DGIdb - OXCARBAZEPINE Drug Record

OXCARBAZEPINE chembl:CHEMBL1068 Approved

Alternate Names:

SPN-804
GP-47680
KIN-493
OXTELLAR XR
OXCARBAZEPINE
TRILEPTAL
TRI476
OCBZ
10,11-DIHYDRO-10-OXO-5H-DIBENZ(B,F)AZEPINE-5-CARBOXAMIDE
chemidplus:28721-07-5
rxcui:32624
chembl:CHEMBL1068
drugbank:00776
pubchem.compound:34312

Drug Info:

FDA Approval	approved
Drug Class	Small Molecule
Drug Indications	anticonvulsant
Drug Class	anticonvulsants
Year of Approval	2000

(4 More Sources)

Publications:

Vohora et al., 2010, Recent advances in adjunctive therapy for epilepsy: focus on sodium channel blockers as third-generation antiepileptic drugs., Drugs Today
Imming et al., 2006, Drugs, their targets and the nature and number of drug targets., Nat Rev Drug Discov
Overington et al., 2006, How many drug targets are there?, Nat Rev Drug Discov
Lu Y et al., 2017, Effects of UGT1A9 genetic polymorphisms on monohydroxylated derivative of oxcarbazepine concentrations and oxcarbazepine monotherapeutic efficacy in Chinese patients with epilepsy., Eur J Clin Pharmacol
Ma CL et al., 2014, Association of SCN1A, SCN2A and ABCC2 gene polymorphisms with the response to antiepileptic drugs in Chinese Han patients with epilepsy., Pharmacogenomics
Kwan P et al., 2008, Multidrug resistance in epilepsy and polymorphisms in the voltage-gated sodium channel genes SCN1A, SCN2A, and SCN3A: correlation among phenotype, genotype, and mRNA expression., Pharmacogenet Genomics
Rädisch S et al., 2014, A comprehensive functional and clinical analysis of ABCC2 and its impact on treatment response to carbamazepine., Pharmacogenomics J
Sporis D et al., 2013, Lack of association between polymorphism in ABCC2 gene and response to antiepileptic drug treatment in Croatian patients with epilepsy., Coll Antropol
Qu J et al., 2012, ABCC2 polymorphisms and haplotype are associated with drug resistance in Chinese epileptic patients., CNS Neurosci Ther
Hilger E et al., 2012, Lack of association between ABCC2 gene variants and treatment response in epilepsy., Pharmacogenomics
Hung CC et al., 2012, Association of polymorphisms in EPHX1, UGT2B7, ABCB1, ABCC2, SCN1A and SCN2A genes with carbamazepine therapy optimization., Pharmacogenomics
Ufer M et al., 2011, Impact of ABCC2 genotype on antiepileptic drug response in Caucasian patients with childhood epilepsy., Pharmacogenet Genomics
Kwan P et al., 2011, Gene-wide tagging study of the association between ABCC2, ABCC5 and ABCG2 genetic polymorphisms and multidrug resistance in epilepsy., Pharmacogenomics
Shen C et al., 2017, Effects of ABCB1, ABCC2, UGT2B7 and HNF4α genetic polymorphisms on oxcarbazepine concentrations and therapeutic efficacy in patients with epilepsy., Seizure
Ma CL et al., 2015, SCN1A, ABCC2 and UGT2B7 gene polymorphisms in association with individualized oxcarbazepine therapy., Pharmacogenomics
Moon J et al., 2016, HLA-B40:02 and DRB104:03 are risk factors for oxcarbazepine-induced maculopapular eruption., Epilepsia
Bertok S et al., 2017, The association of SCN1A p.Thr1067Ala polymorphism with epilepsy risk and the response to antiepileptic drugs in Slovenian children and adolescents with epilepsy., Seizure
Daci A et al., 2015, Polymorphic Variants of SCN1A and EPHX1 Influence Plasma Carbamazepine Concentration, Metabolism and Pharmacoresistance in a Population of Kosovar Albanian Epileptic Patients., PLoS One
Haerian BS et al., 2013, SCN1A, SCN2A and SCN3A gene polymorphisms and responsiveness to antiepileptic drugs: a multicenter cohort study and meta-analysis., Pharmacogenomics
Zhou BT et al., 2012, Effects of SCN1A and GABA receptor genetic polymorphisms on carbamazepine tolerability and efficacy in Chinese patients with partial seizures: 2-year longitudinal clinical follow-up., CNS Neurosci Ther
Kumari R et al., 2011, Pharmacogenomic association study on the role of drug metabolizing, drug transporters and drug target gene polymorphisms in drug-resistant epilepsy in a north Indian population., Indian J Hum Genet
Shorvon S, 2000, Oxcarbazepine: a review., Seizure
Schmidt D et al., 2000, Oxcarbazepine for Treatment of Partial Epilepsy: A Review and Recommendations for Clinical Use., Epilepsy Behav
Thomas AM et al., 2018, Old Friends With New Faces: Are Sodium Channel Blockers the Future of Adjunct Pain Medication Management?, J Pain

OXCARBAZEPINE UGT1A7

Interaction Score: 0.69

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
27900402

Sources:
PharmGKB
OXCARBAZEPINE UGT1A10

Interaction Score: 0.62

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
27900402

Sources:
PharmGKB
OXCARBAZEPINE SCN1A

Interaction Score: 0.57

Interaction Types & Directionality:

blocker (inhibitory)

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Sodium channel alpha subunit blocker

Direct Interaction yes

PMIDs:
28753467 26555147 25155934 23859570 22591328 21747585 10845729 12737829 28842369

Sources:
ChemblInteractions PharmGKB
OXCARBAZEPINE UGT1A8

Interaction Score: 0.56

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
27900402

Sources:
PharmGKB
OXCARBAZEPINE ABCC2

Interaction Score: 0.52

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
25155934 24567120 23697249 22630058 22256867 22188362 21799461 21449672

Sources:
PharmGKB
OXCARBAZEPINE UGT2B7

Interaction Score: 0.44

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
28837897 25823783

Sources:
PharmGKB
OXCARBAZEPINE UGT1A9

Interaction Score: 0.36

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
27900402

Sources:
PharmGKB
OXCARBAZEPINE SCN5A

Interaction Score: 0.22

Interaction Types & Directionality:

blocker (inhibitory)

inhibitor (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Sodium channel alpha subunit blocker

Novel drug target Established target

PMIDs:
20502724 17016423 17139284

Sources:
TdgClinicalTrial ChemblInteractions TEND
OXCARBAZEPINE SCN2A

Interaction Score: 0.21

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Mechanism of Interaction Sodium channel alpha subunit blocker

Direct Interaction yes

PMIDs:
25155934 18784617

Sources:
ChemblInteractions PharmGKB
OXCARBAZEPINE HLA-DRB1

Interaction Score: 0.2

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
27666425

Sources:
PharmGKB
OXCARBAZEPINE HLA-B

Interaction Score: 0.12

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
FDA
OXCARBAZEPINE SCN11A

Interaction Score: 0.1

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Mechanism of Interaction Sodium channel alpha subunit blocker

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions TTD
OXCARBAZEPINE SCN7A

Interaction Score: 0.06

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Mechanism of Interaction Sodium channel alpha subunit blocker

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
OXCARBAZEPINE SCN8A

Interaction Score: 0.06

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Mechanism of Interaction Sodium channel alpha subunit blocker

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
OXCARBAZEPINE SCN3A

Interaction Score: 0.05

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Mechanism of Interaction Sodium channel alpha subunit blocker

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
OXCARBAZEPINE SCN4A

Interaction Score: 0.05

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Mechanism of Interaction Sodium channel alpha subunit blocker

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
OXCARBAZEPINE SCN9A

Interaction Score: 0.05

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Sodium channel alpha subunit blocker

PMIDs:
None found

Sources:
ChemblInteractions
OXCARBAZEPINE SCN10A

Interaction Score: 0.04

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Mechanism of Interaction Sodium channel alpha subunit blocker

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
OXCARBAZEPINE ABCB1

Interaction Score: 0.03

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
28837897

Sources:
PharmGKB
OXCARBAZEPINE VDR

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC

TEND: OXCARBAZEPINE
- Version: 01-August-2011
Alternate Names:

OXCARBAZEPINE Primary Drug Name

Drug Info:

Year of Approval 2000

Drug Class anticonvulsants

Publications:
TdgClinicalTrial: OXCARBAZEPINE
- Version: January-2014
Alternate Names:

Drug Info:

Drug Indications anticonvulsant

Drug Class Small Molecule

FDA Approval approved

Publications:

PharmGKB: oxcarbazepine

Version: 18-August-2020

Alternate Names:

Drug Info:

Publications:

Moon J et al., 2016, HLA-B40:02 and DRB104:03 are risk factors for oxcarbazepine-induced maculopapular eruption., Epilepsia

Kwan P et al., 2011, Gene-wide tagging study of the association between ABCC2, ABCC5 and ABCG2 genetic polymorphisms and multidrug resistance in epilepsy., Pharmacogenomics

Qu J et al., 2012, ABCC2 polymorphisms and haplotype are associated with drug resistance in Chinese epileptic patients., CNS Neurosci Ther

DTC: OXCARBAZEPINE
- Version: 02-September-2020
Alternate Names:

CHEMBL1068 ChEMBL Drug ID

Drug Info:

Publications:
TTD: Oxcarbazepine
- Version: 2020.06.01
Alternate Names:

D0QL3P TTD Drug ID

Drug Info:

Publications:
ChemblDrugs: chembl:CHEMBL1068
- Version: ChEMBL_27
Alternate Names:

Drug Info:

Publications:
ChemblInteractions: CHEMBL1068
- Version: chembl_23
Alternate Names:

Drug Info:

Publications:
FDA: Oxcarbazepine
- Version: 04-September-2020
Alternate Names:

Drug Info:

Publications:

Mechanism of Interaction	Sodium channel alpha subunit blocker
Direct Interaction	yes

blocker (inhibitory)
inhibitor (inhibitory)

blocker (inhibitory)
inhibitor (inhibitory)

OXCARBAZEPINE Drug Record

OXCARBAZEPINE chembl:CHEMBL1068 Approved

Alternate Names:

Drug Info:

Publications:

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 27900402

Sources: PharmGKB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 27900402

Sources: PharmGKB

Interaction Types & Directionality: blocker (inhibitory) inhibitor (inhibitory)

Interaction Info: Mechanism of Interaction Sodium channel alpha subunit blocker Direct Interaction yes

PMIDs: 28753467 26555147 25155934 23859570 22591328 21747585 10845729 12737829 28842369

Sources: ChemblInteractions PharmGKB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 27900402

Sources: PharmGKB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 25155934 24567120 23697249 22630058 22256867 22188362 21799461 21449672

Sources: PharmGKB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 28837897 25823783

Sources: PharmGKB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 27900402

Sources: PharmGKB

Interaction Types & Directionality: blocker (inhibitory) inhibitor (inhibitory)

Interaction Info: Direct Interaction yes Mechanism of Interaction Sodium channel alpha subunit blocker Novel drug target Established target

PMIDs: 20502724 17016423 17139284

Sources: TdgClinicalTrial ChemblInteractions TEND

Interaction Types & Directionality: blocker (inhibitory)

Interaction Info: Mechanism of Interaction Sodium channel alpha subunit blocker Direct Interaction yes

PMIDs: 25155934 18784617

Sources: ChemblInteractions PharmGKB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 27666425

Sources: PharmGKB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: FDA

Interaction Types & Directionality: blocker (inhibitory)

Interaction Info: Mechanism of Interaction Sodium channel alpha subunit blocker Direct Interaction yes

PMIDs: None found

Sources: ChemblInteractions TTD

Interaction Types & Directionality: blocker (inhibitory)

Interaction Info: Mechanism of Interaction Sodium channel alpha subunit blocker Direct Interaction yes

PMIDs: None found

Sources: ChemblInteractions

Interaction Types & Directionality: blocker (inhibitory)

Interaction Info: Mechanism of Interaction Sodium channel alpha subunit blocker Direct Interaction yes

PMIDs: None found

Sources: ChemblInteractions

Interaction Types & Directionality: blocker (inhibitory)

Interaction Info: Mechanism of Interaction Sodium channel alpha subunit blocker Direct Interaction yes

PMIDs: None found

Sources: ChemblInteractions

Interaction Types & Directionality: blocker (inhibitory)

Interaction Info: Mechanism of Interaction Sodium channel alpha subunit blocker Direct Interaction yes

PMIDs: None found

Sources: ChemblInteractions

Interaction Types & Directionality: blocker (inhibitory)

Interaction Info: Direct Interaction yes Mechanism of Interaction Sodium channel alpha subunit blocker

PMIDs: None found

Sources: ChemblInteractions

Interaction Types & Directionality: blocker (inhibitory)

Interaction Info: Mechanism of Interaction Sodium channel alpha subunit blocker Direct Interaction yes

PMIDs: None found

Sources: ChemblInteractions

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 28837897

Interaction Types & Directionality:

n/a

PMIDs:
27900402

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
27900402

Sources:
PharmGKB

Interaction Types & Directionality:

blocker (inhibitory)

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Sodium channel alpha subunit blocker

Direct Interaction yes

PMIDs:
28753467 26555147 25155934 23859570 22591328 21747585 10845729 12737829 28842369

Sources:
ChemblInteractions PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
27900402

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
25155934 24567120 23697249 22630058 22256867 22188362 21799461 21449672

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
28837897 25823783

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
27900402

Sources:
PharmGKB

Interaction Types & Directionality:

blocker (inhibitory)

inhibitor (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Sodium channel alpha subunit blocker

Novel drug target Established target

PMIDs:
20502724 17016423 17139284

Sources:
TdgClinicalTrial ChemblInteractions TEND

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Mechanism of Interaction Sodium channel alpha subunit blocker

Direct Interaction yes

PMIDs:
25155934 18784617

Sources:
ChemblInteractions PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
27666425

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
FDA

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Mechanism of Interaction Sodium channel alpha subunit blocker

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions TTD

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Mechanism of Interaction Sodium channel alpha subunit blocker

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Mechanism of Interaction Sodium channel alpha subunit blocker

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Mechanism of Interaction Sodium channel alpha subunit blocker

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Mechanism of Interaction Sodium channel alpha subunit blocker

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Sodium channel alpha subunit blocker

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Mechanism of Interaction Sodium channel alpha subunit blocker

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

n/a

PMIDs:
28837897

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Alternate Names:

OXCARBAZEPINE Primary Drug Name

Drug Info:

Year of Approval 2000

Drug Class anticonvulsants

Drug Info:

Drug Indications anticonvulsant

Drug Class Small Molecule

FDA Approval approved

Alternate Names:

CHEMBL1068 ChEMBL Drug ID

Alternate Names:

D0QL3P TTD Drug ID