DGIdb - PRAZOSIN Drug Record

PRAZOSIN chembl:CHEMBL2 Approved

Alternate Names:

CP-12299
CP-122991
PRAZOSIN
2-(4-(2-FUROYL)PIPERAZIN-1-YL)-4-AMINO-6,7-DIMETHOXYQUINAZOLINE
MINIPRESS®
HYPOVASE®
PRAZOSINUM
1-(4-AMINO-6,7-DIMETHOXY-2-QUINAZOLINYL)-4-(2-FURANYLCARBONYL)PIPERAZINE
PRAZOSINE
PRAZOSINA
CP-12299-1
rxcui:8629
chembl:CHEMBL2
chemidplus:19216-56-9
pubchem.compound:4893
drugbank:00457

Drug Info:

Drug Categories	quinazolines
Drug Categories	oct2 substrates
Drug Categories	alpha-adrenoreceptor antagonists and diuretics
FDA Approval	1976
Drug Class	small molecule
Drug Indications	antispasmodics
Drug Indications	Antihypertensive Agents
Year of Approval	1976
Drug Class	antispasmodics
Drug Class	antihypertensive agents
Drug Categories	antiadrenergic agents, peripherally acting
Drug Categories	antihypertensive agents indicated for hypertension
Drug Categories	heterocyclic compounds, fused-ring
Drug Categories	oct1 inhibitors
Drug Categories	oct1 substrates
Drug Categories	p-glycoprotein inhibitors
Drug Categories	p-glycoprotein substrates
Drug Categories	peripheral alpha-1 blockers
Drug Categories	vasodilating agents

(4 More Sources)

Publications:

Ishiguro et al., 2002, Identification of binding sites of prazosin, tamsulosin and KMD-3213 with alpha(1)-adrenergic receptor subtypes by molecular modeling., Life Sci.
Eltze, 1996, In functional experiments, risperidone is selective, not for the B, but for the A subtype of alpha 1-adrenoceptors., Eur. J. Pharmacol.
Al-Damluji et al., 2001, alpha(1B) adrenergic receptors in gonadotrophin-releasing hormone neurones: relation to Transport-P., Br. J. Pharmacol.
Cusack et al., 1994, Binding of antidepressants to human brain receptors: focus on newer generation compounds., Psychopharmacology (Berl.)
Chen et al., 2002, TTD: Therapeutic Target Database., Nucleic Acids Res.
Sleight et al., 1993, Binding of antipsychotic drugs at alpha 1A- and alpha 1B-adrenoceptors: risperidone is selective for the alpha 1B-adrenoceptors., Eur. J. Pharmacol.
Sharpe et al., 2003, Allosteric alpha 1-adrenoreceptor antagonism by the conopeptide rho-TIA., J. Biol. Chem.
Thomas et al., 2004, Inhibition of human ether-a-go-go-related gene potassium channels by alpha 1-adrenoceptor antagonists prazosin, doxazosin, and terazosin., Naunyn Schmiedebergs Arch. Pharmacol.
Thomas D et al., 2004, Activation of cardiac human ether-a-go-go related gene potassium currents is regulated by alpha(1A)-adrenoceptors., J Mol Med (Berl)
Rettori et al., 1997, The mechanism of action of alcohol to suppress gonadotropin secretion., Mol. Psychiatry
Morris et al., 2004, Cellular trafficking of human alpha1a-adrenergic receptors is continuous and primarily agonist-independent., Mol. Pharmacol.
Tomiyama et al., 2007, Expressions and mechanical functions of alpha1-adrenoceptor subtypes in hamster ureter., Eur. J. Pharmacol.
Zacharia et al., 2004, Alpha1-adrenoceptor subtypes involved in vasoconstrictor responses to exogenous and neurally released noradrenaline in rat femoral resistance arteries., Br. J. Pharmacol.
Suzuki et al., 2000, Effect of JTH-601, a novel alpha(1)-adrenoceptor antagonist, on prostate function in dogs., Eur. J. Pharmacol.
Chang et al., 2003, Stimulatory effect of cinnamic acid analogues on alpha1A-adrenoceptors in-vitro., J. Pharm. Pharmacol.
Uhlén et al., 1991, Delineation of rat kidney alpha 2A- and alpha 2B-adrenoceptors with [3H]RX821002 radioligand binding: computer modelling reveals that guanfacine is an alpha 2A-selective compound., Eur. J. Pharmacol.
Bylund DB, 1985, Heterogeneity of alpha-2 adrenergic receptors., Pharmacol Biochem Behav
Adams HR, 1983, Pharmacologic problems in circulation research: alpha adrenergic blocking drugs., Circ Shock
Yasuda G et al., 1991, Characterization of prazosin-sensitive alpha 2 B-adrenoceptors expressed by cultured rat IMCD cells., Am J Physiol
Bylund et al., 1988, Alpha-2A and alpha-2B adrenergic receptor subtypes: antagonist binding in tissues and cell lines containing only one subtype., J. Pharmacol. Exp. Ther.
Nagaoka et al., 2008, Amino acids of the human alpha1d-adrenergic receptor involved in antagonist binding., J. Pharmacol. Sci.
Yamamoto et al., 2001, alpha(1)-Adrenoceptor subtypes in the mouse mesenteric artery and abdominal aorta., Br. J. Pharmacol.
Ballard-Croft et al., 2002, Activation of stress-responsive pathways by the sympathetic nervous system in burn trauma., Shock
Ishiguro N et al., 2013, Evaluation and prediction of potential drug-drug interactions of linagliptin using in vitro cell culture methods., Drug Metab Dispos

PRAZOSIN ADRA1B

Interaction Score: 0.43

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Direct Interaction? True

Endogenous Drug? False

Specific Action of the Ligand Inverse agonist

PMIDs:
12270758 8925876 11156594 7855217 11752352 7691623 12824165

Sources:
TEND TdgClinicalTrial DrugBank GuideToPharmacology
PRAZOSIN ADRA1D

Interaction Score: 0.43

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Direct Interaction? True

Endogenous Drug? False

Specific Action of the Ligand Inverse agonist

PMIDs:
18187928 7855217 11682453

Sources:
TEND TdgClinicalTrial DrugBank GuideToPharmacology
PRAZOSIN ADRA2B

Interaction Score: 0.33

Interaction Types & Directionality:

binder

antagonist (inhibitory)

Interaction Info:

Specific Action of the Ligand Antagonist

Endogenous Drug? False

PMIDs:
1666366 2989948 6133635 1719824 2835476

Sources:
DrugBank GuideToPharmacology
PRAZOSIN ADRA1A

Interaction Score: 0.29

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Trial Name -

Novel drug target Established target

Specific Action of the Ligand Inverse agonist

PMIDs:
15258254 17658513 8925876 14980979 10771044 7855217 7691623 12841945

Sources:
TEND TdgClinicalTrial DrugBank GuideToPharmacology
PRAZOSIN MAPK8

Interaction Score: 0.18

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
12095132

Sources:
NCI
PRAZOSIN ADRA2A

Interaction Score: 0.16

Interaction Types & Directionality:

binder

antagonist (inhibitory)

Interaction Info:

Specific Action of the Ligand Antagonist

Endogenous Drug? False

PMIDs:
1666366 2989948 6133635

Sources:
DrugBank GuideToPharmacology
PRAZOSIN NOS1

Interaction Score: 0.14

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
9322222

Sources:
NCI
PRAZOSIN ABCG2

Interaction Score: 0.14

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
23073734

Sources:
DTC
PRAZOSIN ADRA2C

Interaction Score: 0.04

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Specific Action of the Ligand Antagonist

Endogenous Drug? False

PMIDs:
None found

Sources:
GuideToPharmacology
PRAZOSIN KCNH2

Interaction Score: 0.04

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

PMIDs:
15098086 15365637

Sources:
DrugBank
PRAZOSIN HSD17B10

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
PRAZOSIN AR

Interaction Score: 0.0

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
PRAZOSIN CYP3A4

Interaction Score: 0.0

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC

DrugBank: DB00457

Version: 5.1.7

Alternate Names:

PRAZOSIN DrugBank Drug Name

19216-56-9 CAS Number

Alti-prazosin-tab 1mg Drug Brand

Drug Info:

Drug Type small molecule

Drug Groups approved

Drug Categories adrenergic alpha-1 receptor antagonists

Publications:

Eltze, 1996, In functional experiments, risperidone is selective, not for the B, but for the A subtype of alpha 1-adrenoceptors., Eur. J. Pharmacol.

Sleight et al., 1993, Binding of antipsychotic drugs at alpha 1A- and alpha 1B-adrenoceptors: risperidone is selective for the alpha 1B-adrenoceptors., Eur. J. Pharmacol.

Sharpe et al., 2003, Allosteric alpha 1-adrenoreceptor antagonism by the conopeptide rho-TIA., J. Biol. Chem.

TEND: PRAZOSIN
- Version: 01-August-2011
Alternate Names:

PRAZOSIN Primary Drug Name

Drug Info:

Drug Class antihypertensive agents

Drug Class antispasmodics

Year of Approval 1976

Publications:
TdgClinicalTrial: PRAZOSIN
- Version: January-2014
Alternate Names:

Drug Info:

Drug Indications Antihypertensive Agents

Drug Indications antispasmodics

Drug Class small molecule

Publications:
DTC: PRAZOSIN
- Version: 02-September-2020
Alternate Names:

CHEMBL2 ChEMBL Drug ID

Drug Info:

Publications:

Ishiguro N et al., 2013, Evaluation and prediction of potential drug-drug interactions of linagliptin using in vitro cell culture methods., Drug Metab Dispos

NCI: PRAZOSIN

Version: 14-September-2017

Alternate Names:

C767 NCI drug code

Drug Info:

Publications:

Rettori et al., 1997, The mechanism of action of alcohol to suppress gonadotropin secretion., Mol. Psychiatry

Ballard-Croft et al., 2002, Activation of stress-responsive pathways by the sympathetic nervous system in burn trauma., Shock

GuideToPharmacology: 135650849
- Version: 29-September-2020
Alternate Names:

PRAZOSIN GuideToPharmacology Ligand Name

Drug Info:

Publications:
TTD: Prazosin
- Version: 2020.06.01
Alternate Names:

D0WV3U TTD Drug ID

Drug Info:

Publications:
ChemblDrugs: chembl:CHEMBL2
- Version: ChEMBL_27
Alternate Names:

Drug Info:

Publications:

Direct Interaction?	True
Endogenous Drug?	False
Specific Action of the Ligand	Inverse agonist

Specific Action of the Ligand	Antagonist
Endogenous Drug?	False

Trial Name	-
Novel drug target	Established target
Specific Action of the Ligand	Inverse agonist

PRAZOSIN	DrugBank Drug Name
19216-56-9	CAS Number
Alti-prazosin-tab 1mg	Drug Brand

Drug Type	small molecule
Drug Groups	approved
Drug Categories	adrenergic alpha-1 receptor antagonists

binder
antagonist (inhibitory)

binder
antagonist (inhibitory)

PRAZOSIN Drug Record

PRAZOSIN chembl:CHEMBL2 Approved

Alternate Names:

Drug Info:

Publications:

Interaction Types & Directionality: antagonist (inhibitory)

Interaction Info: Direct Interaction? True Endogenous Drug? False Specific Action of the Ligand Inverse agonist

PMIDs: 12270758 8925876 11156594 7855217 11752352 7691623 12824165

Sources: TEND TdgClinicalTrial DrugBank GuideToPharmacology

Interaction Types & Directionality: antagonist (inhibitory)

Interaction Info: Direct Interaction? True Endogenous Drug? False Specific Action of the Ligand Inverse agonist

PMIDs: 18187928 7855217 11682453

Sources: TEND TdgClinicalTrial DrugBank GuideToPharmacology

Interaction Types & Directionality: binder antagonist (inhibitory)

Interaction Info: Specific Action of the Ligand Antagonist Endogenous Drug? False

PMIDs: 1666366 2989948 6133635 1719824 2835476

Sources: DrugBank GuideToPharmacology

Interaction Types & Directionality: antagonist (inhibitory)

Interaction Info: Trial Name - Novel drug target Established target Specific Action of the Ligand Inverse agonist

PMIDs: 15258254 17658513 8925876 14980979 10771044 7855217 7691623 12841945

Sources: TEND TdgClinicalTrial DrugBank GuideToPharmacology

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 12095132

Sources: NCI

Interaction Types & Directionality: binder antagonist (inhibitory)

Interaction Info: Specific Action of the Ligand Antagonist Endogenous Drug? False

PMIDs: 1666366 2989948 6133635

Sources: DrugBank GuideToPharmacology

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 9322222

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 23073734

Sources: DTC

Interaction Types & Directionality: antagonist (inhibitory)

Interaction Info: Specific Action of the Ligand Antagonist Endogenous Drug? False

PMIDs: None found

Sources: GuideToPharmacology

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info:

PMIDs: 15098086 15365637

Sources: DrugBank

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

DrugBank: DB00457

Alternate Names: PRAZOSIN DrugBank Drug Name 19216-56-9 CAS Number Alti-prazosin-tab 1mg Drug Brand

Drug Info: Drug Type small molecule Drug Groups approved Drug Categories adrenergic alpha-1 receptor antagonists

TEND: PRAZOSIN

Alternate Names: PRAZOSIN Primary Drug Name

Drug Info: Drug Class antihypertensive agents Drug Class antispasmodics Year of Approval 1976

Publications:

TdgClinicalTrial: PRAZOSIN

Alternate Names:

Drug Info: Drug Indications Antihypertensive Agents Drug Indications antispasmodics Drug Class small molecule

Publications:

DTC: PRAZOSIN

Alternate Names: CHEMBL2 ChEMBL Drug ID

Drug Info:

Publications: Ishiguro N et al., 2013, Evaluation and prediction of potential drug-drug interactions of linagliptin using in vitro cell culture methods., Drug Metab Dispos

NCI: PRAZOSIN

Alternate Names: C767 NCI drug code

Drug Info:

Publications: Rettori et al., 1997, The mechanism of action of alcohol to suppress gonadotropin secretion., Mol. Psychiatry Ballard-Croft et al., 2002, Activation of stress-responsive pathways by the sympathetic nervous system in burn trauma., Shock

GuideToPharmacology: 135650849

Alternate Names: PRAZOSIN GuideToPharmacology Ligand Name

Drug Info:

Publications:

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Direct Interaction? True

Endogenous Drug? False

Specific Action of the Ligand Inverse agonist

PMIDs:
12270758 8925876 11156594 7855217 11752352 7691623 12824165

Sources:
TEND TdgClinicalTrial DrugBank GuideToPharmacology

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Direct Interaction? True

Endogenous Drug? False

Specific Action of the Ligand Inverse agonist

PMIDs:
18187928 7855217 11682453

Sources:
TEND TdgClinicalTrial DrugBank GuideToPharmacology

Interaction Types & Directionality:

binder

antagonist (inhibitory)

Interaction Info:

Specific Action of the Ligand Antagonist

Endogenous Drug? False

PMIDs:
1666366 2989948 6133635 1719824 2835476

Sources:
DrugBank GuideToPharmacology

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Trial Name -

Novel drug target Established target

Specific Action of the Ligand Inverse agonist

PMIDs:
15258254 17658513 8925876 14980979 10771044 7855217 7691623 12841945

Sources:
TEND TdgClinicalTrial DrugBank GuideToPharmacology

Interaction Types & Directionality:

n/a

PMIDs:
12095132

Sources:
NCI

Interaction Types & Directionality:

binder

antagonist (inhibitory)

Interaction Info:

Specific Action of the Ligand Antagonist

Endogenous Drug? False

PMIDs:
1666366 2989948 6133635

Sources:
DrugBank GuideToPharmacology

Interaction Types & Directionality:

n/a

PMIDs:
9322222

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
23073734

Sources:
DTC

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Specific Action of the Ligand Antagonist

Endogenous Drug? False

PMIDs:
None found

Sources:
GuideToPharmacology

Interaction Types & Directionality:

inhibitor (inhibitory)

PMIDs:
15098086 15365637

Sources:
DrugBank

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Alternate Names:

PRAZOSIN DrugBank Drug Name

19216-56-9 CAS Number

Alti-prazosin-tab 1mg Drug Brand

Drug Info:

Drug Type small molecule

Drug Groups approved

Drug Categories adrenergic alpha-1 receptor antagonists

Alternate Names:

PRAZOSIN Primary Drug Name

Drug Info:

Drug Class antihypertensive agents

Drug Class antispasmodics

Year of Approval 1976

Drug Info:

Drug Indications Antihypertensive Agents

Drug Indications antispasmodics

Drug Class small molecule

Alternate Names:

CHEMBL2 ChEMBL Drug ID

Publications:

Ishiguro N et al., 2013, Evaluation and prediction of potential drug-drug interactions of linagliptin using in vitro cell culture methods., Drug Metab Dispos

Alternate Names:

C767 NCI drug code

Publications:

Rettori et al., 1997, The mechanism of action of alcohol to suppress gonadotropin secretion., Mol. Psychiatry

Ballard-Croft et al., 2002, Activation of stress-responsive pathways by the sympathetic nervous system in burn trauma., Shock

Alternate Names:

PRAZOSIN GuideToPharmacology Ligand Name

Alternate Names:

D0WV3U TTD Drug ID