DGIdb - PRASUGREL Drug Record

PRASUGREL chembl:CHEMBL1201772 Approved

Alternate Names:

PRASUGREL
LY-640315
EFIENT
EFFIENT®
EFFIENT
CS-747
EFIENT®
chembl:CHEMBL1201772
pubchem.compound:6918456
drugbank:06209
rxcui:613391
chemidplus:150322-43-3

Drug Info:

Year of Approval	2009
Drug Class	platelet aggregation inhibitors
FDA Approval	approved
Drug Class	small molecule
Drug Indications	antithrombotic

(2 More Sources)

Publications:

Chan NC et al., 2014, Role of phenotypic and genetic testing in managing clopidogrel therapy., Blood
Sangkuhl K et al., 2011, Platelet aggregation pathway., Pharmacogenet Genomics
Dovlatova et al., 2008, The reversible P2Y antagonist cangrelor influences the ability of the active metabolites of clopidogrel and prasugrel to produce irreversible inhibition of platelet function., J. Thromb. Haemost.
Abell LM et al., 2011, Dissecting the activation of thienopyridines by cytochromes P450 using a pharmacodynamic assay in vitro., J Pharmacol Exp Ther
Xiang Q et al., 2017, Genetic Variants of PEAR1 are Associated with Platelet Function and Antiplatelet Drug Efficacy: A Systematic Review and Meta-Analysis., Curr Pharm Des
Xiang Q et al., 2013, Identification of PEAR1 SNPs and their influences on the variation in prasugrel pharmacodynamics., Pharmacogenomics

PRASUGREL PEAR1

Interaction Score: 5.8

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
28820077 23859572

Sources:
PharmGKB
PRASUGREL P2RY12

Interaction Score: 3.86

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Novel drug target Established target

Trial Name prasugrel, CS-747,Efient

PMIDs:
24951432 20938371 18485086

Sources:
TdgClinicalTrial TEND PharmGKB TTD
PRASUGREL CYP2B6

Interaction Score: 0.48

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
21828263

Sources:
PharmGKB FDA
PRASUGREL NTRK1

Interaction Score: 0.45

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
28820077 23859572

Sources:
PharmGKB
PRASUGREL CYP3A5

Interaction Score: 0.23

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
21828263

Sources:
PharmGKB FDA
PRASUGREL CYP2C9

Interaction Score: 0.04

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
PharmGKB FDA
PRASUGREL CYP3A4

Interaction Score: 0.02

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
21828263

Sources:
PharmGKB
PRASUGREL CYP2C19

Interaction Score: 0.02

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
FDA

TEND: PRASUGREL
- Version: 01-August-2011
Alternate Names:

PRASUGREL Primary Drug Name

Drug Info:

Drug Class platelet aggregation inhibitors

Year of Approval 2009

Publications:
TdgClinicalTrial: PRASUGREL
- Version: January-2014
Alternate Names:

Drug Info:

Drug Indications antithrombotic

Drug Class small molecule

FDA Approval approved

Publications:

PharmGKB: prasugrel

Version: 18-August-2020

Alternate Names:

Drug Info:

Publications:

Sangkuhl K et al., 2011, Platelet aggregation pathway., Pharmacogenet Genomics

Chan NC et al., 2014, Role of phenotypic and genetic testing in managing clopidogrel therapy., Blood

Abell LM et al., 2011, Dissecting the activation of thienopyridines by cytochromes P450 using a pharmacodynamic assay in vitro., J Pharmacol Exp Ther

TTD: Prasugrel
- Version: 2020.06.01
Alternate Names:

D07IRF TTD Drug ID

Drug Info:

Publications:
ChemblDrugs: chembl:CHEMBL1201772
- Version: ChEMBL_27
Alternate Names:

Drug Info:

Publications:
FDA: Prasugrel
- Version: 04-September-2020
Alternate Names:

Drug Info:

Publications:

Novel drug target	Established target
Trial Name	prasugrel, CS-747,Efient

PRASUGREL Drug Record

PRASUGREL chembl:CHEMBL1201772 Approved

Alternate Names:

Drug Info:

Publications:

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 28820077 23859572

Sources: PharmGKB

Interaction Types & Directionality: antagonist (inhibitory)

Interaction Info: Novel drug target Established target Trial Name prasugrel, CS-747,Efient

PMIDs: 24951432 20938371 18485086

Sources: TdgClinicalTrial TEND PharmGKB TTD

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 21828263

Sources: PharmGKB FDA

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 28820077 23859572

Sources: PharmGKB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 21828263

Sources: PharmGKB FDA

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: PharmGKB FDA

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 21828263

Sources: PharmGKB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: FDA

TEND: PRASUGREL

Alternate Names: PRASUGREL Primary Drug Name

Drug Info: Drug Class platelet aggregation inhibitors Year of Approval 2009

Publications:

TdgClinicalTrial: PRASUGREL

Alternate Names:

Drug Info: Drug Indications antithrombotic Drug Class small molecule FDA Approval approved

Publications:

PharmGKB: prasugrel

Alternate Names:

Drug Info:

TTD: Prasugrel

Alternate Names: D07IRF TTD Drug ID

Drug Info:

Publications:

ChemblDrugs: chembl:CHEMBL1201772

Alternate Names:

Drug Info:

Publications:

FDA: Prasugrel

Alternate Names:

Drug Info:

Publications:

Interaction Types & Directionality:

n/a

PMIDs:
28820077 23859572

Sources:
PharmGKB

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Novel drug target Established target

Trial Name prasugrel, CS-747,Efient

PMIDs:
24951432 20938371 18485086

Sources:
TdgClinicalTrial TEND PharmGKB TTD

Interaction Types & Directionality:

n/a

PMIDs:
21828263

Sources:
PharmGKB FDA

Interaction Types & Directionality:

n/a

PMIDs:
28820077 23859572

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
21828263

Sources:
PharmGKB FDA

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
PharmGKB FDA

Interaction Types & Directionality:

n/a

PMIDs:
21828263

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
FDA

Alternate Names:

PRASUGREL Primary Drug Name

Drug Info:

Drug Class platelet aggregation inhibitors

Year of Approval 2009

Drug Info:

Drug Indications antithrombotic

Drug Class small molecule

FDA Approval approved

Alternate Names:

D07IRF TTD Drug ID