DGIdb - PHENYLEPHRINE Drug Record

PHENYLEPHRINE chembl:CHEMBL1215 Approved

Alternate Names:

AB-101 (PHENYLEPHRINE)
J8.601K
CYCLOMYDRIL
DUO-MEDIHALER
PHENYLEPHRINE
(-)-M-HYDROXY-ALPHA-(METHYLAMINOMETHYL)BENZYL ALCOHOL
BENZYL ALCOHOL, M-HYDROXY-ALPHA-((METHYLAMINO)METHYL)-, (-)-
PHENYLEPHRINUM
(-)-M-HYDROXY-Α-(METHYLAMINOMETHYL)BENZYL ALCOHOL
(R)-3-[-1-HYDROXY-2-(METHYLAMINO)ETHYL]PHENOL
FENILEFRINA
L-(3-HYDROXYPHENYL)-N-METHYLETHANOLAMINE
METASYNEPHRINE
PEF100
M-OXEDRINE
BENZENEMETHANOL, 3-HYDROXY-.ALPHA.-[(METHYLAMINO)METHYL]-, (R)-
R(-)-PHENYLEPHRINE
BENZENEMETHANOL, 3-HYDROXY-ALPHA-((METHYLAMINO)METHYL)-, (R)-
pubchem.compound:6041
chembl:CHEMBL1215
chemidplus:59-42-7
rxcui:8163
drugbank:00388

Drug Info:

Drug Class	nasal decongestants
Drug Class	mydriatics
Drug Class	cardiotonic agents
Year of Approval	approved before 1982
FDA Approval	approved
Drug Class	Small Molecule
Drug Indications	for treatment of incontinence

(3 More Sources)

Publications:

Martínez-Salas et al., 2007, Alpha1A-adrenoceptors predominate in the control of blood pressure in mouse mesenteric vascular bed., Auton Autacoid Pharmacol
Tomiyama et al., 2007, Expressions and mechanical functions of alpha1-adrenoceptor subtypes in hamster ureter., Eur. J. Pharmacol.
Baghelai et al., 1999, Delayed myocardial preconditioning by alpha1-adrenoceptors involves inhibition of apoptosis., J. Thorac. Cardiovasc. Surg.
Diez-Fraile et al., 2000, Effect of isoproterenol and dexamethasone on the lipopolysaccharide induced expression of CD11b on bovine neutrophils., Vet. Immunol. Immunopathol.
Chen et al., 2002, TTD: Therapeutic Target Database., Nucleic Acids Res.
Messier et al., 1995, High throughput assays of cloned adrenergic, muscarinic, neurokinin, and neurotrophin receptors in living mammalian cells., Pharmacol. Toxicol.
Fischer et al., 1996, Signals mediating stimulation of cardiomyocyte glucose transport by the alpha-adrenergic agonist phenylephrine., Am. J. Physiol.
Budzyn et al., 2005, Opposing roles of endothelial and smooth muscle phosphatidylinositol 3-kinase in vasoconstriction: effects of rho-kinase and hypertension., J. Pharmacol. Exp. Ther.
McCallum et al., 2005, Vascular responses to IGF-I and insulin are impaired in aortae of hypertensive rats., J. Hypertens.
Nielsen M et al., 2016, The Gly16 Allele of the Gly16Arg Single-Nucleotide Polymorphism in the β₂-Adrenergic Receptor Gene Augments Perioperative Use of Vasopressors: A Retrospective Cohort Study., Anesth Analg
Odekon L et al., 2015, The Effect of β2-Adrenoceptor Genotype on Phenylephrine Dose Administered During Spinal Anesthesia for Cesarean Delivery., Anesth Analg
Xiao et al., 2005, Effects of isoliensinine on proliferation of porcine coronary arterial smooth muscle cells induced by phenylephrine., Yao Xue Xue Bao
Hinokiyama et al., 2006, Vein graft harvesting induces inflammation and impairs vessel reactivity., Ann. Thorac. Surg.
Udelsman et al., 1994, Adrenergic regulation of adrenal and aortic heat shock protein., Surgery
Sullivan et al., 2002, Functional NOS 1 in the rat mesenteric arterial bed., Am. J. Physiol. Heart Circ. Physiol.

PHENYLEPHRINE ITGAM

Interaction Score: 0.88

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
10973693

Sources:
NCI
PHENYLEPHRINE VWF

Interaction Score: 0.63

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
16996954

Sources:
NCI
PHENYLEPHRINE FGF2

Interaction Score: 0.42

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
15875663

Sources:
NCI
PHENYLEPHRINE ADRA1D

Interaction Score: 0.34

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Trial Name PSD-503, phenylephrine

Novel drug target Established target

PMIDs:
None found

Sources:
TdgClinicalTrial PharmGKB
PHENYLEPHRINE ADRA1B

Interaction Score: 0.29

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Trial Name PSD-503, phenylephrine

Novel drug target Established target

PMIDs:
11752352

Sources:
TdgClinicalTrial TEND PharmGKB
PHENYLEPHRINE HSPA4

Interaction Score: 0.28

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
8047983

Sources:
NCI
PHENYLEPHRINE ADRA1A

Interaction Score: 0.25

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Trial Name PSD-503, phenylephrine

Novel drug target Established target

PMIDs:
17584443 17658513

Sources:
TdgClinicalTrial TEND PharmGKB
PHENYLEPHRINE NOS1

Interaction Score: 0.23

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
12124213

Sources:
NCI
PHENYLEPHRINE PIK3CG

Interaction Score: 0.2

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
8928748 15743931 15662223

Sources:
NCI
PHENYLEPHRINE BAX

Interaction Score: 0.18

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
10220693

Sources:
NCI
PHENYLEPHRINE NTRK1

Interaction Score: 0.17

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
7567780

Sources:
NCI
PHENYLEPHRINE ADRB2

Interaction Score: 0.1

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
26771271 25730298

Sources:
PharmGKB
PHENYLEPHRINE DRD1

Interaction Score: 0.03

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
PHENYLEPHRINE DRD2

Interaction Score: 0.03

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
TTD

TEND: PHENYLEPHRINE
- Version: 01-August-2011
Alternate Names:

PHENYLEPHRINE Primary Drug Name

Drug Info:

Year of Approval approved before 1982

Drug Class cardiotonic agents

Drug Class mydriatics

Publications:
TdgClinicalTrial: PHENYLEPHRINE
- Version: January-2014
Alternate Names:

Drug Info:

Drug Indications for treatment of incontinence

Drug Class Small Molecule

FDA Approval approved

Publications:

NCI: PHENYLEPHRINE

Version: 14-September-2017

Alternate Names:

C29363 NCI drug code

Drug Info:

Publications:

Baghelai et al., 1999, Delayed myocardial preconditioning by alpha1-adrenoceptors involves inhibition of apoptosis., J. Thorac. Cardiovasc. Surg.

Messier et al., 1995, High throughput assays of cloned adrenergic, muscarinic, neurokinin, and neurotrophin receptors in living mammalian cells., Pharmacol. Toxicol.

Xiao et al., 2005, Effects of isoliensinine on proliferation of porcine coronary arterial smooth muscle cells induced by phenylephrine., Yao Xue Xue Bao

PharmGKB: phenylephrine

Version: 18-August-2020

Alternate Names:

Drug Info:

Publications:

Nielsen M et al., 2016, The Gly16 Allele of the Gly16Arg Single-Nucleotide Polymorphism in the β₂-Adrenergic Receptor Gene Augments Perioperative Use of Vasopressors: A Retrospective Cohort Study., Anesth Analg

Odekon L et al., 2015, The Effect of β2-Adrenoceptor Genotype on Phenylephrine Dose Administered During Spinal Anesthesia for Cesarean Delivery., Anesth Analg

DTC: PHENYLEPHRINE
- Version: 02-September-2020
Alternate Names:

CHEMBL1215 ChEMBL Drug ID

Drug Info:

Publications:
TTD: Phenylephrine
- Version: 2020.06.01
Alternate Names:

D0O6IU TTD Drug ID

Drug Info:

Publications:
ChemblDrugs: chembl:CHEMBL1215
- Version: ChEMBL_27
Alternate Names:

Drug Info:

Publications:

Trial Name	PSD-503, phenylephrine
Novel drug target	Established target

PHENYLEPHRINE Drug Record

PHENYLEPHRINE chembl:CHEMBL1215 Approved

Alternate Names:

Drug Info:

Publications:

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 10973693

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 16996954

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 15875663

Sources: NCI

Interaction Types & Directionality: agonist (activating)

Interaction Info: Trial Name PSD-503, phenylephrine Novel drug target Established target

PMIDs: None found

Sources: TdgClinicalTrial PharmGKB

Interaction Types & Directionality: agonist (activating)

Interaction Info: Trial Name PSD-503, phenylephrine Novel drug target Established target

PMIDs: 11752352

Sources: TdgClinicalTrial TEND PharmGKB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 8047983

Sources: NCI

Interaction Types & Directionality: agonist (activating)

Interaction Info: Trial Name PSD-503, phenylephrine Novel drug target Established target

PMIDs: 17584443 17658513

Sources: TdgClinicalTrial TEND PharmGKB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 12124213

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 8928748 15743931 15662223

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 10220693

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 7567780

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 26771271 25730298

Sources: PharmGKB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: TTD

TEND: PHENYLEPHRINE

Alternate Names: PHENYLEPHRINE Primary Drug Name

Drug Info: Year of Approval approved before 1982 Drug Class cardiotonic agents Drug Class mydriatics

Publications:

TdgClinicalTrial: PHENYLEPHRINE

Alternate Names:

Drug Info: Drug Indications for treatment of incontinence Drug Class Small Molecule FDA Approval approved

Publications:

NCI: PHENYLEPHRINE

Alternate Names: C29363 NCI drug code

Drug Info:

PharmGKB: phenylephrine

Alternate Names:

Drug Info:

DTC: PHENYLEPHRINE

Alternate Names: CHEMBL1215 ChEMBL Drug ID

Drug Info:

Publications:

TTD: Phenylephrine

Interaction Types & Directionality:

n/a

PMIDs:
10973693

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
16996954

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
15875663

Sources:
NCI

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Trial Name PSD-503, phenylephrine

Novel drug target Established target

PMIDs:
None found

Sources:
TdgClinicalTrial PharmGKB

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Trial Name PSD-503, phenylephrine

Novel drug target Established target

PMIDs:
11752352

Sources:
TdgClinicalTrial TEND PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
8047983

Sources:
NCI

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Trial Name PSD-503, phenylephrine

Novel drug target Established target

PMIDs:
17584443 17658513

Sources:
TdgClinicalTrial TEND PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
12124213

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
8928748 15743931 15662223

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
10220693

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
7567780

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
26771271 25730298

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
TTD

Alternate Names:

PHENYLEPHRINE Primary Drug Name

Drug Info:

Year of Approval approved before 1982

Drug Class cardiotonic agents

Drug Class mydriatics

Drug Info:

Drug Indications for treatment of incontinence

Drug Class Small Molecule

FDA Approval approved

Alternate Names:

C29363 NCI drug code

Alternate Names:

CHEMBL1215 ChEMBL Drug ID

Alternate Names:

D0O6IU TTD Drug ID