory)

Interaction Info:

PMIDs: 17848919 25025989 20392299 12544369

Sources: PharmGKB

Interaction Types & Directionality: agonist (activating) antagonist (inhibitory)

Interaction Info: Trial Name Seroquel Novel drug target Established target

PMIDs: 17563257 11132243 12973385 17848919 16038601

Sources: TdgClinicalTrial TEND

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 26282453

Sources: PharmGKB

Interaction Types & Directionality: antagonist (inhibitory)

Interaction Info: Trial Name Seroquel Novel drug target Established target

PMIDs: 21421319 11132243 11873706 17848919 11752352 10839333

Sources: DTC TdgClinicalTrial TEND TTD

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 23859574 20031235

Sources: PharmGKB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 23859574

Sources: PharmGKB

Interaction Types & Directionality: antagonist (inhibitory)

Interaction Info:

PMIDs: 11132243 17848919

Sources: TEND

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
24751813

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
27217270 23920449 23799528 22566560

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
27092952

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
28694205

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
28694205

Sources:
PharmGKB

Interaction Types & Directionality:

partial agonist (activating)

agonist (activating)

antagonist (inhibitory)

PMIDs:
17563257 11132243 16918396 17848919 12445705 22120873

Sources:
TEND PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
23799528 20631561 20107430

Sources:
PharmGKB

Interaction Types & Directionality:

ligand

antagonist (inhibitory)

Interaction Info:

Trial Name Seroquel

Novel drug target Established target

PMIDs:
11132243 17848919 20504252

Sources:
TdgClinicalTrial TEND PharmGKB

Interaction Types & Directionality:

n/a

Interaction Info:

Novel drug target Established target

Trial Name Seroquel

PMIDs:
None found

Sources:
TdgClinicalTrial TEND

Interaction Types & Directionality:

n/a

PMIDs:
20631561

Sources:
PharmGKB

Interaction Types & Directionality:

ligand

antagonist (inhibitory)

PMIDs:
17848919 25025989 20392299 12544369

Sources:
PharmGKB

Interaction Types & Directionality:

agonist (activating)

antagonist (inhibitory)

Interaction Info:

Trial Name Seroquel

Novel drug target Established target

PMIDs:
17563257 11132243 12973385 17848919 16038601

Sources:
TdgClinicalTrial TEND

Interaction Types & Directionality:

n/a

PMIDs:
26282453

Sources:
PharmGKB

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Trial Name Seroquel

Novel drug target Established target

PMIDs:
21421319 11132243 11873706 17848919 11752352 10839333

Sources:
DTC TdgClinicalTrial TEND TTD

Interaction Types & Directionality:

n/a

PMIDs:
23859574 20031235

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
23859574

Sources:
PharmGKB

Interaction Types & Directionality:

antagonist (inhibitory)

PMIDs:
11132243 17848919

Sources:
TEND

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
24240480 18695978

Sources:
PharmGKB

Interaction Types & Directionality:

antagonist (inhibitory)

PMIDs:
17848919 15337652 22037407

Sources:
TEND

Interaction Types & Directionality:

antagonist (inhibitory)

PMIDs:
11132243 17848919

Sources:
TEND

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
29472872 16871470

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
25025989

Sources:
PharmGKB

Interaction Types & Directionality:

n/a