DGIdb - PROPOFOL Drug Record

PROPOFOL chembl:CHEMBL526 Approved

Alternate Names:

ICI 35-868
DISOPRIVAN
PROPOFOL
DISOPROFOL
NSC-5105
RAPINOVET
ICI-35868
ICI35,868
DIPRIVAN
ICI 35868
DIPRIVAN®
2,6-DIISOPROPYLPHENOL
PROPOFOLUM
2,6-BIS(1-METHYLETHYL)PHENOL
drugbank:00818
pubchem.compound:4943
rxcui:8782
chemidplus:2078-54-8
chembl:CHEMBL526

Drug Info:

Year of Approval	1989
Drug Class	hypnotics and sedatives
FDA Approval	approved
Drug Class	small molecule
Drug Indications	sedative

(3 More Sources)

Publications:

Haeseler et al., 2008, High-affinity blockade of voltage-operated skeletal muscle and neuronal sodium channels by halogenated propofol analogues., Br. J. Pharmacol.
Khan MS et al., 2014, Pharmacogenetics, plasma concentrations, clinical signs and EEG during propofol treatment., Basic Clin Pharmacol Toxicol
Franks, 2006, Molecular targets underlying general anaesthesia., Br. J. Pharmacol.
Nielsen M et al., 2016, The Gly16 Allele of the Gly16Arg Single-Nucleotide Polymorphism in the β₂-Adrenergic Receptor Gene Augments Perioperative Use of Vasopressors: A Retrospective Cohort Study., Anesth Analg
Hirota et al., 2003, The effects of local and intravenous anesthetics on recombinant rat VR1 vanilloid receptors., Anesth. Analg.
Zhang Y et al., 2017, Correlation of MDR1 gene polymorphism with propofol combined with remifentanil anesthesia in pediatric tonsillectomy., Oncotarget
Yamada et al., 2006, The effects of sevoflurane and propofol on QT interval and heterologously expressed human ether-a-go-go related gene currents in Xenopus oocytes., Anesth. Analg.
Mandal et al., 2007, Molecular understanding of Abeta peptide interaction with isoflurane, propofol, and thiopental: NMR spectroscopic study., Biochemistry
Takahashi H et al., 2008, Effect of D256N and Y483D on propofol glucuronidation by human uridine 5'-diphosphate glucuronosyltransferase (UGT1A9)., Basic Clin Pharmacol Toxicol
Wickley et al., 2006, Propofol decreases myofilament Ca2+ sensitivity via a protein kinase C-, nitric oxide synthase-dependent pathway in diabetic cardiomyocytes., Anesthesiology
Gan et al., 2005, [Effects of propofol and isoflurane on serum neuron-specific enolase level in surgical patients with acute craniocerebral trauma: a comparative study]., Di Yi Jun Yi Da Xue Xue Bao

PROPOFOL ENO2

Interaction Score: 0.53

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
16027086

Sources:
NCI
PROPOFOL UGT1A9

Interaction Score: 0.25

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
18816295

Sources:
PharmGKB
PROPOFOL NOS2

Interaction Score: 0.2

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
16645450

Sources:
NCI
PROPOFOL APP

Interaction Score: 0.14

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
17223697

Sources:
NCI
PROPOFOL GABRB3

Interaction Score: 0.14

Interaction Types & Directionality:

positive modulator (activating)

potentiator

Interaction Info:

Trial Name propofol lingual spray

Novel drug target Established target

Trial Name propofol,Diprivan

PMIDs:
16402123

Sources:
TdgClinicalTrial ChemblInteractions TEND
PROPOFOL GABRB2

Interaction Score: 0.12

Interaction Types & Directionality:

positive modulator (activating)

potentiator

Interaction Info:

Trial Name propofol,Diprivan

Novel drug target Established target

Trial Name propofol lingual spray

PMIDs:
16402123

Sources:
TdgClinicalTrial ChemblInteractions TEND
PROPOFOL TRPV1

Interaction Score: 0.12

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
12760991

Sources:
NCI
PROPOFOL NOS1

Interaction Score: 0.11

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
16645450

Sources:
NCI
PROPOFOL SCN2A

Interaction Score: 0.11

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Trial Name propofol lingual spray

Novel drug target Established target

Trial Name propofol,Diprivan

PMIDs:
18574460

Sources:
TdgClinicalTrial TEND
PROPOFOL FAAH

Interaction Score: 0.1

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
TTD
PROPOFOL SCN4A

Interaction Score: 0.1

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Trial Name propofol lingual spray

Novel drug target Established target

Trial Name propofol,Diprivan

PMIDs:
18574460

Sources:
TdgClinicalTrial TEND
PROPOFOL GABRQ

Interaction Score: 0.04

Interaction Types & Directionality:

positive modulator (activating)

Interaction Info:

Mechanism of Interaction GABA-A receptor; anion channel positive allosteric modulator

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
PROPOFOL GABRP

Interaction Score: 0.04

Interaction Types & Directionality:

positive modulator (activating)

Interaction Info:

Mechanism of Interaction GABA-A receptor; anion channel positive allosteric modulator

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
PROPOFOL GABRE

Interaction Score: 0.04

Interaction Types & Directionality:

positive modulator (activating)

Interaction Info:

Mechanism of Interaction GABA-A receptor; anion channel positive allosteric modulator

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
PROPOFOL GABRD

Interaction Score: 0.03

Interaction Types & Directionality:

positive modulator (activating)

Interaction Info:

Mechanism of Interaction GABA-A receptor; anion channel positive allosteric modulator

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
PROPOFOL GABRG1

Interaction Score: 0.03

Interaction Types & Directionality:

positive modulator (activating)

Interaction Info:

Mechanism of Interaction GABA-A receptor; anion channel positive allosteric modulator

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
PROPOFOL GABRB1

Interaction Score: 0.03

Interaction Types & Directionality:

positive modulator (activating)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction GABA-A receptor; anion channel positive allosteric modulator

PMIDs:
None found

Sources:
ChemblInteractions
PROPOFOL ADRB2

Interaction Score: 0.03

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
26771271

Sources:
PharmGKB
PROPOFOL GABRA4

Interaction Score: 0.03

Interaction Types & Directionality:

positive modulator (activating)

Interaction Info:

Mechanism of Interaction GABA-A receptor; anion channel positive allosteric modulator

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
PROPOFOL GABRG2

Interaction Score: 0.03

Interaction Types & Directionality:

positive modulator (activating)

Interaction Info:

Mechanism of Interaction GABA-A receptor; anion channel positive allosteric modulator

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
PROPOFOL GABRA6

Interaction Score: 0.03

Interaction Types & Directionality:

positive modulator (activating)

Interaction Info:

Mechanism of Interaction GABA-A receptor; anion channel positive allosteric modulator

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
PROPOFOL GABRG3

Interaction Score: 0.03

Interaction Types & Directionality:

positive modulator (activating)

Interaction Info:

Mechanism of Interaction GABA-A receptor; anion channel positive allosteric modulator

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
PROPOFOL GABRA5

Interaction Score: 0.03

Interaction Types & Directionality:

positive modulator (activating)

Interaction Info:

Mechanism of Interaction GABA-A receptor; anion channel positive allosteric modulator

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
PROPOFOL GABRA3

Interaction Score: 0.03

Interaction Types & Directionality:

positive modulator (activating)

Interaction Info:

Mechanism of Interaction GABA-A receptor; anion channel positive allosteric modulator

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
PROPOFOL GABRA2

Interaction Score: 0.03

Interaction Types & Directionality:

positive modulator (activating)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction GABA-A receptor; anion channel positive allosteric modulator

PMIDs:
None found

Sources:
ChemblInteractions
PROPOFOL GABRA1

Interaction Score: 0.02

Interaction Types & Directionality:

positive modulator (activating)

Interaction Info:

Mechanism of Interaction GABA-A receptor; anion channel positive allosteric modulator

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
PROPOFOL ABCB1

Interaction Score: 0.02

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
29755652

Sources:
PharmGKB
PROPOFOL KCNH2

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
16368812

Sources:
NCI
PROPOFOL CYP2C9

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
24891132

Sources:
PharmGKB

TEND: PROPOFOL
- Version: 01-August-2011
Alternate Names:

PROPOFOL Primary Drug Name

Drug Info:

Drug Class hypnotics and sedatives

Year of Approval 1989

Publications:
TdgClinicalTrial: PROPOFOL
- Version: January-2014
Alternate Names:

Drug Info:

Drug Indications sedative

Drug Class small molecule

FDA Approval approved

Publications:

NCI: PROPOFOL

Version: 14-September-2017

Alternate Names:

C29384 NCI drug code

Drug Info:

Publications:

Wickley et al., 2006, Propofol decreases myofilament Ca2+ sensitivity via a protein kinase C-, nitric oxide synthase-dependent pathway in diabetic cardiomyocytes., Anesthesiology

Yamada et al., 2006, The effects of sevoflurane and propofol on QT interval and heterologously expressed human ether-a-go-go related gene currents in Xenopus oocytes., Anesth. Analg.

Hirota et al., 2003, The effects of local and intravenous anesthetics on recombinant rat VR1 vanilloid receptors., Anesth. Analg.

PharmGKB: propofol

Version: 18-August-2020

Alternate Names:

Drug Info:

Publications:

Khan MS et al., 2014, Pharmacogenetics, plasma concentrations, clinical signs and EEG during propofol treatment., Basic Clin Pharmacol Toxicol

Takahashi H et al., 2008, Effect of D256N and Y483D on propofol glucuronidation by human uridine 5'-diphosphate glucuronosyltransferase (UGT1A9)., Basic Clin Pharmacol Toxicol

Zhang Y et al., 2017, Correlation of MDR1 gene polymorphism with propofol combined with remifentanil anesthesia in pediatric tonsillectomy., Oncotarget

TTD: Propofol
- Version: 2020.06.01
Alternate Names:

D0A3HB TTD Drug ID

Drug Info:

Publications:
ChemblInteractions: CHEMBL526
- Version: chembl_23
Alternate Names:

Drug Info:

Publications:
ChemblDrugs: chembl:CHEMBL526
- Version: ChEMBL_27
Alternate Names:

Drug Info:

Publications:

Trial Name	propofol lingual spray
Novel drug target	Established target
Trial Name	propofol,Diprivan

Mechanism of Interaction	GABA-A receptor; anion channel positive allosteric modulator
Direct Interaction	yes

positive modulator (activating)
potentiator

positive modulator (activating)
potentiator

PROPOFOL Drug Record

PROPOFOL chembl:CHEMBL526 Approved

Alternate Names:

Drug Info:

Publications:

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 16027086

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 18816295

Sources: PharmGKB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 16645450

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 17223697

Sources: NCI

Interaction Types & Directionality: positive modulator (activating) potentiator

Interaction Info: Trial Name propofol lingual spray Novel drug target Established target Trial Name propofol,Diprivan

PMIDs: 16402123

Sources: TdgClinicalTrial ChemblInteractions TEND

Interaction Types & Directionality: positive modulator (activating) potentiator

Interaction Info: Trial Name propofol,Diprivan Novel drug target Established target Trial Name propofol lingual spray

PMIDs: 16402123

Sources: TdgClinicalTrial ChemblInteractions TEND

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 12760991

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 16645450

Sources: NCI

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Trial Name propofol lingual spray Novel drug target Established target Trial Name propofol,Diprivan

PMIDs: 18574460

Sources: TdgClinicalTrial TEND

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: TTD

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Trial Name propofol lingual spray Novel drug target Established target Trial Name propofol,Diprivan

PMIDs: 18574460

Sources: TdgClinicalTrial TEND

Interaction Types & Directionality: positive modulator (activating)

Interaction Info: Mechanism of Interaction GABA-A receptor; anion channel positive allosteric modulator Direct Interaction yes

PMIDs: None found

Sources: ChemblInteractions

Interaction Types & Directionality: positive modulator (activating)

Interaction Info: Mechanism of Interaction GABA-A receptor; anion channel positive allosteric modulator Direct Interaction yes

PMIDs: None found

Sources: ChemblInteractions

Interaction Types & Directionality: positive modulator (activating)

Interaction Info: Mechanism of Interaction GABA-A receptor; anion channel positive allosteric modulator Direct Interaction yes

PMIDs: None found

Sources: ChemblInteractions

Interaction Types & Directionality: positive modulator (activating)

Interaction Info: Mechanism of Interaction GABA-A receptor; anion channel positive allosteric modulator Direct Interaction yes

PMIDs: None found

Sources: ChemblInteractions

Interaction Types & Directionality: positive modulator (activating)

Interaction Info: Mechanism of Interaction GABA-A receptor; anion channel positive allosteric modulator Direct Interaction yes

PMIDs: None found

Sources: ChemblInteractions

Interaction Types & Directionality: positive modulator (activating)

Interaction Info: Direct Interaction yes Mechanism of Interaction GABA-A receptor; anion channel positive allosteric modulator

PMIDs: None found

Sources: ChemblInteractions

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 26771271

Sources: PharmGKB

Interaction Types & Directionality: positive modulator (activating)

Interaction Info: Mechanism of Interaction GABA-A receptor; anion channel positive allosteric modulator Direct Interaction yes

PMIDs: None found

Interaction Types & Directionality:

n/a

PMIDs:
16027086

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
18816295

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
16645450

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
17223697

Sources:
NCI

Interaction Types & Directionality:

positive modulator (activating)

potentiator

Interaction Info:

Trial Name propofol lingual spray

Novel drug target Established target

Trial Name propofol,Diprivan

PMIDs:
16402123

Sources:
TdgClinicalTrial ChemblInteractions TEND

Interaction Types & Directionality:

positive modulator (activating)

potentiator

Interaction Info:

Trial Name propofol,Diprivan

Novel drug target Established target

Trial Name propofol lingual spray

PMIDs:
16402123

Sources:
TdgClinicalTrial ChemblInteractions TEND

Interaction Types & Directionality:

n/a

PMIDs:
12760991

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
16645450

Sources:
NCI

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Trial Name propofol lingual spray

Novel drug target Established target

Trial Name propofol,Diprivan

PMIDs:
18574460

Sources:
TdgClinicalTrial TEND

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
TTD

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Trial Name propofol lingual spray

Novel drug target Established target

Trial Name propofol,Diprivan

PMIDs:
18574460

Sources:
TdgClinicalTrial TEND

Interaction Types & Directionality:

positive modulator (activating)

Interaction Info:

Mechanism of Interaction GABA-A receptor; anion channel positive allosteric modulator

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

positive modulator (activating)

Interaction Info:

Mechanism of Interaction GABA-A receptor; anion channel positive allosteric modulator

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

positive modulator (activating)

Interaction Info:

Mechanism of Interaction GABA-A receptor; anion channel positive allosteric modulator

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

positive modulator (activating)

Interaction Info:

Mechanism of Interaction GABA-A receptor; anion channel positive allosteric modulator

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

positive modulator (activating)

Interaction Info:

Mechanism of Interaction GABA-A receptor; anion channel positive allosteric modulator

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

positive modulator (activating)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction GABA-A receptor; anion channel positive allosteric modulator

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

n/a

PMIDs:
26771271

Sources:
PharmGKB

Interaction Types & Directionality:

positive modulator (activating)

Interaction Info:

Mechanism of Interaction GABA-A receptor; anion channel positive allosteric modulator

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

positive modulator (activating)

Interaction Info:

Mechanism of Interaction GABA-A receptor; anion channel positive allosteric modulator

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

positive modulator (activating)

Interaction Info:

Mechanism of Interaction GABA-A receptor; anion channel positive allosteric modulator

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

positive modulator (activating)

Interaction Info:

Mechanism of Interaction GABA-A receptor; anion channel positive allosteric modulator

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions