ARRY-614 |
PEXMETINIB |
FDA Approval | not approved |
Drug Class | Small molecule |
Drug Indications | for treatment of myelodysplastic syndrome |
inhibitor (inhibitory) |
Mechanism of Interaction | Tyrosine-protein kinase TIE-2 inhibitor |
Direct Interaction | yes |
Specific Action of the Ligand | Inhibition |
inhibitor (inhibitory) |
Specific Action of the Ligand | Inhibition |
Endogenous Drug? | False |
Direct Interaction? | False |
inhibitor (inhibitory) |
Direct Interaction? | False |
Endogenous Drug? | False |
Specific Action of the Ligand | Inhibition |
inhibitor (inhibitory) |
Specific Action of the Ligand | Inhibition |
Endogenous Drug? | False |
Direct Interaction? | False |
n/a |
Trial Name | ARRY-614 |
Novel drug target | Novel Target |
n/a |
Trial Name | ARRY-614 |
Novel drug target | Novel Target |
inhibitor (inhibitory) |
Specific Action of the Ligand | Inhibition |
Endogenous Drug? | False |
Direct Interaction? | False |
inhibitor (inhibitory) |
Specific Action of the Ligand | Inhibition |
Endogenous Drug? | False |
Direct Interaction? | False |
inhibitor (inhibitory) |
Trial Name | ARRY-614 |
Novel drug target | Novel Target |
Mechanism of Interaction | MAP kinase p38 alpha inhibitor |
inhibitor (inhibitory) |
Specific Action of the Ligand | Inhibition |
Endogenous Drug? | False |
Direct Interaction? | False |
inhibitor (inhibitory) |
Specific Action of the Ligand | Inhibition |
Endogenous Drug? | False |
Direct Interaction? | False |
inhibitor (inhibitory) |
Specific Action of the Ligand | Inhibition |
Endogenous Drug? | False |
Direct Interaction? | False |
inhibitor (inhibitory) |
Specific Action of the Ligand | Inhibition |
Endogenous Drug? | False |
Direct Interaction? | False |
inhibitor (inhibitory) |
Specific Action of the Ligand | Inhibition |
Endogenous Drug? | False |
Direct Interaction? | False |
n/a |
Trial Name | ARRY-614 |
Novel drug target | Established target |
Drug Indications | for treatment of myelodysplastic syndrome |
Drug Class | Small molecule |
FDA Approval | not approved |
PEXMETINIB | GuideToPharmacology Ligand Name |