DGIdb - PODOFILOX Drug Record

PODOFILOX chembl:CHEMBL61 ApprovedAntineoplastic

Alternate Names:

PODOFILOX
NSC-24818
CONDYLOX
WARTICON
PODOPHYLLOTOXIN
CONDYLINE
6,7]NAPHTHO[2,3-D][1,3]DIOXOL-6(5AH)-ONE
PODOPHYLLINIC ACID LACTONE
(-)-PODOPHYLLOTOXIN
9-HYDROXY-5-(3,4,5-TRIMETHOXYPHENYL)-5,8,8A,9-TETRAHYDROFURO[3',4':6,7]NAPHTHO[2,3-D][1,3]DIOXOL-6(5AH)-ONE
PPT
PODOPHYLLOTOXIN 7
9-HYDROXY-5-(3,4,5-TRIMETHOXYPHENYL)-5,8,8A,9-TETRAHYDROFURO[3',4'
drugbank:01179
rxcui:8463
chembl:CHEMBL61
chemidplus:518-28-5
pubchem.compound:10607

Drug Info:

FDA Approval	not approved by the FDA
Drug Class	small molecule
Drug Indications	Keratolytic Agents
Drug Indications	Antineoplastic Agents, Phytogenic
Drug Class	antineoplastic agents, phytogenic
Drug Class	keratolytic agents
Year of Approval	not approved by the fda

(1 More Sources)

Publications:

Kamal A et al., 2011, Synthesis of a new 4-aza-2,3-didehydropodophyllotoxin analogues as potent cytotoxic and antimitotic agents., Bioorg Med Chem
Imperio D et al., 2007, Replacement of the lactone moiety on podophyllotoxin and steganacin analogues with a 1,5-disubstituted 1,2,3-triazole via ruthenium-catalyzed click chemistry., Bioorg Med Chem
Kamal A et al., 2014, Synthesis and biological evaluation of 4-aza-2,3-dihydropyridophenanthrolines as tubulin polymerization inhibitors., Bioorg Med Chem Lett
Clark, 1992, Clinical pharmacology and schedule dependency of the podophyllotoxin derivatives., Semin. Oncol.
Alam et al., Applying linear interaction energy method for binding affinity calculations of podophyllotoxin analogues with tubulin using continuum solvent model and prediction of cytotoxic activity., J. Mol. Graph. Model.
Labruère et al., 2010, Design, synthesis, and biological evaluation of the first podophyllotoxin analogues as potential vascular-disrupting agents., ChemMedChem
Li et al., 2010, Competitive mass spectrometry binding assay for characterization of three binding sites of tubulin., J Mass Spectrom
Screpanti et al., 2010, A screen for kinetochore-microtubule interaction inhibitors identifies novel antitubulin compounds., PLoS ONE
Kim et al., 2010, Structure-based virtual screening of novel tubulin inhibitors and their characterization as anti-mitotic agents., Bioorg. Med. Chem.
Terada et al., 1992, Antitumor agents. I. DNA topoisomerase II inhibitory activity and the structural relationship of podophyllotoxin derivatives as antitumor agents., Chem. Pharm. Bull.
Zhang et al., 1992, Antitumor agents, 130, Novel 4 beta-arylamino derivatives of 3',4'-didemethoxy-3',4'-dioxo-4-deoxypodophyllotoxin as potent inhibitors of human DNA topoisomerase II., J. Nat. Prod.
Chen et al., 2002, TTD: Therapeutic Target Database., Nucleic Acids Res.
Kamal et al., 2005, Synthesis and biological evaluation of new 4beta-anilino- and 4beta-imido-substituted podophyllotoxin congeners., Bioorg. Med. Chem.
Iida et al., 2000, Podophyllotoxin aza-analogue, a novel DNA topoisomerase II inhibitor., Chem. Pharm. Bull.
Ruckdeschel, 1991, Etoposide in the management of non-small cell lung cancer., Cancer
Wolff et al., 1991, Direct photoaffinity labeling of tubulin with colchicine., Proc. Natl. Acad. Sci. U.S.A.

PODOFILOX TUBA4A

Interaction Score: 0.66

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

PMIDs:
1411635 19286405 20979080 20814887 20657644 20810285 21402478 17765552 24953821

Sources:
DTC
PODOFILOX TUBA3C

Interaction Score: 0.51

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
21402478 17765552 24953821

Sources:
DTC
PODOFILOX TUBB4A

Interaction Score: 0.51

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
21402478 17765552 24953821

Sources:
DTC
PODOFILOX TOP2A

Interaction Score: 0.27

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Novel drug target Established target

Trial Name -

PMIDs:
1334447 1331331 11752352 16061385 10783066 1845848

Sources:
TdgClinicalTrial TEND
PODOFILOX NR0B1

Interaction Score: 0.27

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
PODOFILOX TUBB

Interaction Score: 0.26

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

PMIDs:
21402478 17765552 24953821 2011590

Sources:
DTC
PODOFILOX TUBB6

Interaction Score: 0.26

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
21402478 17765552 24953821

Sources:
DTC
PODOFILOX TUBB8

Interaction Score: 0.26

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
21402478 17765552 24953821

Sources:
DTC
PODOFILOX TUBA1B

Interaction Score: 0.26

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
21402478 17765552 24953821

Sources:
DTC
PODOFILOX TUBA1C

Interaction Score: 0.26

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
21402478 17765552 24953821

Sources:
DTC
PODOFILOX TUBA3D

Interaction Score: 0.26

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
21402478 17765552 24953821

Sources:
DTC
PODOFILOX TUBA3E

Interaction Score: 0.26

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
21402478 17765552 24953821

Sources:
DTC
PODOFILOX TUBB2B

Interaction Score: 0.26

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
21402478 17765552 24953821

Sources:
DTC
PODOFILOX TUBA1A

Interaction Score: 0.26

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
21402478 17765552 24953821

Sources:
DTC
PODOFILOX TUBB2A

Interaction Score: 0.26

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
21402478 17765552 24953821

Sources:
DTC
PODOFILOX TUBB3

Interaction Score: 0.26

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
21402478 17765552 24953821

Sources:
DTC
PODOFILOX TUBB4B

Interaction Score: 0.25

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
21402478 17765552 24953821

Sources:
DTC
PODOFILOX TUBB1

Interaction Score: 0.21

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
21402478 17765552 24953821

Sources:
DTC
PODOFILOX TOP2B

Interaction Score: 0.06

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
TTD
PODOFILOX PAX8

Interaction Score: 0.04

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
PODOFILOX GMNN

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
PODOFILOX AR

Interaction Score: 0.0

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
PODOFILOX CYP3A4

Interaction Score: 0.0

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC

TEND: PODOFILOX
- Version: 01-August-2011
Alternate Names:

PODOFILOX Primary Drug Name

Drug Info:

Year of Approval not approved by the fda

Drug Class keratolytic agents

Drug Class antineoplastic agents, phytogenic

Publications:
TdgClinicalTrial: PODOFILOX
- Version: January-2014
Alternate Names:

Drug Info:

Drug Indications Antineoplastic Agents, Phytogenic

Drug Indications Keratolytic Agents

Drug Class small molecule

Publications:

DTC: PODOFILOX

Version: 02-September-2020

Alternate Names:

CHEMBL61 ChEMBL Drug ID

Drug Info:

Publications:

Imperio D et al., 2007, Replacement of the lactone moiety on podophyllotoxin and steganacin analogues with a 1,5-disubstituted 1,2,3-triazole via ruthenium-catalyzed click chemistry., Bioorg Med Chem

Kamal A et al., 2014, Synthesis and biological evaluation of 4-aza-2,3-dihydropyridophenanthrolines as tubulin polymerization inhibitors., Bioorg Med Chem Lett

Kamal A et al., 2011, Synthesis of a new 4-aza-2,3-didehydropodophyllotoxin analogues as potent cytotoxic and antimitotic agents., Bioorg Med Chem

TTD: Podofilox
- Version: 2020.06.01
Alternate Names:

D0D4HN TTD Drug ID

Drug Info:

Publications:
ChemblDrugs: chembl:CHEMBL61
- Version: ChEMBL_27
Alternate Names:

Drug Info:

Publications:

Novel drug target	Established target
Trial Name	-

PODOFILOX Drug Record

PODOFILOX chembl:CHEMBL61 ApprovedAntineoplastic

Alternate Names:

Drug Info:

Publications:

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info:

PMIDs: 1411635 19286405 20979080 20814887 20657644 20810285 21402478 17765552 24953821

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 21402478 17765552 24953821

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 21402478 17765552 24953821

Sources: DTC

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Novel drug target Established target Trial Name -

PMIDs: 1334447 1331331 11752352 16061385 10783066 1845848

Sources: TdgClinicalTrial TEND

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info:

PMIDs: 21402478 17765552 24953821 2011590

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 21402478 17765552 24953821

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 21402478 17765552 24953821

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 21402478 17765552 24953821

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 21402478 17765552 24953821

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 21402478 17765552 24953821

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 21402478 17765552 24953821

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 21402478 17765552 24953821

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 21402478 17765552 24953821

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 21402478 17765552 24953821

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 21402478 17765552 24953821

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 21402478 17765552 24953821

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 21402478 17765552 24953821

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Interaction Types & Directionality:

inhibitor (inhibitory)

PMIDs:
1411635 19286405 20979080 20814887 20657644 20810285 21402478 17765552 24953821

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
21402478 17765552 24953821

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
21402478 17765552 24953821

Sources:
DTC

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Novel drug target Established target

Trial Name -

PMIDs:
1334447 1331331 11752352 16061385 10783066 1845848

Sources:
TdgClinicalTrial TEND

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

inhibitor (inhibitory)

PMIDs:
21402478 17765552 24953821 2011590

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
21402478 17765552 24953821

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
21402478 17765552 24953821

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
21402478 17765552 24953821

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
21402478 17765552 24953821

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
21402478 17765552 24953821

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
21402478 17765552 24953821

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
21402478 17765552 24953821

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
21402478 17765552 24953821

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
21402478 17765552 24953821

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
21402478 17765552 24953821

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
21402478 17765552 24953821

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
21402478 17765552 24953821

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
TTD

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Alternate Names:

PODOFILOX Primary Drug Name

Drug Info:

Year of Approval not approved by the fda

Drug Class keratolytic agents

Drug Class antineoplastic agents, phytogenic

Drug Info:

Drug Indications Antineoplastic Agents, Phytogenic

Drug Indications Keratolytic Agents

Drug Class small molecule

Alternate Names:

CHEMBL61 ChEMBL Drug ID

Alternate Names:

D0D4HN TTD Drug ID