DGIdb - OXPRENOLOL Drug Record

OXPRENOLOL chembl:CHEMBL546 Approved

Alternate Names:

OXPRENOLOL

Drug Info:

Drug Indications	Anti-Arrhythmia Agents
Drug Indications	Antihypertensive Agents
FDA Approval	1983
Drug Class	small molecule
Drug Class	anti-arrhythmia agents
Year of Approval	1983
Drug Class	antihypertensive agents
Drug Categories	sympatholytics
Drug Categories	agents causing hyperkalemia
Drug Categories	antiarrhythmic agents
Drug Categories	beta blocking agents and thiazides
Drug Categories	beta blocking agents, non-selective, and thiazides
Drug Categories	bradycardia-causing agents
Drug Categories	cytochrome p-450 cyp2d6 inhibitors (strength unknown)
Drug Categories	cytochrome p-450 cyp2d6 substrates
Drug Categories	cytochrome p-450 enzyme inhibitors
Drug Categories	cytochrome p-450 substrates
Drug Categories	moderate risk qtc-prolonging agents
Drug Categories	oct2 inhibitors
Drug Categories	qtc prolonging agents
Drug Categories	vasodilating agents

(1 More Sources)

Publications:

Fujita et al., 1998, Adrenergic agonists suppress the proliferation of microglia through beta 2-adrenergic receptor., Neurosci. Lett.
Sekut et al., 1995, Anti-inflammatory activity of salmeterol: down-regulation of cytokine production., Clin. Exp. Immunol.
Prinz et al., 2001, beta-adrenergic receptor stimulation selectively inhibits IL-12p40 release in microglia., Brain Res.
Overington et al., 2006, How many drug targets are there?, Nat Rev Drug Discov
Imming et al., 2006, Drugs, their targets and the nature and number of drug targets., Nat Rev Drug Discov
Campbell et al., Effects of prolonged administration of oxprenolol on severity of ischaemic arrhythmias, enzyme leakage, infarct size, and intracellular cardiac muscle action potentials., J. Cardiovasc. Pharmacol.
Lemmer, 1982, [Pharmacological basis for the therapy of cardiovascular disease with beta-adrenoceptor blocking drugs (author's transl)]., Herz
Abrahamsson, 1986, The beta 1- and beta 2-adrenoceptor stimulatory effects of alprenolol, oxprenolol and pindolol: a study in the isolated right atrium and uterus of the rat., Br. J. Pharmacol.
Chen et al., 2002, TTD: Therapeutic Target Database., Nucleic Acids Res.
Fève B et al., 1991, Atypical beta-adrenergic receptor in 3T3-F442A adipocytes. Pharmacological and molecular relationship with the human beta 3-adrenergic receptor., J Biol Chem

OXPRENOLOL ADRB1

Interaction Score: 1.5

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
6202960 6124492 2871880 11752352 17139284 17016423

Sources:
TEND TdgClinicalTrial TTD DrugBank
OXPRENOLOL ADRB2

Interaction Score: 0.92

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
9509999 7882570 11311890 17139284 17016423

Sources:
TEND TdgClinicalTrial DrugBank
OXPRENOLOL ADRB3

Interaction Score: 0.73

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
1682311

Sources:
DrugBank

DrugBank: DB01580

Version: 5.1.7

Alternate Names:

OXPRENOLOL DrugBank Drug Name

6452-71-7 CAS Number

Slow Trasicor Tab 160mg Drug Brand

Drug Info:

Drug Type small molecule

Drug Groups approved

Drug Categories adrenergic agents

Publications:

Fujita et al., 1998, Adrenergic agonists suppress the proliferation of microglia through beta 2-adrenergic receptor., Neurosci. Lett.

Sekut et al., 1995, Anti-inflammatory activity of salmeterol: down-regulation of cytokine production., Clin. Exp. Immunol.

Prinz et al., 2001, beta-adrenergic receptor stimulation selectively inhibits IL-12p40 release in microglia., Brain Res.

TEND: OXPRENOLOL
- Version: 01-August-2011
Alternate Names:

OXPRENOLOL Primary Drug Name

Drug Info:

Drug Class antihypertensive agents

Year of Approval 1983

Drug Class anti-arrhythmia agents

Publications:
TdgClinicalTrial: OXPRENOLOL
- Version: January-2014
Alternate Names:

Drug Info:

Drug Class small molecule

FDA Approval 1983

Drug Indications Antihypertensive Agents

Publications:
TTD: Oxprenolol
- Version: 2020.06.01
Alternate Names:

D0X2MB TTD Drug ID

Drug Info:

Publications:
ChemblDrugs: chembl:CHEMBL546
- Version: ChEMBL_27
Alternate Names:

Drug Info:

Publications:

OXPRENOLOL	DrugBank Drug Name
6452-71-7	CAS Number
Slow Trasicor Tab 160mg	Drug Brand

Drug Type	small molecule
Drug Groups	approved
Drug Categories	adrenergic agents

Trial Name	-
Novel drug target	Established target

Trial Name	-
Novel drug target	Established target

OXPRENOLOL Drug Record

OXPRENOLOL chembl:CHEMBL546 Approved

Alternate Names:

Drug Info:

Publications:

OXPRENOLOL ADRB1

Interaction Types & Directionality: antagonist (inhibitory)

Interaction Info: Trial Name - Novel drug target Established target

PMIDs: 6202960 6124492 2871880 11752352 17139284 17016423

Sources: TEND TdgClinicalTrial TTD DrugBank

OXPRENOLOL ADRB2

Interaction Types & Directionality: antagonist (inhibitory)

Interaction Info: Trial Name - Novel drug target Established target

PMIDs: 9509999 7882570 11311890 17139284 17016423

Sources: TEND TdgClinicalTrial DrugBank

OXPRENOLOL ADRB3

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 1682311

Sources: DrugBank

DrugBank: DB01580

Alternate Names: OXPRENOLOL DrugBank Drug Name 6452-71-7 CAS Number Slow Trasicor Tab 160mg Drug Brand

Drug Info: Drug Type small molecule Drug Groups approved Drug Categories adrenergic agents

TEND: OXPRENOLOL

Alternate Names: OXPRENOLOL Primary Drug Name

Drug Info: Drug Class antihypertensive agents Year of Approval 1983 Drug Class anti-arrhythmia agents

Publications:

TdgClinicalTrial: OXPRENOLOL

Alternate Names:

Drug Info: Drug Class small molecule FDA Approval 1983 Drug Indications Antihypertensive Agents

Publications:

TTD: Oxprenolol

Alternate Names: D0X2MB TTD Drug ID

Drug Info:

Publications:

ChemblDrugs: chembl:CHEMBL546

Alternate Names:

Drug Info:

Publications:

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
6202960 6124492 2871880 11752352 17139284 17016423

Sources:
TEND TdgClinicalTrial TTD DrugBank

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
9509999 7882570 11311890 17139284 17016423

Sources:
TEND TdgClinicalTrial DrugBank

Interaction Types & Directionality:

n/a

PMIDs:
1682311

Sources:
DrugBank

Alternate Names:

OXPRENOLOL DrugBank Drug Name

6452-71-7 CAS Number

Slow Trasicor Tab 160mg Drug Brand

Drug Info:

Drug Type small molecule

Drug Groups approved

Drug Categories adrenergic agents

Alternate Names:

OXPRENOLOL Primary Drug Name

Drug Info:

Drug Class antihypertensive agents

Year of Approval 1983

Drug Class anti-arrhythmia agents

Drug Info:

Drug Class small molecule

FDA Approval 1983

Drug Indications Antihypertensive Agents

Alternate Names:

D0X2MB TTD Drug ID