DGIdb - PRAZOSIN Drug Record

PRAZOSIN chembl:CHEMBL2 Approved

Alternate Names:

CP-12299
CP-122991
PRAZOSIN
2-(4-(2-FUROYL)PIPERAZIN-1-YL)-4-AMINO-6,7-DIMETHOXYQUINAZOLINE
MINIPRESS®
HYPOVASE®
PRAZOSINUM
1-(4-AMINO-6,7-DIMETHOXY-2-QUINAZOLINYL)-4-(2-FURANYLCARBONYL)PIPERAZINE
PRAZOSINE
PRAZOSINA
CP-12299-1
rxcui:8629
chembl:CHEMBL2
chemidplus:19216-56-9
pubchem.compound:4893
drugbank:00457

Drug Info:

FDA Approval	1976
Drug Class	small molecule
Drug Indications	antispasmodics
Drug Indications	Antihypertensive Agents
Year of Approval	1976
Drug Class	antispasmodics
Drug Class	antihypertensive agents

(2 More Sources)

Publications:

Cusack et al., 1994, Binding of antidepressants to human brain receptors: focus on newer generation compounds., Psychopharmacology (Berl.)
Eltze, 1996, In functional experiments, risperidone is selective, not for the B, but for the A subtype of alpha 1-adrenoceptors., Eur. J. Pharmacol.
Ishiguro et al., 2002, Identification of binding sites of prazosin, tamsulosin and KMD-3213 with alpha(1)-adrenergic receptor subtypes by molecular modeling., Life Sci.
Chen et al., 2002, TTD: Therapeutic Target Database., Nucleic Acids Res.
Sleight et al., 1993, Binding of antipsychotic drugs at alpha 1A- and alpha 1B-adrenoceptors: risperidone is selective for the alpha 1B-adrenoceptors., Eur. J. Pharmacol.
Sharpe et al., 2003, Allosteric alpha 1-adrenoreceptor antagonism by the conopeptide rho-TIA., J. Biol. Chem.
Al-Damluji et al., 2001, alpha(1B) adrenergic receptors in gonadotrophin-releasing hormone neurones: relation to Transport-P., Br. J. Pharmacol.
Rettori et al., 1997, The mechanism of action of alcohol to suppress gonadotropin secretion., Mol. Psychiatry
Morris et al., 2004, Cellular trafficking of human alpha1a-adrenergic receptors is continuous and primarily agonist-independent., Mol. Pharmacol.
Suzuki et al., 2000, Effect of JTH-601, a novel alpha(1)-adrenoceptor antagonist, on prostate function in dogs., Eur. J. Pharmacol.
Tomiyama et al., 2007, Expressions and mechanical functions of alpha1-adrenoceptor subtypes in hamster ureter., Eur. J. Pharmacol.
Chang et al., 2003, Stimulatory effect of cinnamic acid analogues on alpha1A-adrenoceptors in-vitro., J. Pharm. Pharmacol.
Zacharia et al., 2004, Alpha1-adrenoceptor subtypes involved in vasoconstrictor responses to exogenous and neurally released noradrenaline in rat femoral resistance arteries., Br. J. Pharmacol.
Nagaoka et al., 2008, Amino acids of the human alpha1d-adrenergic receptor involved in antagonist binding., J. Pharmacol. Sci.
Yamamoto et al., 2001, alpha(1)-Adrenoceptor subtypes in the mouse mesenteric artery and abdominal aorta., Br. J. Pharmacol.
Ballard-Croft et al., 2002, Activation of stress-responsive pathways by the sympathetic nervous system in burn trauma., Shock
Ishiguro N et al., 2013, Evaluation and prediction of potential drug-drug interactions of linagliptin using in vitro cell culture methods., Drug Metab Dispos

PRAZOSIN ADRA1D

Interaction Score: 1.32

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
18187928 7855217 11682453

Sources:
TdgClinicalTrial TEND
PRAZOSIN ADRA1B

Interaction Score: 1.03

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Novel drug target Established target

Trial Name -

PMIDs:
7855217 8925876 12270758 11752352 7691623 12824165 11156594

Sources:
TdgClinicalTrial TEND
PRAZOSIN ADRA1A

Interaction Score: 0.79

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
7855217 15258254 10771044 17658513 12841945 14980979 8925876 7691623

Sources:
TdgClinicalTrial TEND
PRAZOSIN NOS1

Interaction Score: 0.36

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
9322222

Sources:
NCI
PRAZOSIN MAPK8

Interaction Score: 0.34

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
12095132

Sources:
NCI
PRAZOSIN ABCG2

Interaction Score: 0.22

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
23073734

Sources:
DTC
PRAZOSIN HSD17B10

Interaction Score: 0.02

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
PRAZOSIN AR

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
PRAZOSIN CYP3A4

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC

TEND: PRAZOSIN
- Version: 01-August-2011
Alternate Names:

PRAZOSIN Primary Drug Name

Drug Info:

Drug Class antihypertensive agents

Drug Class antispasmodics

Year of Approval 1976

Publications:
TdgClinicalTrial: PRAZOSIN
- Version: January-2014
Alternate Names:

Drug Info:

Drug Indications Antihypertensive Agents

Drug Indications antispasmodics

Drug Class small molecule

Publications:
DTC: PRAZOSIN
- Version: 02-September-2020
Alternate Names:

CHEMBL2 ChEMBL Drug ID

Drug Info:

Publications:

Ishiguro N et al., 2013, Evaluation and prediction of potential drug-drug interactions of linagliptin using in vitro cell culture methods., Drug Metab Dispos

NCI: PRAZOSIN

Version: 14-September-2017

Alternate Names:

C767 NCI drug code

Drug Info:

Publications:

Rettori et al., 1997, The mechanism of action of alcohol to suppress gonadotropin secretion., Mol. Psychiatry

Ballard-Croft et al., 2002, Activation of stress-responsive pathways by the sympathetic nervous system in burn trauma., Shock

TTD: Prazosin
- Version: 2020.06.01
Alternate Names:

D0WV3U TTD Drug ID

Drug Info:

Publications:
ChemblDrugs: chembl:CHEMBL2
- Version: ChEMBL_27
Alternate Names:

Drug Info:

Publications:

Trial Name	-
Novel drug target	Established target

Novel drug target	Established target
Trial Name	-

Trial Name	-
Novel drug target	Established target

PRAZOSIN Drug Record

PRAZOSIN chembl:CHEMBL2 Approved

Alternate Names:

Drug Info:

Publications:

Interaction Types & Directionality: antagonist (inhibitory)

Interaction Info: Trial Name - Novel drug target Established target

PMIDs: 18187928 7855217 11682453

Sources: TdgClinicalTrial TEND

Interaction Types & Directionality: antagonist (inhibitory)

Interaction Info: Novel drug target Established target Trial Name -

PMIDs: 7855217 8925876 12270758 11752352 7691623 12824165 11156594

Sources: TdgClinicalTrial TEND

Interaction Types & Directionality: antagonist (inhibitory)

Interaction Info: Trial Name - Novel drug target Established target

PMIDs: 7855217 15258254 10771044 17658513 12841945 14980979 8925876 7691623

Sources: TdgClinicalTrial TEND

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 9322222

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 12095132

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 23073734

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

TEND: PRAZOSIN

Alternate Names: PRAZOSIN Primary Drug Name

Drug Info: Drug Class antihypertensive agents Drug Class antispasmodics Year of Approval 1976

Publications:

TdgClinicalTrial: PRAZOSIN

Alternate Names:

Drug Info: Drug Indications Antihypertensive Agents Drug Indications antispasmodics Drug Class small molecule

Publications:

DTC: PRAZOSIN

Alternate Names: CHEMBL2 ChEMBL Drug ID

Drug Info:

Publications: Ishiguro N et al., 2013, Evaluation and prediction of potential drug-drug interactions of linagliptin using in vitro cell culture methods., Drug Metab Dispos

NCI: PRAZOSIN

Alternate Names: C767 NCI drug code

Drug Info:

Publications: Rettori et al., 1997, The mechanism of action of alcohol to suppress gonadotropin secretion., Mol. Psychiatry Ballard-Croft et al., 2002, Activation of stress-responsive pathways by the sympathetic nervous system in burn trauma., Shock

TTD: Prazosin

Alternate Names: D0WV3U TTD Drug ID

Drug Info:

Publications:

ChemblDrugs: chembl:CHEMBL2

Alternate Names:

Drug Info:

Publications:

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
18187928 7855217 11682453

Sources:
TdgClinicalTrial TEND

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Novel drug target Established target

Trial Name -

PMIDs:
7855217 8925876 12270758 11752352 7691623 12824165 11156594

Sources:
TdgClinicalTrial TEND

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
7855217 15258254 10771044 17658513 12841945 14980979 8925876 7691623

Sources:
TdgClinicalTrial TEND

Interaction Types & Directionality:

n/a

PMIDs:
9322222

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
12095132

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
23073734

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Alternate Names:

PRAZOSIN Primary Drug Name

Drug Info:

Drug Class antihypertensive agents

Drug Class antispasmodics

Year of Approval 1976

Drug Info:

Drug Indications Antihypertensive Agents

Drug Indications antispasmodics

Drug Class small molecule

Alternate Names:

CHEMBL2 ChEMBL Drug ID

Publications:

Ishiguro N et al., 2013, Evaluation and prediction of potential drug-drug interactions of linagliptin using in vitro cell culture methods., Drug Metab Dispos

Alternate Names:

C767 NCI drug code

Publications:

Rettori et al., 1997, The mechanism of action of alcohol to suppress gonadotropin secretion., Mol. Psychiatry

Ballard-Croft et al., 2002, Activation of stress-responsive pathways by the sympathetic nervous system in burn trauma., Shock

Alternate Names:

D0WV3U TTD Drug ID