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PENBUTOLOL Drug Record

  • Summary
  • Interactions
  • Claims
  • PENBUTOLOL chembl:CHEMBL1290 Approved

    Alternate Names:

    PENBUTOLOL
    LEVATOL
    (2S)-1-(TERT-BUTYLAMINO)-3-(2-CYCLOPENTYLPHENOXY)PROPAN-2-OL
    HOE 893
    HOE 893D
    2-PROPANOL, 1-(2-CYCLOPENTYLPHENOXY)-3-((1,1-DIMETHYLETHYL)AMINO)-, (S)-
    HOE-39-893D
    HOE-893D
    1-(TERT-BUTYLAMINO)-3-(O-CYCLOPENTYLPHENOXY)PROPAN-2-OL
    PENBUTOLOLUM
    LEVATOL®
    rxcui:7973
    drugbank:01359
    chemidplus:38363-40-5
    chembl:CHEMBL1290
    pubchem.compound:37464

    Drug Info:

    FDA Approval 1987
    Drug Class small molecule
    Drug Indications Antihypertensive Agents
    Drug Class antihypertensive agents
    Year of Approval 1987
    Drug Categories amino alcohols
    Drug Categories agents causing hyperkalemia
    Drug Categories antidepressive agents
    Drug Categories central nervous system depressants
    Drug Categories cytochrome p-450 cyp2d6 substrates
    Drug Categories cytochrome p-450 substrates
    Drug Categories drugs that are mainly renally excreted
    Drug Categories serotonin 5-ht1 receptor antagonists
    Drug Categories serotonin agents
    Drug Categories serotonin receptor antagonists
    (1 More Sources)

    Publications:

    Hjorth et al., 1993, In vivo microdialysis evidence for central serotonin1A and serotonin1B autoreceptor blocking properties of the beta adrenoceptor antagonist (-)penbutolol., J. Pharmacol. Exp. Ther.
    Doze et al., 2002, Synthesis and evaluation of radiolabeled antagonists for imaging of beta-adrenoceptors in the brain with PET., Neurochem. Int.
    Venter et al., 1982, Ethnic differences in beta-1-adrenoceptor sensitivity., S. Afr. Med. J.
    Sánchez, 1993, Effect of serotonergic drugs on footshock-induced ultrasonic vocalization in adult male rats., Behav Pharmacol
    Frishman et al., 1990, Penbutolol and carteolol: two new beta-adrenergic blockers with partial agonism., J Clin Pharmacol
    Hjorth et al., 1996, Raphe 5-HT1A autoreceptors, but not postsynaptic 5-HT1A receptors or beta-adrenoceptors, restrain the citalopram-induced increase in extracellular 5-hydroxytryptamine in vivo., Eur. J. Pharmacol.
    Kulkarni et al., 1977, Beta-2 adrenoceptor blocking activity of penbutolol and propranolol at very low doses., Clin. Pharmacol. Ther.
    Ijzerman et al., 1987, The membrane stabilizing activity of beta-adrenoceptor ligands. Quantitative evaluation of the interaction of phenoxypropanolamines with the [3H]batrachotoxinin A 20-alpha-benzoate binding site on voltage-sensitive sodium channels in rat brain., Biochem. Pharmacol.
    Hjorth, 1992, (-)-Penbutolol as a blocker of central 5-HT1A receptor-mediated responses., Eur. J. Pharmacol.
    Rabiner et al., 2000, beta-blocker binding to human 5-HT(1A) receptors in vivo and in vitro: implications for antidepressant therapy., Neuropsychopharmacology
  • PENBUTOLOL   ADRB1

    Interaction Score: 0.9

    Interaction Types & Directionality:
    partial agonist (activating)
    antagonist (inhibitory)

    Interaction Info:
    Trial Name -
    Novel drug target Established target

    PMIDs:
    11738481 6755764 11224195 2189902


    Sources:
    TEND TdgClinicalTrial TTD DrugBank

  • PENBUTOLOL   ADRB2

    Interaction Score: 0.78

    Interaction Types & Directionality:
    partial agonist (activating)
    antagonist (inhibitory)

    Interaction Info:
    Trial Name -
    Novel drug target Established target

    PMIDs:
    8982649 11224195 16716 2446632 8098761 2189902


    Sources:
    TEND TdgClinicalTrial DrugBank

  • PENBUTOLOL   HTR1B

    Interaction Score: 0.37

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:

    PMIDs:
    8098761


    Sources:
    DrugBank

  • PENBUTOLOL   HTR1A

    Interaction Score: 0.28

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:

    PMIDs:
    1468487 10942852


    Sources:
    DrugBank

  • DrugBank: DB01359

    • Version: 5.1.7

    Alternate Names:
    PENBUTOLOL DrugBank Drug Name
    38363-40-5 CAS Number
    Betapressin Drug Brand

    Drug Info:
    Drug Type small molecule
    Drug Groups approved
    Drug Groups investigational

    Publications:
    Doze et al., 2002, Synthesis and evaluation of radiolabeled antagonists for imaging of beta-adrenoceptors in the brain with PET., Neurochem. Int.
    Venter et al., 1982, Ethnic differences in beta-1-adrenoceptor sensitivity., S. Afr. Med. J.
    Sánchez, 1993, Effect of serotonergic drugs on footshock-induced ultrasonic vocalization in adult male rats., Behav Pharmacol

  • TEND: PENBUTOLOL

    • Version: 01-August-2011

    Alternate Names:
    PENBUTOLOL Primary Drug Name

    Drug Info:
    Year of Approval 1987
    Drug Class antihypertensive agents

    Publications:

  • TdgClinicalTrial: PENBUTOLOL

    • Version: January-2014

    Alternate Names:

    Drug Info:
    Drug Indications Antihypertensive Agents
    Drug Class small molecule
    FDA Approval 1987

    Publications:

  • TTD: Penbutolol

    • Version: 2020.06.01

    Alternate Names:
    D0W8SB TTD Drug ID

    Drug Info:

    Publications:

  • ChemblDrugs: chembl:CHEMBL1290

    • Version: ChEMBL_27

    Alternate Names:

    Drug Info:

    Publications:

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DGIdb (v4.2.0 - sha1 afd9f30b) • Last updated 2020-10-21