DGIdb - OXPRENOLOL Drug Record

OXPRENOLOL chembl:CHEMBL546 Approved

Alternate Names:

OXPRENOLOL

Drug Info:

Drug Indications	Anti-Arrhythmia Agents
Drug Indications	Antihypertensive Agents
FDA Approval	1983
Drug Class	small molecule
Drug Class	anti-arrhythmia agents
Year of Approval	1983
Drug Class	antihypertensive agents

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Publications:

Prinz et al., 2001, beta-adrenergic receptor stimulation selectively inhibits IL-12p40 release in microglia., Brain Res.
Sekut et al., 1995, Anti-inflammatory activity of salmeterol: down-regulation of cytokine production., Clin. Exp. Immunol.
Imming et al., 2006, Drugs, their targets and the nature and number of drug targets., Nat Rev Drug Discov
Overington et al., 2006, How many drug targets are there?, Nat Rev Drug Discov
Fujita et al., 1998, Adrenergic agonists suppress the proliferation of microglia through beta 2-adrenergic receptor., Neurosci. Lett.
Abrahamsson, 1986, The beta 1- and beta 2-adrenoceptor stimulatory effects of alprenolol, oxprenolol and pindolol: a study in the isolated right atrium and uterus of the rat., Br. J. Pharmacol.
Chen et al., 2002, TTD: Therapeutic Target Database., Nucleic Acids Res.
Campbell et al., Effects of prolonged administration of oxprenolol on severity of ischaemic arrhythmias, enzyme leakage, infarct size, and intracellular cardiac muscle action potentials., J. Cardiovasc. Pharmacol.
Lemmer, 1982, [Pharmacological basis for the therapy of cardiovascular disease with beta-adrenoceptor blocking drugs (author's transl)]., Herz

OXPRENOLOL ADRB1

Interaction Score: 3.35

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
2871880 11752352 6202960 17016423 17139284 6124492

Sources:
TdgClinicalTrial TEND TTD
OXPRENOLOL ADRB2

Interaction Score: 1.69

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
11311890 7882570 17016423 17139284 9509999

Sources:
TdgClinicalTrial TEND

TEND: OXPRENOLOL
- Version: 01-August-2011
Alternate Names:

OXPRENOLOL Primary Drug Name

Drug Info:

Drug Class antihypertensive agents

Year of Approval 1983

Drug Class anti-arrhythmia agents

Publications:
TdgClinicalTrial: OXPRENOLOL
- Version: January-2014
Alternate Names:

Drug Info:

Drug Class small molecule

FDA Approval 1983

Drug Indications Antihypertensive Agents

Publications:
TTD: Oxprenolol
- Version: 2020.06.01
Alternate Names:

D0X2MB TTD Drug ID

Drug Info:

Publications:
ChemblDrugs: chembl:CHEMBL546
- Version: ChEMBL_27
Alternate Names:

Drug Info:

Publications:

Trial Name	-
Novel drug target	Established target

Trial Name	-
Novel drug target	Established target

OXPRENOLOL Drug Record

OXPRENOLOL chembl:CHEMBL546 Approved

Alternate Names:

Drug Info:

Publications:

OXPRENOLOL ADRB1

Interaction Types & Directionality: antagonist (inhibitory)

Interaction Info: Trial Name - Novel drug target Established target

PMIDs: 2871880 11752352 6202960 17016423 17139284 6124492

Sources: TdgClinicalTrial TEND TTD

OXPRENOLOL ADRB2

Interaction Types & Directionality: antagonist (inhibitory)

Interaction Info: Trial Name - Novel drug target Established target

PMIDs: 11311890 7882570 17016423 17139284 9509999

Sources: TdgClinicalTrial TEND

TEND: OXPRENOLOL

Alternate Names: OXPRENOLOL Primary Drug Name

Drug Info: Drug Class antihypertensive agents Year of Approval 1983 Drug Class anti-arrhythmia agents

Publications:

TdgClinicalTrial: OXPRENOLOL

Alternate Names:

Drug Info: Drug Class small molecule FDA Approval 1983 Drug Indications Antihypertensive Agents

Publications:

TTD: Oxprenolol

Alternate Names: D0X2MB TTD Drug ID

Drug Info:

Publications:

ChemblDrugs: chembl:CHEMBL546

Alternate Names:

Drug Info:

Publications:

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
2871880 11752352 6202960 17016423 17139284 6124492

Sources:
TdgClinicalTrial TEND TTD

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
11311890 7882570 17016423 17139284 9509999

Sources:
TdgClinicalTrial TEND

Alternate Names:

OXPRENOLOL Primary Drug Name

Drug Info:

Drug Class antihypertensive agents

Year of Approval 1983

Drug Class anti-arrhythmia agents

Drug Info:

Drug Class small molecule

FDA Approval 1983

Drug Indications Antihypertensive Agents

Alternate Names:

D0X2MB TTD Drug ID