DGIdb - PENBUTOLOL Drug Record

PENBUTOLOL chembl:CHEMBL1290 Approved

Alternate Names:

PENBUTOLOL
LEVATOL
(2S)-1-(TERT-BUTYLAMINO)-3-(2-CYCLOPENTYLPHENOXY)PROPAN-2-OL
HOE 893
HOE 893D
2-PROPANOL, 1-(2-CYCLOPENTYLPHENOXY)-3-((1,1-DIMETHYLETHYL)AMINO)-, (S)-
HOE-39-893D
HOE-893D
1-(TERT-BUTYLAMINO)-3-(O-CYCLOPENTYLPHENOXY)PROPAN-2-OL
PENBUTOLOLUM
LEVATOL®
rxcui:7973
drugbank:01359
chemidplus:38363-40-5
chembl:CHEMBL1290
pubchem.compound:37464

Drug Info:

FDA Approval	1987
Drug Class	small molecule
Drug Indications	Antihypertensive Agents
Drug Class	antihypertensive agents
Year of Approval	1987
Drug Categories	amino alcohols
Drug Categories	agents causing hyperkalemia
Drug Categories	antidepressive agents
Drug Categories	central nervous system depressants
Drug Categories	cytochrome p-450 cyp2d6 substrates
Drug Categories	cytochrome p-450 substrates
Drug Categories	drugs that are mainly renally excreted
Drug Categories	serotonin 5-ht1 receptor antagonists
Drug Categories	serotonin agents
Drug Categories	serotonin receptor antagonists

(1 More Sources)

Publications:

Hjorth et al., 1993, In vivo microdialysis evidence for central serotonin1A and serotonin1B autoreceptor blocking properties of the beta adrenoceptor antagonist (-)penbutolol., J. Pharmacol. Exp. Ther.
Doze et al., 2002, Synthesis and evaluation of radiolabeled antagonists for imaging of beta-adrenoceptors in the brain with PET., Neurochem. Int.
Venter et al., 1982, Ethnic differences in beta-1-adrenoceptor sensitivity., S. Afr. Med. J.
Sánchez, 1993, Effect of serotonergic drugs on footshock-induced ultrasonic vocalization in adult male rats., Behav Pharmacol
Frishman et al., 1990, Penbutolol and carteolol: two new beta-adrenergic blockers with partial agonism., J Clin Pharmacol
Hjorth et al., 1996, Raphe 5-HT1A autoreceptors, but not postsynaptic 5-HT1A receptors or beta-adrenoceptors, restrain the citalopram-induced increase in extracellular 5-hydroxytryptamine in vivo., Eur. J. Pharmacol.
Kulkarni et al., 1977, Beta-2 adrenoceptor blocking activity of penbutolol and propranolol at very low doses., Clin. Pharmacol. Ther.
Ijzerman et al., 1987, The membrane stabilizing activity of beta-adrenoceptor ligands. Quantitative evaluation of the interaction of phenoxypropanolamines with the [3H]batrachotoxinin A 20-alpha-benzoate binding site on voltage-sensitive sodium channels in rat brain., Biochem. Pharmacol.
Hjorth, 1992, (-)-Penbutolol as a blocker of central 5-HT1A receptor-mediated responses., Eur. J. Pharmacol.
Rabiner et al., 2000, beta-blocker binding to human 5-HT(1A) receptors in vivo and in vitro: implications for antidepressant therapy., Neuropsychopharmacology

PENBUTOLOL ADRB1

Interaction Score: 0.9

Interaction Types & Directionality:

partial agonist (activating)

antagonist (inhibitory)

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
11738481 6755764 11224195 2189902

Sources:
TEND TdgClinicalTrial TTD DrugBank
PENBUTOLOL ADRB2

Interaction Score: 0.78

Interaction Types & Directionality:

partial agonist (activating)

antagonist (inhibitory)

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
8982649 11224195 16716 2446632 8098761 2189902

Sources:
TEND TdgClinicalTrial DrugBank
PENBUTOLOL HTR1B

Interaction Score: 0.37

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

PMIDs:
8098761

Sources:
DrugBank
PENBUTOLOL HTR1A

Interaction Score: 0.28

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

PMIDs:
1468487 10942852

Sources:
DrugBank

DrugBank: DB01359

Version: 5.1.7

Alternate Names:

PENBUTOLOL DrugBank Drug Name

38363-40-5 CAS Number

Betapressin Drug Brand

Drug Info:

Drug Type small molecule

Drug Groups approved

Drug Groups investigational

Publications:

Doze et al., 2002, Synthesis and evaluation of radiolabeled antagonists for imaging of beta-adrenoceptors in the brain with PET., Neurochem. Int.

Venter et al., 1982, Ethnic differences in beta-1-adrenoceptor sensitivity., S. Afr. Med. J.

Sánchez, 1993, Effect of serotonergic drugs on footshock-induced ultrasonic vocalization in adult male rats., Behav Pharmacol

TEND: PENBUTOLOL
- Version: 01-August-2011
Alternate Names:

PENBUTOLOL Primary Drug Name

Drug Info:

Year of Approval 1987

Drug Class antihypertensive agents

Publications:
TdgClinicalTrial: PENBUTOLOL
- Version: January-2014
Alternate Names:

Drug Info:

Drug Indications Antihypertensive Agents

Drug Class small molecule

FDA Approval 1987

Publications:
TTD: Penbutolol
- Version: 2020.06.01
Alternate Names:

D0W8SB TTD Drug ID

Drug Info:

Publications:
ChemblDrugs: chembl:CHEMBL1290
- Version: ChEMBL_27
Alternate Names:

Drug Info:

Publications:

PENBUTOLOL	DrugBank Drug Name
38363-40-5	CAS Number
Betapressin	Drug Brand

Drug Type	small molecule
Drug Groups	approved
Drug Groups	investigational

partial agonist (activating)
antagonist (inhibitory)

Trial Name	-
Novel drug target	Established target

partial agonist (activating)
antagonist (inhibitory)

Trial Name	-
Novel drug target	Established target

PENBUTOLOL Drug Record

PENBUTOLOL chembl:CHEMBL1290 Approved

Alternate Names:

Drug Info:

Publications:

PENBUTOLOL ADRB1

Interaction Types & Directionality: partial agonist (activating) antagonist (inhibitory)

Interaction Info: Trial Name - Novel drug target Established target

PMIDs: 11738481 6755764 11224195 2189902

Sources: TEND TdgClinicalTrial TTD DrugBank

PENBUTOLOL ADRB2

Interaction Types & Directionality: partial agonist (activating) antagonist (inhibitory)

Interaction Info: Trial Name - Novel drug target Established target

PMIDs: 8982649 11224195 16716 2446632 8098761 2189902

Sources: TEND TdgClinicalTrial DrugBank

PENBUTOLOL HTR1B

Interaction Types & Directionality: antagonist (inhibitory)

Interaction Info:

PMIDs: 8098761

Sources: DrugBank

PENBUTOLOL HTR1A

Interaction Types & Directionality: antagonist (inhibitory)

Interaction Info:

PMIDs: 1468487 10942852

Sources: DrugBank

DrugBank: DB01359

Alternate Names: PENBUTOLOL DrugBank Drug Name 38363-40-5 CAS Number Betapressin Drug Brand

Drug Info: Drug Type small molecule Drug Groups approved Drug Groups investigational

TEND: PENBUTOLOL

Alternate Names: PENBUTOLOL Primary Drug Name

Drug Info: Year of Approval 1987 Drug Class antihypertensive agents

Publications:

TdgClinicalTrial: PENBUTOLOL

Alternate Names:

Drug Info: Drug Indications Antihypertensive Agents Drug Class small molecule FDA Approval 1987

Publications:

TTD: Penbutolol

Alternate Names: D0W8SB TTD Drug ID

Drug Info:

Publications:

ChemblDrugs: chembl:CHEMBL1290

Alternate Names:

Drug Info:

Publications:

Interaction Types & Directionality:

partial agonist (activating)

antagonist (inhibitory)

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
11738481 6755764 11224195 2189902

Sources:
TEND TdgClinicalTrial TTD DrugBank

Interaction Types & Directionality:

partial agonist (activating)

antagonist (inhibitory)

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
8982649 11224195 16716 2446632 8098761 2189902

Sources:
TEND TdgClinicalTrial DrugBank

Interaction Types & Directionality:

antagonist (inhibitory)

PMIDs:
8098761

Sources:
DrugBank

Interaction Types & Directionality:

antagonist (inhibitory)

PMIDs:
1468487 10942852

Sources:
DrugBank

Alternate Names:

PENBUTOLOL DrugBank Drug Name

38363-40-5 CAS Number

Betapressin Drug Brand

Drug Info:

Drug Type small molecule

Drug Groups approved

Drug Groups investigational

Alternate Names:

PENBUTOLOL Primary Drug Name

Drug Info:

Year of Approval 1987

Drug Class antihypertensive agents

Drug Info:

Drug Indications Antihypertensive Agents

Drug Class small molecule

FDA Approval 1987

Alternate Names:

D0W8SB TTD Drug ID