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PSEUDOEPHEDRINE Drug Record

  • Summary
  • Interactions
  • Claims
  • PSEUDOEPHEDRINE chembl:CHEMBL1590 Approved

    Alternate Names:

    PSEUDOEPHEDRINE
    PSEUDOEPHEDRINE D-FORM
    PSI-EPHEDRINE
    (+)-PSEUDOEPHEDRINE
    PSEUDOPHEDRINE SULPHATE
    (+)-THREO-EPHEDRINE
    D-ISOEPHEDRINE
    ISOEPHEDRINE
    D-PSI-2-METHYLAMINO-1-PHENYL-1-PROPANOL
    (+) THREO-2-(METHYLAMINO)-1-PHENYL-1-PROPANOL
    Ψ-EPHEDRINE
    (+)-(1S,2S)-PSEUDOEPHEDRINE
    (1S,2S)-PSEUDOEPHEDRINE
    SUDAFED®
    PSI-EPHEDRIN
    (1S,2S)-(+)-PSEUDOEPHEDRINE
    (+)-PSI-EPHEDRINE
    PSEUDOEPHEDRINE HYDROCHLORIDE
    PSEUDOEFEDRINA
    2-(METHYLAMINO)-1-PHENYL-1-PROPANOL
    PSEUDOEPHEDRINUM
    L-(+)-PSEUDOEPHEDRINE
    D-PSI-EPHEDRINE
    D-PSEUDOEPHEDRINE BASE
    PSEUDOÉPHÉDRINE
    SINUTAB®
    D-PSEUDOEPHEDRINE
    L(+)-PSI-EPHEDRINE
    TRANS-EPHEDRINE
    drugbank:00852
    chembl:CHEMBL1590
    chemidplus:90-82-4
    pubchem.compound:7028
    rxcui:8896

    Drug Info:

    FDA Approval approved
    Drug Class Small Molecule
    Drug Indications antiallergy agent
    Drug Categories nasal decongestants for systemic use
    Drug Categories sympathomimetics
    Year of Approval approved before 1982
    Drug Class vasoconstrictor agents
    Drug Class bronchodilator agents
    Drug Class nasal decongestants
    Drug Categories adrenergic alpha-1 receptor agonists
    Drug Categories adrenergic alpha-2 receptor agonists
    Drug Categories adrenergic alpha-agonists
    Drug Categories adrenergic beta-agonists
    Drug Categories agents producing tachycardia
    Drug Categories agents that produce hypertension
    Drug Categories alpha-and beta-adrenergic agonists
    Drug Categories hyperglycemia-associated agents
    Drug Categories monoamine oxidase a inhibitors for interaction with monoamine oxidase a substrates
    Drug Categories norepinephrine releasing agent
    Drug Categories serotonergic drugs shown to increase risk of serotonin syndrome
    Drug Categories sympathomimetic (adrenergic) agents
    (2 More Sources)

    Publications:

    Fiebich et al., 2012, Pseudoephedrine inhibits T-cell activation by targeting NF-κB, NFAT and AP-1 signaling pathways., Immunopharmacol Immunotoxicol
    Wee et al., 2004, Reinforcing effect of pseudoephedrine isomers and the mechanism of action., Eur. J. Pharmacol.
    Foley et al., 2002, Stereospecific inhibition of monoamine uptake transporters by meta-hydroxyephedrine isomers., J Neural Transm (Vienna)
    Overington et al., 2006, How many drug targets are there?, Nat Rev Drug Discov
    Imming et al., 2006, Drugs, their targets and the nature and number of drug targets., Nat Rev Drug Discov
    Johnson DA et al., 1993, The pharmacology of alpha-adrenergic decongestants., Pharmacotherapy
    Wellington et al., 2001, Cetirizine/pseudoephedrine., Drugs
    Wu et al., 2014, Pseudoephedrine/ephedrine shows potent anti-inflammatory activity against TNF-α-mediated acute liver failure induced by lipopolysaccharide/D-galactosamine., Eur. J. Pharmacol.
    Vansal et al., 1999, Direct effects of ephedrine isomers on human beta-adrenergic receptor subtypes., Biochem. Pharmacol.
  • PSEUDOEPHEDRINE   NFATC1

    Interaction Score: 4.94

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:

    PMIDs:
    21631396


    Sources:
    DrugBank

  • PSEUDOEPHEDRINE   ATF1

    Interaction Score: 4.94

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:

    PMIDs:
    21631396


    Sources:
    DrugBank

  • PSEUDOEPHEDRINE   GLA

    Interaction Score: 0.21

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • PSEUDOEPHEDRINE   IL2

    Interaction Score: 0.13

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:

    PMIDs:
    21631396


    Sources:
    DrugBank

  • PSEUDOEPHEDRINE   SLC6A2

    Interaction Score: 0.13

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Trial Name fexofenadine + ps/
    Novel drug target Established target

    PMIDs:
    12373557 15189772


    Sources:
    TdgClinicalTrial DrugBank

  • PSEUDOEPHEDRINE   SLC6A3

    Interaction Score: 0.12

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Trial Name fexofenadine + ps/
    Novel drug target Established target

    PMIDs:
    12373557 15189772


    Sources:
    TdgClinicalTrial DrugBank

  • PSEUDOEPHEDRINE   ADRA2A

    Interaction Score: 0.11

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Trial Name fexofenadine + ps/
    Novel drug target Established target

    PMIDs:
    17139284 17016423 7507588


    Sources:
    TEND TdgClinicalTrial DrugBank

  • PSEUDOEPHEDRINE   ADRA1A

    Interaction Score: 0.1

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Trial Name fexofenadine + ps/
    Novel drug target Established target

    PMIDs:
    11772135 17139284 17016423 7507588


    Sources:
    TEND TdgClinicalTrial DrugBank

  • PSEUDOEPHEDRINE   TNF

    Interaction Score: 0.08

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:

    PMIDs:
    24365491 21631396


    Sources:
    DrugBank

  • PSEUDOEPHEDRINE   SLC6A4

    Interaction Score: 0.08

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Trial Name fexofenadine + ps/
    Novel drug target Established target

    PMIDs:
    15189772


    Sources:
    TdgClinicalTrial DrugBank

  • PSEUDOEPHEDRINE   ADRB2

    Interaction Score: 0.08

    Interaction Types & Directionality:
    partial agonist (activating)

    Interaction Info:

    PMIDs:
    17139284 10449190 17016423


    Sources:
    TEND DrugBank

  • PSEUDOEPHEDRINE   PKM

    Interaction Score: 0.06

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • PSEUDOEPHEDRINE   NFKB1

    Interaction Score: 0.05

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:

    PMIDs:
    21631396


    Sources:
    DrugBank

  • PSEUDOEPHEDRINE   ADRB1

    Interaction Score: 0.04

    Interaction Types & Directionality:
    partial agonist (activating)
    agonist (activating)

    Interaction Info:

    PMIDs:
    10449190


    Sources:
    DrugBank

  • PSEUDOEPHEDRINE   ALOX15B

    Interaction Score: 0.04

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • PSEUDOEPHEDRINE   THPO

    Interaction Score: 0.03

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • PSEUDOEPHEDRINE   ALOX15

    Interaction Score: 0.02

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • PSEUDOEPHEDRINE   DRD2

    Interaction Score: 0.01

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    TTD

  • PSEUDOEPHEDRINE   HSD17B10

    Interaction Score: 0.01

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • PSEUDOEPHEDRINE   CYP2C9

    Interaction Score: 0.01

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • PSEUDOEPHEDRINE   CYP2C19

    Interaction Score: 0.01

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • PSEUDOEPHEDRINE   CYP2D6

    Interaction Score: 0.0

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • PSEUDOEPHEDRINE   CYP3A4

    Interaction Score: 0.0

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • DrugBank: DB00852

    • Version: 5.1.7

    Alternate Names:
    90-82-4 CAS Number
    12 Hour Allergy D Drug Brand
    12 Hour Allergy and Congestion Drug Brand

    Drug Info:
    Drug Type small molecule
    Drug Groups approved
    Drug Categories adrenergic agonists

    Publications:
    Foley et al., 2002, Stereospecific inhibition of monoamine uptake transporters by meta-hydroxyephedrine isomers., J Neural Transm (Vienna)
    Wee et al., 2004, Reinforcing effect of pseudoephedrine isomers and the mechanism of action., Eur. J. Pharmacol.
    Wellington et al., 2001, Cetirizine/pseudoephedrine., Drugs

  • TdgClinicalTrial: PSEUDOEPHEDRINE

    • Version: January-2014

    Alternate Names:

    Drug Info:
    Drug Indications antiallergy agent
    Drug Class Small Molecule
    FDA Approval approved

    Publications:

  • TEND: PSEUDOEPHEDRINE

    • Version: 01-August-2011

    Alternate Names:

    Drug Info:
    Drug Class nasal decongestants
    Drug Class bronchodilator agents
    Drug Class vasoconstrictor agents

    Publications:

  • DTC: PSEUDOEPHEDRINE

    • Version: 02-September-2020

    Alternate Names:
    CHEMBL1590 ChEMBL Drug ID

    Drug Info:

    Publications:

  • TTD: Pseudoephedrine

    • Version: 2020.06.01

    Alternate Names:
    D00HHS TTD Drug ID

    Drug Info:

    Publications:

  • ChemblDrugs: chembl:CHEMBL1590

    • Version: ChEMBL_27

    Alternate Names:

    Drug Info:

    Publications:

Disclaimer: This resource is intended for purely research purposes. It should not be used for emergencies or medical or professional advice.

A finding of a drug-gene interaction or potentially druggable category does not necessarily indicate effectiveness (or lack thereof) of any drug or treatment regimen. A finding of no interaction or no potentially druggable category does not necessarily indicate lack of effectiveness of any drug or treatment regimen. Drug-gene interactions or potentially druggable categories are not presented in ranked order of potential or predicted efficacy.

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DGIdb (v4.2.0 - sha1 afd9f30b) • Last updated 2020-10-21