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PODOFILOX Drug Record

  • Summary
  • Interactions
  • Claims
  • PODOFILOX chembl:CHEMBL61 ApprovedAntineoplastic

    Alternate Names:

    PODOFILOX
    NSC-24818
    CONDYLOX
    WARTICON
    PODOPHYLLOTOXIN
    CONDYLINE
    6,7]NAPHTHO[2,3-D][1,3]DIOXOL-6(5AH)-ONE
    PODOPHYLLINIC ACID LACTONE
    (-)-PODOPHYLLOTOXIN
    9-HYDROXY-5-(3,4,5-TRIMETHOXYPHENYL)-5,8,8A,9-TETRAHYDROFURO[3',4':6,7]NAPHTHO[2,3-D][1,3]DIOXOL-6(5AH)-ONE
    PPT
    PODOPHYLLOTOXIN 7
    9-HYDROXY-5-(3,4,5-TRIMETHOXYPHENYL)-5,8,8A,9-TETRAHYDROFURO[3',4'
    drugbank:01179
    rxcui:8463
    chembl:CHEMBL61
    chemidplus:518-28-5
    pubchem.compound:10607

    Drug Info:

    FDA Approval not approved by the FDA
    Drug Class small molecule
    Drug Indications Keratolytic Agents
    Drug Indications Antineoplastic Agents, Phytogenic
    Drug Class antineoplastic agents, phytogenic
    Drug Class keratolytic agents
    Year of Approval not approved by the fda
    (1 More Sources)

    Publications:

    Kamal A et al., 2011, Synthesis of a new 4-aza-2,3-didehydropodophyllotoxin analogues as potent cytotoxic and antimitotic agents., Bioorg Med Chem
    Imperio D et al., 2007, Replacement of the lactone moiety on podophyllotoxin and steganacin analogues with a 1,5-disubstituted 1,2,3-triazole via ruthenium-catalyzed click chemistry., Bioorg Med Chem
    Kamal A et al., 2014, Synthesis and biological evaluation of 4-aza-2,3-dihydropyridophenanthrolines as tubulin polymerization inhibitors., Bioorg Med Chem Lett
    Clark, 1992, Clinical pharmacology and schedule dependency of the podophyllotoxin derivatives., Semin. Oncol.
    Alam et al., Applying linear interaction energy method for binding affinity calculations of podophyllotoxin analogues with tubulin using continuum solvent model and prediction of cytotoxic activity., J. Mol. Graph. Model.
    Labruère et al., 2010, Design, synthesis, and biological evaluation of the first podophyllotoxin analogues as potential vascular-disrupting agents., ChemMedChem
    Li et al., 2010, Competitive mass spectrometry binding assay for characterization of three binding sites of tubulin., J Mass Spectrom
    Screpanti et al., 2010, A screen for kinetochore-microtubule interaction inhibitors identifies novel antitubulin compounds., PLoS ONE
    Kim et al., 2010, Structure-based virtual screening of novel tubulin inhibitors and their characterization as anti-mitotic agents., Bioorg. Med. Chem.
    Terada et al., 1992, Antitumor agents. I. DNA topoisomerase II inhibitory activity and the structural relationship of podophyllotoxin derivatives as antitumor agents., Chem. Pharm. Bull.
    Zhang et al., 1992, Antitumor agents, 130, Novel 4 beta-arylamino derivatives of 3',4'-didemethoxy-3',4'-dioxo-4-deoxypodophyllotoxin as potent inhibitors of human DNA topoisomerase II., J. Nat. Prod.
    Chen et al., 2002, TTD: Therapeutic Target Database., Nucleic Acids Res.
    Kamal et al., 2005, Synthesis and biological evaluation of new 4beta-anilino- and 4beta-imido-substituted podophyllotoxin congeners., Bioorg. Med. Chem.
    Iida et al., 2000, Podophyllotoxin aza-analogue, a novel DNA topoisomerase II inhibitor., Chem. Pharm. Bull.
    Ruckdeschel, 1991, Etoposide in the management of non-small cell lung cancer., Cancer
    Wolff et al., 1991, Direct photoaffinity labeling of tubulin with colchicine., Proc. Natl. Acad. Sci. U.S.A.
  • PODOFILOX   TUBA4A

    Interaction Score: 0.66

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:

    PMIDs:
    1411635 19286405 20979080 20814887 20657644 20810285 21402478 17765552 24953821


    Sources:
    DTC

  • PODOFILOX   TUBA3C

    Interaction Score: 0.51

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    21402478 17765552 24953821


    Sources:
    DTC

  • PODOFILOX   TUBB4A

    Interaction Score: 0.51

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    21402478 17765552 24953821


    Sources:
    DTC

  • PODOFILOX   TOP2A

    Interaction Score: 0.27

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Novel drug target Established target
    Trial Name -

    PMIDs:
    1334447 1331331 11752352 16061385 10783066 1845848


    Sources:
    TdgClinicalTrial TEND

  • PODOFILOX   NR0B1

    Interaction Score: 0.27

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • PODOFILOX   TUBB

    Interaction Score: 0.26

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:

    PMIDs:
    21402478 17765552 24953821 2011590


    Sources:
    DTC

  • PODOFILOX   TUBB6

    Interaction Score: 0.26

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    21402478 17765552 24953821


    Sources:
    DTC

  • PODOFILOX   TUBB8

    Interaction Score: 0.26

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    21402478 17765552 24953821


    Sources:
    DTC

  • PODOFILOX   TUBA1B

    Interaction Score: 0.26

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    21402478 17765552 24953821


    Sources:
    DTC

  • PODOFILOX   TUBA1C

    Interaction Score: 0.26

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    21402478 17765552 24953821


    Sources:
    DTC

  • PODOFILOX   TUBA3D

    Interaction Score: 0.26

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    21402478 17765552 24953821


    Sources:
    DTC

  • PODOFILOX   TUBA3E

    Interaction Score: 0.26

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    21402478 17765552 24953821


    Sources:
    DTC

  • PODOFILOX   TUBB2B

    Interaction Score: 0.26

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    21402478 17765552 24953821


    Sources:
    DTC

  • PODOFILOX   TUBA1A

    Interaction Score: 0.26

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    21402478 17765552 24953821


    Sources:
    DTC

  • PODOFILOX   TUBB2A

    Interaction Score: 0.26

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    21402478 17765552 24953821


    Sources:
    DTC

  • PODOFILOX   TUBB3

    Interaction Score: 0.26

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    21402478 17765552 24953821


    Sources:
    DTC

  • PODOFILOX   TUBB4B

    Interaction Score: 0.25

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    21402478 17765552 24953821


    Sources:
    DTC

  • PODOFILOX   TUBB1

    Interaction Score: 0.21

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    21402478 17765552 24953821


    Sources:
    DTC

  • PODOFILOX   TOP2B

    Interaction Score: 0.06

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    TTD

  • PODOFILOX   PAX8

    Interaction Score: 0.04

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • PODOFILOX   GMNN

    Interaction Score: 0.01

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • PODOFILOX   AR

    Interaction Score: 0.0

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • PODOFILOX   CYP3A4

    Interaction Score: 0.0

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • TEND: PODOFILOX

    • Version: 01-August-2011

    Alternate Names:
    PODOFILOX Primary Drug Name

    Drug Info:
    Year of Approval not approved by the fda
    Drug Class keratolytic agents
    Drug Class antineoplastic agents, phytogenic

    Publications:

  • TdgClinicalTrial: PODOFILOX

    • Version: January-2014

    Alternate Names:

    Drug Info:
    Drug Indications Antineoplastic Agents, Phytogenic
    Drug Indications Keratolytic Agents
    Drug Class small molecule

    Publications:

  • DTC: PODOFILOX

    • Version: 02-September-2020

    Alternate Names:
    CHEMBL61 ChEMBL Drug ID

    Drug Info:

    Publications:
    Imperio D et al., 2007, Replacement of the lactone moiety on podophyllotoxin and steganacin analogues with a 1,5-disubstituted 1,2,3-triazole via ruthenium-catalyzed click chemistry., Bioorg Med Chem
    Kamal A et al., 2014, Synthesis and biological evaluation of 4-aza-2,3-dihydropyridophenanthrolines as tubulin polymerization inhibitors., Bioorg Med Chem Lett
    Kamal A et al., 2011, Synthesis of a new 4-aza-2,3-didehydropodophyllotoxin analogues as potent cytotoxic and antimitotic agents., Bioorg Med Chem

  • TTD: Podofilox

    • Version: 2020.06.01

    Alternate Names:
    D0D4HN TTD Drug ID

    Drug Info:

    Publications:

  • ChemblDrugs: chembl:CHEMBL61

    • Version: ChEMBL_27

    Alternate Names:

    Drug Info:

    Publications:

Disclaimer: This resource is intended for purely research purposes. It should not be used for emergencies or medical or professional advice.

A finding of a drug-gene interaction or potentially druggable category does not necessarily indicate effectiveness (or lack thereof) of any drug or treatment regimen. A finding of no interaction or no potentially druggable category does not necessarily indicate lack of effectiveness of any drug or treatment regimen. Drug-gene interactions or potentially druggable categories are not presented in ranked order of potential or predicted efficacy.

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DGIdb (v4.2.0 - sha1 afd9f30b) • Last updated 2020-10-21