DGIdb - PROCHLORPERAZINE Drug Record

PROCHLORPERAZINE chembl:CHEMBL728 Approved

Alternate Names:

COMPRO
STEMETIL EFF
PROCHLORPERAZINE MESILATE
COMPAZINE
PROCHLORPERAZINE
PROCLOPERAZINE
PROCHLORPÉRAZINE
EMETIRAL
PROCHLORPERAZINE EDISYLATE
2-CHLORO-10-(3-(4-METHYL-1-PIPERAZINYL)PROPYL)PHENOTHIAZINE
PROCLORPERAZINA
2-CHLORO-10-(3-(1-METHYL-4-PIPERAZINYL)PROPYL)-PHENOTHIAZINE
PROCHLORPROMAZINE
BUCCASTEM®
CHLORMEPRAZINE
PROCHLORPERAZINUM
CAPAZINE
PROCHLORPERMAZINE
PROCHLORPERAZINE MALEATE
COMPAZINE®
CHLORO-3 (N-METHYLPIPERAZINYL-3 PROPYL)-10 PHENOTHIAZINE
3-CHLORO-10-(3-(1-METHYL-4-PIPERAZINYL)PROPYL)PHENOTHIAZINE
N-(GAMMA-(4'-METHYLPIPERAZINYL-1')PROPYL)-3-CHLOROPHENOTHIAZINE
PROCHLORPERAZIN
3-CHLORO-10-(3-(4-METHYL-1-PIPERAZINYL)PROPYL)PHENOTHIAZINE
CHLOROPERNAZINE
chembl:CHEMBL728
drugbank:00433
rxcui:8704
pubchem.compound:4917
chemidplus:58-38-8

Drug Info:

Year of Approval	1956
Drug Class	antipsychotic agents
Drug Class	antiemetics
Drug Class	small molecule
Drug Indications	antiemetic
FDA Approval	approved
Drug Class	Small Molecule
Drug Indications	antimigraine agent

(4 More Sources)

Publications:

Tashiro M et al., 2014, Impact of genetic and non-genetic factors on clinical responses to prochlorperazine in oxycodone-treated cancer patients., Clin Chim Acta
Callan et al., 2008, Prochlorperazine vs. promethazine for headache treatment in the emergency department: a randomized controlled trial., J Emerg Med
Vinson, 2006, Development of a simplified instrument for the diagnosis and grading of akathisia in a cohort of patients receiving prochlorperazine., J Emerg Med
Roberge, 2006, Antiemetic-related dystonic reaction unmasked by removal of a scopolamine transdermal patch., J Emerg Med
Chen et al., 2002, TTD: Therapeutic Target Database., Nucleic Acids Res.
Narita et al., 2008, Suppression of dopamine-related side effects of morphine by aripiprazole, a dopamine system stabilizer., Eur. J. Pharmacol.
Hamik et al., 1989, Differential interactions of traditional and novel antiemetics with dopamine D2 and 5-hydroxytryptamine3 receptors., Cancer Chemother. Pharmacol.
Golembiewski et al., 2006, Pharmacological prophylaxis and management of adult postoperative/postdischarge nausea and vomiting., J. Perianesth. Nurs.
Alex et al., 1995, Compatibility and activity of aldesleukin (recombinant interleukin-2) in presence of selected drugs during simulated Y-site administration: evaluation of three methods., Am J Health Syst Pharm
Sakatis MZ et al., 2012, Preclinical strategy to reduce clinical hepatotoxicity using in vitro bioactivation data for >200 compounds., Chem Res Toxicol
Isah AO et al., 1991, Clinical pharmacology of prochlorperazine in healthy young males., Br J Clin Pharmacol

PROCHLORPERAZINE ANKK1

Interaction Score: 0.47

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
24360851

Sources:
PharmGKB
PROCHLORPERAZINE DRD2

Interaction Score: 0.22

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Trial Name AZ-001, Staccato prochlorperazine

Novel drug target Established target

Trial Name buccal prochlorperazine maleate,Emezine

PMIDs:
24360851 18534808 17044574 16677982 11752352 18955042 2527092 17169748

Sources:
TdgClinicalTrial ChemblInteractions TEND PharmGKB TTD
PROCHLORPERAZINE IL2

Interaction Score: 0.18

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
8564607

Sources:
NCI
PROCHLORPERAZINE RAPGEF4

Interaction Score: 0.06

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
PROCHLORPERAZINE MCL1

Interaction Score: 0.06

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
PROCHLORPERAZINE HRH1

Interaction Score: 0.04

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

PMIDs:
1768559

Sources:
TEND
PROCHLORPERAZINE HTR2A

Interaction Score: 0.03

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
TEND
PROCHLORPERAZINE MPHOSPH8

Interaction Score: 0.02

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
PROCHLORPERAZINE DRD1

Interaction Score: 0.02

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

PMIDs:
None found

Sources:
TEND
PROCHLORPERAZINE CBX1

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
PROCHLORPERAZINE CYP2C9

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
22931300

Sources:
DTC
PROCHLORPERAZINE CYP2C19

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
22931300

Sources:
DTC
PROCHLORPERAZINE ATXN2

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
PROCHLORPERAZINE CYP2D6

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
22931300

Sources:
DTC
PROCHLORPERAZINE BAZ2B

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
PROCHLORPERAZINE TP53

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
PROCHLORPERAZINE IDH1

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
PROCHLORPERAZINE KDM4A

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
PROCHLORPERAZINE CYP3A4

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
22931300

Sources:
DTC
PROCHLORPERAZINE GMNN

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
PROCHLORPERAZINE CYP1A2

Interaction Score: 0.0

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
PROCHLORPERAZINE EHMT2

Interaction Score: 0.0

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC

TEND: PROCHLORPERAZINE
- Version: 01-August-2011
Alternate Names:

PROCHLORPERAZINE Primary Drug Name

Drug Info:

Drug Class antiemetics

Drug Class antipsychotic agents

Year of Approval 1956

Publications:
TdgClinicalTrial: PROCHLORPERAZINE
- Version: January-2014
Alternate Names:

Drug Info:

Drug Indications antimigraine agent

Drug Class Small Molecule

FDA Approval approved

Publications:
DTC: PROCHLORPERAZINE
- Version: 02-September-2020
Alternate Names:

CHEMBL728 ChEMBL Drug ID

Drug Info:

Publications:

Sakatis MZ et al., 2012, Preclinical strategy to reduce clinical hepatotoxicity using in vitro bioactivation data for >200 compounds., Chem Res Toxicol

NCI: PROCHLORPERAZINE

Version: 14-September-2017

Alternate Names:

C774 NCI drug code

Drug Info:

Publications:

Alex et al., 1995, Compatibility and activity of aldesleukin (recombinant interleukin-2) in presence of selected drugs during simulated Y-site administration: evaluation of three methods., Am J Health Syst Pharm

PharmGKB: prochlorperazine
- Version: 18-August-2020
Alternate Names:

Drug Info:

Publications:

Tashiro M et al., 2014, Impact of genetic and non-genetic factors on clinical responses to prochlorperazine in oxycodone-treated cancer patients., Clin Chim Acta
TTD: Prochlorperazine
- Version: 2020.06.01
Alternate Names:

D0B2UZ TTD Drug ID

Drug Info:

Publications:
ChemblInteractions: CHEMBL728
- Version: chembl_23
Alternate Names:

Drug Info:

Publications:
ChemblDrugs: chembl:CHEMBL728
- Version: ChEMBL_27
Alternate Names:

Drug Info:

Publications:

Trial Name	AZ-001, Staccato prochlorperazine
Novel drug target	Established target
Trial Name	buccal prochlorperazine maleate,Emezine

PROCHLORPERAZINE Drug Record

PROCHLORPERAZINE chembl:CHEMBL728 Approved

Alternate Names:

Drug Info:

Publications:

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 24360851

Sources: PharmGKB

Interaction Types & Directionality: antagonist (inhibitory)

Interaction Info: Trial Name AZ-001, Staccato prochlorperazine Novel drug target Established target Trial Name buccal prochlorperazine maleate,Emezine

PMIDs: 24360851 18534808 17044574 16677982 11752352 18955042 2527092 17169748

Sources: TdgClinicalTrial ChemblInteractions TEND PharmGKB TTD

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 8564607

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: antagonist (inhibitory)

Interaction Info:

PMIDs: 1768559

Sources: TEND

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: TEND

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: antagonist (inhibitory)

Interaction Info:

PMIDs: None found

Sources: TEND

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 22931300

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 22931300

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 22931300

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 22931300

Interaction Types & Directionality:

n/a

PMIDs:
24360851

Sources:
PharmGKB

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Trial Name AZ-001, Staccato prochlorperazine

Novel drug target Established target

Trial Name buccal prochlorperazine maleate,Emezine

PMIDs:
24360851 18534808 17044574 16677982 11752352 18955042 2527092 17169748

Sources:
TdgClinicalTrial ChemblInteractions TEND PharmGKB TTD

Interaction Types & Directionality:

n/a

PMIDs:
8564607

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

antagonist (inhibitory)

PMIDs:
1768559

Sources:
TEND

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
TEND

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

antagonist (inhibitory)

PMIDs:
None found

Sources:
TEND

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
22931300

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
22931300

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
22931300

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
22931300

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Alternate Names:

PROCHLORPERAZINE Primary Drug Name

Drug Info:

Drug Class antiemetics

Drug Class antipsychotic agents

Year of Approval 1956

Drug Info:

Drug Indications antimigraine agent

Drug Class Small Molecule

FDA Approval approved

Alternate Names:

CHEMBL728 ChEMBL Drug ID

Publications:

Sakatis MZ et al., 2012, Preclinical strategy to reduce clinical hepatotoxicity using in vitro bioactivation data for >200 compounds., Chem Res Toxicol

Alternate Names:

C774 NCI drug code

Publications:

Alex et al., 1995, Compatibility and activity of aldesleukin (recombinant interleukin-2) in presence of selected drugs during simulated Y-site administration: evaluation of three methods., Am J Health Syst Pharm

Publications:

Tashiro M et al., 2014, Impact of genetic and non-genetic factors on clinical responses to prochlorperazine in oxycodone-treated cancer patients., Clin Chim Acta

Alternate Names:

D0B2UZ TTD Drug ID