DGIdb - PLICAMYCIN Drug Record

PLICAMYCIN chembl:CHEMBL1237054 ApprovedAntineoplastic

Alternate Names:

PLICAMYCIN
MITHRAMYCIN
LA-7017
A-2371
MITHRACIN
NSC-24559
PA-144
ANTIBIOTIC LA-7017
MITHRAMYCINE
AUREOLIC ACID
PLICAMYCINE
PLICAMYCINUM
MITHRAMYCINUM
chembl:CHEMBL1237054
chemidplus:18378-89-7
pubchem.compound:52945526
drugbank:06810
rxcui:6995

Drug Info:

Drug Categories	coloring agents
Drug Groups	investigational
Drug Categories	calcium-regulating hormones and agents
Drug Categories	compounds used in a research, industrial, or household setting

(2 More Sources)

Publications:

Sakatis MZ et al., 2012, Preclinical strategy to reduce clinical hepatotoxicity using in vitro bioactivation data for >200 compounds., Chem Res Toxicol
Estève et al., 2007, Molecular mechanisms of transactivation and doxorubicin-mediated repression of survivin gene in cancer cells., J. Biol. Chem.

PLICAMYCIN BIRC5

Interaction Score: 0.5

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
17124180

Sources:
NCI
PLICAMYCIN CYP2C9

Interaction Score: 0.04

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
22931300

Sources:
DTC
PLICAMYCIN CYP2C19

Interaction Score: 0.04

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
22931300

Sources:
DTC
PLICAMYCIN CYP1A2

Interaction Score: 0.03

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
22931300

Sources:
DTC
PLICAMYCIN CYP2D6

Interaction Score: 0.03

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
22931300

Sources:
DTC
PLICAMYCIN CYP3A4

Interaction Score: 0.02

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
22931300

Sources:
DTC

DrugBank: DB06810

Version: 5.1.7

Alternate Names:

PLICAMYCIN DrugBank Drug Name

18378-89-7 CAS Number

Mithracin Drug Brand

Drug Info:

Drug Type small molecule

Drug Groups approved

Drug Groups investigational

Publications:

Lombó et al., 2006, The aureolic acid family of antitumor compounds: structure, mode of action, biosynthesis, and novel derivatives., Appl. Microbiol. Biotechnol.

Hampshire et al., 2008, The effects of local DNA sequence on the interaction of ligands with their preferred binding sites., Biochimie

Fox et al., 1985, Investigations into the sequence-selective binding of mithramycin and related ligands to DNA., Nucleic Acids Res.

NCI: MITHRAMYCIN
- Version: 14-September-2017
Alternate Names:

C658 NCI drug code

Drug Info:

Publications:

Estève et al., 2007, Molecular mechanisms of transactivation and doxorubicin-mediated repression of survivin gene in cancer cells., J. Biol. Chem.
DTC: PLICAMYCIN
- Version: 02-September-2020
Alternate Names:

CHEMBL1237054 ChEMBL Drug ID

Drug Info:

Publications:

Sakatis MZ et al., 2012, Preclinical strategy to reduce clinical hepatotoxicity using in vitro bioactivation data for >200 compounds., Chem Res Toxicol
TTD: Plicamycin
- Version: 2020.06.01
Alternate Names:

D06EPF TTD Drug ID

Drug Info:

Publications:
ChemblDrugs: chembl:CHEMBL1237054
- Version: ChEMBL_27
Alternate Names:

Drug Info:

Publications:
MyCancerGenomeClinicalTrial: PLICAMYCIN
- Version: 30-February-2014
Alternate Names:

Drug Info:

Publications:

PLICAMYCIN	DrugBank Drug Name
18378-89-7	CAS Number
Mithracin	Drug Brand

Drug Type	small molecule
Drug Groups	approved
Drug Groups	investigational

PLICAMYCIN Drug Record

PLICAMYCIN chembl:CHEMBL1237054 ApprovedAntineoplastic

Alternate Names:

Drug Info:

Publications:

PLICAMYCIN BIRC5

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 17124180

Sources: NCI

PLICAMYCIN CYP2C9

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 22931300

Sources: DTC

PLICAMYCIN CYP2C19

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 22931300

Sources: DTC

PLICAMYCIN CYP1A2

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 22931300

Sources: DTC

PLICAMYCIN CYP2D6

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 22931300

Sources: DTC

PLICAMYCIN CYP3A4

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 22931300

Sources: DTC

DrugBank: DB06810

Alternate Names: PLICAMYCIN DrugBank Drug Name 18378-89-7 CAS Number Mithracin Drug Brand

Drug Info: Drug Type small molecule Drug Groups approved Drug Groups investigational

NCI: MITHRAMYCIN

Alternate Names: C658 NCI drug code

Drug Info:

Publications: Estève et al., 2007, Molecular mechanisms of transactivation and doxorubicin-mediated repression of survivin gene in cancer cells., J. Biol. Chem.

DTC: PLICAMYCIN

Alternate Names: CHEMBL1237054 ChEMBL Drug ID

Drug Info:

Publications: Sakatis MZ et al., 2012, Preclinical strategy to reduce clinical hepatotoxicity using in vitro bioactivation data for &gt;200 compounds., Chem Res Toxicol

TTD: Plicamycin

Alternate Names: D06EPF TTD Drug ID

Drug Info:

Publications:

ChemblDrugs: chembl:CHEMBL1237054

Alternate Names:

Drug Info:

Publications:

MyCancerGenomeClinicalTrial: PLICAMYCIN

Alternate Names:

Drug Info:

Publications:

Interaction Types & Directionality:

n/a

PMIDs:
17124180

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
22931300

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
22931300

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
22931300

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
22931300

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
22931300

Sources:
DTC

Alternate Names:

PLICAMYCIN DrugBank Drug Name

18378-89-7 CAS Number

Mithracin Drug Brand

Drug Info:

Drug Type small molecule

Drug Groups approved

Drug Groups investigational

Alternate Names:

C658 NCI drug code

Publications:

Estève et al., 2007, Molecular mechanisms of transactivation and doxorubicin-mediated repression of survivin gene in cancer cells., J. Biol. Chem.

Alternate Names:

CHEMBL1237054 ChEMBL Drug ID

Publications:

Sakatis MZ et al., 2012, Preclinical strategy to reduce clinical hepatotoxicity using in vitro bioactivation data for >200 compounds., Chem Res Toxicol

Alternate Names:

D06EPF TTD Drug ID