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PENICILLAMINE Drug Record

  • Summary
  • Interactions
  • Claims
  • PENICILLAMINE chembl:CHEMBL1430 ApprovedImmunotherapy

    Alternate Names:

    D PENICILLAMINE
    D MERCAPTOVALINE
    DEPEN
    TROLOVOL
    DIMETHYLCYSTEINE
    CUPRIMINE
    PENICILLAMINE
    NSC-81549
    DISTAMINE
    PA
    (S)-3,3-DIMETHYLCYSTEINE
    3-MERCAPTO-D-VALINE
    D-BETA,BETA-DIMETHYLCYSTEINE
    (−)-PENICILLAMINE
    D-(−)-PENICILLAMINE
    D-(-)-PENICILLAMINE
    (-)-PENICILLAMINE
    D-Β,Β-DIMETHYLCYSTEINE
    (S)-2-AMINO-3-MERCAPTO-3-METHYLBUTANOIC ACID
    chemidplus:52-67-5
    pubchem.compound:5852
    rxcui:7975
    drugbank:00859
    chembl:CHEMBL1430

    Drug Info:

    (0 More Sources)

    Publications:

    Park et al., 1979, Mechanism of action of penicillamine in the treatment of avian muscular dystrophy., Ann. N. Y. Acad. Sci.
    Lira et al., 2007, Nitric oxide increases GLUT4 expression and regulates AMPK signaling in skeletal muscle., Am. J. Physiol. Endocrinol. Metab.
    Vargas et al., 1987, Comparison of the effects of auranofin, gold sodium thiomalate, and penicillamine on resorption of cultured fetal rat long bones., J. Bone Miner. Res.
    Shiono et al., 2001, Iron accumulation in the liver of male patients with Wilson's disease., Am. J. Gastroenterol.
    Mestdagh et al., 1992, Effect of L-penicillamine hydantoin, an analogue of glutathione, on rat liver glutathione peroxidase, reductase and transferase reactions., Biochem. Pharmacol.
    Oyadomari et al., 2001, Nitric oxide-induced apoptosis in pancreatic beta cells is mediated by the endoplasmic reticulum stress pathway., Proc. Natl. Acad. Sci. U.S.A.
    McGrowder et al., 2001, Effects of S-nitroso-N-acetyl-penicillamine administration on glucose tolerance and plasma levels of insulin and glucagon in the dog., Nitric Oxide
  • PENICILLAMINE   PGD

    Interaction Score: 8.83

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    289317


    Sources:
    NCI

  • PENICILLAMINE   STS

    Interaction Score: 1.96

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    1567476


    Sources:
    NCI

  • PENICILLAMINE   CP

    Interaction Score: 1.26

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    11721763


    Sources:
    NCI

  • PENICILLAMINE   GCG

    Interaction Score: 1.1

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    11485378


    Sources:
    NCI

  • PENICILLAMINE   PTH

    Interaction Score: 1.04

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    3137774


    Sources:
    NCI

  • PENICILLAMINE   DDIT3

    Interaction Score: 0.68

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    11526215


    Sources:
    NCI

  • PENICILLAMINE   SLC2A4

    Interaction Score: 0.4

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    17666490


    Sources:
    NCI

  • NCI: PENICILLAMINE

    • Version: 14-September-2017

    Alternate Names:
    C729 NCI drug code

    Drug Info:

    Publications:
    Park et al., 1979, Mechanism of action of penicillamine in the treatment of avian muscular dystrophy., Ann. N. Y. Acad. Sci.
    Vargas et al., 1987, Comparison of the effects of auranofin, gold sodium thiomalate, and penicillamine on resorption of cultured fetal rat long bones., J. Bone Miner. Res.
    Oyadomari et al., 2001, Nitric oxide-induced apoptosis in pancreatic beta cells is mediated by the endoplasmic reticulum stress pathway., Proc. Natl. Acad. Sci. U.S.A.

  • TTD: Penicillamine

    • Version: 2020.06.01

    Alternate Names:
    D08HZC TTD Drug ID

    Drug Info:

    Publications:

  • ChemblDrugs: chembl:CHEMBL1430

    • Version: ChEMBL_27

    Alternate Names:

    Drug Info:

    Publications:

Disclaimer: This resource is intended for purely research purposes. It should not be used for emergencies or medical or professional advice.

A finding of a drug-gene interaction or potentially druggable category does not necessarily indicate effectiveness (or lack thereof) of any drug or treatment regimen. A finding of no interaction or no potentially druggable category does not necessarily indicate lack of effectiveness of any drug or treatment regimen. Drug-gene interactions or potentially druggable categories are not presented in ranked order of potential or predicted efficacy.

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DGIdb (v4.2.0 - sha1 afd9f30b) • Last updated 2020-10-21