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PINDOLOL Drug Record

  • Summary
  • Interactions
  • Claims
  • PINDOLOL chembl:CHEMBL500 Approved

    Alternate Names:

    LB-46
    PRINODOLOL
    VISKEN
    BETADREN
    PINDOLOL
    BETAPINDOL
    VISKEN®
    PINDOLOLUM
    VKN646
    1-(1H-INDOL-4-YLOXY)-3-(PROPAN-2-YLAMINO)-PROPAN-2-OL
    4-(2-HYDROXY-3-ISOPROPYLAMINOPROPOXY)-INDOLE
    1-(1H-INDOL-4-YLOXY)-3-(ISOPROPYLAMINO)PROPAN-2-OL
    1-(1H-INDOL-4-YLOXY)-3-[(1-METHYLETHYL)AMINO]PROPAN-2-OL
    chemidplus:13523-86-9
    drugbank:00960
    pubchem.compound:4828
    rxcui:8332
    chembl:CHEMBL500

    Drug Info:

    FDA Approval 1982
    Drug Class small molecule
    Drug Indications Antihypertensive Agents
    Year of Approval 1982
    Drug Class antihypertensive agents
    (3 More Sources)

    Publications:

    Watkins et al., 1996, Loss of [125I]-pindolol binding to beta-adrenoceptors on rat nodose ganglion after chronic isoprenaline treatment., J. Auton. Nerv. Syst.
    Berendsen et al., 1990, Antagonism of 8-OH-DPAT-induced behaviour in rats., Eur. J. Pharmacol.
    Brodde et al., 1988, Chronic beta-adrenoceptor antagonist treatment modulates human cardiac and vascular beta-adrenoceptor density in a subtype-selective fashion., J Hypertens Suppl
    Joseph et al., 2003, Intrinsic sympathomimetic activity of (-)-pindolol mediated through a (-)-propranolol-resistant site of the beta1-adrenoceptor in human atrium and recombinant receptors., Naunyn Schmiedebergs Arch. Pharmacol.
    Chen et al., 2002, TTD: Therapeutic Target Database., Nucleic Acids Res.
    Doggrell, 1991, Effects of (+/-)- (+)- and (-)-metoprolol, (+/-)- (+)- and (-)-pindolol, (+/-)-mepindolol and (+/-)-bopindolol on the rat left atria and portal vein., Gen. Pharmacol.
    el Tayar N et al., 1988, Modeling of beta-adrenoceptors based on molecular electrostatic potential studies of agonists and antagonists., J Med Chem
    Wheeldon et al., 1991, The effect of pindolol on creatine kinase is not due to beta 2-adrenoceptor partial agonist activity., Br J Clin Pharmacol
    Rubenstein et al., 2006, Molecular dynamics of a biophysical model for beta2-adrenergic and G protein-coupled receptor activation., J. Mol. Graph. Model.
    Dejgaard et al., 1991, Adrenergic receptors are a fallible index of adrenergic denervation hypersensitivity., Scand. J. Clin. Lab. Invest.
    Doggrell, 1990, Relaxant and beta 2-adrenoceptor blocking activities of (+/- )-, (+)- and (-)-pindolol on the rat isolated aorta., J. Pharm. Pharmacol.
  • PINDOLOL   ADRB1

    Interaction Score: 2.98

    Interaction Types & Directionality:
    partial agonist (activating)
    agonist (activating)

    Interaction Info:
    Trial Name -
    Novel drug target Established target
    Mechanism of Interaction Beta-1 adrenergic receptor partial agonist

    PMIDs:
    8884690 2148726 2907348 14608456 11752352 1687398 2903243


    Sources:
    DTC TdgClinicalTrial ChemblInteractions TEND TTD

  • PINDOLOL   ADRB2

    Interaction Score: 1.93

    Interaction Types & Directionality:
    partial agonist (activating)
    agonist (activating)

    Interaction Info:
    Mechanism of Interaction Beta-2 adrenergic receptor partial agonist
    Direct Interaction yes
    Trial Name -

    PMIDs:
    2903243 1678274 16574446 1666931 11752352 1687398 1979630


    Sources:
    DTC TdgClinicalTrial ChemblInteractions TEND PharmGKB

  • PINDOLOL   GLA

    Interaction Score: 1.72

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • TdgClinicalTrial: PINDOLOL

    • Version: January-2014

    Alternate Names:

    Drug Info:
    Drug Indications Antihypertensive Agents
    Drug Class small molecule
    FDA Approval 1982

    Publications:

  • TEND: PINDOLOL

    • Version: 01-August-2011

    Alternate Names:

    Drug Info:
    Drug Class antihypertensive agents
    Year of Approval 1982

    Publications:

  • DTC: PINDOLOL

    • Version: 02-September-2020

    Alternate Names:
    CHEMBL500 ChEMBL Drug ID

    Drug Info:

    Publications:
    el Tayar N et al., 1988, Modeling of beta-adrenoceptors based on molecular electrostatic potential studies of agonists and antagonists., J Med Chem

  • TTD: Pindolol

    • Version: 2020.06.01

    Alternate Names:
    D0F2PO TTD Drug ID

    Drug Info:

    Publications:

  • ChemblDrugs: chembl:CHEMBL500

    • Version: ChEMBL_27

    Alternate Names:

    Drug Info:

    Publications:

  • PharmGKB: pindolol

    • Version: 18-August-2020

    Alternate Names:

    Drug Info:

    Publications:

  • ChemblInteractions: CHEMBL500

    • Version: chembl_23

    Alternate Names:

    Drug Info:

    Publications:

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A finding of a drug-gene interaction or potentially druggable category does not necessarily indicate effectiveness (or lack thereof) of any drug or treatment regimen. A finding of no interaction or no potentially druggable category does not necessarily indicate lack of effectiveness of any drug or treatment regimen. Drug-gene interactions or potentially druggable categories are not presented in ranked order of potential or predicted efficacy.

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DGIdb (v4.2.0 - sha1 afd9f30b) • Last updated 2020-10-21