• Search
      • Search Interactions Search Categories
    • Browse
      • Browse Categories Browse Sources
    • Information
      • About Publications Interaction Types & Directionalities Interaction Score & Query Score API Documentation FAQ Known Data Clients News Contact
    • Downloads
      • Data Source Code

OXPRENOLOL Drug Record

  • Summary
  • Interactions
  • Claims
  • OXPRENOLOL chembl:CHEMBL546 Approved

    Alternate Names:

    OXPRENOLOL

    Drug Info:

    Drug Indications Anti-Arrhythmia Agents
    Drug Indications Antihypertensive Agents
    FDA Approval 1983
    Drug Class small molecule
    Drug Class anti-arrhythmia agents
    Year of Approval 1983
    Drug Class antihypertensive agents
    Drug Categories sympatholytics
    Drug Categories agents causing hyperkalemia
    Drug Categories antiarrhythmic agents
    Drug Categories beta blocking agents and thiazides
    Drug Categories beta blocking agents, non-selective, and thiazides
    Drug Categories bradycardia-causing agents
    Drug Categories cytochrome p-450 cyp2d6 inhibitors (strength unknown)
    Drug Categories cytochrome p-450 cyp2d6 substrates
    Drug Categories cytochrome p-450 enzyme inhibitors
    Drug Categories cytochrome p-450 substrates
    Drug Categories moderate risk qtc-prolonging agents
    Drug Categories oct2 inhibitors
    Drug Categories qtc prolonging agents
    Drug Categories vasodilating agents
    (1 More Sources)

    Publications:

    Fujita et al., 1998, Adrenergic agonists suppress the proliferation of microglia through beta 2-adrenergic receptor., Neurosci. Lett.
    Sekut et al., 1995, Anti-inflammatory activity of salmeterol: down-regulation of cytokine production., Clin. Exp. Immunol.
    Prinz et al., 2001, beta-adrenergic receptor stimulation selectively inhibits IL-12p40 release in microglia., Brain Res.
    Overington et al., 2006, How many drug targets are there?, Nat Rev Drug Discov
    Imming et al., 2006, Drugs, their targets and the nature and number of drug targets., Nat Rev Drug Discov
    Campbell et al., Effects of prolonged administration of oxprenolol on severity of ischaemic arrhythmias, enzyme leakage, infarct size, and intracellular cardiac muscle action potentials., J. Cardiovasc. Pharmacol.
    Lemmer, 1982, [Pharmacological basis for the therapy of cardiovascular disease with beta-adrenoceptor blocking drugs (author's transl)]., Herz
    Abrahamsson, 1986, The beta 1- and beta 2-adrenoceptor stimulatory effects of alprenolol, oxprenolol and pindolol: a study in the isolated right atrium and uterus of the rat., Br. J. Pharmacol.
    Chen et al., 2002, TTD: Therapeutic Target Database., Nucleic Acids Res.
    Fève B et al., 1991, Atypical beta-adrenergic receptor in 3T3-F442A adipocytes. Pharmacological and molecular relationship with the human beta 3-adrenergic receptor., J Biol Chem
  • OXPRENOLOL   ADRB1

    Interaction Score: 1.5

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Trial Name -
    Novel drug target Established target

    PMIDs:
    6202960 6124492 2871880 11752352 17139284 17016423


    Sources:
    TEND TdgClinicalTrial TTD DrugBank

  • OXPRENOLOL   ADRB2

    Interaction Score: 0.92

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Trial Name -
    Novel drug target Established target

    PMIDs:
    9509999 7882570 11311890 17139284 17016423


    Sources:
    TEND TdgClinicalTrial DrugBank

  • OXPRENOLOL   ADRB3

    Interaction Score: 0.73

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    1682311


    Sources:
    DrugBank

  • DrugBank: DB01580

    • Version: 5.1.7

    Alternate Names:
    OXPRENOLOL DrugBank Drug Name
    6452-71-7 CAS Number
    Slow Trasicor Tab 160mg Drug Brand

    Drug Info:
    Drug Type small molecule
    Drug Groups approved
    Drug Categories adrenergic agents

    Publications:
    Fujita et al., 1998, Adrenergic agonists suppress the proliferation of microglia through beta 2-adrenergic receptor., Neurosci. Lett.
    Sekut et al., 1995, Anti-inflammatory activity of salmeterol: down-regulation of cytokine production., Clin. Exp. Immunol.
    Prinz et al., 2001, beta-adrenergic receptor stimulation selectively inhibits IL-12p40 release in microglia., Brain Res.

  • TEND: OXPRENOLOL

    • Version: 01-August-2011

    Alternate Names:
    OXPRENOLOL Primary Drug Name

    Drug Info:
    Drug Class antihypertensive agents
    Year of Approval 1983
    Drug Class anti-arrhythmia agents

    Publications:

  • TdgClinicalTrial: OXPRENOLOL

    • Version: January-2014

    Alternate Names:

    Drug Info:
    Drug Class small molecule
    FDA Approval 1983
    Drug Indications Antihypertensive Agents

    Publications:

  • TTD: Oxprenolol

    • Version: 2020.06.01

    Alternate Names:
    D0X2MB TTD Drug ID

    Drug Info:

    Publications:

  • ChemblDrugs: chembl:CHEMBL546

    • Version: ChEMBL_27

    Alternate Names:

    Drug Info:

    Publications:

Disclaimer: This resource is intended for purely research purposes. It should not be used for emergencies or medical or professional advice.

A finding of a drug-gene interaction or potentially druggable category does not necessarily indicate effectiveness (or lack thereof) of any drug or treatment regimen. A finding of no interaction or no potentially druggable category does not necessarily indicate lack of effectiveness of any drug or treatment regimen. Drug-gene interactions or potentially druggable categories are not presented in ranked order of potential or predicted efficacy.

The dgidb.org website does not provide any medical or healthcare products, services or advice, and is not for medical emergencies or urgent situations. IF YOU THINK YOU MAY HAVE A MEDICAL EMERGENCY, CALL YOUR DOCTOR OR 911 IMMEDIATELY. Information contained on this website is not a substitute for a doctor's medical judgment or advice. We recommend that you discuss your specific, individual health concerns with your doctor or health care professional.

DGIdb (v4.2.0 - sha1 afd9f30b) • Last updated 2020-10-21