DGIdb - PREDNISOLONE Drug Record

PREDNISOLONE chembl:CHEMBL131 ApprovedAntineoplasticImmunotherapy

Alternate Names:

NSC-9900
CORTALONE
DELTACORTRIL
DELTALONE
HYDELTRA
PRECORTISYL FTE
FERNISOLONE-P
PRED-G
METICORTELONE
SCHERIPROCT
DELTA-CORTEF
DEKOTIL
PREDNISOLONE
POLY-PRED
DESOWEN
METI-DERM
PRECORTISYL
NEO-DELTA-CORTEF
STERANE
SERVISONE
HYDELTRA-TBA
NSC-9120
PEVANTI
VERDESO
TRIDESILON
PRELONE
DILACORT
DELTA-DEHYDROCORTISOL
3,20-DIOXO-11BETA,17ALPHA,21-TRIHYDROXY-1,4-PREGNADIENE
METACORTANDRALONE
1,4-PREGNADIENE-3,20-DIONE-11BETA,17ALPHA,21-TRIOL
PREDNISOLONA
DELTA(1)-DEHYDROCORTISOL
(11BETA)-11,17,21-TRIHYDROXYPREGNA-1,4-DIENE-3,20-DIONE
DELTA(1)-HYDROCORTISONE
PEDIAPRED®
1,4-PREGNADIENE-11BETA,17ALPHA,21-TRIOL-3,20-DIONE
PRDL
HYDRORETROCORTINE
IMS904
DELTA(1)-DEHYDROHYDROCORTISONE
ORAPRED®
DELTA-HYDROCORTISONE
PREDNISOLONUM
DELTA-DEHYDROHYDROCORTISONE
DELTA.1-CORTISOL
drugbank:00860
chembl:CHEMBL131
chemidplus:50-24-8
pubchem.compound:5755
rxcui:8638

Drug Info:

Drug Class	Small Molecule
FDA Approval	approved
Drug Indications	antiinflammatory agent,corticosteroid
Drug Categories	pregnadienes
Drug Class	glucocorticoids
Drug Class	anti-inflammatory agents
Year of Approval	approved before 1982
Drug Categories	adrenals
Drug Categories	agents for treatment of hemorrhoids and anal fissures for topical use
Drug Categories	alimentary tract and metabolism
Drug Categories	antidiarrheals, intestinal antiinflammatory/antiinfective agents
Drug Categories	antidotes
Drug Categories	corticosteroid hormone receptor agonists
Drug Categories	corticosteroids
Drug Categories	corticosteroids acting locally
Drug Categories	corticosteroids for local oral treatment
Drug Categories	corticosteroids for systemic use
Drug Categories	corticosteroids for systemic use, plain
Drug Categories	corticosteroids, dermatological preparations
Drug Categories	corticosteroids, weak (group i)
Drug Categories	cytochrome p-450 cyp3a inducers
Drug Categories	cytochrome p-450 cyp3a substrates
Drug Categories	cytochrome p-450 cyp3a4 inducers
Drug Categories	cytochrome p-450 cyp3a4 inducers (strength unknown)
Drug Categories	cytochrome p-450 enzyme inducers
Drug Categories	cytochrome p-450 substrates
Drug Categories	dermatologicals
Drug Categories	fused-ring compounds
Drug Categories	intestinal antiinflammatory agents
Drug Categories	nasal preparations
Drug Categories	ophthalmological and otological preparations
Drug Categories	otologicals
Drug Categories	p-glycoprotein substrates
Drug Categories	prednisolone and prodrugs
Drug Categories	stomatological preparations
Drug Categories	systemic hormonal preparations, excl. sex hormones and insulins
Drug Categories	vasoprotectives

(7 More Sources)

Publications:

Dewson et al., 2003, Conformational change and mitochondrial translocation of Bax accompany proteasome inhibitor-induced apoptosis of chronic lymphocytic leukemic cells., Oncogene
Cario et al., 1999, A microdeletion syndrome due to a 3-Mb deletion on 19q13.2--Diamond-Blackfan anemia associated with macrocephaly, hypotonia, and psychomotor retardation., Clin. Genet.
Fujita et al., 2007, Successful treatment of primary Sjögren's syndrome with chronic natural killer lymphocytosis by high-dose prednisolone and indomethacin farnesil., Intern. Med.
Furugen et al., 2008, Legionella pneumophila infection induces programmed cell death, caspase activation, and release of high-mobility group box 1 protein in A549 alveolar epithelial cells: inhibition by methyl prednisolone., Respir. Res.
Gregers J et al., 2015, Polymorphisms in the ABCB1 gene and effect on outcome and toxicity in childhood acute lymphoblastic leukemia., Pharmacogenomics J
Asano T et al., 2003, ABCB1 C3435T and G2677T/A polymorphism decreased the risk for steroid-induced osteonecrosis of the femoral head after kidney transplantation., Pharmacogenetics
Hodsman et al., 1991, Differential effects of inhaled budesonide and oral prednisolone on serum osteocalcin., J. Clin. Endocrinol. Metab.
Rendic S et al., 1997, Human cytochrome P450 enzymes: a status report summarizing their reactions, substrates, inducers, and inhibitors., Drug Metab Rev
Usui et al., 2003, Induction of CYP3As in HepG2 cells by several drugs. Association between induction of CYP3A4 and expression of glucocorticoid receptor., Biol. Pharm. Bull.
Yamada et al., 1996, Dissociation between serum interleukin-6 rise and other parameters of disease activity in subacute thyroiditis during treatment with corticosteroid., J. Clin. Endocrinol. Metab.
Yamamoto et al., 1987, Effect of prednisolone and salicylate on serum thyroglobulin level in patients with subacute thyroiditis., Clin. Endocrinol. (Oxf)
Boudinot et al., 1986, Receptor-mediated pharmacodynamics of prednisolone in the rat., J Pharmacokinet Biopharm
Ikonomidis et al., 2009, Lowering interleukin-1 activity with anakinra improves myocardial deformation in rheumatoid arthritis., Heart
Ueda, 1990, Effect of corticosteroids on some hemostatic parameters in children with minimal change nephrotic syndrome., Nephron
Pikman et al., 2017, Synergistic Drug Combinations with a CDK4/6 Inhibitor in T-cell Acute Lymphoblastic Leukemia., Clin. Cancer Res.
Izawa et al., 1982, Dynamics of glucocorticoid receptor and induction of tyrosine aminotransferase in rat liver., Endocrinol. Jpn.
Tuncer et al., 1994, The effect of high-dose methylprednisolone combined chemotherapy on CD34-positive cells in acute lymphoblastic leukemia., Hematol Pathol
Gutierrez-Camino A et al., 2017, PNPLA3 rs738409 and Hepatotoxicity in Children With B-cell Acute Lymphoblastic Leukemia: A Validation Study in a Spanish Cohort., Clin Pharmacol Ther
Yilmaz et al., 2006, Effects of additional Vitamin E and selenium supply on G6PDH activity in rats treated with high doses of glucocorticoid., Neurosci. Lett.
Nozawa et al., 1984, [Modulation of alkaline phosphatase by butyrate and prednisolone in uterine cervical cancer cell line (SKG-III)]., Nippon Sanka Fujinka Gakkai Zasshi
Nayak et al., 1990, Serum apolipoproteins A and B, lecithin: cholesterol acyl transferase activities and urinary cholesterol levels in nephrotic syndrome patients before and during steroid treatment., Nephron

PREDNISOLONE ALPP

Interaction Score: 1.46

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
6699450

Sources:
NCI
PREDNISOLONE DSE

Interaction Score: 1.09

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
PharmGKB
PREDNISOLONE LCAT

Interaction Score: 1.09

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
2314540

Sources:
NCI
PREDNISOLONE CD34

Interaction Score: 1.09

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
7532164

Sources:
NCI
PREDNISOLONE TSPYL1

Interaction Score: 1.09

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
PharmGKB
PREDNISOLONE LOH19CR1

Interaction Score: 0.87

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
10450869

Sources:
NCI
PREDNISOLONE PNPLA3

Interaction Score: 0.73

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
28744905

Sources:
PharmGKB
PREDNISOLONE TG

Interaction Score: 0.36

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
8636270 3427792

Sources:
NCI
PREDNISOLONE TAT

Interaction Score: 0.34

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
6127207

Sources:
NCI
PREDNISOLONE HMGB1

Interaction Score: 0.34

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
18447956

Sources:
NCI
PREDNISOLONE NOTCH1

Interaction Score: 0.26

Interaction Types & Directionality:

n/a

Interaction Info:

combination therapy Ribociclib + Prednisolone

Indication/Tumor Type T-cell adult acute lymphocytic leukemia

Response Type sensitive

PMIDs:
28151717

Sources:
JAX-CKB
PREDNISOLONE RB1

Interaction Score: 0.19

Interaction Types & Directionality:

n/a

Interaction Info:

combination therapy Ribociclib + Prednisolone

Indication/Tumor Type T-cell adult acute lymphocytic leukemia

Response Type sensitive

PMIDs:
28151717

Sources:
JAX-CKB
PREDNISOLONE BGLAP

Interaction Score: 0.16

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
1997509

Sources:
NCI
PREDNISOLONE FCGR3B

Interaction Score: 0.15

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
17329922

Sources:
NCI
PREDNISOLONE PLG

Interaction Score: 0.14

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
2079995

Sources:
NCI
PREDNISOLONE FCGR3A

Interaction Score: 0.14

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
17329922

Sources:
NCI
PREDNISOLONE NR3C1

Interaction Score: 0.11

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Specific Action of the Ligand Full agonist

Endogenous Drug? False

Direct Interaction? True

PMIDs:
2879901 19482847

Sources:
DrugBank TdgClinicalTrial ChemblInteractions TEND GuideToPharmacology TTD
PREDNISOLONE BAX

Interaction Score: 0.09

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
12730678

Sources:
NCI
PREDNISOLONE NR3C2

Interaction Score: 0.08

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Direct Interaction? False

Endogenous Drug? False

Specific Action of the Ligand Agonist

PMIDs:
None found

Sources:
GuideToPharmacology
PREDNISOLONE ANXA1

Interaction Score: 0.08

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
TEND
PREDNISOLONE G6PD

Interaction Score: 0.06

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
16324786

Sources:
NCI
PREDNISOLONE CYP3A5

Interaction Score: 0.04

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
12673034

Sources:
NCI
PREDNISOLONE ABCB1

Interaction Score: 0.03

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
25582575 14583680

Sources:
PharmGKB
PREDNISOLONE CYP3A4

Interaction Score: 0.0

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
9187528

Sources:
PharmGKB
PREDNISOLONE NFE2L2

Interaction Score: 0.0

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
PREDNISOLONE AR

Interaction Score: 0.0

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC

DrugBank: DB00860

Version: 5.1.7

Alternate Names:

PREDNISOLONE DrugBank Drug Name

50-24-8 CAS Number

Ak-Pred Drug Brand

Drug Info:

Drug Type small molecule

Drug Groups approved

Drug Groups vet_approved

Publications:

Ikonomidis et al., 2009, Lowering interleukin-1 activity with anakinra improves myocardial deformation in rheumatoid arthritis., Heart

Boudinot et al., 1986, Receptor-mediated pharmacodynamics of prednisolone in the rat., J Pharmacokinet Biopharm

TEND: PREDNISOLONE
- Version: 01-August-2011
Alternate Names:

PREDNISOLONE Primary Drug Name

Drug Info:

Year of Approval approved before 1982

Drug Class anti-inflammatory agents

Drug Class glucocorticoids

Publications:
TdgClinicalTrial: PREDNISOLONE
- Version: January-2014
Alternate Names:

Drug Info:

Drug Indications antiinflammatory agent,corticosteroid

Drug Class Small Molecule

FDA Approval approved

Publications:

NCI: PREDNISOLONE

Version: 14-September-2017

Alternate Names:

C769 NCI drug code

Drug Info:

Publications:

Dewson et al., 2003, Conformational change and mitochondrial translocation of Bax accompany proteasome inhibitor-induced apoptosis of chronic lymphocytic leukemic cells., Oncogene

Cario et al., 1999, A microdeletion syndrome due to a 3-Mb deletion on 19q13.2--Diamond-Blackfan anemia associated with macrocephaly, hypotonia, and psychomotor retardation., Clin. Genet.

Usui et al., 2003, Induction of CYP3As in HepG2 cells by several drugs. Association between induction of CYP3A4 and expression of glucocorticoid receptor., Biol. Pharm. Bull.

JAX-CKB: Prednisolone
- Version: 27-September-2017
Alternate Names:

Drug Info:

Publications:

Pikman et al., 2017, Synergistic Drug Combinations with a CDK4/6 Inhibitor in T-cell Acute Lymphoblastic Leukemia., Clin. Cancer Res.

PharmGKB: prednisolone

Version: 18-August-2020

Alternate Names:

Drug Info:

Publications:

Rendic S et al., 1997, Human cytochrome P450 enzymes: a status report summarizing their reactions, substrates, inducers, and inhibitors., Drug Metab Rev

Asano T et al., 2003, ABCB1 C3435T and G2677T/A polymorphism decreased the risk for steroid-induced osteonecrosis of the femoral head after kidney transplantation., Pharmacogenetics

Gregers J et al., 2015, Polymorphisms in the ABCB1 gene and effect on outcome and toxicity in childhood acute lymphoblastic leukemia., Pharmacogenomics J

TTD: Prednisolone
- Version: 2020.06.01
Alternate Names:

D0D1SG TTD Drug ID

Drug Info:

Publications:
GuideToPharmacology: 135650850
- Version: 29-September-2020
Alternate Names:

PREDNISOLONE GuideToPharmacology Ligand Name

Drug Info:

Publications:
DTC: PREDNISOLONE
- Version: 02-September-2020
Alternate Names:

CHEMBL131 ChEMBL Drug ID

Drug Info:

Publications:
ChemblDrugs: chembl:CHEMBL131
- Version: ChEMBL_27
Alternate Names:

Drug Info:

Publications:
ChemblInteractions: CHEMBL131
- Version: chembl_23
Alternate Names:

Drug Info:

Publications:

combination therapy	Ribociclib + Prednisolone
Indication/Tumor Type	T-cell adult acute lymphocytic leukemia
Response Type	sensitive

Specific Action of the Ligand	Full agonist
Endogenous Drug?	False
Direct Interaction?	True

PREDNISOLONE	DrugBank Drug Name
50-24-8	CAS Number
Ak-Pred	Drug Brand

Drug Type	small molecule
Drug Groups	approved
Drug Groups	vet_approved

PREDNISOLONE Drug Record

PREDNISOLONE chembl:CHEMBL131 ApprovedAntineoplasticImmunotherapy

Alternate Names:

Drug Info:

Publications:

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 6699450

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: PharmGKB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 2314540

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 7532164

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: PharmGKB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 10450869

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 28744905

Sources: PharmGKB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 8636270 3427792

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 6127207

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 18447956

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info: combination therapy Ribociclib + Prednisolone Indication/Tumor Type T-cell adult acute lymphocytic leukemia Response Type sensitive

PMIDs: 28151717

Sources: JAX-CKB

Interaction Types & Directionality: n/a

Interaction Info: combination therapy Ribociclib + Prednisolone Indication/Tumor Type T-cell adult acute lymphocytic leukemia Response Type sensitive

PMIDs: 28151717

Sources: JAX-CKB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 1997509

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 17329922

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 2079995

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 17329922

Sources: NCI

Interaction Types & Directionality: agonist (activating)

Interaction Info: Specific Action of the Ligand Full agonist Endogenous Drug? False Direct Interaction? True

PMIDs: 2879901 19482847

Sources: DrugBank TdgClinicalTrial ChemblInteractions TEND GuideToPharmacology TTD

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 12730678

Sources: NCI

Interaction Types & Directionality: agonist (activating)

Interaction Info: Direct Interaction? False Endogenous Drug? False Specific Action of the Ligand Agonist

PMIDs: None found

Interaction Types & Directionality:

n/a

PMIDs:
6699450

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
2314540

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
7532164

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
10450869

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
28744905

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
8636270 3427792

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
6127207

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
18447956

Sources:
NCI

Interaction Types & Directionality:

n/a

Interaction Info:

combination therapy Ribociclib + Prednisolone

Indication/Tumor Type T-cell adult acute lymphocytic leukemia

Response Type sensitive

PMIDs:
28151717

Sources:
JAX-CKB

Interaction Types & Directionality:

n/a

Interaction Info:

combination therapy Ribociclib + Prednisolone

Indication/Tumor Type T-cell adult acute lymphocytic leukemia

Response Type sensitive

PMIDs:
28151717

Sources:
JAX-CKB

Interaction Types & Directionality:

n/a

PMIDs:
1997509

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
17329922

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
2079995

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
17329922

Sources:
NCI

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Specific Action of the Ligand Full agonist

Endogenous Drug? False

Direct Interaction? True

PMIDs:
2879901 19482847

Sources:
DrugBank TdgClinicalTrial ChemblInteractions TEND GuideToPharmacology TTD

Interaction Types & Directionality:

n/a

PMIDs:
12730678

Sources:
NCI

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Direct Interaction? False

Endogenous Drug? False

Specific Action of the Ligand Agonist

PMIDs:
None found

Sources:
GuideToPharmacology

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
TEND

Interaction Types & Directionality:

n/a

PMIDs:
16324786

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
12673034

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
25582575 14583680

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
9187528

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a