DGIdb - PERIFOSINE Drug Record

PERIFOSINE chembl:CHEMBL372764 Antineoplastic

Alternate Names:

NSC-639966
KRX-0401
PERIFOSINE

Drug Info:

FDA Approval	not approved
Drug Class	small molecule
Drug Indications	antineoplastic agent
Drug Type	small molecule
Drug Groups	investigational
Drug Categories	alcohols
Drug Categories	amines
Drug Categories	amino alcohols
Drug Categories	ammonium compounds
Drug Categories	ethanolamines
Drug Categories	nitrogen compounds
Drug Categories	onium compounds
Drug Categories	quaternary ammonium compounds
Drug Categories	trimethyl ammonium compounds

(4 More Sources)

Publications:

Liu et al., 2009, Genetic alterations in the phosphoinositide 3-kinase/Akt signaling pathway confer sensitivity of thyroid cancer cells to therapeutic targeting of Akt and mammalian target of rapamycin., Cancer Res.
Shome D et al., 2008, Ulcerative keratitis in gastrointestinal stromal tumor patients treated with perifosine., Ophthalmology
Sasano et al., 2015, Preclinical Efficacy for AKT Targeting in Clear Cell Carcinoma of the Ovary., Mol. Cancer Res.
Knowling M et al., 2006, A phase II study of perifosine (D-21226) in patients with previously untreated metastatic or locally advanced soft tissue sarcoma: A National Cancer Institute of Canada Clinical Trials Group trial., Invest New Drugs

PERIFOSINE AKT1

Interaction Score: 0.73

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Trial Name perifosine, KRX-0401

Novel drug target Novel Target

Indication/Tumor Type ovarian clear cell carcinoma

PMIDs:
18201764 25519148

Sources:
MyCancerGenomeClinicalTrial JAX-CKB TdgClinicalTrial DrugBank TALC
PERIFOSINE PRKCA

Interaction Score: 0.56

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
16528479

Sources:
DrugBank
PERIFOSINE AKT3

Interaction Score: 0.35

Interaction Types & Directionality:

n/a

Interaction Info:

Novel drug target Novel Target

Trial Name perifosine, KRX-0401

PMIDs:
None found

Sources:
TdgClinicalTrial
PERIFOSINE AKT2

Interaction Score: 0.32

Interaction Types & Directionality:

n/a

Interaction Info:

Trial Name perifosine, KRX-0401

Novel drug target Novel Target

PMIDs:
None found

Sources:
TdgClinicalTrial
PERIFOSINE PIK3CA

Interaction Score: 0.11

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
19706758

Sources:
CIViC
PERIFOSINE MAPK1

Interaction Score: 0.09

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
16528479

Sources:
DrugBank
PERIFOSINE PIK3CG

Interaction Score: 0.07

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
TTD

DrugBank: DB06641

Version: 5.1.7

Alternate Names:

PERIFOSINE DrugBank Drug Name

157716-52-4 CAS Number

CHEMBL372764 ChEMBL ID

Drug Info:

Drug Type small molecule

Drug Groups investigational

Drug Categories alcohols

Publications:

Knowling M et al., 2006, A phase II study of perifosine (D-21226) in patients with previously untreated metastatic or locally advanced soft tissue sarcoma: A National Cancer Institute of Canada Clinical Trials Group trial., Invest New Drugs

Shome D et al., 2008, Ulcerative keratitis in gastrointestinal stromal tumor patients treated with perifosine., Ophthalmology

TdgClinicalTrial: PERIFOSINE
- Version: January-2014
Alternate Names:

Drug Info:

Drug Indications antineoplastic agent

Drug Class small molecule

FDA Approval not approved

Publications:
JAX-CKB: Perifosine
- Version: 27-September-2017
Alternate Names:

Drug Info:

Publications:

Sasano et al., 2015, Preclinical Efficacy for AKT Targeting in Clear Cell Carcinoma of the Ovary., Mol. Cancer Res.

CIViC: PERIFOSINE

Version: 14-September-2020

Alternate Names:

Drug Info:

Publications:

Liu et al., 2009, Genetic alterations in the phosphoinositide 3-kinase/Akt signaling pathway confer sensitivity of thyroid cancer cells to therapeutic targeting of Akt and mammalian target of rapamycin., Cancer Res.

TALC: PERIFOSINE
- Version: 12-May-2016
Alternate Names:

PERIFOSINE Primary Drug Name

PERIFOSINE Drug Generic Name

KRX-0401 Drug Synonym

Drug Info:

Publications:
TTD: Perifosine
- Version: 2020.06.01
Alternate Names:

D0R1VU TTD Drug ID

Drug Info:

Publications:
ChemblDrugs: chembl:CHEMBL372764
- Version: ChEMBL_27
Alternate Names:

Drug Info:

Publications:
MyCancerGenomeClinicalTrial: PERIFOSINE
- Version: 30-February-2014
Alternate Names:

Drug Info:

Publications:

Trial Name	perifosine, KRX-0401
Novel drug target	Novel Target
Indication/Tumor Type	ovarian clear cell carcinoma

PERIFOSINE	DrugBank Drug Name
157716-52-4	CAS Number
CHEMBL372764	ChEMBL ID

PERIFOSINE	Primary Drug Name
PERIFOSINE	Drug Generic Name
KRX-0401	Drug Synonym

PERIFOSINE Drug Record

PERIFOSINE chembl:CHEMBL372764 Antineoplastic

Alternate Names:

Drug Info:

Publications:

PERIFOSINE AKT1

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Trial Name perifosine, KRX-0401 Novel drug target Novel Target Indication/Tumor Type ovarian clear cell carcinoma

PMIDs: 18201764 25519148

Sources: MyCancerGenomeClinicalTrial JAX-CKB TdgClinicalTrial DrugBank TALC

PERIFOSINE PRKCA

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 16528479

Sources: DrugBank

PERIFOSINE AKT3

Interaction Types & Directionality: n/a

Interaction Info: Novel drug target Novel Target Trial Name perifosine, KRX-0401

PMIDs: None found

Sources: TdgClinicalTrial

PERIFOSINE AKT2

Interaction Types & Directionality: n/a

Interaction Info: Trial Name perifosine, KRX-0401 Novel drug target Novel Target

PMIDs: None found

Sources: TdgClinicalTrial

PERIFOSINE PIK3CA

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 19706758

Sources: CIViC

PERIFOSINE MAPK1

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 16528479

Sources: DrugBank

PERIFOSINE PIK3CG

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: TTD

DrugBank: DB06641

Alternate Names: PERIFOSINE DrugBank Drug Name 157716-52-4 CAS Number CHEMBL372764 ChEMBL ID

Drug Info: Drug Type small molecule Drug Groups investigational Drug Categories alcohols

TdgClinicalTrial: PERIFOSINE

Alternate Names:

Drug Info: Drug Indications antineoplastic agent Drug Class small molecule FDA Approval not approved

Publications:

JAX-CKB: Perifosine

Alternate Names:

Drug Info:

Publications: Sasano et al., 2015, Preclinical Efficacy for AKT Targeting in Clear Cell Carcinoma of the Ovary., Mol. Cancer Res.

CIViC: PERIFOSINE

Alternate Names:

Drug Info:

Publications: Liu et al., 2009, Genetic alterations in the phosphoinositide 3-kinase/Akt signaling pathway confer sensitivity of thyroid cancer cells to therapeutic targeting of Akt and mammalian target of rapamycin., Cancer Res.

TALC: PERIFOSINE

Alternate Names: PERIFOSINE Primary Drug Name PERIFOSINE Drug Generic Name KRX-0401 Drug Synonym

Drug Info:

Publications:

TTD: Perifosine

Alternate Names: D0R1VU TTD Drug ID

Drug Info:

Publications:

ChemblDrugs: chembl:CHEMBL372764

Alternate Names:

Drug Info:

Publications:

MyCancerGenomeClinicalTrial: PERIFOSINE

Alternate Names:

Drug Info:

Publications:

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Trial Name perifosine, KRX-0401

Novel drug target Novel Target

Indication/Tumor Type ovarian clear cell carcinoma

PMIDs:
18201764 25519148

Sources:
MyCancerGenomeClinicalTrial JAX-CKB TdgClinicalTrial DrugBank TALC

Interaction Types & Directionality:

n/a

PMIDs:
16528479

Sources:
DrugBank

Interaction Types & Directionality:

n/a

Interaction Info:

Novel drug target Novel Target

Trial Name perifosine, KRX-0401

PMIDs:
None found

Sources:
TdgClinicalTrial

Interaction Types & Directionality:

n/a

Interaction Info:

Trial Name perifosine, KRX-0401

Novel drug target Novel Target

PMIDs:
None found

Sources:
TdgClinicalTrial

Interaction Types & Directionality:

n/a

PMIDs:
19706758

Sources:
CIViC

Interaction Types & Directionality:

n/a

PMIDs:
16528479

Sources:
DrugBank

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
TTD

Alternate Names:

PERIFOSINE DrugBank Drug Name

157716-52-4 CAS Number

CHEMBL372764 ChEMBL ID

Drug Info:

Drug Type small molecule

Drug Groups investigational

Drug Categories alcohols

Drug Info:

Drug Indications antineoplastic agent

Drug Class small molecule

FDA Approval not approved

Publications:

Sasano et al., 2015, Preclinical Efficacy for AKT Targeting in Clear Cell Carcinoma of the Ovary., Mol. Cancer Res.

Publications:

Liu et al., 2009, Genetic alterations in the phosphoinositide 3-kinase/Akt signaling pathway confer sensitivity of thyroid cancer cells to therapeutic targeting of Akt and mammalian target of rapamycin., Cancer Res.

Alternate Names:

PERIFOSINE Primary Drug Name

PERIFOSINE Drug Generic Name

KRX-0401 Drug Synonym

Alternate Names:

D0R1VU TTD Drug ID