DGIdb - QUERCETIN Drug Record

QUERCETIN chembl:CHEMBL50 Antineoplastic

Alternate Names:

NSC 57655
NSC 9219
SOPHORETIN
NSC-57655
LDN 0052529
NSC-9219
MELETIN
XANTHAURINE
LDN-0052529
C.I. NATURAL RED 1
QUERCETIN

Drug Info:

Drug Categories	flavonols
Drug Categories	flavonoids
Drug Categories	chromones
Drug Class	Kinase Inhibitors
Drug Groups	investigational
Drug Categories	compounds used in a research, industrial, or household setting
Drug Categories	comt inhibitors
Drug Categories	comt substrates
Drug Categories	cytochrome p-450 cyp2c8 inhibitors (strength unknown)
Drug Categories	cytochrome p-450 enzyme inhibitors
Drug Categories	heterocyclic compounds, fused-ring
Drug Categories	oatp1b1/slco1b1 inhibitors
Drug Categories	p-glycoprotein inhibitors

(2 More Sources)

Publications:

Wang RE et al., 2009, Inhibition of heat shock induction of heat shock protein 70 and enhancement of heat shock protein 27 phosphorylation by quercetin derivatives., J Med Chem
Tanigawa et al., 2007, Action of Nrf2 and Keap1 in ARE-mediated NQO1 expression by quercetin., Free Radic. Biol. Med.
Angeloni et al., 2007, Role of quercetin and its in vivo metabolites in protecting H9c2 cells against oxidative stress., Biochimie
Amrutha K et al., 2014, Discovery of lesser known flavones as inhibitors of NF-κB signaling in MDA-MB-231 breast cancer cells--A SAR study., Bioorg Med Chem Lett
Lee et al., 2006, Quercetin arrests G2/M phase and induces caspase-dependent cell death in U937 cells., Cancer Lett.
Berman et al., 2000, The Protein Data Bank., Nucleic Acids Res.
Sabbah DA et al., 2012, Biological evaluation and docking studies of recently identified inhibitors of phosphoinositide-3-kinases., Bioorg Med Chem Lett
Kim et al., 2005, Quercetin decreases the expression of ErbB2 and ErbB3 proteins in HT-29 human colon cancer cells., J. Nutr. Biochem.
Lam et al., 2005, Fourier transform infrared spectroscopy evaluation of low density lipoprotein oxidation in the presence of quercetin, catechin, and alpha-tocopherol., Lipids
Aligiannis et al., 2001, Flavonoids as cycline-dependent kinase inhibitors: inhibition of cdc 25 phosphatase activity by flavonoids belonging to the quercetin and kaempferol series., Planta Med.
Kurata et al., 1992, Effects of phenol compounds, glutathione analogues and a diuretic drug on glutathione S-transferase, glutathione reductase and glutathione peroxidase from canine erythrocytes., Comp. Biochem. Physiol., B
Ciolino et al., 1999, Dietary flavonols quercetin and kaempferol are ligands of the aryl hydrocarbon receptor that affect CYP1A1 transcription differentially., Biochem. J.
Vasquez-Martinez Y et al., 2007, Structure-activity relationship studies of flavonoids as potent inhibitors of human platelet 12-hLO, reticulocyte 15-hLO-1, and prostate epithelial 15-hLO-2., Bioorg Med Chem
Nazir N et al., 2011, Evaluation of antioxidant and antimicrobial activities of Bergenin and its derivatives obtained by chemoenzymatic synthesis., Eur J Med Chem
Ueno et al., 1984, Interaction between quercetin and superoxide radicals. Reduction of the quercetin mutagenicity., J. Pharmacobio-dyn.
Sassano MF et al., 2013, Colloidal aggregation causes inhibition of G protein-coupled receptors., J Med Chem
Fiorelli et al., 1999, Estrogen synthesis in human colon cancer epithelial cells., J. Steroid Biochem. Mol. Biol.
Zahir A et al., 1996, DNA topoisomerase I inhibitors: cytotoxic flavones from Lethedon tannaensis., J Nat Prod
Larocca et al., 1991, Antiproliferative activity of quercetin on normal bone marrow and leukaemic progenitors., Br. J. Haematol.
Imming et al., 2006, Drugs, their targets and the nature and number of drug targets., Nat Rev Drug Discov
Overington et al., 2006, How many drug targets are there?, Nat Rev Drug Discov
Aquino et al., 1998, The constitutive heat shock protein-70 is required for optimal expression of myelin basic protein during differentiation of oligodendrocytes., Neurochem. Res.
Deora et al., Down-modulation of P210bcr/abl induces apoptosis/differentiation in K562 leukemic blast cells., Tumori
Constantinou A et al., 1995, Flavonoids as DNA topoisomerase antagonists and poisons: structure-activity relationships., J Nat Prod
Atrahimovich D et al., 2013, The effects and mechanism of flavonoid-rePON1 interactions. Structure-activity relationship study., Bioorg Med Chem
Maggiolini M et al., 2001, Estrogen receptor alpha mediates the proliferative but not the cytotoxic dose-dependent effects of two major phytoestrogens on human breast cancer cells., Mol Pharmacol
Kuiper GG et al., 1998, Interaction of estrogenic chemicals and phytoestrogens with estrogen receptor beta., Endocrinology
van der Woude H et al., 2005, The stimulation of cell proliferation by quercetin is mediated by the estrogen receptor., Mol Nutr Food Res
Leung LK et al., 2004, Effect of dietary flavonols on oestrogen receptor transactivation and cell death induction., Br J Nutr
Lau AJ et al., 2015, 3-Hydroxyflavone and structural analogues differentially activate pregnane X receptor: Implication for inflammatory bowel disease., Pharmacol Res
Shimizu M et al., 2015, Quercetin represses apolipoprotein B expression by inhibiting the transcriptional activity of C/EBPβ., PLoS One
Flaveny CA et al., 2009, Ligand selectivity and gene regulation by the human aryl hydrocarbon receptor in transgenic mice., Mol Pharmacol
Wang RE et al., 2011, Biotinylated quercetin as an intrinsic photoaffinity proteomics probe for the identification of quercetin target proteins., Bioorg Med Chem
Hintzpeter J et al., 2015, Curcumin is a tight-binding inhibitor of the most efficient human daunorubicin reductase--Carbonyl reductase 1., Chem Biol Interact
Buryanovskyy et al., 2004, Crystal structure of quinone reductase 2 in complex with resveratrol., Biochemistry
Shimada T et al., 2010, Structure-function relationships of inhibition of human cytochromes P450 1A1, 1A2, 1B1, 2C9, and 3A4 by 33 flavonoid derivatives., Chem Res Toxicol
Hong H et al., 2015, Human sex hormone-binding globulin binding affinities of 125 structurally diverse chemicals and comparison with their binding to androgen receptor, estrogen receptor, and α-fetoprotein., Toxicol Sci

QUERCETIN RUVBL2

Interaction Score: 1.08

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
21798748

Sources:
DrugBank
QUERCETIN HSPA2

Interaction Score: 1.08

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
21798748

Sources:
DrugBank
QUERCETIN EIF3F

Interaction Score: 1.08

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
21798748

Sources:
DrugBank
QUERCETIN CEBPB

Interaction Score: 1.08

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

PMIDs:
25875015

Sources:
DrugBank
QUERCETIN HIBCH

Interaction Score: 1.08

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
10592235

Sources:
DrugBank
QUERCETIN CSNK2B

Interaction Score: 0.54

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
21798748

Sources:
DrugBank
QUERCETIN STK17B

Interaction Score: 0.54

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
10592235

Sources:
DrugBank
QUERCETIN UGT3A1

Interaction Score: 0.54

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
10592235

Sources:
DrugBank
QUERCETIN ATP5C1

Interaction Score: 0.54

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
10592235

Sources:
DrugBank
QUERCETIN UBA1

Interaction Score: 0.36

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
21798748

Sources:
DrugBank
QUERCETIN SF3B3

Interaction Score: 0.36

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
21798748

Sources:
DrugBank
QUERCETIN ATP5A1

Interaction Score: 0.36

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
10592235

Sources:
DrugBank
QUERCETIN ATP5B

Interaction Score: 0.36

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
10592235

Sources:
DrugBank
QUERCETIN GABPA

Interaction Score: 0.36

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
17462537

Sources:
NCI
QUERCETIN HSF1

Interaction Score: 0.36

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
19296652

Sources:
DTC
QUERCETIN ACTB

Interaction Score: 0.27

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
21798748

Sources:
DrugBank
QUERCETIN CD34

Interaction Score: 0.27

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
1772777

Sources:
NCI
QUERCETIN PKN3

Interaction Score: 0.27

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

PMIDs:
None found

Sources:
MyCancerGenome
QUERCETIN CDC25C

Interaction Score: 0.27

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
11488465

Sources:
NCI
QUERCETIN MBP

Interaction Score: 0.22

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
9482255

Sources:
NCI
QUERCETIN PKN1

Interaction Score: 0.14

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

PMIDs:
None found

Sources:
MyCancerGenome
QUERCETIN CBR1

Interaction Score: 0.11

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
25541467

Sources:
DrugBank
QUERCETIN PON1

Interaction Score: 0.11

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
23623675

Sources:
DTC
QUERCETIN HCK

Interaction Score: 0.09

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
10592235 17016423 17139284

Sources:
DrugBank
QUERCETIN XDH

Interaction Score: 0.09

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
21474216 6099408

Sources:
DTC NCI
QUERCETIN E2F1

Interaction Score: 0.07

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
16274926

Sources:
NCI
QUERCETIN APOB

Interaction Score: 0.06

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
16149735

Sources:
NCI
QUERCETIN PRKCH

Interaction Score: 0.05

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

PMIDs:
None found

Sources:
MyCancerGenome
QUERCETIN PRKD1

Interaction Score: 0.05

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

PMIDs:
None found

Sources:
MyCancerGenome
QUERCETIN GSR

Interaction Score: 0.05

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
1478066

Sources:
NCI
QUERCETIN PRKCZ

Interaction Score: 0.05

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

PMIDs:
None found

Sources:
MyCancerGenome
QUERCETIN PRKCI

Interaction Score: 0.05

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

PMIDs:
None found

Sources:
MyCancerGenome
QUERCETIN GALK1

Interaction Score: 0.05

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
QUERCETIN NQO2

Interaction Score: 0.04

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

PMIDs:
15350128

Sources:
DrugBank
QUERCETIN CYP1A1

Interaction Score: 0.04

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
10359656

Sources:
NCI
QUERCETIN AVPR2

Interaction Score: 0.04

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
23437772

Sources:
DTC
QUERCETIN SHBG

Interaction Score: 0.04

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
25349334

Sources:
DrugBank
QUERCETIN PIK3C2A

Interaction Score: 0.04

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

PMIDs:
None found

Sources:
MyCancerGenome
QUERCETIN PIK3R6

Interaction Score: 0.03

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

PMIDs:
None found

Sources:
MyCancerGenome
QUERCETIN PIK3R4

Interaction Score: 0.03

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

PMIDs:
None found

Sources:
MyCancerGenome
QUERCETIN PIK3C2B

Interaction Score: 0.03

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

PMIDs:
None found

Sources:
MyCancerGenome
QUERCETIN PRKCE

Interaction Score: 0.03

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

PMIDs:
None found

Sources:
MyCancerGenome
QUERCETIN HSPB1

Interaction Score: 0.03

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
19296652

Sources:
DTC
QUERCETIN CYP1B1

Interaction Score: 0.03

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
21053930

Sources:
DrugBank
QUERCETIN PIK3C3

Interaction Score: 0.03

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

PMIDs:
None found

Sources:
MyCancerGenome
QUERCETIN GPR35

Interaction Score: 0.03

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
QUERCETIN PIK3C2G

Interaction Score: 0.03

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

PMIDs:
None found

Sources:
MyCancerGenome
QUERCETIN CYP19A1

Interaction Score: 0.03

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
10704911

Sources:
NCI
QUERCETIN PRKCQ

Interaction Score: 0.03

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

PMIDs:
None found

Sources:
MyCancerGenome
QUERCETIN ESR2

Interaction Score: 0.03

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
11502892 9751507 15937998 15182386

Sources:
DrugBank
QUERCETIN PKN2

Interaction Score: 0.03

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

PMIDs:
None found

Sources:
MyCancerGenome
QUERCETIN PRKCB

Interaction Score: 0.03

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

PMIDs:
None found

Sources:
MyCancerGenome
QUERCETIN CSNK2A1

Interaction Score: 0.02

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
21798748

Sources:
DrugBank
QUERCETIN PIK3CB

Interaction Score: 0.02

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

PMIDs:
17045724

Sources:
MyCancerGenome NCI
QUERCETIN MAPK3

Interaction Score: 0.02

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
17045724

Sources:
NCI
QUERCETIN PIM1

Interaction Score: 0.02

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
10592235

Sources:
DrugBank
QUERCETIN BAX

Interaction Score: 0.02

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
15741050

Sources:
NCI
QUERCETIN NFKB2

Interaction Score: 0.02

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
25190466

Sources:
DTC
QUERCETIN PRKCG

Interaction Score: 0.02

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

PMIDs:
None found

Sources:
MyCancerGenome
QUERCETIN RELA

Interaction Score: 0.02

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
25190466

Sources:
DTC
QUERCETIN PRKCA

Interaction Score: 0.02

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

PMIDs:
None found

Sources:
MyCancerGenome
QUERCETIN PIK3CA

Interaction Score: 0.02

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

PMIDs:
22212721 17045724

Sources:
DTC MyCancerGenome NCI
QUERCETIN PIK3R5

Interaction Score: 0.02

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

PMIDs:
None found

Sources:
MyCancerGenome
QUERCETIN TOP2A

Interaction Score: 0.02

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
8759170 7769390

Sources:
DTC
QUERCETIN PRKD2

Interaction Score: 0.02

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

PMIDs:
None found

Sources:
MyCancerGenome
QUERCETIN PIK3R3

Interaction Score: 0.02

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

PMIDs:
None found

Sources:
MyCancerGenome
QUERCETIN PIK3R1

Interaction Score: 0.02

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

PMIDs:
None found

Sources:
MyCancerGenome
QUERCETIN PRKCD

Interaction Score: 0.02

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

PMIDs:
None found

Sources:
MyCancerGenome
QUERCETIN PIK3R2

Interaction Score: 0.01

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

PMIDs:
None found

Sources:
MyCancerGenome
QUERCETIN PRKD3

Interaction Score: 0.01

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

PMIDs:
None found

Sources:
MyCancerGenome
QUERCETIN PIK3CG

Interaction Score: 0.01

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

PMIDs:
10592235

Sources:
DrugBank MyCancerGenome
QUERCETIN AHR

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
19299563

Sources:
DrugBank
QUERCETIN ABL1

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
9349317

Sources:
NCI
QUERCETIN NFKB1

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
25190466

Sources:
DTC
QUERCETIN ESR1

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
11502892 9751507 15937998 15182386

Sources:
DrugBank
QUERCETIN TOP1

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
8759170

Sources:
DTC
QUERCETIN ALOX15B

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
QUERCETIN PIK3CD

Interaction Score: 0.01

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

PMIDs:
None found

Sources:
MyCancerGenome
QUERCETIN NR1I2

Interaction Score: 0.01

Interaction Types & Directionality:

activator (activating)

Interaction Info:

PMIDs:
26238175

Sources:
DrugBank
QUERCETIN ALOX15

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
17869117

Sources:
DTC
QUERCETIN F2

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
QUERCETIN HSP90AA1

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
21798748

Sources:
DrugBank
QUERCETIN BLM

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
QUERCETIN MPHOSPH8

Interaction Score: 0.0

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
QUERCETIN HIF1A

Interaction Score: 0.0

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
QUERCETIN POLH

Interaction Score: 0.0

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
QUERCETIN RECQL

Interaction Score: 0.0

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
QUERCETIN APEX1

Interaction Score: 0.0

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
QUERCETIN POLB

Interaction Score: 0.0

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
QUERCETIN DRD1

Interaction Score: 0.0

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
QUERCETIN FEN1

Interaction Score: 0.0

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
QUERCETIN YES1

Interaction Score: 0.0

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
QUERCETIN POLI

Interaction Score: 0.0

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
QUERCETIN HPGD

Interaction Score: 0.0

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
QUERCETIN POLK

Interaction Score: 0.0

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
QUERCETIN KDM4E

Interaction Score: 0.0

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
QUERCETIN ATAD5

Interaction Score: 0.0

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
QUERCETIN ALDH1A1

Interaction Score: 0.0

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
QUERCETIN HSD17B10

Interaction Score: 0.0

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
QUERCETIN CYP2C9

Interaction Score: 0.0

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
QUERCETIN MAPT

Interaction Score: 0.0

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
QUERCETIN CYP2C19

Interaction Score: 0.0

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
QUERCETIN CYP1A2

Interaction Score: 0.0

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
QUERCETIN EHMT2

Interaction Score: 0.0

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
QUERCETIN CYP3A4

Interaction Score: 0.0

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC

DrugBank: DB04216

Version: 5.1.7

Alternate Names:

QUERCETIN DrugBank Drug Name

117-39-5 CAS Number

CHEMBL50 ChEMBL ID

Drug Info:

Drug Type small molecule

Drug Groups experimental

Drug Groups investigational

Publications:

Berman et al., 2000, The Protein Data Bank., Nucleic Acids Res.

Leung LK et al., 2004, Effect of dietary flavonols on oestrogen receptor transactivation and cell death induction., Br J Nutr

van der Woude H et al., 2005, The stimulation of cell proliferation by quercetin is mediated by the estrogen receptor., Mol Nutr Food Res

MyCancerGenome: SOPHORETIN
- Version: 20-Jun-2017
Alternate Names:

SOPHORETIN Generic Name

QUERCETIN Generic Name

Drug Info:

Drug Class Kinase Inhibitors

Publications:

NCI: QUERCETIN

Version: 14-September-2017

Alternate Names:

C792 NCI drug code

Drug Info:

Publications:

Tanigawa et al., 2007, Action of Nrf2 and Keap1 in ARE-mediated NQO1 expression by quercetin., Free Radic. Biol. Med.

Ciolino et al., 1999, Dietary flavonols quercetin and kaempferol are ligands of the aryl hydrocarbon receptor that affect CYP1A1 transcription differentially., Biochem. J.

Larocca et al., 1991, Antiproliferative activity of quercetin on normal bone marrow and leukaemic progenitors., Br. J. Haematol.

DTC: QUERCETIN

Version: 02-September-2020

Alternate Names:

CHEMBL50 ChEMBL Drug ID

Drug Info:

Publications:

Wang RE et al., 2009, Inhibition of heat shock induction of heat shock protein 70 and enhancement of heat shock protein 27 phosphorylation by quercetin derivatives., J Med Chem

Atrahimovich D et al., 2013, The effects and mechanism of flavonoid-rePON1 interactions. Structure-activity relationship study., Bioorg Med Chem

Constantinou A et al., 1995, Flavonoids as DNA topoisomerase antagonists and poisons: structure-activity relationships., J Nat Prod

TTD: Quercetin
- Version: 2020.06.01
Alternate Names:

D0K8KX TTD Drug ID

Drug Info:

Publications:
ChemblDrugs: chembl:CHEMBL50
- Version: ChEMBL_27
Alternate Names:

Drug Info:

Publications:

QUERCETIN	DrugBank Drug Name
117-39-5	CAS Number
CHEMBL50	ChEMBL ID

Drug Type	small molecule
Drug Groups	experimental
Drug Groups	investigational

QUERCETIN Drug Record

QUERCETIN chembl:CHEMBL50 Antineoplastic

Alternate Names:

Drug Info:

Publications:

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 21798748

Sources: DrugBank

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 21798748

Sources: DrugBank

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 21798748

Sources: DrugBank

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info:

PMIDs: 25875015

Sources: DrugBank

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 10592235

Sources: DrugBank

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 21798748

Sources: DrugBank

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 10592235

Sources: DrugBank

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 10592235

Sources: DrugBank

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 10592235

Sources: DrugBank

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 21798748

Sources: DrugBank

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 21798748

Sources: DrugBank

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 10592235

Sources: DrugBank

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 10592235

Sources: DrugBank

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 17462537

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 19296652

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 21798748

Sources: DrugBank

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 1772777

Sources: NCI

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info:

PMIDs: None found

Sources: MyCancerGenome

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 11488465

Interaction Types & Directionality:

n/a

PMIDs:
21798748

Sources:
DrugBank

Interaction Types & Directionality:

n/a

PMIDs:
21798748

Sources:
DrugBank

Interaction Types & Directionality:

n/a

PMIDs:
21798748

Sources:
DrugBank

Interaction Types & Directionality:

inhibitor (inhibitory)

PMIDs:
25875015

Sources:
DrugBank

Interaction Types & Directionality:

n/a

PMIDs:
10592235

Sources:
DrugBank

Interaction Types & Directionality:

n/a

PMIDs:
21798748

Sources:
DrugBank

Interaction Types & Directionality:

n/a

PMIDs:
10592235

Sources:
DrugBank

Interaction Types & Directionality:

n/a

PMIDs:
10592235

Sources:
DrugBank

Interaction Types & Directionality:

n/a

PMIDs:
10592235

Sources:
DrugBank

Interaction Types & Directionality:

n/a

PMIDs:
21798748

Sources:
DrugBank

Interaction Types & Directionality:

n/a

PMIDs:
21798748

Sources:
DrugBank

Interaction Types & Directionality:

n/a

PMIDs:
10592235

Sources:
DrugBank

Interaction Types & Directionality:

n/a

PMIDs:
10592235

Sources:
DrugBank

Interaction Types & Directionality:

n/a

PMIDs:
17462537

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
19296652

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
21798748

Sources:
DrugBank

Interaction Types & Directionality:

n/a

PMIDs:
1772777

Sources:
NCI

Interaction Types & Directionality:

inhibitor (inhibitory)

PMIDs:
None found

Sources:
MyCancerGenome

Interaction Types & Directionality:

n/a

PMIDs:
11488465

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
9482255

Sources:
NCI

Interaction Types & Directionality:

inhibitor (inhibitory)

PMIDs:
None found

Sources:
MyCancerGenome

Interaction Types & Directionality:

n/a

PMIDs:
25541467

Sources:
DrugBank

Interaction Types & Directionality:

n/a

PMIDs:
23623675

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
10592235 17016423 17139284

Sources:
DrugBank

Interaction Types & Directionality:

n/a

PMIDs:
21474216 6099408

Sources:
DTC NCI

Interaction Types & Directionality:

n/a

PMIDs:
16274926

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
16149735