DGIdb - QUERCETIN Drug Record

NSC 57655
NSC 9219
SOPHORETIN
NSC-57655
LDN 0052529
NSC-9219
MELETIN
XANTHAURINE
LDN-0052529
C.I. NATURAL RED 1
QUERCETIN

Drug Categories	specialty uses of chemicals
Drug Categories	pyrans
Drug Categories	protective agents
Drug Categories	physiological effects of drugs
Drug Categories	pharmacologic actions
Drug Categories	p-glycoprotein/abcb1 inhibitors
Drug Categories	molecular mechanisms of pharmacological action
Drug Categories	heterocyclic compounds, 2-ring
Drug Categories	heterocyclic compounds, 1-ring
Drug Categories	heterocyclic compounds
Drug Categories	flavonols
Drug Categories	flavonoids
Drug Categories	cytochrome p-450 cyp2c8 inhibitors
Drug Categories	chromones
Drug Categories	chemical actions and uses
Drug Categories	benzopyrans
Drug Categories	bcrp/abcg2 inhibitors
Drug Categories	antioxidants
Drug Groups	experimental
Drug Type	small molecule
Drug Class	Kinase Inhibitors
Drug Categories	p-glycoprotein inhibitors
Drug Categories	oatp1b1/slco1b1 inhibitors
Drug Categories	heterocyclic compounds, fused-ring
Drug Categories	cytochrome p-450 enzyme inhibitors
Drug Categories	cytochrome p-450 cyp2c8 inhibitors (strength unknown)
Drug Categories	comt substrates
Drug Categories	comt inhibitors
Drug Categories	compounds used in a research, industrial, or household setting
Drug Groups	investigational

(2 More Sources)

Wang RE et al., 2009, Inhibition of heat shock induction of heat shock protein 70 and enhancement of heat shock protein 27 phosphorylation by quercetin derivatives., J Med Chem
Tanigawa et al., 2007, Action of Nrf2 and Keap1 in ARE-mediated NQO1 expression by quercetin., Free Radic. Biol. Med.
Angeloni et al., 2007, Role of quercetin and its in vivo metabolites in protecting H9c2 cells against oxidative stress., Biochimie
Amrutha K et al., 2014, Discovery of lesser known flavones as inhibitors of NF-κB signaling in MDA-MB-231 breast cancer cells--A SAR study., Bioorg Med Chem Lett
Lee et al., 2006, Quercetin arrests G2/M phase and induces caspase-dependent cell death in U937 cells., Cancer Lett.
Berman et al., 2000, The Protein Data Bank., Nucleic Acids Res.
Sabbah DA et al., 2012, Biological evaluation and docking studies of recently identified inhibitors of phosphoinositide-3-kinases., Bioorg Med Chem Lett
Kim et al., 2005, Quercetin decreases the expression of ErbB2 and ErbB3 proteins in HT-29 human colon cancer cells., J. Nutr. Biochem.
Lam et al., 2005, Fourier transform infrared spectroscopy evaluation of low density lipoprotein oxidation in the presence of quercetin, catechin, and alpha-tocopherol., Lipids
Aligiannis et al., 2001, Flavonoids as cycline-dependent kinase inhibitors: inhibition of cdc 25 phosphatase activity by flavonoids belonging to the quercetin and kaempferol series., Planta Med.
Kurata et al., 1992, Effects of phenol compounds, glutathione analogues and a diuretic drug on glutathione S-transferase, glutathione reductase and glutathione peroxidase from canine erythrocytes., Comp. Biochem. Physiol., B
Ciolino et al., 1999, Dietary flavonols quercetin and kaempferol are ligands of the aryl hydrocarbon receptor that affect CYP1A1 transcription differentially., Biochem. J.
Vasquez-Martinez Y et al., 2007, Structure-activity relationship studies of flavonoids as potent inhibitors of human platelet 12-hLO, reticulocyte 15-hLO-1, and prostate epithelial 15-hLO-2., Bioorg Med Chem
Nazir N et al., 2011, Evaluation of antioxidant and antimicrobial activities of Bergenin and its derivatives obtained by chemoenzymatic synthesis., Eur J Med Chem
Ueno et al., 1984, Interaction between quercetin and superoxide radicals. Reduction of the quercetin mutagenicity., J. Pharmacobio-dyn.
Sassano MF et al., 2013, Colloidal aggregation causes inhibition of G protein-coupled receptors., J Med Chem
Fiorelli et al., 1999, Estrogen synthesis in human colon cancer epithelial cells., J. Steroid Biochem. Mol. Biol.
Zahir A et al., 1996, DNA topoisomerase I inhibitors: cytotoxic flavones from Lethedon tannaensis., J Nat Prod
Larocca et al., 1991, Antiproliferative activity of quercetin on normal bone marrow and leukaemic progenitors., Br. J. Haematol.
Imming et al., 2006, Drugs, their targets and the nature and number of drug targets., Nat Rev Drug Discov
Overington et al., 2006, How many drug targets are there?, Nat Rev Drug Discov
Aquino et al., 1998, The constitutive heat shock protein-70 is required for optimal expression of myelin basic protein during differentiation of oligodendrocytes., Neurochem. Res.
Deora et al., Down-modulation of P210bcr/abl induces apoptosis/differentiation in K562 leukemic blast cells., Tumori
Constantinou A et al., 1995, Flavonoids as DNA topoisomerase antagonists and poisons: structure-activity relationships., J Nat Prod
Atrahimovich D et al., 2013, The effects and mechanism of flavonoid-rePON1 interactions. Structure-activity relationship study., Bioorg Med Chem
Wang RE et al., 2011, Biotinylated quercetin as an intrinsic photoaffinity proteomics probe for the identification of quercetin target proteins., Bioorg Med Chem
Hong H et al., 2015, Human sex hormone-binding globulin binding affinities of 125 structurally diverse chemicals and comparison with their binding to androgen receptor, estrogen receptor, and α-fetoprotein., Toxicol Sci
Kuiper GG et al., 1998, Interaction of estrogenic chemicals and phytoestrogens with estrogen receptor beta., Endocrinology
Leung LK et al., 2004, Effect of dietary flavonols on oestrogen receptor transactivation and cell death induction., Br J Nutr
van der Woude H et al., 2005, The stimulation of cell proliferation by quercetin is mediated by the estrogen receptor., Mol Nutr Food Res
Maggiolini M et al., 2001, Estrogen receptor alpha mediates the proliferative but not the cytotoxic dose-dependent effects of two major phytoestrogens on human breast cancer cells., Mol Pharmacol
Flaveny CA et al., 2009, Ligand selectivity and gene regulation by the human aryl hydrocarbon receptor in transgenic mice., Mol Pharmacol
Shimizu M et al., 2015, Quercetin represses apolipoprotein B expression by inhibiting the transcriptional activity of C/EBPβ., PLoS One
Hintzpeter J et al., 2015, Curcumin is a tight-binding inhibitor of the most efficient human daunorubicin reductase--Carbonyl reductase 1., Chem Biol Interact
Lau AJ et al., 2015, 3-Hydroxyflavone and structural analogues differentially activate pregnane X receptor: Implication for inflammatory bowel disease., Pharmacol Res
Shimada T et al., 2010, Structure-function relationships of inhibition of human cytochromes P450 1A1, 1A2, 1B1, 2C9, and 3A4 by 33 flavonoid derivatives., Chem Res Toxicol
Buryanovskyy et al., 2004, Crystal structure of quinone reductase 2 in complex with resveratrol., Biochemistry

Version: 5.1.7

Version: 14-September-2017

Version: 02-September-2020

QUERCETIN Drug Record

QUERCETIN chembl:CHEMBL50 Antineoplastic

Alternate Names:

Drug Info:

Publications:

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info:

Publications: Angeloni et al., 2007, Role of quercetin and its in vivo metabolites in protecting H9c2 cells against oxidative stress., Biochimie

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info:

Publications: Sabbah DA et al., 2012, Biological evaluation and docking studies of recently identified inhibitors of phosphoinositide-3-kinases., Bioorg Med Chem Lett Angeloni et al., 2007, Role of quercetin and its in vivo metabolites in protecting H9c2 cells against oxidative stress., Biochimie

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info:

Publications: Berman et al., 2000, The Protein Data Bank., Nucleic Acids Res.

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info:

Publications: Shimizu M et al., 2015, Quercetin represses apolipoprotein B expression by inhibiting the transcriptional activity of C/EBPβ., PLoS One

Interaction Types & Directionality: activator (activating)

Interaction Info:

Publications: Lau AJ et al., 2015, 3-Hydroxyflavone and structural analogues differentially activate pregnane X receptor: Implication for inflammatory bowel disease., Pharmacol Res

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info:

Publications: Buryanovskyy et al., 2004, Crystal structure of quinone reductase 2 in complex with resveratrol., Biochemistry

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info:

Publications:

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info:

Publications:

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info:

Publications:

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info:

Publications:

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info:

Publications:

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info:

Publications:

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info:

Publications:

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info:

Publications:

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info:

Publications:

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info:

Publications:

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info:

Publications:

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info:

Publications:

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info:

Publications:

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info:

Publications:

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info:

Publications:

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info:

Publications:

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info:

Publications:

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info:

Publications:

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info:

Publications:

Interaction Types & Directionality:

inhibitor (inhibitory)

Publications:

Angeloni et al., 2007, Role of quercetin and its in vivo metabolites in protecting H9c2 cells against oxidative stress., Biochimie

Interaction Types & Directionality:

inhibitor (inhibitory)

Publications:

Sabbah DA et al., 2012, Biological evaluation and docking studies of recently identified inhibitors of phosphoinositide-3-kinases., Bioorg Med Chem Lett

Angeloni et al., 2007, Role of quercetin and its in vivo metabolites in protecting H9c2 cells against oxidative stress., Biochimie

Interaction Types & Directionality:

inhibitor (inhibitory)

Publications:

Berman et al., 2000, The Protein Data Bank., Nucleic Acids Res.

Interaction Types & Directionality:

inhibitor (inhibitory)

Publications:

Shimizu M et al., 2015, Quercetin represses apolipoprotein B expression by inhibiting the transcriptional activity of C/EBPβ., PLoS One

Interaction Types & Directionality:

activator (activating)

Publications:

Lau AJ et al., 2015, 3-Hydroxyflavone and structural analogues differentially activate pregnane X receptor: Implication for inflammatory bowel disease., Pharmacol Res

Interaction Types & Directionality:

inhibitor (inhibitory)

Publications:

Buryanovskyy et al., 2004, Crystal structure of quinone reductase 2 in complex with resveratrol., Biochemistry

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Types & Directionality:

n/a

Publications:

Wang RE et al., 2009, Inhibition of heat shock induction of heat shock protein 70 and enhancement of heat shock protein 27 phosphorylation by quercetin derivatives., J Med Chem

Interaction Types & Directionality:

n/a

Publications:

Wang RE et al., 2009, Inhibition of heat shock induction of heat shock protein 70 and enhancement of heat shock protein 27 phosphorylation by quercetin derivatives., J Med Chem

Interaction Types & Directionality:

n/a

Publications:

Tanigawa et al., 2007, Action of Nrf2 and Keap1 in ARE-mediated NQO1 expression by quercetin., Free Radic. Biol. Med.

Interaction Types & Directionality:

n/a

Publications:

Amrutha K et al., 2014, Discovery of lesser known flavones as inhibitors of NF-κB signaling in MDA-MB-231 breast cancer cells--A SAR study., Bioorg Med Chem Lett