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PREDNISONE Drug Record

  • Summary
  • Interactions
  • Claims
  • PREDNISONE chembl:CHEMBL635 ApprovedAntineoplasticImmunotherapy

    Alternate Names:

    CORTANCYL
    PREDNISONE INTENSOL
    STERAPRED
    NSC-10023
    PREDNISONE TABLETS
    PREDNICEN-M
    METICORTEN
    RAYOS
    PARACORT
    FERNISONE
    LIQUID PRED
    LODOTRA
    ORASONE
    SERVISONE
    DELTA-DOME
    CORTAN
    DECORTISYL
    PREDNISONE
    DELTASONE
    DEHYDROCORTISONE
    LODOTRA®
    STERAPRED®
    17,21-DIHYDROXYPREGNA-1,4-DIENE-3,11,20-TRIONE
    PREDNISONUM
    1,4-PREGNADIENE-17ALPHA,21-DIOL-3,11,20-TRIONE
    PREDNISONA
    1,2-DEHYDROCORTISONE
    PREDNISON
    rxcui:8640
    chembl:CHEMBL635
    drugbank:00635
    chemidplus:53-03-2
    pubchem.compound:5865

    Drug Info:

    Drug Class glucocorticoids
    Year of Approval approved before 1982
    Drug Class anti-inflammatory agents
    FDA Approval approved
    Drug Class Small Molecule
    Drug Indications antiinflammatory agent,corticosteroid
    (4 More Sources)

    Publications:

    Ettinger et al., 1988, Prednisone increases very low density lipoprotein and high density lipoprotein in healthy men., Metab. Clin. Exp.
    Anderer et al., 2000, Polymorphisms within glutathione S-transferase genes and initial response to glucocorticoids in childhood acute lymphoblastic leukaemia., Pharmacogenetics
    Ammersbach et al., The effect of glucocorticoids on canine lymphocyte marker expression and apoptosis., J. Vet. Intern. Med.
    Jordheim LP et al., 2015, Single nucleotide polymorphisms in ABCB1 and CBR1 can predict toxicity to R-CHOP type regimens in patients with diffuse non-Hodgkin lymphoma., Haematologica
    Zheng H et al., 2002, The MDR1 polymorphisms at exons 21 and 26 predict steroid weaning in pediatric heart transplant patients., Hum Immunol
    Broussolle et al., 1989, Rapid effectiveness of prednisone and thionamides combined therapy in severe amiodarone iodine-induced thyrotoxicosis. Comparison of two groups of patients with apparently normal thyroid glands., J. Endocrinol. Invest.
    Sakatis MZ et al., 2012, Preclinical strategy to reduce clinical hepatotoxicity using in vitro bioactivation data for >200 compounds., Chem Res Toxicol
    Kurzawski M et al., 2005, The impact of thiopurine s-methyltransferase polymorphism on azathioprine-induced myelotoxicity in renal transplant recipients., Ther Drug Monit
    Friel et al., 2006, Suppression of adrenal function by low-dose prednisone: assessment with 24-hour urinary steroid hormone profiles--a review of five cases., Altern Med Rev
    Liu et al., 2006, [Effects of jingui shenqi pill combined prednisone on expression of glucocorticoid receptor and its clinical effect in treating bullous pemphigoid patients]., Zhongguo Zhong Xi Yi Jie He Za Zhi
    Yano et al., 2006, Glucocorticoids suppress tumor angiogenesis and in vivo growth of prostate cancer cells., Clin. Cancer Res.
    Díez et al., 2007, Pharmacological therapy of Cushing's syndrome: drugs and indications., Mini Rev Med Chem
    Chen et al., 2002, TTD: Therapeutic Target Database., Nucleic Acids Res.
    Yano et al., 2006, Glucocorticoids suppress tumor lymphangiogenesis of prostate cancer cells., Clin. Cancer Res.
    Czock D et al., 2005, Pharmacokinetics and pharmacodynamics of systemically administered glucocorticoids., Clin Pharmacokinet
    Pietrasiewicz et al., Studies on the interaction of antidepressant drugs with adrenocorticotropic hormone or prednisone in rats., Pol J Pharmacol
    Perez-Andreu V et al., 2013, Inherited GATA3 variants are associated with Ph-like childhood acute lymphoblastic leukemia and risk of relapse., Nat Genet
    Lavignac et al., 1996, [Immunohistochemical study of lesions in Horton's temporal arteritis before and during corticotherapy]., Rev Med Interne
    Fracchia et al., 2000, Serum interferon gamma in primary biliary cirrhosis: effect of ursodeoxycholic acid and prednisone therapy alone and in combination., Eur J Gastroenterol Hepatol
    Karol SE et al., 2016, Genetic risk factors for the development of osteonecrosis in children under age 10 treated for acute lymphoblastic leukemia., Blood
    Favis R et al., 2011, Genetic variation associated with bortezomib-induced peripheral neuropathy., Pharmacogenet Genomics
    Butrym A et al., 2016, Dual role of the CXCL12 polymorphism in patients with chronic lymphocytic leukemia., HLA
    Wu et al., 1998, [Clinical study on improving effect of Buyang Huanwu decoction on plasma thromboxane B2, 6-keto-prostaglandin F1 alpha, endothelin and calcitonin gene related peptide in primary nephrotic syndrome patients]., Zhongguo Zhong Xi Yi Jie He Za Zhi
    Wender et al., [Myelin basic protein stimulation index of CD 2 cells in the course of steroid treatment]., Neurol. Neurochir. Pol.
    Casonato et al., 1988, Factor VIII/von Willebrand factor abnormalities during L-asparaginase treatment in patients with acute lymphoblastic leukemia., Acta Haematol.
    Kalra S et al., 2018, Association of CYP2C19*2 and ALDH1A1*1/*2 variants with disease outcome in breast cancer patients: results of a global screening array., Eur J Clin Pharmacol
    Rossi D et al., 2009, Analysis of the host pharmacogenetic background for prediction of outcome and toxicity in diffuse large B-cell lymphoma treated with R-CHOP21., Leukemia
    López-López E et al., 2014, Pharmacogenetics of microRNAs and microRNAs biogenesis machinery in pediatric acute lymphoblastic leukemia., PLoS One
  • PREDNISONE   MBP

    Interaction Score: 0.77

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    10612091


    Sources:
    NCI

  • PREDNISONE   GSTA1

    Interaction Score: 0.64

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    29938344 19448608


    Sources:
    PharmGKB

  • PREDNISONE   DROSHA

    Interaction Score: 0.55

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    24614921


    Sources:
    PharmGKB

  • PREDNISONE   CXCL12

    Interaction Score: 0.55

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    27173875


    Sources:
    PharmGKB

  • PREDNISONE   MC2R

    Interaction Score: 0.55

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    9112644


    Sources:
    NCI

  • PREDNISONE   TPMT

    Interaction Score: 0.43

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    16044099


    Sources:
    PharmGKB

  • PREDNISONE   LINC00251

    Interaction Score: 0.39

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    26590194


    Sources:
    PharmGKB

  • PREDNISONE   DOK5

    Interaction Score: 0.39

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    26590194


    Sources:
    PharmGKB

  • PREDNISONE   BMP7

    Interaction Score: 0.39

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    26590194


    Sources:
    PharmGKB

  • PREDNISONE   PTPRC

    Interaction Score: 0.32

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    17063711


    Sources:
    NCI

  • PREDNISONE   GATA3

    Interaction Score: 0.3

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    24141364


    Sources:
    PharmGKB

  • PREDNISONE   VWF

    Interaction Score: 0.28

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    3146197


    Sources:
    NCI

  • PREDNISONE   IFNG

    Interaction Score: 0.23

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    10784002


    Sources:
    NCI

  • PREDNISONE   APOE

    Interaction Score: 0.23

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    3185288


    Sources:
    NCI

  • PREDNISONE   CTLA4

    Interaction Score: 0.21

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    21228734


    Sources:
    PharmGKB

  • PREDNISONE   TG

    Interaction Score: 0.21

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    2745931


    Sources:
    NCI

  • PREDNISONE   ITGB2

    Interaction Score: 0.2

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    8976974


    Sources:
    NCI

  • PREDNISONE   CALCA

    Interaction Score: 0.18

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    11475715


    Sources:
    NCI

  • PREDNISONE   GSTM1

    Interaction Score: 0.18

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    11186134


    Sources:
    NCI

  • PREDNISONE   NR3C1

    Interaction Score: 0.18

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Mechanism of Interaction Glucocorticoid receptor agonist
    Direct Interaction yes
    Trial Name ATL-2502,Colal-Pred

    PMIDs:
    16597193 17121036 16707595 17504182 11752352 17062674 15634032


    Sources:
    DTC TdgClinicalTrial ChemblInteractions TEND TTD

  • PREDNISONE   TYMSOS

    Interaction Score: 0.15

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    PharmGKB

  • PREDNISONE   ANXA1

    Interaction Score: 0.1

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    TEND

  • PREDNISONE   GSTP1

    Interaction Score: 0.08

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    11186134


    Sources:
    NCI

  • PREDNISONE   TYMS

    Interaction Score: 0.05

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    PharmGKB

  • PREDNISONE   ABCB1

    Interaction Score: 0.02

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    25637052 12175731


    Sources:
    PharmGKB

  • PREDNISONE   CYP2C9

    Interaction Score: 0.01

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    22931300


    Sources:
    DTC

  • PREDNISONE   CYP1A2

    Interaction Score: 0.01

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    22931300


    Sources:
    DTC

  • PREDNISONE   CYP2D6

    Interaction Score: 0.01

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    22931300


    Sources:
    DTC

  • PREDNISONE   HSD17B10

    Interaction Score: 0.0

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • PREDNISONE   CYP3A4

    Interaction Score: 0.0

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    22931300


    Sources:
    DTC

  • PREDNISONE   CYP2C19

    Interaction Score: 0.0

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    PharmGKB

  • PREDNISONE   AR

    Interaction Score: 0.0

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • TEND: PREDNISONE

    • Version: 01-August-2011

    Alternate Names:
    PREDNISONE Primary Drug Name

    Drug Info:
    Drug Class anti-inflammatory agents
    Year of Approval approved before 1982
    Drug Class glucocorticoids

    Publications:

  • TdgClinicalTrial: PREDNISONE

    • Version: January-2014

    Alternate Names:

    Drug Info:
    Drug Indications antiinflammatory agent,corticosteroid
    Drug Class Small Molecule
    FDA Approval approved

    Publications:

  • NCI: PREDNISONE

    • Version: 14-September-2017

    Alternate Names:
    C770 NCI drug code

    Drug Info:

    Publications:
    Ettinger et al., 1988, Prednisone increases very low density lipoprotein and high density lipoprotein in healthy men., Metab. Clin. Exp.
    Anderer et al., 2000, Polymorphisms within glutathione S-transferase genes and initial response to glucocorticoids in childhood acute lymphoblastic leukaemia., Pharmacogenetics
    Fracchia et al., 2000, Serum interferon gamma in primary biliary cirrhosis: effect of ursodeoxycholic acid and prednisone therapy alone and in combination., Eur J Gastroenterol Hepatol

  • DTC: PREDNISONE

    • Version: 02-September-2020

    Alternate Names:
    CHEMBL635 ChEMBL Drug ID

    Drug Info:

    Publications:
    Sakatis MZ et al., 2012, Preclinical strategy to reduce clinical hepatotoxicity using in vitro bioactivation data for >200 compounds., Chem Res Toxicol

  • PharmGKB: prednisone

    • Version: 18-August-2020

    Alternate Names:

    Drug Info:

    Publications:
    Kurzawski M et al., 2005, The impact of thiopurine s-methyltransferase polymorphism on azathioprine-induced myelotoxicity in renal transplant recipients., Ther Drug Monit
    Perez-Andreu V et al., 2013, Inherited GATA3 variants are associated with Ph-like childhood acute lymphoblastic leukemia and risk of relapse., Nat Genet
    Favis R et al., 2011, Genetic variation associated with bortezomib-induced peripheral neuropathy., Pharmacogenet Genomics

  • TTD: Prednisone

    • Version: 2020.06.01

    Alternate Names:
    D0IL7L TTD Drug ID

    Drug Info:

    Publications:

  • ChemblDrugs: chembl:CHEMBL635

    • Version: ChEMBL_27

    Alternate Names:

    Drug Info:

    Publications:

  • ChemblInteractions: CHEMBL635

    • Version: chembl_23

    Alternate Names:

    Drug Info:

    Publications:

Disclaimer: This resource is intended for purely research purposes. It should not be used for emergencies or medical or professional advice.

A finding of a drug-gene interaction or potentially druggable category does not necessarily indicate effectiveness (or lack thereof) of any drug or treatment regimen. A finding of no interaction or no potentially druggable category does not necessarily indicate lack of effectiveness of any drug or treatment regimen. Drug-gene interactions or potentially druggable categories are not presented in ranked order of potential or predicted efficacy.

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DGIdb (v4.2.0 - sha1 afd9f30b) • Last updated 2020-10-21