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PRASTERONE Drug Record

  • Summary
  • Interactions
  • Claims
  • PRASTERONE chembl:CHEMBL90593 Approved

    Alternate Names:

    EM-760
    NSC-9896
    DEHYDROANDROSTERONE
    INTRAROSA
    PRASTERONE
    DEHYDROEPIANDROSTERONE
    ENZYMATIC THERAPY
    NATROL DHEA
    DHEA

    Drug Info:

    FDA Approval approved
    Drug Class small molecule
    Drug Indications hormone supplement for increasing bone mineral density in patients with systemic lupus erythematosus
    (2 More Sources)

    Publications:

    Chen et al., 2005, Direct agonist/antagonist functions of dehydroepiandrosterone., Endocrinology
    Solano et al., 2006, Metformin prevents embryonic resorption induced by hyperandrogenisation with dehydroepiandrosterone in mice., Reprod. Fertil. Dev.
    Wang et al., 1997, Effects of dehydroepiandrosterone and calorie restriction on the Bcl-2/Bax-mediated apoptotic pathway in p53-deficient mice., Cancer Lett.
    Garcia de Yebenes et al., 1995, Effects of dehydroepiandrosterone (DHEA) on pituitary prolactin and arcuate nucleus neuron tyrosine hydroxylase mRNA levels in the rat., J. Neuroendocrinol.
    Campbell et al., 2004, The phosphatidylinositol/AKT/atypical PKC pathway is involved in the improved insulin sensitivity by DHEA in muscle and liver of rats in vivo., Life Sci.
    Ziegler et al., 2006, DHEA reduces NGF-mediated cell survival in serum-deprived PC12 cells., Ann. N. Y. Acad. Sci.
    Hammer et al., 2005, Sex steroid metabolism in human peripheral blood mononuclear cells changes with aging., J. Clin. Endocrinol. Metab.
    Lee et al., 2005, Investigation of efflux transport of dehydroepiandrosterone sulfate and mitoxantrone at the mouse blood-brain barrier: a minor role of breast cancer resistance protein., J. Pharmacol. Exp. Ther.
    Piroli et al., 2002, Dehydroepiandrosterone regulation of prolactin gene expression in the anterior pituitary does not depend on galanin induction., Neuro Endocrinol. Lett.
    Shin et al., 2005, Modulation of collagen metabolism by the topical application of dehydroepiandrosterone to human skin., J. Invest. Dermatol.
    Sato et al., 2008, Testosterone and DHEA activate the glucose metabolism-related signaling pathway in skeletal muscle., Am. J. Physiol. Endocrinol. Metab.
    Taguchi et al., 2006, Suppressive effects of dehydroepiandrosterone and the nuclear factor-kappaB inhibitor parthenolide on corticotroph tumor cell growth and function in vitro and in vivo., J. Endocrinol.
    Suzuki et al., 2004, Mitotic and neurogenic effects of dehydroepiandrosterone (DHEA) on human neural stem cell cultures derived from the fetal cortex., Proc. Natl. Acad. Sci. U.S.A.
  • PRASTERONE   GAL

    Interaction Score: 1.37

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    12195234


    Sources:
    NCI

  • PRASTERONE   IRS1

    Interaction Score: 0.98

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    15501480


    Sources:
    NCI

  • PRASTERONE   TH

    Interaction Score: 0.49

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    8704732


    Sources:
    NCI

  • PRASTERONE   CCN2

    Interaction Score: 0.36

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    15675949


    Sources:
    NCI

  • PRASTERONE   GFAP

    Interaction Score: 0.27

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    14973190


    Sources:
    NCI

  • PRASTERONE   IL2

    Interaction Score: 0.21

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    16091484


    Sources:
    NCI

  • PRASTERONE   BIRC5

    Interaction Score: 0.19

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    16461558


    Sources:
    NCI

  • PRASTERONE   NOS1

    Interaction Score: 0.18

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    16836960


    Sources:
    NCI

  • PRASTERONE   MAPK3

    Interaction Score: 0.17

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    17102100


    Sources:
    NCI

  • PRASTERONE   SLC2A4

    Interaction Score: 0.16

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    18349113


    Sources:
    NCI

  • PRASTERONE   BAX

    Interaction Score: 0.14

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    9177459


    Sources:
    NCI

  • PRASTERONE   PIK3CB

    Interaction Score: 0.13

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    15501480


    Sources:
    NCI

  • PRASTERONE   ABCG2

    Interaction Score: 0.11

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    15448171


    Sources:
    NCI

  • PRASTERONE   PIK3CA

    Interaction Score: 0.05

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    15501480


    Sources:
    NCI

  • PRASTERONE   G6PD

    Interaction Score: 0.05

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    TTD

  • PRASTERONE   TARDBP

    Interaction Score: 0.03

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • PRASTERONE   AR

    Interaction Score: 0.02

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Trial Name prasterone, GL-701,Prestara
    Novel drug target Established target

    PMIDs:
    15994348


    Sources:
    DTC TdgClinicalTrial TTD

  • PRASTERONE   CYP3A4

    Interaction Score: 0.0

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • TdgClinicalTrial: PRASTERONE

    • Version: January-2014

    Alternate Names:

    Drug Info:
    Drug Indications hormone supplement for increasing bone mineral density in patients with systemic lupus erythematosus
    Drug Class small molecule
    FDA Approval approved

    Publications:

  • NCI: DEHYDROEPIANDROSTERONE

    • Version: 14-September-2017

    Alternate Names:
    C2265 NCI drug code

    Drug Info:

    Publications:
    Garcia de Yebenes et al., 1995, Effects of dehydroepiandrosterone (DHEA) on pituitary prolactin and arcuate nucleus neuron tyrosine hydroxylase mRNA levels in the rat., J. Neuroendocrinol.
    Lee et al., 2005, Investigation of efflux transport of dehydroepiandrosterone sulfate and mitoxantrone at the mouse blood-brain barrier: a minor role of breast cancer resistance protein., J. Pharmacol. Exp. Ther.

  • NCI: DHEA

    • Version: 14-September-2017

    Alternate Names:
    C2265 NCI drug code

    Drug Info:

    Publications:
    Solano et al., 2006, Metformin prevents embryonic resorption induced by hyperandrogenisation with dehydroepiandrosterone in mice., Reprod. Fertil. Dev.
    Campbell et al., 2004, The phosphatidylinositol/AKT/atypical PKC pathway is involved in the improved insulin sensitivity by DHEA in muscle and liver of rats in vivo., Life Sci.
    Garcia de Yebenes et al., 1995, Effects of dehydroepiandrosterone (DHEA) on pituitary prolactin and arcuate nucleus neuron tyrosine hydroxylase mRNA levels in the rat., J. Neuroendocrinol.

  • DTC: PRASTERONE

    • Version: 02-September-2020

    Alternate Names:
    CHEMBL90593 ChEMBL Drug ID

    Drug Info:

    Publications:

  • TTD: Prasterone

    • Version: 2020.06.01

    Alternate Names:
    D0K0EK TTD Drug ID

    Drug Info:

    Publications:

  • ChemblDrugs: chembl:CHEMBL90593

    • Version: ChEMBL_27

    Alternate Names:

    Drug Info:

    Publications:

Disclaimer: This resource is intended for purely research purposes. It should not be used for emergencies or medical or professional advice.

A finding of a drug-gene interaction or potentially druggable category does not necessarily indicate effectiveness (or lack thereof) of any drug or treatment regimen. A finding of no interaction or no potentially druggable category does not necessarily indicate lack of effectiveness of any drug or treatment regimen. Drug-gene interactions or potentially druggable categories are not presented in ranked order of potential or predicted efficacy.

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DGIdb (v4.2.0 - sha1 afd9f30b) • Last updated 2020-10-21