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PERIFOSINE Drug Record

  • Summary
  • Interactions
  • Claims
  • PERIFOSINE chembl:CHEMBL372764 Antineoplastic

    Alternate Names:

    NSC-639966
    KRX-0401
    PERIFOSINE

    Drug Info:

    FDA Approval not approved
    Drug Class small molecule
    Drug Indications antineoplastic agent
    Drug Type small molecule
    Drug Groups investigational
    Drug Categories alcohols
    Drug Categories amines
    Drug Categories amino alcohols
    Drug Categories ammonium compounds
    Drug Categories ethanolamines
    Drug Categories nitrogen compounds
    Drug Categories onium compounds
    Drug Categories quaternary ammonium compounds
    Drug Categories trimethyl ammonium compounds
    (4 More Sources)

    Publications:

    Liu et al., 2009, Genetic alterations in the phosphoinositide 3-kinase/Akt signaling pathway confer sensitivity of thyroid cancer cells to therapeutic targeting of Akt and mammalian target of rapamycin., Cancer Res.
    Shome D et al., 2008, Ulcerative keratitis in gastrointestinal stromal tumor patients treated with perifosine., Ophthalmology
    Sasano et al., 2015, Preclinical Efficacy for AKT Targeting in Clear Cell Carcinoma of the Ovary., Mol. Cancer Res.
    Knowling M et al., 2006, A phase II study of perifosine (D-21226) in patients with previously untreated metastatic or locally advanced soft tissue sarcoma: A National Cancer Institute of Canada Clinical Trials Group trial., Invest New Drugs
  • PERIFOSINE   AKT1

    Interaction Score: 0.73

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Trial Name perifosine, KRX-0401
    Novel drug target Novel Target
    Indication/Tumor Type ovarian clear cell carcinoma

    PMIDs:
    18201764 25519148


    Sources:
    MyCancerGenomeClinicalTrial JAX-CKB TdgClinicalTrial DrugBank TALC

  • PERIFOSINE   PRKCA

    Interaction Score: 0.56

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    16528479


    Sources:
    DrugBank

  • PERIFOSINE   AKT3

    Interaction Score: 0.35

    Interaction Types & Directionality:
    n/a

    Interaction Info:
    Novel drug target Novel Target
    Trial Name perifosine, KRX-0401

    PMIDs:
    None found


    Sources:
    TdgClinicalTrial

  • PERIFOSINE   AKT2

    Interaction Score: 0.32

    Interaction Types & Directionality:
    n/a

    Interaction Info:
    Trial Name perifosine, KRX-0401
    Novel drug target Novel Target

    PMIDs:
    None found


    Sources:
    TdgClinicalTrial

  • PERIFOSINE   PIK3CA

    Interaction Score: 0.11

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    19706758


    Sources:
    CIViC

  • PERIFOSINE   MAPK1

    Interaction Score: 0.09

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    16528479


    Sources:
    DrugBank

  • PERIFOSINE   PIK3CG

    Interaction Score: 0.07

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    TTD

  • DrugBank: DB06641

    • Version: 5.1.7

    Alternate Names:
    PERIFOSINE DrugBank Drug Name
    157716-52-4 CAS Number
    CHEMBL372764 ChEMBL ID

    Drug Info:
    Drug Type small molecule
    Drug Groups investigational
    Drug Categories alcohols

    Publications:
    Knowling M et al., 2006, A phase II study of perifosine (D-21226) in patients with previously untreated metastatic or locally advanced soft tissue sarcoma: A National Cancer Institute of Canada Clinical Trials Group trial., Invest New Drugs
    Shome D et al., 2008, Ulcerative keratitis in gastrointestinal stromal tumor patients treated with perifosine., Ophthalmology

  • TdgClinicalTrial: PERIFOSINE

    • Version: January-2014

    Alternate Names:

    Drug Info:
    Drug Indications antineoplastic agent
    Drug Class small molecule
    FDA Approval not approved

    Publications:

  • JAX-CKB: Perifosine

    • Version: 27-September-2017

    Alternate Names:

    Drug Info:

    Publications:
    Sasano et al., 2015, Preclinical Efficacy for AKT Targeting in Clear Cell Carcinoma of the Ovary., Mol. Cancer Res.

  • CIViC: PERIFOSINE

    • Version: 14-September-2020

    Alternate Names:

    Drug Info:

    Publications:
    Liu et al., 2009, Genetic alterations in the phosphoinositide 3-kinase/Akt signaling pathway confer sensitivity of thyroid cancer cells to therapeutic targeting of Akt and mammalian target of rapamycin., Cancer Res.

  • TALC: PERIFOSINE

    • Version: 12-May-2016

    Alternate Names:
    PERIFOSINE Primary Drug Name
    PERIFOSINE Drug Generic Name
    KRX-0401 Drug Synonym

    Drug Info:

    Publications:

  • TTD: Perifosine

    • Version: 2020.06.01

    Alternate Names:
    D0R1VU TTD Drug ID

    Drug Info:

    Publications:

  • ChemblDrugs: chembl:CHEMBL372764

    • Version: ChEMBL_27

    Alternate Names:

    Drug Info:

    Publications:

  • MyCancerGenomeClinicalTrial: PERIFOSINE

    • Version: 30-February-2014

    Alternate Names:

    Drug Info:

    Publications:

Disclaimer: This resource is intended for purely research purposes. It should not be used for emergencies or medical or professional advice.

A finding of a drug-gene interaction or potentially druggable category does not necessarily indicate effectiveness (or lack thereof) of any drug or treatment regimen. A finding of no interaction or no potentially druggable category does not necessarily indicate lack of effectiveness of any drug or treatment regimen. Drug-gene interactions or potentially druggable categories are not presented in ranked order of potential or predicted efficacy.

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DGIdb (v4.2.0 - sha1 afd9f30b) • Last updated 2020-10-21