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PERPHENAZINE Drug Record

  • Summary
  • Interactions
  • Claims
  • PERPHENAZINE chembl:CHEMBL567 Approved

    Alternate Names:

    NSC-150866
    DECENTAN
    TRILAFON-LA
    TRILAFON
    PERPHENAZINE
    PERPHENAZINE FENDIZOATE
    FENTAZIN
    CHLORPIPRAZINE
    PERPHENAZINE MALEATE
    ETAPERAZINE
    FENTAZIN®
    2-(4-[3-(2-CHLORO-10H-PHENOTHIAZIN-10-YL)PROPYL]-1-PIPERAZINYL)ETHANOL
    GAMMA-(4-(BETA-HYDROXYETHYL)PIPERAZIN-1-YL)PROPYL-2-CHLOROPHENOTHIAZINE
    DECENTAN®
    4-[3-(2-CHLOROPHENOTHIAZIN-10-YL)PROPYL]-1-PIPERAZINEETHANOL
    4-[3-(2-CHLORO-10H-PHENOTHIAZIN-10-YL)PROPYL]-1-PIPERAZINEETHANOL
    PERPHENAZINUM
    TRILAFON®
    ETAPERAZIN
    PERFENAZINE
    2-CHLORO-10-(3-(4-(2-HYDROXYETHYL)PIPERAZIN-1-YL)PROPYL)PHENOTHIAZINE
    PERPHÉNAZINE
    PERFENAZINA
    PERPHENAZIN
    ETHAPERAZINE
    pubchem.compound:4748
    drugbank:00850
    chemidplus:58-39-9
    rxcui:8076
    chembl:CHEMBL567

    Drug Info:

    Drug Class antipsychotic agents
    Year of Approval 1957
    FDA Approval 1957
    Drug Class small molecule
    Drug Indications Antipsychotic Agents
    (4 More Sources)

    Publications:

    Høyberg et al., 1993, Risperidone versus perphenazine in the treatment of chronic schizophrenic patients with acute exacerbations., Acta Psychiatr Scand
    Talvik et al., 2004, A cross-validation study on the relationship between central D2 receptor occupancy and serum perphenazine concentration., Psychopharmacology (Berl.)
    Farde et al., 1989, D1- and D2-dopamine receptor occupancy during treatment with conventional and atypical neuroleptics., Psychopharmacology (Berl.)
    Seeman, 2002, Atypical antipsychotics: mechanism of action., Can J Psychiatry
    Chen et al., 2002, TTD: Therapeutic Target Database., Nucleic Acids Res.
    Qin et al., 1994, Dopamine receptor blockade increases dopamine D2 receptor and glutamic acid decarboxylase mRNAs in mouse substantia nigra., Eur. J. Pharmacol.
    Dolzan et al., 2007, Polymorphisms in dopamine receptor DRD1 and DRD2 genes and psychopathological and extrapyramidal symptoms in patients on long-term antipsychotic treatment., Am. J. Med. Genet. B Neuropsychiatr. Genet.
    Dahl-Puustinen ML et al., 1989, Disposition of perphenazine is related to polymorphic debrisoquin hydroxylation in human beings., Clin Pharmacol Ther
  • PERPHENAZINE   DRD2

    Interaction Score: 0.25

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Novel drug target Established target
    Trial Name -
    Direct Interaction yes

    PMIDs:
    7508675 15007534 2573104 11873706 11752352 7828655


    Sources:
    TdgClinicalTrial ChemblInteractions TEND TTD

  • PERPHENAZINE   UBE2N

    Interaction Score: 0.16

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • PERPHENAZINE   DRD1

    Interaction Score: 0.13

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Novel drug target Established target
    Trial Name -

    PMIDs:
    2573104 17455212


    Sources:
    DTC TdgClinicalTrial TEND

  • PERPHENAZINE   THPO

    Interaction Score: 0.05

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • PERPHENAZINE   RAD52

    Interaction Score: 0.05

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • PERPHENAZINE   RGS4

    Interaction Score: 0.04

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    PharmGKB

  • PERPHENAZINE   MPHOSPH8

    Interaction Score: 0.03

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • PERPHENAZINE   MTOR

    Interaction Score: 0.03

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • PERPHENAZINE   CYP2D6

    Interaction Score: 0.03

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    2743709


    Sources:
    DTC PharmGKB FDA

  • PERPHENAZINE   CBX1

    Interaction Score: 0.02

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • PERPHENAZINE   ATXN2

    Interaction Score: 0.02

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • PERPHENAZINE   KCNH2

    Interaction Score: 0.01

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • PERPHENAZINE   TP53

    Interaction Score: 0.01

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • PERPHENAZINE   GMNN

    Interaction Score: 0.01

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • PERPHENAZINE   CYP1A2

    Interaction Score: 0.01

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • TEND: PERPHENAZINE

    • Version: 01-August-2011

    Alternate Names:
    PERPHENAZINE Primary Drug Name

    Drug Info:
    Year of Approval 1957
    Drug Class antipsychotic agents

    Publications:

  • TdgClinicalTrial: PERPHENAZINE

    • Version: January-2014

    Alternate Names:

    Drug Info:
    Drug Class small molecule
    Drug Indications Antipsychotic Agents
    FDA Approval 1957

    Publications:

  • PharmGKB: perphenazine

    • Version: 18-August-2020

    Alternate Names:

    Drug Info:

    Publications:
    Dahl-Puustinen ML et al., 1989, Disposition of perphenazine is related to polymorphic debrisoquin hydroxylation in human beings., Clin Pharmacol Ther

  • DTC: PERPHENAZINE

    • Version: 02-September-2020

    Alternate Names:
    CHEMBL567 ChEMBL Drug ID

    Drug Info:

    Publications:

  • TTD: Perphenazine

    • Version: 2020.06.01

    Alternate Names:
    D02HED TTD Drug ID

    Drug Info:

    Publications:

  • ChemblDrugs: chembl:CHEMBL567

    • Version: ChEMBL_27

    Alternate Names:

    Drug Info:

    Publications:

  • FDA: Perphenazine

    • Version: 04-September-2020

    Alternate Names:

    Drug Info:

    Publications:

  • ChemblInteractions: CHEMBL567

    • Version: chembl_23

    Alternate Names:

    Drug Info:

    Publications:

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A finding of a drug-gene interaction or potentially druggable category does not necessarily indicate effectiveness (or lack thereof) of any drug or treatment regimen. A finding of no interaction or no potentially druggable category does not necessarily indicate lack of effectiveness of any drug or treatment regimen. Drug-gene interactions or potentially druggable categories are not presented in ranked order of potential or predicted efficacy.

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DGIdb (v4.2.0 - sha1 afd9f30b) • Last updated 2020-10-21