DGIdb - PERAMPANEL Drug Record

PERAMPANEL chembl:CHEMBL1214124 Approved

Alternate Names:

PERAMPANEL
FYCOMPA
ER-155055-90
E2007
E-2007
PERAMPANELUM
E 2007
PÉRAMPANEL
FYCOMPA®
3-(2-CYANOPHENYL)-5-(2-PYRIDYL)-1-PHENYL-1,2-DIHYDROPYRIDIN-2-ONE
drugbank:08883
chembl:CHEMBL1214124
pubchem.compound:9924495
rxcui:1356552
chemidplus:380917-97-5

Drug Info:

FDA Approval	not approved
Drug Class	Small molecule
Drug Indications	anticonvulsant
Drug Categories	ampa receptor antagonists
Drug Categories	cytochrome p-450 cyp1a2 substrates
Drug Categories	cytochrome p-450 cyp2b6 inducers
Drug Categories	cytochrome p-450 cyp2b6 inducers (weak)
Drug Categories	cytochrome p-450 cyp2b6 substrates
Drug Categories	cytochrome p-450 cyp3a substrates
Drug Categories	cytochrome p-450 cyp3a4 inducers
Drug Categories	cytochrome p-450 cyp3a4 inducers (strength unknown)
Drug Categories	cytochrome p-450 cyp3a5 substrates
Drug Categories	cytochrome p-450 enzyme inducers
Drug Categories	cytochrome p-450 substrates
Drug Categories	miscellaneous anticonvulsants
Drug Categories	noncompetitive ampa glutamate receptor antagonist

(1 More Sources)

Publications:

Hanada et al., 2011, Perampanel: a novel, orally active, noncompetitive AMPA-receptor antagonist that reduces seizure activity in rodent models of epilepsy., Epilepsia

PERAMPANEL GRIA1

Interaction Score: 2.15

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Glutamate receptor ionotropic AMPA antagonist

Trial Name E2007

PMIDs:
21635236

Sources:
TdgClinicalTrial TTD DrugBank ChemblInteractions
PERAMPANEL GRIA4

Interaction Score: 1.94

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Trial Name E2007

Novel drug target Established target

Direct Interaction yes

PMIDs:
None found

Sources:
TdgClinicalTrial TTD ChemblInteractions
PERAMPANEL GRIA3

Interaction Score: 1.52

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Mechanism of Interaction Glutamate receptor ionotropic AMPA antagonist

Direct Interaction yes

Trial Name E2007

PMIDs:
None found

Sources:
TdgClinicalTrial TTD ChemblInteractions
PERAMPANEL GRIA2

Interaction Score: 0.87

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Mechanism of Interaction Glutamate receptor ionotropic AMPA antagonist

Direct Interaction yes

Trial Name E2007

PMIDs:
None found

Sources:
TdgClinicalTrial TTD ChemblInteractions

DrugBank: DB08883
- Version: 5.1.7
Alternate Names:

PERAMPANEL DrugBank Drug Name

380917-97-5 CAS Number

Fycompa Drug Brand

Drug Info:

Drug Type small molecule

Drug Groups approved

Drug Categories ampa receptor antagonists

Publications:

Hanada et al., 2011, Perampanel: a novel, orally active, noncompetitive AMPA-receptor antagonist that reduces seizure activity in rodent models of epilepsy., Epilepsia
TdgClinicalTrial: PERAMPANEL
- Version: January-2014
Alternate Names:

Drug Info:

Drug Indications anticonvulsant

Drug Class Small molecule

FDA Approval not approved

Publications:
TTD: E-2007
- Version: 2020.06.01
Alternate Names:

D0U3ED TTD Drug ID

Drug Info:

Publications:
ChemblDrugs: chembl:CHEMBL1214124
- Version: ChEMBL_27
Alternate Names:

Drug Info:

Publications:
ChemblInteractions: CHEMBL1214124
- Version: chembl_23
Alternate Names:

Drug Info:

Publications:

Direct Interaction	yes
Mechanism of Interaction	Glutamate receptor ionotropic AMPA antagonist
Trial Name	E2007

Trial Name	E2007
Novel drug target	Established target
Direct Interaction	yes

PERAMPANEL	DrugBank Drug Name
380917-97-5	CAS Number
Fycompa	Drug Brand

Drug Type	small molecule
Drug Groups	approved
Drug Categories	ampa receptor antagonists

PERAMPANEL Drug Record

PERAMPANEL chembl:CHEMBL1214124 Approved

Alternate Names:

Drug Info:

Publications:

PERAMPANEL GRIA1

Interaction Types & Directionality: antagonist (inhibitory)

Interaction Info: Direct Interaction yes Mechanism of Interaction Glutamate receptor ionotropic AMPA antagonist Trial Name E2007

PMIDs: 21635236

Sources: TdgClinicalTrial TTD DrugBank ChemblInteractions

PERAMPANEL GRIA4

Interaction Types & Directionality: antagonist (inhibitory)

Interaction Info: Trial Name E2007 Novel drug target Established target Direct Interaction yes

PMIDs: None found

Sources: TdgClinicalTrial TTD ChemblInteractions

PERAMPANEL GRIA3

Interaction Types & Directionality: antagonist (inhibitory)

Interaction Info: Mechanism of Interaction Glutamate receptor ionotropic AMPA antagonist Direct Interaction yes Trial Name E2007

PMIDs: None found

Sources: TdgClinicalTrial TTD ChemblInteractions

PERAMPANEL GRIA2

Interaction Types & Directionality: antagonist (inhibitory)

Interaction Info: Mechanism of Interaction Glutamate receptor ionotropic AMPA antagonist Direct Interaction yes Trial Name E2007

PMIDs: None found

Sources: TdgClinicalTrial TTD ChemblInteractions

DrugBank: DB08883

Alternate Names: PERAMPANEL DrugBank Drug Name 380917-97-5 CAS Number Fycompa Drug Brand

Drug Info: Drug Type small molecule Drug Groups approved Drug Categories ampa receptor antagonists

Publications: Hanada et al., 2011, Perampanel: a novel, orally active, noncompetitive AMPA-receptor antagonist that reduces seizure activity in rodent models of epilepsy., Epilepsia

TdgClinicalTrial: PERAMPANEL

Alternate Names:

Drug Info: Drug Indications anticonvulsant Drug Class Small molecule FDA Approval not approved

Publications:

TTD: E-2007

Alternate Names: D0U3ED TTD Drug ID

Drug Info:

Publications:

ChemblDrugs: chembl:CHEMBL1214124

Alternate Names:

Drug Info:

Publications:

ChemblInteractions: CHEMBL1214124

Alternate Names:

Drug Info:

Publications:

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Glutamate receptor ionotropic AMPA antagonist

Trial Name E2007

PMIDs:
21635236

Sources:
TdgClinicalTrial TTD DrugBank ChemblInteractions

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Trial Name E2007

Novel drug target Established target

Direct Interaction yes

PMIDs:
None found

Sources:
TdgClinicalTrial TTD ChemblInteractions

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Mechanism of Interaction Glutamate receptor ionotropic AMPA antagonist

Direct Interaction yes

Trial Name E2007

PMIDs:
None found

Sources:
TdgClinicalTrial TTD ChemblInteractions

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Mechanism of Interaction Glutamate receptor ionotropic AMPA antagonist

Direct Interaction yes

Trial Name E2007

PMIDs:
None found

Sources:
TdgClinicalTrial TTD ChemblInteractions

Alternate Names:

PERAMPANEL DrugBank Drug Name

380917-97-5 CAS Number

Fycompa Drug Brand

Drug Info:

Drug Type small molecule

Drug Groups approved

Drug Categories ampa receptor antagonists

Publications:

Hanada et al., 2011, Perampanel: a novel, orally active, noncompetitive AMPA-receptor antagonist that reduces seizure activity in rodent models of epilepsy., Epilepsia

Drug Info:

Drug Indications anticonvulsant

Drug Class Small molecule

FDA Approval not approved

Alternate Names:

D0U3ED TTD Drug ID