DGIdb - PERPHENAZINE Drug Record

PERPHENAZINE chembl:CHEMBL567 Approved

Alternate Names:

NSC-150866
DECENTAN
TRILAFON-LA
TRILAFON
PERPHENAZINE
PERPHENAZINE FENDIZOATE
FENTAZIN
CHLORPIPRAZINE
PERPHENAZINE MALEATE
ETAPERAZINE
FENTAZIN®
2-(4-[3-(2-CHLORO-10H-PHENOTHIAZIN-10-YL)PROPYL]-1-PIPERAZINYL)ETHANOL
GAMMA-(4-(BETA-HYDROXYETHYL)PIPERAZIN-1-YL)PROPYL-2-CHLOROPHENOTHIAZINE
DECENTAN®
4-[3-(2-CHLOROPHENOTHIAZIN-10-YL)PROPYL]-1-PIPERAZINEETHANOL
4-[3-(2-CHLORO-10H-PHENOTHIAZIN-10-YL)PROPYL]-1-PIPERAZINEETHANOL
PERPHENAZINUM
TRILAFON®
ETAPERAZIN
PERFENAZINE
2-CHLORO-10-(3-(4-(2-HYDROXYETHYL)PIPERAZIN-1-YL)PROPYL)PHENOTHIAZINE
PERPHÉNAZINE
PERFENAZINA
PERPHENAZIN
ETHAPERAZINE
pubchem.compound:4748
drugbank:00850
chemidplus:58-39-9
rxcui:8076
chembl:CHEMBL567

Drug Info:

Drug Class	antipsychotic agents
Year of Approval	1957
FDA Approval	1957
Drug Class	small molecule
Drug Indications	Antipsychotic Agents

(4 More Sources)

Publications:

Høyberg et al., 1993, Risperidone versus perphenazine in the treatment of chronic schizophrenic patients with acute exacerbations., Acta Psychiatr Scand
Talvik et al., 2004, A cross-validation study on the relationship between central D2 receptor occupancy and serum perphenazine concentration., Psychopharmacology (Berl.)
Farde et al., 1989, D1- and D2-dopamine receptor occupancy during treatment with conventional and atypical neuroleptics., Psychopharmacology (Berl.)
Seeman, 2002, Atypical antipsychotics: mechanism of action., Can J Psychiatry
Chen et al., 2002, TTD: Therapeutic Target Database., Nucleic Acids Res.
Qin et al., 1994, Dopamine receptor blockade increases dopamine D2 receptor and glutamic acid decarboxylase mRNAs in mouse substantia nigra., Eur. J. Pharmacol.
Dolzan et al., 2007, Polymorphisms in dopamine receptor DRD1 and DRD2 genes and psychopathological and extrapyramidal symptoms in patients on long-term antipsychotic treatment., Am. J. Med. Genet. B Neuropsychiatr. Genet.
Dahl-Puustinen ML et al., 1989, Disposition of perphenazine is related to polymorphic debrisoquin hydroxylation in human beings., Clin Pharmacol Ther

PERPHENAZINE DRD2

Interaction Score: 0.25

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Novel drug target Established target

Trial Name -

Direct Interaction yes

PMIDs:
7508675 15007534 2573104 11873706 11752352 7828655

Sources:
TdgClinicalTrial ChemblInteractions TEND TTD
PERPHENAZINE UBE2N

Interaction Score: 0.16

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
PERPHENAZINE DRD1

Interaction Score: 0.13

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Novel drug target Established target

Trial Name -

PMIDs:
2573104 17455212

Sources:
DTC TdgClinicalTrial TEND
PERPHENAZINE THPO

Interaction Score: 0.05

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
PERPHENAZINE RAD52

Interaction Score: 0.05

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
PERPHENAZINE RGS4

Interaction Score: 0.04

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
PharmGKB
PERPHENAZINE MPHOSPH8

Interaction Score: 0.03

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
PERPHENAZINE MTOR

Interaction Score: 0.03

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
PERPHENAZINE CYP2D6

Interaction Score: 0.03

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
2743709

Sources:
DTC PharmGKB FDA
PERPHENAZINE CBX1

Interaction Score: 0.02

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
PERPHENAZINE ATXN2

Interaction Score: 0.02

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
PERPHENAZINE KCNH2

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
PERPHENAZINE TP53

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
PERPHENAZINE GMNN

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
PERPHENAZINE CYP1A2

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC

TEND: PERPHENAZINE
- Version: 01-August-2011
Alternate Names:

PERPHENAZINE Primary Drug Name

Drug Info:

Year of Approval 1957

Drug Class antipsychotic agents

Publications:
TdgClinicalTrial: PERPHENAZINE
- Version: January-2014
Alternate Names:

Drug Info:

Drug Class small molecule

Drug Indications Antipsychotic Agents

FDA Approval 1957

Publications:
PharmGKB: perphenazine
- Version: 18-August-2020
Alternate Names:

Drug Info:

Publications:

Dahl-Puustinen ML et al., 1989, Disposition of perphenazine is related to polymorphic debrisoquin hydroxylation in human beings., Clin Pharmacol Ther
DTC: PERPHENAZINE
- Version: 02-September-2020
Alternate Names:

CHEMBL567 ChEMBL Drug ID

Drug Info:

Publications:
TTD: Perphenazine
- Version: 2020.06.01
Alternate Names:

D02HED TTD Drug ID

Drug Info:

Publications:
ChemblDrugs: chembl:CHEMBL567
- Version: ChEMBL_27
Alternate Names:

Drug Info:

Publications:
FDA: Perphenazine
- Version: 04-September-2020
Alternate Names:

Drug Info:

Publications:
ChemblInteractions: CHEMBL567
- Version: chembl_23
Alternate Names:

Drug Info:

Publications:

Novel drug target	Established target
Trial Name	-
Direct Interaction	yes

PERPHENAZINE Drug Record

PERPHENAZINE chembl:CHEMBL567 Approved

Alternate Names:

Drug Info:

Publications:

Interaction Types & Directionality: antagonist (inhibitory)

Interaction Info: Novel drug target Established target Trial Name - Direct Interaction yes

PMIDs: 7508675 15007534 2573104 11873706 11752352 7828655

Sources: TdgClinicalTrial ChemblInteractions TEND TTD

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: antagonist (inhibitory)

Interaction Info: Novel drug target Established target Trial Name -

PMIDs: 2573104 17455212

Sources: DTC TdgClinicalTrial TEND

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: PharmGKB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 2743709

Sources: DTC PharmGKB FDA

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

TEND: PERPHENAZINE

Alternate Names: PERPHENAZINE Primary Drug Name

Drug Info: Year of Approval 1957 Drug Class antipsychotic agents

Publications:

TdgClinicalTrial: PERPHENAZINE

Alternate Names:

Drug Info: Drug Class small molecule Drug Indications Antipsychotic Agents FDA Approval 1957

Publications:

PharmGKB: perphenazine

Alternate Names:

Drug Info:

Publications: Dahl-Puustinen ML et al., 1989, Disposition of perphenazine is related to polymorphic debrisoquin hydroxylation in human beings., Clin Pharmacol Ther

DTC: PERPHENAZINE

Alternate Names: CHEMBL567 ChEMBL Drug ID

Drug Info:

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Novel drug target Established target

Trial Name -

Direct Interaction yes

PMIDs:
7508675 15007534 2573104 11873706 11752352 7828655

Sources:
TdgClinicalTrial ChemblInteractions TEND TTD

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Novel drug target Established target

Trial Name -

PMIDs:
2573104 17455212

Sources:
DTC TdgClinicalTrial TEND

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
2743709

Sources:
DTC PharmGKB FDA

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Alternate Names:

PERPHENAZINE Primary Drug Name

Drug Info:

Year of Approval 1957

Drug Class antipsychotic agents

Drug Info:

Drug Class small molecule

Drug Indications Antipsychotic Agents

FDA Approval 1957

Publications:

Dahl-Puustinen ML et al., 1989, Disposition of perphenazine is related to polymorphic debrisoquin hydroxylation in human beings., Clin Pharmacol Ther

Alternate Names:

CHEMBL567 ChEMBL Drug ID

Alternate Names:

D02HED TTD Drug ID