DGIdb - PREDNISONE Drug Record

PREDNISONE chembl:CHEMBL635 ApprovedAntineoplasticImmunotherapy

Alternate Names:

CORTANCYL
PREDNISONE INTENSOL
STERAPRED
NSC-10023
PREDNISONE TABLETS
PREDNICEN-M
METICORTEN
RAYOS
PARACORT
FERNISONE
LIQUID PRED
LODOTRA
ORASONE
SERVISONE
DELTA-DOME
CORTAN
DECORTISYL
PREDNISONE
DELTASONE
DEHYDROCORTISONE
LODOTRA®
STERAPRED®
17,21-DIHYDROXYPREGNA-1,4-DIENE-3,11,20-TRIONE
PREDNISONUM
1,4-PREGNADIENE-17ALPHA,21-DIOL-3,11,20-TRIONE
PREDNISONA
1,2-DEHYDROCORTISONE
PREDNISON
rxcui:8640
chembl:CHEMBL635
drugbank:00635
chemidplus:53-03-2
pubchem.compound:5865

Drug Info:

Drug Class	glucocorticoids
Year of Approval	approved before 1982
Drug Class	anti-inflammatory agents
FDA Approval	approved
Drug Class	Small Molecule
Drug Indications	antiinflammatory agent,corticosteroid

(4 More Sources)

Publications:

Ettinger et al., 1988, Prednisone increases very low density lipoprotein and high density lipoprotein in healthy men., Metab. Clin. Exp.
Anderer et al., 2000, Polymorphisms within glutathione S-transferase genes and initial response to glucocorticoids in childhood acute lymphoblastic leukaemia., Pharmacogenetics
Ammersbach et al., The effect of glucocorticoids on canine lymphocyte marker expression and apoptosis., J. Vet. Intern. Med.
Jordheim LP et al., 2015, Single nucleotide polymorphisms in ABCB1 and CBR1 can predict toxicity to R-CHOP type regimens in patients with diffuse non-Hodgkin lymphoma., Haematologica
Zheng H et al., 2002, The MDR1 polymorphisms at exons 21 and 26 predict steroid weaning in pediatric heart transplant patients., Hum Immunol
Broussolle et al., 1989, Rapid effectiveness of prednisone and thionamides combined therapy in severe amiodarone iodine-induced thyrotoxicosis. Comparison of two groups of patients with apparently normal thyroid glands., J. Endocrinol. Invest.
Sakatis MZ et al., 2012, Preclinical strategy to reduce clinical hepatotoxicity using in vitro bioactivation data for >200 compounds., Chem Res Toxicol
Kurzawski M et al., 2005, The impact of thiopurine s-methyltransferase polymorphism on azathioprine-induced myelotoxicity in renal transplant recipients., Ther Drug Monit
Friel et al., 2006, Suppression of adrenal function by low-dose prednisone: assessment with 24-hour urinary steroid hormone profiles--a review of five cases., Altern Med Rev
Liu et al., 2006, [Effects of jingui shenqi pill combined prednisone on expression of glucocorticoid receptor and its clinical effect in treating bullous pemphigoid patients]., Zhongguo Zhong Xi Yi Jie He Za Zhi
Yano et al., 2006, Glucocorticoids suppress tumor angiogenesis and in vivo growth of prostate cancer cells., Clin. Cancer Res.
Díez et al., 2007, Pharmacological therapy of Cushing's syndrome: drugs and indications., Mini Rev Med Chem
Chen et al., 2002, TTD: Therapeutic Target Database., Nucleic Acids Res.
Yano et al., 2006, Glucocorticoids suppress tumor lymphangiogenesis of prostate cancer cells., Clin. Cancer Res.
Czock D et al., 2005, Pharmacokinetics and pharmacodynamics of systemically administered glucocorticoids., Clin Pharmacokinet
Pietrasiewicz et al., Studies on the interaction of antidepressant drugs with adrenocorticotropic hormone or prednisone in rats., Pol J Pharmacol
Perez-Andreu V et al., 2013, Inherited GATA3 variants are associated with Ph-like childhood acute lymphoblastic leukemia and risk of relapse., Nat Genet
Lavignac et al., 1996, [Immunohistochemical study of lesions in Horton's temporal arteritis before and during corticotherapy]., Rev Med Interne
Fracchia et al., 2000, Serum interferon gamma in primary biliary cirrhosis: effect of ursodeoxycholic acid and prednisone therapy alone and in combination., Eur J Gastroenterol Hepatol
Karol SE et al., 2016, Genetic risk factors for the development of osteonecrosis in children under age 10 treated for acute lymphoblastic leukemia., Blood
Favis R et al., 2011, Genetic variation associated with bortezomib-induced peripheral neuropathy., Pharmacogenet Genomics
Butrym A et al., 2016, Dual role of the CXCL12 polymorphism in patients with chronic lymphocytic leukemia., HLA
Wu et al., 1998, [Clinical study on improving effect of Buyang Huanwu decoction on plasma thromboxane B2, 6-keto-prostaglandin F1 alpha, endothelin and calcitonin gene related peptide in primary nephrotic syndrome patients]., Zhongguo Zhong Xi Yi Jie He Za Zhi
Wender et al., [Myelin basic protein stimulation index of CD 2 cells in the course of steroid treatment]., Neurol. Neurochir. Pol.
Casonato et al., 1988, Factor VIII/von Willebrand factor abnormalities during L-asparaginase treatment in patients with acute lymphoblastic leukemia., Acta Haematol.
Kalra S et al., 2018, Association of CYP2C192 and ALDH1A11/*2 variants with disease outcome in breast cancer patients: results of a global screening array., Eur J Clin Pharmacol
Rossi D et al., 2009, Analysis of the host pharmacogenetic background for prediction of outcome and toxicity in diffuse large B-cell lymphoma treated with R-CHOP21., Leukemia
López-López E et al., 2014, Pharmacogenetics of microRNAs and microRNAs biogenesis machinery in pediatric acute lymphoblastic leukemia., PLoS One

PREDNISONE MBP

Interaction Score: 0.77

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
10612091

Sources:
NCI
PREDNISONE GSTA1

Interaction Score: 0.64

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
29938344 19448608

Sources:
PharmGKB
PREDNISONE DROSHA

Interaction Score: 0.55

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
24614921

Sources:
PharmGKB
PREDNISONE CXCL12

Interaction Score: 0.55

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
27173875

Sources:
PharmGKB
PREDNISONE MC2R

Interaction Score: 0.55

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
9112644

Sources:
NCI
PREDNISONE TPMT

Interaction Score: 0.43

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
16044099

Sources:
PharmGKB
PREDNISONE LINC00251

Interaction Score: 0.39

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
26590194

Sources:
PharmGKB
PREDNISONE DOK5

Interaction Score: 0.39

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
26590194

Sources:
PharmGKB
PREDNISONE BMP7

Interaction Score: 0.39

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
26590194

Sources:
PharmGKB
PREDNISONE PTPRC

Interaction Score: 0.32

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
17063711

Sources:
NCI
PREDNISONE GATA3

Interaction Score: 0.3

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
24141364

Sources:
PharmGKB
PREDNISONE VWF

Interaction Score: 0.28

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
3146197

Sources:
NCI
PREDNISONE IFNG

Interaction Score: 0.23

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
10784002

Sources:
NCI
PREDNISONE APOE

Interaction Score: 0.23

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
3185288

Sources:
NCI
PREDNISONE CTLA4

Interaction Score: 0.21

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
21228734

Sources:
PharmGKB
PREDNISONE TG

Interaction Score: 0.21

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
2745931

Sources:
NCI
PREDNISONE ITGB2

Interaction Score: 0.2

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
8976974

Sources:
NCI
PREDNISONE CALCA

Interaction Score: 0.18

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
11475715

Sources:
NCI
PREDNISONE GSTM1

Interaction Score: 0.18

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
11186134

Sources:
NCI
PREDNISONE NR3C1

Interaction Score: 0.18

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Mechanism of Interaction Glucocorticoid receptor agonist

Direct Interaction yes

Trial Name ATL-2502,Colal-Pred

PMIDs:
16597193 17121036 16707595 17504182 11752352 17062674 15634032

Sources:
DTC TdgClinicalTrial ChemblInteractions TEND TTD
PREDNISONE TYMSOS

Interaction Score: 0.15

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
PharmGKB
PREDNISONE ANXA1

Interaction Score: 0.1

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
TEND
PREDNISONE GSTP1

Interaction Score: 0.08

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
11186134

Sources:
NCI
PREDNISONE TYMS

Interaction Score: 0.05

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
PharmGKB
PREDNISONE ABCB1

Interaction Score: 0.02

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
25637052 12175731

Sources:
PharmGKB
PREDNISONE CYP2C9

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
22931300

Sources:
DTC
PREDNISONE CYP1A2

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
22931300

Sources:
DTC
PREDNISONE CYP2D6

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
22931300

Sources:
DTC
PREDNISONE HSD17B10

Interaction Score: 0.0

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
PREDNISONE CYP3A4

Interaction Score: 0.0

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
22931300

Sources:
DTC
PREDNISONE CYP2C19

Interaction Score: 0.0

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
PharmGKB
PREDNISONE AR

Interaction Score: 0.0

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC

TEND: PREDNISONE
- Version: 01-August-2011
Alternate Names:

PREDNISONE Primary Drug Name

Drug Info:

Drug Class anti-inflammatory agents

Year of Approval approved before 1982

Drug Class glucocorticoids

Publications:
TdgClinicalTrial: PREDNISONE
- Version: January-2014
Alternate Names:

Drug Info:

Drug Indications antiinflammatory agent,corticosteroid

Drug Class Small Molecule

FDA Approval approved

Publications:

NCI: PREDNISONE

Version: 14-September-2017

Alternate Names:

C770 NCI drug code

Drug Info:

Publications:

Ettinger et al., 1988, Prednisone increases very low density lipoprotein and high density lipoprotein in healthy men., Metab. Clin. Exp.

Anderer et al., 2000, Polymorphisms within glutathione S-transferase genes and initial response to glucocorticoids in childhood acute lymphoblastic leukaemia., Pharmacogenetics

Fracchia et al., 2000, Serum interferon gamma in primary biliary cirrhosis: effect of ursodeoxycholic acid and prednisone therapy alone and in combination., Eur J Gastroenterol Hepatol

DTC: PREDNISONE
- Version: 02-September-2020
Alternate Names:

CHEMBL635 ChEMBL Drug ID

Drug Info:

Publications:

Sakatis MZ et al., 2012, Preclinical strategy to reduce clinical hepatotoxicity using in vitro bioactivation data for >200 compounds., Chem Res Toxicol

PharmGKB: prednisone

Version: 18-August-2020

Alternate Names:

Drug Info:

Publications:

Kurzawski M et al., 2005, The impact of thiopurine s-methyltransferase polymorphism on azathioprine-induced myelotoxicity in renal transplant recipients., Ther Drug Monit

Perez-Andreu V et al., 2013, Inherited GATA3 variants are associated with Ph-like childhood acute lymphoblastic leukemia and risk of relapse., Nat Genet

Favis R et al., 2011, Genetic variation associated with bortezomib-induced peripheral neuropathy., Pharmacogenet Genomics

TTD: Prednisone
- Version: 2020.06.01
Alternate Names:

D0IL7L TTD Drug ID

Drug Info:

Publications:
ChemblDrugs: chembl:CHEMBL635
- Version: ChEMBL_27
Alternate Names:

Drug Info:

Publications:
ChemblInteractions: CHEMBL635
- Version: chembl_23
Alternate Names:

Drug Info:

Publications:

Mechanism of Interaction	Glucocorticoid receptor agonist
Direct Interaction	yes
Trial Name	ATL-2502,Colal-Pred

PREDNISONE Drug Record

PREDNISONE chembl:CHEMBL635 ApprovedAntineoplasticImmunotherapy

Alternate Names:

Drug Info:

Publications:

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 10612091

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 29938344 19448608

Sources: PharmGKB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 24614921

Sources: PharmGKB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 27173875

Sources: PharmGKB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 9112644

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 16044099

Sources: PharmGKB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 26590194

Sources: PharmGKB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 26590194

Sources: PharmGKB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 26590194

Sources: PharmGKB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 17063711

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 24141364

Sources: PharmGKB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 3146197

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 10784002

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 3185288

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 21228734

Sources: PharmGKB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 2745931

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 8976974

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 11475715

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 11186134

Interaction Types & Directionality:

n/a

PMIDs:
10612091

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
29938344 19448608

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
24614921

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
27173875

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
9112644

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
16044099

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
26590194

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
26590194

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
26590194

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
17063711

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
24141364

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
3146197

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
10784002

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
3185288

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
21228734

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
2745931

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
8976974

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
11475715

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
11186134

Sources:
NCI

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Mechanism of Interaction Glucocorticoid receptor agonist

Direct Interaction yes

Trial Name ATL-2502,Colal-Pred

PMIDs:
16597193 17121036 16707595 17504182 11752352 17062674 15634032

Sources:
DTC TdgClinicalTrial ChemblInteractions TEND TTD

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
TEND

Interaction Types & Directionality:

n/a

PMIDs:
11186134

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
25637052 12175731

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
22931300

Sources:
DTC

Interaction Types & Directionality:

n/a