• Search
      • Search Interactions Search Categories
    • Browse
      • Browse Categories Browse Sources
    • Information
      • About Publications Interaction Types & Directionalities Interaction Score & Query Score API Documentation FAQ Known Data Clients News Contact
    • Downloads
      • Data Source Code

PERPHENAZINE Drug Record

  • Summary
  • Interactions
  • Claims
  • PERPHENAZINE chembl:CHEMBL567 Approved

    Alternate Names:

    NSC-150866
    DECENTAN
    TRILAFON-LA
    TRILAFON
    PERPHENAZINE
    PERPHENAZINE FENDIZOATE
    FENTAZIN
    CHLORPIPRAZINE
    PERPHENAZINE MALEATE
    ETAPERAZINE
    FENTAZIN®
    2-(4-[3-(2-CHLORO-10H-PHENOTHIAZIN-10-YL)PROPYL]-1-PIPERAZINYL)ETHANOL
    GAMMA-(4-(BETA-HYDROXYETHYL)PIPERAZIN-1-YL)PROPYL-2-CHLOROPHENOTHIAZINE
    DECENTAN®
    4-[3-(2-CHLOROPHENOTHIAZIN-10-YL)PROPYL]-1-PIPERAZINEETHANOL
    4-[3-(2-CHLORO-10H-PHENOTHIAZIN-10-YL)PROPYL]-1-PIPERAZINEETHANOL
    PERPHENAZINUM
    TRILAFON®
    ETAPERAZIN
    PERFENAZINE
    2-CHLORO-10-(3-(4-(2-HYDROXYETHYL)PIPERAZIN-1-YL)PROPYL)PHENOTHIAZINE
    PERPHÉNAZINE
    PERFENAZINA
    PERPHENAZIN
    ETHAPERAZINE
    pubchem.compound:4748
    drugbank:00850
    chemidplus:58-39-9
    rxcui:8076
    chembl:CHEMBL567

    Drug Info:

    Drug Class antipsychotic agents
    Year of Approval 1957
    Drug Categories phenothiazines with piperazine structure
    FDA Approval 1957
    Drug Class small molecule
    Drug Indications Antipsychotic Agents
    Drug Categories cytochrome p-450 cyp2c18 substrates
    Drug Categories cytochrome p-450 cyp2d6 inhibitors (strength unknown)
    Drug Categories cytochrome p-450 cyp3a substrates
    Drug Categories cytochrome p-450 enzyme inhibitors
    Drug Categories cytochrome p-450 substrates
    Drug Categories dopamine d2 receptor antagonists
    Drug Categories drugs causing inadvertant photosensitivity
    Drug Categories heterocyclic compounds, fused-ring
    Drug Categories neurotoxic agents
    Drug Categories photosensitizing agents
    (6 More Sources)

    Publications:

    Farde et al., 1989, D1- and D2-dopamine receptor occupancy during treatment with conventional and atypical neuroleptics., Psychopharmacology (Berl.)
    Høyberg et al., 1993, Risperidone versus perphenazine in the treatment of chronic schizophrenic patients with acute exacerbations., Acta Psychiatr Scand
    Seeman, 2002, Atypical antipsychotics: mechanism of action., Can J Psychiatry
    Chen et al., 2002, TTD: Therapeutic Target Database., Nucleic Acids Res.
    Talvik et al., 2004, A cross-validation study on the relationship between central D2 receptor occupancy and serum perphenazine concentration., Psychopharmacology (Berl.)
    Qin et al., 1994, Dopamine receptor blockade increases dopamine D2 receptor and glutamic acid decarboxylase mRNAs in mouse substantia nigra., Eur. J. Pharmacol.
    Dolzan et al., 2007, Polymorphisms in dopamine receptor DRD1 and DRD2 genes and psychopathological and extrapyramidal symptoms in patients on long-term antipsychotic treatment., Am. J. Med. Genet. B Neuropsychiatr. Genet.
    Dahl-Puustinen ML et al., 1989, Disposition of perphenazine is related to polymorphic debrisoquin hydroxylation in human beings., Clin Pharmacol Ther
    Edlind et al., 2002, Antifungal activity in Saccharomyces cerevisiae is modulated by calcium signalling., Mol. Microbiol.
    Natochin YuV et al., 1987, Water and sodium transport: effects of calcium channel blocker and calmodulin antagonists on the apical and basolateral membranes of amphibian epithelia., Gen. Physiol. Biophys.
    Kawai et al., 2001, Fission yeast tor1 functions in response to various stresses including nitrogen starvation, high osmolarity, and high temperature., Curr. Genet.
    Mongin et al., 1999, Volume-dependent taurine release from cultured astrocytes requires permissive [Ca(2+)](i) and calmodulin., Am. J. Physiol.
  • PERPHENAZINE   CALM1

    Interaction Score: 0.52

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:

    PMIDs:
    12366848 2885243 11409178 10516112


    Sources:
    DrugBank

  • PERPHENAZINE   DRD2

    Interaction Score: 0.16

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Novel drug target Established target
    Trial Name -
    Specific Action of the Ligand Antagonist

    PMIDs:
    2573104 7508675 11873706 11752352 15007534 7828655


    Sources:
    TEND TdgClinicalTrial TTD DrugBank GuideToPharmacology ChemblInteractions

  • PERPHENAZINE   UBE2N

    Interaction Score: 0.11

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • PERPHENAZINE   DRD1

    Interaction Score: 0.09

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Novel drug target Established target
    Trial Name -

    PMIDs:
    2573104 17455212


    Sources:
    TEND DTC TdgClinicalTrial DrugBank

  • PERPHENAZINE   HTR6

    Interaction Score: 0.05

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Specific Action of the Ligand Inverse agonist
    Endogenous Drug? False

    PMIDs:
    None found


    Sources:
    GuideToPharmacology

  • PERPHENAZINE   HTR7

    Interaction Score: 0.04

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Endogenous Drug? False
    Specific Action of the Ligand Inverse agonist

    PMIDs:
    None found


    Sources:
    GuideToPharmacology

  • PERPHENAZINE   THPO

    Interaction Score: 0.04

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • PERPHENAZINE   RAD52

    Interaction Score: 0.03

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • PERPHENAZINE   RGS4

    Interaction Score: 0.03

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    PharmGKB

  • PERPHENAZINE   MPHOSPH8

    Interaction Score: 0.02

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • PERPHENAZINE   HTR2C

    Interaction Score: 0.02

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Specific Action of the Ligand Antagonist
    Endogenous Drug? False

    PMIDs:
    None found


    Sources:
    GuideToPharmacology

  • PERPHENAZINE   MTOR

    Interaction Score: 0.02

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • PERPHENAZINE   CYP2D6

    Interaction Score: 0.02

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    2743709


    Sources:
    DTC FDA PharmGKB

  • PERPHENAZINE   HRH1

    Interaction Score: 0.01

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Specific Action of the Ligand Antagonist
    Endogenous Drug? False

    PMIDs:
    None found


    Sources:
    GuideToPharmacology

  • PERPHENAZINE   CBX1

    Interaction Score: 0.01

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • PERPHENAZINE   HTR2A

    Interaction Score: 0.01

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Specific Action of the Ligand Antagonist
    Endogenous Drug? False

    PMIDs:
    None found


    Sources:
    GuideToPharmacology

  • PERPHENAZINE   ATXN2

    Interaction Score: 0.01

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • PERPHENAZINE   KCNH2

    Interaction Score: 0.01

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • PERPHENAZINE   TP53

    Interaction Score: 0.01

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • PERPHENAZINE   GMNN

    Interaction Score: 0.01

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • PERPHENAZINE   CYP1A2

    Interaction Score: 0.0

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • DrugBank: DB00850

    • Version: 5.1.7

    Alternate Names:
    PERPHENAZINE DrugBank Drug Name
    58-39-9 CAS Number
    Apo Peram Tab 2-25 Drug Brand

    Drug Info:
    Drug Type small molecule
    Drug Groups approved
    Drug Categories antipsychotic agents

    Publications:
    Farde et al., 1989, D1- and D2-dopamine receptor occupancy during treatment with conventional and atypical neuroleptics., Psychopharmacology (Berl.)
    Høyberg et al., 1993, Risperidone versus perphenazine in the treatment of chronic schizophrenic patients with acute exacerbations., Acta Psychiatr Scand
    Seeman, 2002, Atypical antipsychotics: mechanism of action., Can J Psychiatry

  • TEND: PERPHENAZINE

    • Version: 01-August-2011

    Alternate Names:
    PERPHENAZINE Primary Drug Name

    Drug Info:
    Year of Approval 1957
    Drug Class antipsychotic agents

    Publications:

  • TdgClinicalTrial: PERPHENAZINE

    • Version: January-2014

    Alternate Names:

    Drug Info:
    Drug Class small molecule
    Drug Indications Antipsychotic Agents
    FDA Approval 1957

    Publications:

  • PharmGKB: perphenazine

    • Version: 18-August-2020

    Alternate Names:

    Drug Info:

    Publications:
    Dahl-Puustinen ML et al., 1989, Disposition of perphenazine is related to polymorphic debrisoquin hydroxylation in human beings., Clin Pharmacol Ther

  • DTC: PERPHENAZINE

    • Version: 02-September-2020

    Alternate Names:
    CHEMBL567 ChEMBL Drug ID

    Drug Info:

    Publications:

  • TTD: Perphenazine

    • Version: 2020.06.01

    Alternate Names:
    D02HED TTD Drug ID

    Drug Info:

    Publications:

  • GuideToPharmacology: 135650810

    • Version: 29-September-2020

    Alternate Names:
    PERPHENAZINE GuideToPharmacology Ligand Name

    Drug Info:

    Publications:

  • ChemblDrugs: chembl:CHEMBL567

    • Version: ChEMBL_27

    Alternate Names:

    Drug Info:

    Publications:

  • FDA: Perphenazine

    • Version: 04-September-2020

    Alternate Names:

    Drug Info:

    Publications:

  • ChemblInteractions: CHEMBL567

    • Version: chembl_23

    Alternate Names:

    Drug Info:

    Publications:

Disclaimer: This resource is intended for purely research purposes. It should not be used for emergencies or medical or professional advice.

A finding of a drug-gene interaction or potentially druggable category does not necessarily indicate effectiveness (or lack thereof) of any drug or treatment regimen. A finding of no interaction or no potentially druggable category does not necessarily indicate lack of effectiveness of any drug or treatment regimen. Drug-gene interactions or potentially druggable categories are not presented in ranked order of potential or predicted efficacy.

The dgidb.org website does not provide any medical or healthcare products, services or advice, and is not for medical emergencies or urgent situations. IF YOU THINK YOU MAY HAVE A MEDICAL EMERGENCY, CALL YOUR DOCTOR OR 911 IMMEDIATELY. Information contained on this website is not a substitute for a doctor's medical judgment or advice. We recommend that you discuss your specific, individual health concerns with your doctor or health care professional.

DGIdb (v4.2.0 - sha1 afd9f30b) • Last updated 2020-10-21