DGIdb - PENICILLAMINE Drug Record

PENICILLAMINE chembl:CHEMBL1430 ApprovedImmunotherapy

Alternate Names:

D PENICILLAMINE
D MERCAPTOVALINE
DEPEN
TROLOVOL
DIMETHYLCYSTEINE
CUPRIMINE
PENICILLAMINE
NSC-81549
DISTAMINE
PA
(S)-3,3-DIMETHYLCYSTEINE
3-MERCAPTO-D-VALINE
D-BETA,BETA-DIMETHYLCYSTEINE
(−)-PENICILLAMINE
D-(−)-PENICILLAMINE
D-(-)-PENICILLAMINE
(-)-PENICILLAMINE
D-Β,Β-DIMETHYLCYSTEINE
(S)-2-AMINO-3-MERCAPTO-3-METHYLBUTANOIC ACID
chemidplus:52-67-5
pubchem.compound:5852
rxcui:7975
drugbank:00859
chembl:CHEMBL1430

Drug Info:

Drug Categories	specific antirheumatic agents
Drug Categories	penicillamine and similar agents
Drug Categories	agents causing muscle toxicity
Drug Categories	compounds used in a research, industrial, or household setting
Drug Categories	heavy metal antagonists
Drug Categories	immunosuppressive agents
Drug Categories	myelosuppressive agents

(0 More Sources)

Publications:

Park et al., 1979, Mechanism of action of penicillamine in the treatment of avian muscular dystrophy., Ann. N. Y. Acad. Sci.
Lira et al., 2007, Nitric oxide increases GLUT4 expression and regulates AMPK signaling in skeletal muscle., Am. J. Physiol. Endocrinol. Metab.
Vargas et al., 1987, Comparison of the effects of auranofin, gold sodium thiomalate, and penicillamine on resorption of cultured fetal rat long bones., J. Bone Miner. Res.
Shiono et al., 2001, Iron accumulation in the liver of male patients with Wilson's disease., Am. J. Gastroenterol.
Mestdagh et al., 1992, Effect of L-penicillamine hydantoin, an analogue of glutathione, on rat liver glutathione peroxidase, reductase and transferase reactions., Biochem. Pharmacol.
Oyadomari et al., 2001, Nitric oxide-induced apoptosis in pancreatic beta cells is mediated by the endoplasmic reticulum stress pathway., Proc. Natl. Acad. Sci. U.S.A.
McGrowder et al., 2001, Effects of S-nitroso-N-acetyl-penicillamine administration on glucose tolerance and plasma levels of insulin and glucagon in the dog., Nitric Oxide

PENICILLAMINE PGD

Interaction Score: 2.71

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
289317

Sources:
NCI
PENICILLAMINE STS

Interaction Score: 1.8

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
1567476

Sources:
NCI
PENICILLAMINE GCG

Interaction Score: 1.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
11485378

Sources:
NCI
PENICILLAMINE PTH

Interaction Score: 0.95

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
3137774

Sources:
NCI
PENICILLAMINE CP

Interaction Score: 0.81

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
11721763

Sources:
NCI
PENICILLAMINE DDIT3

Interaction Score: 0.62

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
11526215

Sources:
NCI
PENICILLAMINE SLC2A4

Interaction Score: 0.37

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
17666490

Sources:
NCI

DrugBank: DB00859
- Version: 5.1.7
Alternate Names:

PENICILLAMINE DrugBank Drug Name

52-67-5 CAS Number

Atamir Drug Brand

Drug Info:

Drug Type small molecule

Drug Groups approved

Drug Categories agents causing muscle toxicity

Publications:

Brewer, 2006, Novel therapeutic approaches to the treatment of Wilson's disease., Expert Opin Pharmacother

NCI: PENICILLAMINE

Version: 14-September-2017

Alternate Names:

C729 NCI drug code

Drug Info:

Publications:

Park et al., 1979, Mechanism of action of penicillamine in the treatment of avian muscular dystrophy., Ann. N. Y. Acad. Sci.

Vargas et al., 1987, Comparison of the effects of auranofin, gold sodium thiomalate, and penicillamine on resorption of cultured fetal rat long bones., J. Bone Miner. Res.

Oyadomari et al., 2001, Nitric oxide-induced apoptosis in pancreatic beta cells is mediated by the endoplasmic reticulum stress pathway., Proc. Natl. Acad. Sci. U.S.A.

TTD: Penicillamine
- Version: 2020.06.01
Alternate Names:

D08HZC TTD Drug ID

Drug Info:

Publications:
ChemblDrugs: chembl:CHEMBL1430
- Version: ChEMBL_27
Alternate Names:

Drug Info:

Publications:

PENICILLAMINE	DrugBank Drug Name
52-67-5	CAS Number
Atamir	Drug Brand

Drug Type	small molecule
Drug Groups	approved
Drug Categories	agents causing muscle toxicity

PENICILLAMINE Drug Record

PENICILLAMINE chembl:CHEMBL1430 ApprovedImmunotherapy

Alternate Names:

Drug Info:

Publications:

PENICILLAMINE PGD

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 289317

Sources: NCI

PENICILLAMINE STS

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 1567476

Sources: NCI

PENICILLAMINE GCG

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 11485378

Sources: NCI

PENICILLAMINE PTH

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 3137774

Sources: NCI

PENICILLAMINE CP

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 11721763

Sources: NCI

PENICILLAMINE DDIT3

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 11526215

Sources: NCI

PENICILLAMINE SLC2A4

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 17666490

Sources: NCI

DrugBank: DB00859

Alternate Names: PENICILLAMINE DrugBank Drug Name 52-67-5 CAS Number Atamir Drug Brand

Drug Info: Drug Type small molecule Drug Groups approved Drug Categories agents causing muscle toxicity

Publications: Brewer, 2006, Novel therapeutic approaches to the treatment of Wilson's disease., Expert Opin Pharmacother

NCI: PENICILLAMINE

Alternate Names: C729 NCI drug code

Drug Info:

TTD: Penicillamine

Alternate Names: D08HZC TTD Drug ID

Drug Info:

Publications:

ChemblDrugs: chembl:CHEMBL1430

Alternate Names:

Drug Info:

Publications:

Interaction Types & Directionality:

n/a

PMIDs:
289317

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
1567476

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
11485378

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
3137774

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
11721763

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
11526215

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
17666490

Sources:
NCI

Alternate Names:

PENICILLAMINE DrugBank Drug Name

52-67-5 CAS Number

Atamir Drug Brand

Drug Info:

Drug Type small molecule

Drug Groups approved

Drug Categories agents causing muscle toxicity

Publications:

Brewer, 2006, Novel therapeutic approaches to the treatment of Wilson's disease., Expert Opin Pharmacother

Alternate Names:

C729 NCI drug code

Alternate Names:

D08HZC TTD Drug ID