• Search
      • Search Interactions Search Categories
    • Browse
      • Browse Categories Browse Sources
    • Information
      • About Publications Interaction Types & Directionalities Interaction Score & Query Score API Documentation FAQ Known Data Clients News Contact
    • Downloads
      • Data Source Code

PRAZOSIN Drug Record

  • Summary
  • Interactions
  • Claims
  • PRAZOSIN chembl:CHEMBL2 Approved

    Alternate Names:

    CP-12299
    CP-122991
    PRAZOSIN
    2-(4-(2-FUROYL)PIPERAZIN-1-YL)-4-AMINO-6,7-DIMETHOXYQUINAZOLINE
    MINIPRESS®
    HYPOVASE®
    PRAZOSINUM
    1-(4-AMINO-6,7-DIMETHOXY-2-QUINAZOLINYL)-4-(2-FURANYLCARBONYL)PIPERAZINE
    PRAZOSINE
    PRAZOSINA
    CP-12299-1
    rxcui:8629
    chembl:CHEMBL2
    chemidplus:19216-56-9
    pubchem.compound:4893
    drugbank:00457

    Drug Info:

    Drug Categories quinazolines
    Drug Categories oct2 substrates
    Drug Categories alpha-adrenoreceptor antagonists and diuretics
    FDA Approval 1976
    Drug Class small molecule
    Drug Indications antispasmodics
    Drug Indications Antihypertensive Agents
    Year of Approval 1976
    Drug Class antispasmodics
    Drug Class antihypertensive agents
    Drug Categories antiadrenergic agents, peripherally acting
    Drug Categories antihypertensive agents indicated for hypertension
    Drug Categories heterocyclic compounds, fused-ring
    Drug Categories oct1 inhibitors
    Drug Categories oct1 substrates
    Drug Categories p-glycoprotein inhibitors
    Drug Categories p-glycoprotein substrates
    Drug Categories peripheral alpha-1 blockers
    Drug Categories vasodilating agents
    (4 More Sources)

    Publications:

    Ishiguro et al., 2002, Identification of binding sites of prazosin, tamsulosin and KMD-3213 with alpha(1)-adrenergic receptor subtypes by molecular modeling., Life Sci.
    Eltze, 1996, In functional experiments, risperidone is selective, not for the B, but for the A subtype of alpha 1-adrenoceptors., Eur. J. Pharmacol.
    Al-Damluji et al., 2001, alpha(1B) adrenergic receptors in gonadotrophin-releasing hormone neurones: relation to Transport-P., Br. J. Pharmacol.
    Cusack et al., 1994, Binding of antidepressants to human brain receptors: focus on newer generation compounds., Psychopharmacology (Berl.)
    Chen et al., 2002, TTD: Therapeutic Target Database., Nucleic Acids Res.
    Sleight et al., 1993, Binding of antipsychotic drugs at alpha 1A- and alpha 1B-adrenoceptors: risperidone is selective for the alpha 1B-adrenoceptors., Eur. J. Pharmacol.
    Sharpe et al., 2003, Allosteric alpha 1-adrenoreceptor antagonism by the conopeptide rho-TIA., J. Biol. Chem.
    Thomas et al., 2004, Inhibition of human ether-a-go-go-related gene potassium channels by alpha 1-adrenoceptor antagonists prazosin, doxazosin, and terazosin., Naunyn Schmiedebergs Arch. Pharmacol.
    Thomas D et al., 2004, Activation of cardiac human ether-a-go-go related gene potassium currents is regulated by alpha(1A)-adrenoceptors., J Mol Med (Berl)
    Rettori et al., 1997, The mechanism of action of alcohol to suppress gonadotropin secretion., Mol. Psychiatry
    Morris et al., 2004, Cellular trafficking of human alpha1a-adrenergic receptors is continuous and primarily agonist-independent., Mol. Pharmacol.
    Tomiyama et al., 2007, Expressions and mechanical functions of alpha1-adrenoceptor subtypes in hamster ureter., Eur. J. Pharmacol.
    Zacharia et al., 2004, Alpha1-adrenoceptor subtypes involved in vasoconstrictor responses to exogenous and neurally released noradrenaline in rat femoral resistance arteries., Br. J. Pharmacol.
    Suzuki et al., 2000, Effect of JTH-601, a novel alpha(1)-adrenoceptor antagonist, on prostate function in dogs., Eur. J. Pharmacol.
    Chang et al., 2003, Stimulatory effect of cinnamic acid analogues on alpha1A-adrenoceptors in-vitro., J. Pharm. Pharmacol.
    Uhlén et al., 1991, Delineation of rat kidney alpha 2A- and alpha 2B-adrenoceptors with [3H]RX821002 radioligand binding: computer modelling reveals that guanfacine is an alpha 2A-selective compound., Eur. J. Pharmacol.
    Bylund DB, 1985, Heterogeneity of alpha-2 adrenergic receptors., Pharmacol Biochem Behav
    Adams HR, 1983, Pharmacologic problems in circulation research: alpha adrenergic blocking drugs., Circ Shock
    Yasuda G et al., 1991, Characterization of prazosin-sensitive alpha 2 B-adrenoceptors expressed by cultured rat IMCD cells., Am J Physiol
    Bylund et al., 1988, Alpha-2A and alpha-2B adrenergic receptor subtypes: antagonist binding in tissues and cell lines containing only one subtype., J. Pharmacol. Exp. Ther.
    Nagaoka et al., 2008, Amino acids of the human alpha1d-adrenergic receptor involved in antagonist binding., J. Pharmacol. Sci.
    Yamamoto et al., 2001, alpha(1)-Adrenoceptor subtypes in the mouse mesenteric artery and abdominal aorta., Br. J. Pharmacol.
    Ballard-Croft et al., 2002, Activation of stress-responsive pathways by the sympathetic nervous system in burn trauma., Shock
    Ishiguro N et al., 2013, Evaluation and prediction of potential drug-drug interactions of linagliptin using in vitro cell culture methods., Drug Metab Dispos
  • PRAZOSIN   ADRA1B

    Interaction Score: 0.43

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Direct Interaction? True
    Endogenous Drug? False
    Specific Action of the Ligand Inverse agonist

    PMIDs:
    12270758 8925876 11156594 7855217 11752352 7691623 12824165


    Sources:
    TEND TdgClinicalTrial DrugBank GuideToPharmacology

  • PRAZOSIN   ADRA1D

    Interaction Score: 0.43

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Direct Interaction? True
    Endogenous Drug? False
    Specific Action of the Ligand Inverse agonist

    PMIDs:
    18187928 7855217 11682453


    Sources:
    TEND TdgClinicalTrial DrugBank GuideToPharmacology

  • PRAZOSIN   ADRA2B

    Interaction Score: 0.33

    Interaction Types & Directionality:
    binder
    antagonist (inhibitory)

    Interaction Info:
    Specific Action of the Ligand Antagonist
    Endogenous Drug? False

    PMIDs:
    1666366 2989948 6133635 1719824 2835476


    Sources:
    DrugBank GuideToPharmacology

  • PRAZOSIN   ADRA1A

    Interaction Score: 0.29

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Trial Name -
    Novel drug target Established target
    Specific Action of the Ligand Inverse agonist

    PMIDs:
    15258254 17658513 8925876 14980979 10771044 7855217 7691623 12841945


    Sources:
    TEND TdgClinicalTrial DrugBank GuideToPharmacology

  • PRAZOSIN   MAPK8

    Interaction Score: 0.18

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    12095132


    Sources:
    NCI

  • PRAZOSIN   ADRA2A

    Interaction Score: 0.16

    Interaction Types & Directionality:
    binder
    antagonist (inhibitory)

    Interaction Info:
    Specific Action of the Ligand Antagonist
    Endogenous Drug? False

    PMIDs:
    1666366 2989948 6133635


    Sources:
    DrugBank GuideToPharmacology

  • PRAZOSIN   NOS1

    Interaction Score: 0.14

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    9322222


    Sources:
    NCI

  • PRAZOSIN   ABCG2

    Interaction Score: 0.14

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    23073734


    Sources:
    DTC

  • PRAZOSIN   ADRA2C

    Interaction Score: 0.04

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Specific Action of the Ligand Antagonist
    Endogenous Drug? False

    PMIDs:
    None found


    Sources:
    GuideToPharmacology

  • PRAZOSIN   KCNH2

    Interaction Score: 0.04

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:

    PMIDs:
    15098086 15365637


    Sources:
    DrugBank

  • PRAZOSIN   HSD17B10

    Interaction Score: 0.01

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • PRAZOSIN   AR

    Interaction Score: 0.0

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • PRAZOSIN   CYP3A4

    Interaction Score: 0.0

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • DrugBank: DB00457

    • Version: 5.1.7

    Alternate Names:
    PRAZOSIN DrugBank Drug Name
    19216-56-9 CAS Number
    Alti-prazosin-tab 1mg Drug Brand

    Drug Info:
    Drug Type small molecule
    Drug Groups approved
    Drug Categories adrenergic alpha-1 receptor antagonists

    Publications:
    Eltze, 1996, In functional experiments, risperidone is selective, not for the B, but for the A subtype of alpha 1-adrenoceptors., Eur. J. Pharmacol.
    Sleight et al., 1993, Binding of antipsychotic drugs at alpha 1A- and alpha 1B-adrenoceptors: risperidone is selective for the alpha 1B-adrenoceptors., Eur. J. Pharmacol.
    Sharpe et al., 2003, Allosteric alpha 1-adrenoreceptor antagonism by the conopeptide rho-TIA., J. Biol. Chem.

  • TEND: PRAZOSIN

    • Version: 01-August-2011

    Alternate Names:
    PRAZOSIN Primary Drug Name

    Drug Info:
    Drug Class antihypertensive agents
    Drug Class antispasmodics
    Year of Approval 1976

    Publications:

  • TdgClinicalTrial: PRAZOSIN

    • Version: January-2014

    Alternate Names:

    Drug Info:
    Drug Indications Antihypertensive Agents
    Drug Indications antispasmodics
    Drug Class small molecule

    Publications:

  • DTC: PRAZOSIN

    • Version: 02-September-2020

    Alternate Names:
    CHEMBL2 ChEMBL Drug ID

    Drug Info:

    Publications:
    Ishiguro N et al., 2013, Evaluation and prediction of potential drug-drug interactions of linagliptin using in vitro cell culture methods., Drug Metab Dispos

  • NCI: PRAZOSIN

    • Version: 14-September-2017

    Alternate Names:
    C767 NCI drug code

    Drug Info:

    Publications:
    Rettori et al., 1997, The mechanism of action of alcohol to suppress gonadotropin secretion., Mol. Psychiatry
    Ballard-Croft et al., 2002, Activation of stress-responsive pathways by the sympathetic nervous system in burn trauma., Shock

  • GuideToPharmacology: 135650849

    • Version: 29-September-2020

    Alternate Names:
    PRAZOSIN GuideToPharmacology Ligand Name

    Drug Info:

    Publications:

  • TTD: Prazosin

    • Version: 2020.06.01

    Alternate Names:
    D0WV3U TTD Drug ID

    Drug Info:

    Publications:

  • ChemblDrugs: chembl:CHEMBL2

    • Version: ChEMBL_27

    Alternate Names:

    Drug Info:

    Publications:

Disclaimer: This resource is intended for purely research purposes. It should not be used for emergencies or medical or professional advice.

A finding of a drug-gene interaction or potentially druggable category does not necessarily indicate effectiveness (or lack thereof) of any drug or treatment regimen. A finding of no interaction or no potentially druggable category does not necessarily indicate lack of effectiveness of any drug or treatment regimen. Drug-gene interactions or potentially druggable categories are not presented in ranked order of potential or predicted efficacy.

The dgidb.org website does not provide any medical or healthcare products, services or advice, and is not for medical emergencies or urgent situations. IF YOU THINK YOU MAY HAVE A MEDICAL EMERGENCY, CALL YOUR DOCTOR OR 911 IMMEDIATELY. Information contained on this website is not a substitute for a doctor's medical judgment or advice. We recommend that you discuss your specific, individual health concerns with your doctor or health care professional.

DGIdb (v4.2.0 - sha1 afd9f30b) • Last updated 2020-10-21