DGIdb - PROPRANOLOL Drug Record

PROPRANOLOL chembl:CHEMBL27 Approved

Alternate Names:

INDERIDE-80/25
AY-64043-
INDERIDE-40/25
INDERAL
PROPRANOLOL

Drug Info:

Drug Categories	phenoxypropanolamines
Drug Class	anti-arrhythmia agents
Drug Class	antihypertensive agents
Year of Approval	1967
FDA Approval	approved
Drug Class	Small Molecule
Drug Indications	for treatment of cancer cachexia
Drug Categories	agents causing hyperkalemia
Drug Categories	antiarrhythmic agents
Drug Categories	antihypertensive agents indicated for hypertension
Drug Categories	beta blocking agents and thiazides
Drug Categories	beta blocking agents, non-selective
Drug Categories	beta blocking agents, non-selective, and thiazides
Drug Categories	cytochrome p-450 cyp3a substrates
Drug Categories	cytochrome p-450 cyp3a5 substrates
Drug Categories	cytochrome p-450 cyp3a7 substrates
Drug Categories	cytochrome p-450 enzyme inhibitors
Drug Categories	cytochrome p-450 substrates
Drug Categories	drugs that are mainly renally excreted
Drug Categories	moderate risk qtc-prolonging agents
Drug Categories	monoamine oxidase a inhibitors for interaction with monoamine oxidase a substrates
Drug Categories	oct2 inhibitors
Drug Categories	p-glycoprotein inhibitors
Drug Categories	p-glycoprotein substrates
Drug Categories	qtc prolonging agents
Drug Categories	vasodilating agents

(6 More Sources)

Publications:

Woiciechowsky et al., 2004, Brain-IL-1 beta triggers astrogliosis through induction of IL-6: inhibition by propranolol and IL-10., Med. Sci. Monit.
Illingworth et al., 2006, Classical polarization in hybrid QM/MM methods., J Phys Chem A
el Tayar N et al., 1988, Modeling of beta-adrenoceptors based on molecular electrostatic potential studies of agonists and antagonists., J Med Chem
Horinouchi et al., 2007, Different changes of plasma membrane beta-adrenoceptors in rat heart after chronic administration of propranolol, atenolol and bevantolol., Life Sci.
Chen et al., 2002, TTD: Therapeutic Target Database., Nucleic Acids Res.
Rouget et al., 2006, Stimulation of the ADRB3 adrenergic receptor induces relaxation of human placental arteries: influence of preeclampsia., Biol. Reprod.
MacDonald ML et al., 2006, Identifying off-target effects and hidden phenotypes of drugs in human cells., Nat Chem Biol
Isaza et al., 2005, Polymorphic variants of the beta2-adrenergic receptor (ADRB2) gene and ADRB2-related propanolol-induced dyslipidemia in the Colombian population., Methods Find Exp Clin Pharmacol
Rezmann-Vitti et al., 2004, Site-directed mutagenesis of the rat beta1-adrenoceptor. Involvement of Tyr356 (7.43) in (+/-)cyanopindolol but not (+/-)[125Iodo]cyanopindolol binding., Eur J Med Chem
Lewis et al., 2004, Overexpression of beta 1-adrenoceptors in adult rat ventricular myocytes enhances CGP 12177A cardiostimulation: implications for 'putative' beta 4-adrenoceptor pharmacology., Br. J. Pharmacol.
Yazawa et al., 2007, Verrucotoxin, a stonefish venom, modulates calcium channel activity in guinea-pig ventricular myocytes., Br. J. Pharmacol.
D'Emanuele et al., 2004, The use of a dendrimer-propranolol prodrug to bypass efflux transporters and enhance oral bioavailability., J Control Release
Bailey et al., 1998, Evidence for different 5-HT1B/1D receptors mediating vasoconstriction of equine digital arteries and veins., Eur. J. Pharmacol.
Choppin et al., 1995, Presence of vasoconstrictor 5HT1-like receptors revealed by precontraction of rabbit isolated mesenteric artery., Br. J. Pharmacol.
Kaliman et al., 1999, Regulation of delta-aminolevulinate synthase activity during the development of oxidative stress., Biochemistry Mosc.
Sakatis MZ et al., 2012, Preclinical strategy to reduce clinical hepatotoxicity using in vitro bioactivation data for >200 compounds., Chem Res Toxicol
Smejkal-Jagar et al., 1995, Serotonin and serotoninergic agents affect proliferation of normal and transformed lymphoid cells., Immunopharmacol Immunotoxicol
Ward et al., 2004, Development of an in vivo preclinical screen model to estimate absorption and first-pass hepatic extraction of xenobiotics. II. Use of ketoconazole to identify P-glycoprotein/CYP3A-limited bioavailability in the monkey., Drug Metab. Dispos.
Buchhorn et al., 2003, Effects of therapeutic beta blockade on myocardial function and cardiac remodelling in congenital cardiac disease., Cardiol Young
Reid et al., 2005, Effects of a beta-blocker on bone turnover in normal postmenopausal women: a randomized controlled trial., J. Clin. Endocrinol. Metab.
Van Hoomissen et al., 2004, Effects of beta-adrenoreceptor blockade during chronic exercise on contextual fear conditioning and mRNA for galanin and brain-derived neurotrophic factor., Behav. Neurosci.
Kozawa et al., 2001, Stimulatory effect of basic fibroblast growth factor on induction of heat shock protein 27 in osteoblasts: role of protein kinase C., Arch. Biochem. Biophys.
Berg et al., 2010, Role of beta1-3-adrenoceptors in blood pressure control at rest and during tyramine-induced norepinephrine release in spontaneously hypertensive rats., Hypertension
Hirose et al., 1997, Pituitary adenylate cyclase-activating polypeptide-27 causes a biphasic chronotropic effect and atrial fibrillation in autonomically decentralized, anesthetized dogs., J. Pharmacol. Exp. Ther.

PROPRANOLOL ADCYAP1

Interaction Score: 2.99

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
9353360

Sources:
NCI
PROPRANOLOL HSPB2

Interaction Score: 0.66

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
11368160

Sources:
NCI
PROPRANOLOL CTGF

Interaction Score: 0.31

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
12691286

Sources:
NCI
PROPRANOLOL ADRB1

Interaction Score: 0.28

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Trial Name VT-122

Novel drug target Established target

PMIDs:
15236843 2903243 14757703 17628611 17572694 11752352 16177222

Sources:
TEND DTC TdgClinicalTrial TTD DrugBank
PROPRANOLOL GFAP

Interaction Score: 0.24

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
15328477

Sources:
NCI
PROPRANOLOL ADRB3

Interaction Score: 0.23

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Specific Action of the Ligand Antagonist

Endogenous Drug? False

Direct Interaction? True

PMIDs:
20231523 11752352

Sources:
DrugBank GuideToPharmacology
PROPRANOLOL BGLAP

Interaction Score: 0.22

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
15998769

Sources:
NCI
PROPRANOLOL ADRB2

Interaction Score: 0.22

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Direct Interaction? True

Endogenous Drug? False

Specific Action of the Ligand Antagonist

PMIDs:
16706406 2903243 17628611 11752352 16177222 16680159 16082424

Sources:
TEND DTC PharmGKB DrugBank GuideToPharmacology
PROPRANOLOL HTR1B

Interaction Score: 0.12

Interaction Types & Directionality:

other/unknown

Interaction Info:

PMIDs:
9760032 7881730

Sources:
DrugBank
PROPRANOLOL BDNF

Interaction Score: 0.09

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
15598146

Sources:
NCI
PROPRANOLOL G6PD

Interaction Score: 0.08

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
10395986

Sources:
NCI
PROPRANOLOL HTR1A

Interaction Score: 0.04

Interaction Types & Directionality:

other/unknown

Interaction Info:

PMIDs:
7759768

Sources:
DrugBank
PROPRANOLOL ABCB1

Interaction Score: 0.04

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
15023456

Sources:
NCI PharmGKB
PROPRANOLOL CYP2D6

Interaction Score: 0.02

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
22931300

Sources:
DTC FDA
PROPRANOLOL CYP2C9

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
22931300

Sources:
DTC
PROPRANOLOL CYP3A4

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
14744938 22931300

Sources:
NCI DTC
PROPRANOLOL CYP2C19

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
22931300

Sources:
DTC
PROPRANOLOL CYP1A2

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
22931300

Sources:
DTC
PROPRANOLOL EHMT2

Interaction Score: 0.0

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC

DrugBank: DB00571

Version: 5.1.7

Alternate Names:

525-66-6 CAS Number

Angilol Drug Brand

Apo Propranolol Tab 10mg Drug Brand

Drug Info:

Drug Type small molecule

Drug Groups approved

Drug Groups investigational

Publications:

Illingworth et al., 2006, Classical polarization in hybrid QM/MM methods., J Phys Chem A

Horinouchi et al., 2007, Different changes of plasma membrane beta-adrenoceptors in rat heart after chronic administration of propranolol, atenolol and bevantolol., Life Sci.

Chen et al., 2002, TTD: Therapeutic Target Database., Nucleic Acids Res.

TdgClinicalTrial: PROPRANOLOL
- Version: January-2014
Alternate Names:

Drug Info:

Drug Indications for treatment of cancer cachexia

Drug Class Small Molecule

FDA Approval approved

Publications:
TEND: PROPRANOLOL
- Version: 01-August-2011
Alternate Names:

Drug Info:

Year of Approval 1967

Drug Class antihypertensive agents

Drug Class anti-arrhythmia agents

Publications:

DTC: PROPRANOLOL

Version: 02-September-2020

Alternate Names:

CHEMBL27 ChEMBL Drug ID

Drug Info:

Publications:

Sakatis MZ et al., 2012, Preclinical strategy to reduce clinical hepatotoxicity using in vitro bioactivation data for >200 compounds., Chem Res Toxicol

el Tayar N et al., 1988, Modeling of beta-adrenoceptors based on molecular electrostatic potential studies of agonists and antagonists., J Med Chem

MacDonald ML et al., 2006, Identifying off-target effects and hidden phenotypes of drugs in human cells., Nat Chem Biol

NCI: PROPRANOLOL

Version: 14-September-2017

Alternate Names:

C29382 NCI drug code

Drug Info:

Publications:

Woiciechowsky et al., 2004, Brain-IL-1 beta triggers astrogliosis through induction of IL-6: inhibition by propranolol and IL-10., Med. Sci. Monit.

Van Hoomissen et al., 2004, Effects of beta-adrenoreceptor blockade during chronic exercise on contextual fear conditioning and mRNA for galanin and brain-derived neurotrophic factor., Behav. Neurosci.

Kozawa et al., 2001, Stimulatory effect of basic fibroblast growth factor on induction of heat shock protein 27 in osteoblasts: role of protein kinase C., Arch. Biochem. Biophys.

TTD: Propranolol
- Version: 2020.06.01
Alternate Names:

D04JEE TTD Drug ID

Drug Info:

Publications:
ChemblDrugs: chembl:CHEMBL27
- Version: ChEMBL_27
Alternate Names:

Drug Info:

Publications:
GuideToPharmacology: 135650858
- Version: 29-September-2020
Alternate Names:

Drug Info:

Publications:
PharmGKB: propranolol
- Version: 18-August-2020
Alternate Names:

Drug Info:

Publications:
FDA: Propranolol
- Version: 04-September-2020
Alternate Names:

Drug Info:

Publications:

Specific Action of the Ligand	Antagonist
Endogenous Drug?	False
Direct Interaction?	True

525-66-6	CAS Number
Angilol	Drug Brand
Apo Propranolol Tab 10mg	Drug Brand

Drug Type	small molecule
Drug Groups	approved
Drug Groups	investigational

Trial Name	VT-122
Novel drug target	Established target

PROPRANOLOL Drug Record

PROPRANOLOL chembl:CHEMBL27 Approved

Alternate Names:

Drug Info:

Publications:

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 9353360

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 11368160

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 12691286

Sources: NCI

Interaction Types & Directionality: antagonist (inhibitory)

Interaction Info: Trial Name VT-122 Novel drug target Established target

PMIDs: 15236843 2903243 14757703 17628611 17572694 11752352 16177222

Sources: TEND DTC TdgClinicalTrial TTD DrugBank

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 15328477

Sources: NCI

Interaction Types & Directionality: antagonist (inhibitory)

Interaction Info: Specific Action of the Ligand Antagonist Endogenous Drug? False Direct Interaction? True

PMIDs: 20231523 11752352

Sources: DrugBank GuideToPharmacology

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 15998769

Sources: NCI

Interaction Types & Directionality: antagonist (inhibitory)

Interaction Info: Direct Interaction? True Endogenous Drug? False Specific Action of the Ligand Antagonist

PMIDs: 16706406 2903243 17628611 11752352 16177222 16680159 16082424

Sources: TEND DTC PharmGKB DrugBank GuideToPharmacology

Interaction Types & Directionality: other/unknown

Interaction Info:

PMIDs: 9760032 7881730

Sources: DrugBank

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 15598146

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 10395986

Sources: NCI

Interaction Types & Directionality: other/unknown

Interaction Info:

PMIDs: 7759768

Sources: DrugBank

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 15023456

Sources: NCI PharmGKB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 22931300

Sources: DTC FDA

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 22931300

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 14744938 22931300

Sources: NCI DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 22931300

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 22931300

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Interaction Types & Directionality:

n/a

PMIDs:
9353360

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
11368160

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
12691286

Sources:
NCI

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Trial Name VT-122

Novel drug target Established target

PMIDs:
15236843 2903243 14757703 17628611 17572694 11752352 16177222

Sources:
TEND DTC TdgClinicalTrial TTD DrugBank

Interaction Types & Directionality:

n/a

PMIDs:
15328477

Sources:
NCI

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Specific Action of the Ligand Antagonist

Endogenous Drug? False

Direct Interaction? True

PMIDs:
20231523 11752352

Sources:
DrugBank GuideToPharmacology

Interaction Types & Directionality:

n/a

PMIDs:
15998769

Sources:
NCI

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Direct Interaction? True

Endogenous Drug? False

Specific Action of the Ligand Antagonist

PMIDs:
16706406 2903243 17628611 11752352 16177222 16680159 16082424

Sources:
TEND DTC PharmGKB DrugBank GuideToPharmacology

Interaction Types & Directionality:

other/unknown

PMIDs:
9760032 7881730

Sources:
DrugBank

Interaction Types & Directionality:

n/a

PMIDs:
15598146

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
10395986

Sources:
NCI

Interaction Types & Directionality:

other/unknown

PMIDs:
7759768

Sources:
DrugBank

Interaction Types & Directionality:

n/a

PMIDs:
15023456

Sources:
NCI PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
22931300

Sources:
DTC FDA

Interaction Types & Directionality:

n/a

PMIDs:
22931300

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
14744938 22931300

Sources:
NCI DTC

Interaction Types & Directionality:

n/a

PMIDs:
22931300

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
22931300

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Alternate Names:

525-66-6 CAS Number

Angilol Drug Brand

Apo Propranolol Tab 10mg Drug Brand

Drug Info:

Drug Type small molecule

Drug Groups approved

Drug Groups investigational

Drug Info:

Drug Indications for treatment of cancer cachexia

Drug Class Small Molecule

FDA Approval approved

Drug Info:

Year of Approval 1967

Drug Class antihypertensive agents

Drug Class anti-arrhythmia agents

Alternate Names:

CHEMBL27 ChEMBL Drug ID

Alternate Names:

C29382 NCI drug code

Alternate Names:

D04JEE TTD Drug ID