DGIdb - PERPHENAZINE Drug Record

PERPHENAZINE chembl:CHEMBL567 Approved

Alternate Names:

NSC-150866
DECENTAN
TRILAFON-LA
TRILAFON
PERPHENAZINE
PERPHENAZINE FENDIZOATE
FENTAZIN
CHLORPIPRAZINE
PERPHENAZINE MALEATE
ETAPERAZINE
FENTAZIN®
2-(4-[3-(2-CHLORO-10H-PHENOTHIAZIN-10-YL)PROPYL]-1-PIPERAZINYL)ETHANOL
GAMMA-(4-(BETA-HYDROXYETHYL)PIPERAZIN-1-YL)PROPYL-2-CHLOROPHENOTHIAZINE
DECENTAN®
4-[3-(2-CHLOROPHENOTHIAZIN-10-YL)PROPYL]-1-PIPERAZINEETHANOL
4-[3-(2-CHLORO-10H-PHENOTHIAZIN-10-YL)PROPYL]-1-PIPERAZINEETHANOL
PERPHENAZINUM
TRILAFON®
ETAPERAZIN
PERFENAZINE
2-CHLORO-10-(3-(4-(2-HYDROXYETHYL)PIPERAZIN-1-YL)PROPYL)PHENOTHIAZINE
PERPHÉNAZINE
PERFENAZINA
PERPHENAZIN
ETHAPERAZINE
pubchem.compound:4748
drugbank:00850
chemidplus:58-39-9
rxcui:8076
chembl:CHEMBL567

Drug Info:

Drug Class	antipsychotic agents
Year of Approval	1957
Drug Categories	phenothiazines with piperazine structure
FDA Approval	1957
Drug Class	small molecule
Drug Indications	Antipsychotic Agents
Drug Categories	cytochrome p-450 cyp2c18 substrates
Drug Categories	cytochrome p-450 cyp2d6 inhibitors (strength unknown)
Drug Categories	cytochrome p-450 cyp3a substrates
Drug Categories	cytochrome p-450 enzyme inhibitors
Drug Categories	cytochrome p-450 substrates
Drug Categories	dopamine d2 receptor antagonists
Drug Categories	drugs causing inadvertant photosensitivity
Drug Categories	heterocyclic compounds, fused-ring
Drug Categories	neurotoxic agents
Drug Categories	photosensitizing agents

(6 More Sources)

Publications:

Farde et al., 1989, D1- and D2-dopamine receptor occupancy during treatment with conventional and atypical neuroleptics., Psychopharmacology (Berl.)
Høyberg et al., 1993, Risperidone versus perphenazine in the treatment of chronic schizophrenic patients with acute exacerbations., Acta Psychiatr Scand
Seeman, 2002, Atypical antipsychotics: mechanism of action., Can J Psychiatry
Chen et al., 2002, TTD: Therapeutic Target Database., Nucleic Acids Res.
Talvik et al., 2004, A cross-validation study on the relationship between central D2 receptor occupancy and serum perphenazine concentration., Psychopharmacology (Berl.)
Qin et al., 1994, Dopamine receptor blockade increases dopamine D2 receptor and glutamic acid decarboxylase mRNAs in mouse substantia nigra., Eur. J. Pharmacol.
Dolzan et al., 2007, Polymorphisms in dopamine receptor DRD1 and DRD2 genes and psychopathological and extrapyramidal symptoms in patients on long-term antipsychotic treatment., Am. J. Med. Genet. B Neuropsychiatr. Genet.
Dahl-Puustinen ML et al., 1989, Disposition of perphenazine is related to polymorphic debrisoquin hydroxylation in human beings., Clin Pharmacol Ther
Edlind et al., 2002, Antifungal activity in Saccharomyces cerevisiae is modulated by calcium signalling., Mol. Microbiol.
Natochin YuV et al., 1987, Water and sodium transport: effects of calcium channel blocker and calmodulin antagonists on the apical and basolateral membranes of amphibian epithelia., Gen. Physiol. Biophys.
Kawai et al., 2001, Fission yeast tor1 functions in response to various stresses including nitrogen starvation, high osmolarity, and high temperature., Curr. Genet.
Mongin et al., 1999, Volume-dependent taurine release from cultured astrocytes requires permissive [Ca(2+)](i) and calmodulin., Am. J. Physiol.

PERPHENAZINE CALM1

Interaction Score: 0.52

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

PMIDs:
12366848 2885243 11409178 10516112

Sources:
DrugBank
PERPHENAZINE DRD2

Interaction Score: 0.16

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Novel drug target Established target

Trial Name -

Specific Action of the Ligand Antagonist

PMIDs:
2573104 7508675 11873706 11752352 15007534 7828655

Sources:
TEND TdgClinicalTrial TTD DrugBank GuideToPharmacology ChemblInteractions
PERPHENAZINE UBE2N

Interaction Score: 0.11

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
PERPHENAZINE DRD1

Interaction Score: 0.09

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Novel drug target Established target

Trial Name -

PMIDs:
2573104 17455212

Sources:
TEND DTC TdgClinicalTrial DrugBank
PERPHENAZINE HTR6

Interaction Score: 0.05

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Specific Action of the Ligand Inverse agonist

Endogenous Drug? False

PMIDs:
None found

Sources:
GuideToPharmacology
PERPHENAZINE HTR7

Interaction Score: 0.04

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Endogenous Drug? False

Specific Action of the Ligand Inverse agonist

PMIDs:
None found

Sources:
GuideToPharmacology
PERPHENAZINE THPO

Interaction Score: 0.04

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
PERPHENAZINE RAD52

Interaction Score: 0.03

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
PERPHENAZINE RGS4

Interaction Score: 0.03

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
PharmGKB
PERPHENAZINE MPHOSPH8

Interaction Score: 0.02

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
PERPHENAZINE HTR2C

Interaction Score: 0.02

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Specific Action of the Ligand Antagonist

Endogenous Drug? False

PMIDs:
None found

Sources:
GuideToPharmacology
PERPHENAZINE MTOR

Interaction Score: 0.02

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
PERPHENAZINE CYP2D6

Interaction Score: 0.02

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
2743709

Sources:
DTC FDA PharmGKB
PERPHENAZINE HRH1

Interaction Score: 0.01

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Specific Action of the Ligand Antagonist

Endogenous Drug? False

PMIDs:
None found

Sources:
GuideToPharmacology
PERPHENAZINE CBX1

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
PERPHENAZINE HTR2A

Interaction Score: 0.01

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Specific Action of the Ligand Antagonist

Endogenous Drug? False

PMIDs:
None found

Sources:
GuideToPharmacology
PERPHENAZINE ATXN2

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
PERPHENAZINE KCNH2

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
PERPHENAZINE TP53

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
PERPHENAZINE GMNN

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
PERPHENAZINE CYP1A2

Interaction Score: 0.0

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC

DrugBank: DB00850

Version: 5.1.7

Alternate Names:

PERPHENAZINE DrugBank Drug Name

58-39-9 CAS Number

Apo Peram Tab 2-25 Drug Brand

Drug Info:

Drug Type small molecule

Drug Groups approved

Drug Categories antipsychotic agents

Publications:

Farde et al., 1989, D1- and D2-dopamine receptor occupancy during treatment with conventional and atypical neuroleptics., Psychopharmacology (Berl.)

Høyberg et al., 1993, Risperidone versus perphenazine in the treatment of chronic schizophrenic patients with acute exacerbations., Acta Psychiatr Scand

Seeman, 2002, Atypical antipsychotics: mechanism of action., Can J Psychiatry

TEND: PERPHENAZINE
- Version: 01-August-2011
Alternate Names:

PERPHENAZINE Primary Drug Name

Drug Info:

Year of Approval 1957

Drug Class antipsychotic agents

Publications:
TdgClinicalTrial: PERPHENAZINE
- Version: January-2014
Alternate Names:

Drug Info:

Drug Class small molecule

Drug Indications Antipsychotic Agents

FDA Approval 1957

Publications:
PharmGKB: perphenazine
- Version: 18-August-2020
Alternate Names:

Drug Info:

Publications:

Dahl-Puustinen ML et al., 1989, Disposition of perphenazine is related to polymorphic debrisoquin hydroxylation in human beings., Clin Pharmacol Ther
DTC: PERPHENAZINE
- Version: 02-September-2020
Alternate Names:

CHEMBL567 ChEMBL Drug ID

Drug Info:

Publications:
TTD: Perphenazine
- Version: 2020.06.01
Alternate Names:

D02HED TTD Drug ID

Drug Info:

Publications:
GuideToPharmacology: 135650810
- Version: 29-September-2020
Alternate Names:

PERPHENAZINE GuideToPharmacology Ligand Name

Drug Info:

Publications:
ChemblDrugs: chembl:CHEMBL567
- Version: ChEMBL_27
Alternate Names:

Drug Info:

Publications:
FDA: Perphenazine
- Version: 04-September-2020
Alternate Names:

Drug Info:

Publications:
ChemblInteractions: CHEMBL567
- Version: chembl_23
Alternate Names:

Drug Info:

Publications:

Novel drug target	Established target
Trial Name	-
Specific Action of the Ligand	Antagonist

Specific Action of the Ligand	Inverse agonist
Endogenous Drug?	False

PERPHENAZINE	DrugBank Drug Name
58-39-9	CAS Number
Apo Peram Tab 2-25	Drug Brand

Drug Type	small molecule
Drug Groups	approved
Drug Categories	antipsychotic agents

PERPHENAZINE Drug Record

PERPHENAZINE chembl:CHEMBL567 Approved

Alternate Names:

Drug Info:

Publications:

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info:

PMIDs: 12366848 2885243 11409178 10516112

Sources: DrugBank

Interaction Types & Directionality: antagonist (inhibitory)

Interaction Info: Novel drug target Established target Trial Name - Specific Action of the Ligand Antagonist

PMIDs: 2573104 7508675 11873706 11752352 15007534 7828655

Sources: TEND TdgClinicalTrial TTD DrugBank GuideToPharmacology ChemblInteractions

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: antagonist (inhibitory)

Interaction Info: Novel drug target Established target Trial Name -

PMIDs: 2573104 17455212

Sources: TEND DTC TdgClinicalTrial DrugBank

Interaction Types & Directionality: antagonist (inhibitory)

Interaction Info: Specific Action of the Ligand Inverse agonist Endogenous Drug? False

PMIDs: None found

Sources: GuideToPharmacology

Interaction Types & Directionality: antagonist (inhibitory)

Interaction Info: Endogenous Drug? False Specific Action of the Ligand Inverse agonist

PMIDs: None found

Sources: GuideToPharmacology

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: PharmGKB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: antagonist (inhibitory)

Interaction Info: Specific Action of the Ligand Antagonist Endogenous Drug? False

PMIDs: None found

Sources: GuideToPharmacology

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 2743709

Sources: DTC FDA PharmGKB

Interaction Types & Directionality: antagonist (inhibitory)

Interaction Info: Specific Action of the Ligand Antagonist Endogenous Drug? False

PMIDs: None found

Sources: GuideToPharmacology

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: antagonist (inhibitory)

Interaction Info: Specific Action of the Ligand Antagonist Endogenous Drug? False

PMIDs: None found

Sources: GuideToPharmacology

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Interaction Types & Directionality:

inhibitor (inhibitory)

PMIDs:
12366848 2885243 11409178 10516112

Sources:
DrugBank

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Novel drug target Established target

Trial Name -

Specific Action of the Ligand Antagonist

PMIDs:
2573104 7508675 11873706 11752352 15007534 7828655

Sources:
TEND TdgClinicalTrial TTD DrugBank GuideToPharmacology ChemblInteractions

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Novel drug target Established target

Trial Name -

PMIDs:
2573104 17455212

Sources:
TEND DTC TdgClinicalTrial DrugBank

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Specific Action of the Ligand Inverse agonist

Endogenous Drug? False

PMIDs:
None found

Sources:
GuideToPharmacology

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Endogenous Drug? False

Specific Action of the Ligand Inverse agonist

PMIDs:
None found

Sources:
GuideToPharmacology

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Specific Action of the Ligand Antagonist

Endogenous Drug? False

PMIDs:
None found

Sources:
GuideToPharmacology

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
2743709

Sources:
DTC FDA PharmGKB

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Specific Action of the Ligand Antagonist

Endogenous Drug? False

PMIDs:
None found

Sources:
GuideToPharmacology

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Specific Action of the Ligand Antagonist

Endogenous Drug? False

PMIDs:
None found

Sources:
GuideToPharmacology

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Alternate Names:

PERPHENAZINE DrugBank Drug Name

58-39-9 CAS Number

Apo Peram Tab 2-25 Drug Brand

Drug Info:

Drug Type small molecule

Drug Groups approved

Drug Categories antipsychotic agents

Alternate Names:

PERPHENAZINE Primary Drug Name

Drug Info:

Year of Approval 1957

Drug Class antipsychotic agents

Drug Info:

Drug Class small molecule

Drug Indications Antipsychotic Agents

FDA Approval 1957

Publications:

Dahl-Puustinen ML et al., 1989, Disposition of perphenazine is related to polymorphic debrisoquin hydroxylation in human beings., Clin Pharmacol Ther

Alternate Names:

CHEMBL567 ChEMBL Drug ID

Alternate Names:

D02HED TTD Drug ID

Alternate Names:

PERPHENAZINE GuideToPharmacology Ligand Name