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PROPRANOLOL Drug Record

  • Summary
  • Interactions
  • Claims
  • PROPRANOLOL chembl:CHEMBL27 Approved

    Alternate Names:

    INDERIDE-80/25
    AY-64043-
    INDERIDE-40/25
    INDERAL
    PROPRANOLOL

    Drug Info:

    Drug Categories phenoxypropanolamines
    Drug Class anti-arrhythmia agents
    Drug Class antihypertensive agents
    Year of Approval 1967
    FDA Approval approved
    Drug Class Small Molecule
    Drug Indications for treatment of cancer cachexia
    Drug Categories agents causing hyperkalemia
    Drug Categories antiarrhythmic agents
    Drug Categories antihypertensive agents indicated for hypertension
    Drug Categories beta blocking agents and thiazides
    Drug Categories beta blocking agents, non-selective
    Drug Categories beta blocking agents, non-selective, and thiazides
    Drug Categories cytochrome p-450 cyp3a substrates
    Drug Categories cytochrome p-450 cyp3a5 substrates
    Drug Categories cytochrome p-450 cyp3a7 substrates
    Drug Categories cytochrome p-450 enzyme inhibitors
    Drug Categories cytochrome p-450 substrates
    Drug Categories drugs that are mainly renally excreted
    Drug Categories moderate risk qtc-prolonging agents
    Drug Categories monoamine oxidase a inhibitors for interaction with monoamine oxidase a substrates
    Drug Categories oct2 inhibitors
    Drug Categories p-glycoprotein inhibitors
    Drug Categories p-glycoprotein substrates
    Drug Categories qtc prolonging agents
    Drug Categories vasodilating agents
    (6 More Sources)

    Publications:

    Woiciechowsky et al., 2004, Brain-IL-1 beta triggers astrogliosis through induction of IL-6: inhibition by propranolol and IL-10., Med. Sci. Monit.
    Illingworth et al., 2006, Classical polarization in hybrid QM/MM methods., J Phys Chem A
    el Tayar N et al., 1988, Modeling of beta-adrenoceptors based on molecular electrostatic potential studies of agonists and antagonists., J Med Chem
    Horinouchi et al., 2007, Different changes of plasma membrane beta-adrenoceptors in rat heart after chronic administration of propranolol, atenolol and bevantolol., Life Sci.
    Chen et al., 2002, TTD: Therapeutic Target Database., Nucleic Acids Res.
    Rouget et al., 2006, Stimulation of the ADRB3 adrenergic receptor induces relaxation of human placental arteries: influence of preeclampsia., Biol. Reprod.
    MacDonald ML et al., 2006, Identifying off-target effects and hidden phenotypes of drugs in human cells., Nat Chem Biol
    Isaza et al., 2005, Polymorphic variants of the beta2-adrenergic receptor (ADRB2) gene and ADRB2-related propanolol-induced dyslipidemia in the Colombian population., Methods Find Exp Clin Pharmacol
    Rezmann-Vitti et al., 2004, Site-directed mutagenesis of the rat beta1-adrenoceptor. Involvement of Tyr356 (7.43) in (+/-)cyanopindolol but not (+/-)[125Iodo]cyanopindolol binding., Eur J Med Chem
    Lewis et al., 2004, Overexpression of beta 1-adrenoceptors in adult rat ventricular myocytes enhances CGP 12177A cardiostimulation: implications for 'putative' beta 4-adrenoceptor pharmacology., Br. J. Pharmacol.
    Yazawa et al., 2007, Verrucotoxin, a stonefish venom, modulates calcium channel activity in guinea-pig ventricular myocytes., Br. J. Pharmacol.
    D'Emanuele et al., 2004, The use of a dendrimer-propranolol prodrug to bypass efflux transporters and enhance oral bioavailability., J Control Release
    Bailey et al., 1998, Evidence for different 5-HT1B/1D receptors mediating vasoconstriction of equine digital arteries and veins., Eur. J. Pharmacol.
    Choppin et al., 1995, Presence of vasoconstrictor 5HT1-like receptors revealed by precontraction of rabbit isolated mesenteric artery., Br. J. Pharmacol.
    Kaliman et al., 1999, Regulation of delta-aminolevulinate synthase activity during the development of oxidative stress., Biochemistry Mosc.
    Sakatis MZ et al., 2012, Preclinical strategy to reduce clinical hepatotoxicity using in vitro bioactivation data for >200 compounds., Chem Res Toxicol
    Smejkal-Jagar et al., 1995, Serotonin and serotoninergic agents affect proliferation of normal and transformed lymphoid cells., Immunopharmacol Immunotoxicol
    Ward et al., 2004, Development of an in vivo preclinical screen model to estimate absorption and first-pass hepatic extraction of xenobiotics. II. Use of ketoconazole to identify P-glycoprotein/CYP3A-limited bioavailability in the monkey., Drug Metab. Dispos.
    Buchhorn et al., 2003, Effects of therapeutic beta blockade on myocardial function and cardiac remodelling in congenital cardiac disease., Cardiol Young
    Reid et al., 2005, Effects of a beta-blocker on bone turnover in normal postmenopausal women: a randomized controlled trial., J. Clin. Endocrinol. Metab.
    Van Hoomissen et al., 2004, Effects of beta-adrenoreceptor blockade during chronic exercise on contextual fear conditioning and mRNA for galanin and brain-derived neurotrophic factor., Behav. Neurosci.
    Kozawa et al., 2001, Stimulatory effect of basic fibroblast growth factor on induction of heat shock protein 27 in osteoblasts: role of protein kinase C., Arch. Biochem. Biophys.
    Berg et al., 2010, Role of beta1-3-adrenoceptors in blood pressure control at rest and during tyramine-induced norepinephrine release in spontaneously hypertensive rats., Hypertension
    Hirose et al., 1997, Pituitary adenylate cyclase-activating polypeptide-27 causes a biphasic chronotropic effect and atrial fibrillation in autonomically decentralized, anesthetized dogs., J. Pharmacol. Exp. Ther.
  • PROPRANOLOL   ADCYAP1

    Interaction Score: 2.99

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    9353360


    Sources:
    NCI

  • PROPRANOLOL   HSPB2

    Interaction Score: 0.66

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    11368160


    Sources:
    NCI

  • PROPRANOLOL   CTGF

    Interaction Score: 0.31

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    12691286


    Sources:
    NCI

  • PROPRANOLOL   ADRB1

    Interaction Score: 0.28

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Trial Name VT-122
    Novel drug target Established target

    PMIDs:
    15236843 2903243 14757703 17628611 17572694 11752352 16177222


    Sources:
    TEND DTC TdgClinicalTrial TTD DrugBank

  • PROPRANOLOL   GFAP

    Interaction Score: 0.24

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    15328477


    Sources:
    NCI

  • PROPRANOLOL   ADRB3

    Interaction Score: 0.23

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Specific Action of the Ligand Antagonist
    Endogenous Drug? False
    Direct Interaction? True

    PMIDs:
    20231523 11752352


    Sources:
    DrugBank GuideToPharmacology

  • PROPRANOLOL   BGLAP

    Interaction Score: 0.22

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    15998769


    Sources:
    NCI

  • PROPRANOLOL   ADRB2

    Interaction Score: 0.22

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Direct Interaction? True
    Endogenous Drug? False
    Specific Action of the Ligand Antagonist

    PMIDs:
    16706406 2903243 17628611 11752352 16177222 16680159 16082424


    Sources:
    TEND DTC PharmGKB DrugBank GuideToPharmacology

  • PROPRANOLOL   HTR1B

    Interaction Score: 0.12

    Interaction Types & Directionality:
    other/unknown

    Interaction Info:

    PMIDs:
    9760032 7881730


    Sources:
    DrugBank

  • PROPRANOLOL   BDNF

    Interaction Score: 0.09

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    15598146


    Sources:
    NCI

  • PROPRANOLOL   G6PD

    Interaction Score: 0.08

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    10395986


    Sources:
    NCI

  • PROPRANOLOL   HTR1A

    Interaction Score: 0.04

    Interaction Types & Directionality:
    other/unknown

    Interaction Info:

    PMIDs:
    7759768


    Sources:
    DrugBank

  • PROPRANOLOL   ABCB1

    Interaction Score: 0.04

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    15023456


    Sources:
    NCI PharmGKB

  • PROPRANOLOL   CYP2D6

    Interaction Score: 0.02

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    22931300


    Sources:
    DTC FDA

  • PROPRANOLOL   CYP2C9

    Interaction Score: 0.01

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    22931300


    Sources:
    DTC

  • PROPRANOLOL   CYP3A4

    Interaction Score: 0.01

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    14744938 22931300


    Sources:
    NCI DTC

  • PROPRANOLOL   CYP2C19

    Interaction Score: 0.01

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    22931300


    Sources:
    DTC

  • PROPRANOLOL   CYP1A2

    Interaction Score: 0.01

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    22931300


    Sources:
    DTC

  • PROPRANOLOL   EHMT2

    Interaction Score: 0.0

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • DrugBank: DB00571

    • Version: 5.1.7

    Alternate Names:
    525-66-6 CAS Number
    Angilol Drug Brand
    Apo Propranolol Tab 10mg Drug Brand

    Drug Info:
    Drug Type small molecule
    Drug Groups approved
    Drug Groups investigational

    Publications:
    Illingworth et al., 2006, Classical polarization in hybrid QM/MM methods., J Phys Chem A
    Horinouchi et al., 2007, Different changes of plasma membrane beta-adrenoceptors in rat heart after chronic administration of propranolol, atenolol and bevantolol., Life Sci.
    Chen et al., 2002, TTD: Therapeutic Target Database., Nucleic Acids Res.

  • TdgClinicalTrial: PROPRANOLOL

    • Version: January-2014

    Alternate Names:

    Drug Info:
    Drug Indications for treatment of cancer cachexia
    Drug Class Small Molecule
    FDA Approval approved

    Publications:

  • TEND: PROPRANOLOL

    • Version: 01-August-2011

    Alternate Names:

    Drug Info:
    Year of Approval 1967
    Drug Class antihypertensive agents
    Drug Class anti-arrhythmia agents

    Publications:

  • DTC: PROPRANOLOL

    • Version: 02-September-2020

    Alternate Names:
    CHEMBL27 ChEMBL Drug ID

    Drug Info:

    Publications:
    Sakatis MZ et al., 2012, Preclinical strategy to reduce clinical hepatotoxicity using in vitro bioactivation data for >200 compounds., Chem Res Toxicol
    el Tayar N et al., 1988, Modeling of beta-adrenoceptors based on molecular electrostatic potential studies of agonists and antagonists., J Med Chem
    MacDonald ML et al., 2006, Identifying off-target effects and hidden phenotypes of drugs in human cells., Nat Chem Biol

  • NCI: PROPRANOLOL

    • Version: 14-September-2017

    Alternate Names:
    C29382 NCI drug code

    Drug Info:

    Publications:
    Woiciechowsky et al., 2004, Brain-IL-1 beta triggers astrogliosis through induction of IL-6: inhibition by propranolol and IL-10., Med. Sci. Monit.
    Van Hoomissen et al., 2004, Effects of beta-adrenoreceptor blockade during chronic exercise on contextual fear conditioning and mRNA for galanin and brain-derived neurotrophic factor., Behav. Neurosci.
    Kozawa et al., 2001, Stimulatory effect of basic fibroblast growth factor on induction of heat shock protein 27 in osteoblasts: role of protein kinase C., Arch. Biochem. Biophys.

  • TTD: Propranolol

    • Version: 2020.06.01

    Alternate Names:
    D04JEE TTD Drug ID

    Drug Info:

    Publications:

  • ChemblDrugs: chembl:CHEMBL27

    • Version: ChEMBL_27

    Alternate Names:

    Drug Info:

    Publications:

  • GuideToPharmacology: 135650858

    • Version: 29-September-2020

    Alternate Names:

    Drug Info:

    Publications:

  • PharmGKB: propranolol

    • Version: 18-August-2020

    Alternate Names:

    Drug Info:

    Publications:

  • FDA: Propranolol

    • Version: 04-September-2020

    Alternate Names:

    Drug Info:

    Publications:

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A finding of a drug-gene interaction or potentially druggable category does not necessarily indicate effectiveness (or lack thereof) of any drug or treatment regimen. A finding of no interaction or no potentially druggable category does not necessarily indicate lack of effectiveness of any drug or treatment regimen. Drug-gene interactions or potentially druggable categories are not presented in ranked order of potential or predicted efficacy.

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DGIdb (v4.2.0 - sha1 afd9f30b) • Last updated 2021-04-13