DGIdb - PRASTERONE Drug Record

PRASTERONE chembl:CHEMBL90593 Approved

Alternate Names:

EM-760
NSC-9896
DEHYDROANDROSTERONE
INTRAROSA
PRASTERONE
DEHYDROEPIANDROSTERONE
ENZYMATIC THERAPY
NATROL DHEA
DHEA

Drug Info:

FDA Approval	approved
Drug Class	small molecule
Drug Indications	hormone supplement for increasing bone mineral density in patients with systemic lupus erythematosus

(2 More Sources)

Publications:

Chen et al., 2005, Direct agonist/antagonist functions of dehydroepiandrosterone., Endocrinology
Solano et al., 2006, Metformin prevents embryonic resorption induced by hyperandrogenisation with dehydroepiandrosterone in mice., Reprod. Fertil. Dev.
Wang et al., 1997, Effects of dehydroepiandrosterone and calorie restriction on the Bcl-2/Bax-mediated apoptotic pathway in p53-deficient mice., Cancer Lett.
Garcia de Yebenes et al., 1995, Effects of dehydroepiandrosterone (DHEA) on pituitary prolactin and arcuate nucleus neuron tyrosine hydroxylase mRNA levels in the rat., J. Neuroendocrinol.
Campbell et al., 2004, The phosphatidylinositol/AKT/atypical PKC pathway is involved in the improved insulin sensitivity by DHEA in muscle and liver of rats in vivo., Life Sci.
Ziegler et al., 2006, DHEA reduces NGF-mediated cell survival in serum-deprived PC12 cells., Ann. N. Y. Acad. Sci.
Hammer et al., 2005, Sex steroid metabolism in human peripheral blood mononuclear cells changes with aging., J. Clin. Endocrinol. Metab.
Lee et al., 2005, Investigation of efflux transport of dehydroepiandrosterone sulfate and mitoxantrone at the mouse blood-brain barrier: a minor role of breast cancer resistance protein., J. Pharmacol. Exp. Ther.
Piroli et al., 2002, Dehydroepiandrosterone regulation of prolactin gene expression in the anterior pituitary does not depend on galanin induction., Neuro Endocrinol. Lett.
Shin et al., 2005, Modulation of collagen metabolism by the topical application of dehydroepiandrosterone to human skin., J. Invest. Dermatol.
Sato et al., 2008, Testosterone and DHEA activate the glucose metabolism-related signaling pathway in skeletal muscle., Am. J. Physiol. Endocrinol. Metab.
Taguchi et al., 2006, Suppressive effects of dehydroepiandrosterone and the nuclear factor-kappaB inhibitor parthenolide on corticotroph tumor cell growth and function in vitro and in vivo., J. Endocrinol.
Suzuki et al., 2004, Mitotic and neurogenic effects of dehydroepiandrosterone (DHEA) on human neural stem cell cultures derived from the fetal cortex., Proc. Natl. Acad. Sci. U.S.A.

PRASTERONE GAL

Interaction Score: 1.37

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
12195234

Sources:
NCI
PRASTERONE IRS1

Interaction Score: 0.98

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
15501480

Sources:
NCI
PRASTERONE TH

Interaction Score: 0.49

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
8704732

Sources:
NCI
PRASTERONE CCN2

Interaction Score: 0.36

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
15675949

Sources:
NCI
PRASTERONE GFAP

Interaction Score: 0.27

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
14973190

Sources:
NCI
PRASTERONE IL2

Interaction Score: 0.21

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
16091484

Sources:
NCI
PRASTERONE BIRC5

Interaction Score: 0.19

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
16461558

Sources:
NCI
PRASTERONE NOS1

Interaction Score: 0.18

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
16836960

Sources:
NCI
PRASTERONE MAPK3

Interaction Score: 0.17

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
17102100

Sources:
NCI
PRASTERONE SLC2A4

Interaction Score: 0.16

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
18349113

Sources:
NCI
PRASTERONE BAX

Interaction Score: 0.14

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
9177459

Sources:
NCI
PRASTERONE PIK3CB

Interaction Score: 0.13

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
15501480

Sources:
NCI
PRASTERONE ABCG2

Interaction Score: 0.11

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
15448171

Sources:
NCI
PRASTERONE PIK3CA

Interaction Score: 0.05

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
15501480

Sources:
NCI
PRASTERONE G6PD

Interaction Score: 0.05

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
TTD
PRASTERONE TARDBP

Interaction Score: 0.03

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
PRASTERONE AR

Interaction Score: 0.02

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Trial Name prasterone, GL-701,Prestara

Novel drug target Established target

PMIDs:
15994348

Sources:
DTC TdgClinicalTrial TTD
PRASTERONE CYP3A4

Interaction Score: 0.0

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC

TdgClinicalTrial: PRASTERONE
- Version: January-2014
Alternate Names:

Drug Info:

Drug Indications hormone supplement for increasing bone mineral density in patients with systemic lupus erythematosus

Drug Class small molecule

FDA Approval approved

Publications:

NCI: DEHYDROEPIANDROSTERONE

Version: 14-September-2017

Alternate Names:

C2265 NCI drug code

Drug Info:

Publications:

Garcia de Yebenes et al., 1995, Effects of dehydroepiandrosterone (DHEA) on pituitary prolactin and arcuate nucleus neuron tyrosine hydroxylase mRNA levels in the rat., J. Neuroendocrinol.

Lee et al., 2005, Investigation of efflux transport of dehydroepiandrosterone sulfate and mitoxantrone at the mouse blood-brain barrier: a minor role of breast cancer resistance protein., J. Pharmacol. Exp. Ther.

NCI: DHEA

Version: 14-September-2017

Alternate Names:

C2265 NCI drug code

Drug Info:

Publications:

Solano et al., 2006, Metformin prevents embryonic resorption induced by hyperandrogenisation with dehydroepiandrosterone in mice., Reprod. Fertil. Dev.

Campbell et al., 2004, The phosphatidylinositol/AKT/atypical PKC pathway is involved in the improved insulin sensitivity by DHEA in muscle and liver of rats in vivo., Life Sci.

Garcia de Yebenes et al., 1995, Effects of dehydroepiandrosterone (DHEA) on pituitary prolactin and arcuate nucleus neuron tyrosine hydroxylase mRNA levels in the rat., J. Neuroendocrinol.

DTC: PRASTERONE
- Version: 02-September-2020
Alternate Names:

CHEMBL90593 ChEMBL Drug ID

Drug Info:

Publications:
TTD: Prasterone
- Version: 2020.06.01
Alternate Names:

D0K0EK TTD Drug ID

Drug Info:

Publications:
ChemblDrugs: chembl:CHEMBL90593
- Version: ChEMBL_27
Alternate Names:

Drug Info:

Publications:

Trial Name	prasterone, GL-701,Prestara
Novel drug target	Established target

PRASTERONE Drug Record

PRASTERONE chembl:CHEMBL90593 Approved

Alternate Names:

Drug Info:

Publications:

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 12195234

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 15501480

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 8704732

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 15675949

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 14973190

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 16091484

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 16461558

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 16836960

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 17102100

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 18349113

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 9177459

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 15501480

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 15448171

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 15501480

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: TTD

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: agonist (activating)

Interaction Info: Trial Name prasterone, GL-701,Prestara Novel drug target Established target

PMIDs: 15994348

Sources: DTC TdgClinicalTrial TTD

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

TdgClinicalTrial: PRASTERONE

Alternate Names:

Drug Info: Drug Indications hormone supplement for increasing bone mineral density in patients with systemic lupus erythematosus Drug Class small molecule FDA Approval approved

Interaction Types & Directionality:

n/a

PMIDs:
12195234

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
15501480

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
8704732

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
15675949

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
14973190

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
16091484

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
16461558

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
16836960

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
17102100

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
18349113

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
9177459

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
15501480

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
15448171

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
15501480

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
TTD

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Trial Name prasterone, GL-701,Prestara

Novel drug target Established target

PMIDs:
15994348

Sources:
DTC TdgClinicalTrial TTD

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Drug Info:

Drug Indications hormone supplement for increasing bone mineral density in patients with systemic lupus erythematosus

Drug Class small molecule

FDA Approval approved

Alternate Names:

C2265 NCI drug code

Alternate Names:

C2265 NCI drug code

Alternate Names:

CHEMBL90593 ChEMBL Drug ID

Alternate Names:

D0K0EK TTD Drug ID