DGIdb - NIZATIDINE Drug Record

NIZATIDINE chembl:CHEMBL3183075 Approved

Alternate Names:

AXID AR
NIZATIDINE
LY-139037
LY 139037
ZINGA 150
ZINGA 300
AXID

Drug Info:

Year of Approval	1988
Drug Class	gi anti-ulcer agents, antihistamines
FDA Approval	1988
Drug Class	small molecule
Drug Indications	GI Anti-Ulcer Agents, antihistamines

(2 More Sources)

Publications:

Okabe et al., 1989, [Effects of nizatidine, a new histamine H2-receptor antagonist, on gastric acid secretion and various gastric and duodenal lesions in rats: comparison with cimetidine]., Nippon Yakurigaku Zasshi
Meredith et al., 1985, Nizatidine, a new histamine H2-receptor antagonist, and hepatic oxidative drug metabolism in the rat: a comparison with structurally related compounds., Toxicol. Appl. Pharmacol.
Lin et al., 1986, Actions of nizatidine, a selective histamine H2-receptor antagonist, on gastric acid secretion in dogs, rats and frogs., J. Pharmacol. Exp. Ther.
Chen et al., 2002, TTD: Therapeutic Target Database., Nucleic Acids Res.
Kounenis et al., 1987, The excitatory effect of the new histamine H2-receptor antagonist nizatidine (LY 139037) on the guinea pig ileum., J. Pharmacobio-dyn.
Enriz et al., 1991, [Theoretical conformation study of tiotidine and nizatidine, two strong histamine H2-receptor antagonists]., Acta Cient. Venez.
Itoh et al., 2002, Effects of histamine H(2)-receptor antagonists on human plasma levels of calcitonin gene-related peptide, substance P and vasoactive intestinal peptide., J. Pharm. Pharmacol.

NIZATIDINE HRH2

Interaction Score: 20.61

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Mechanism of Interaction Histamine H2 receptor antagonist

Direct Interaction yes

Trial Name -

PMIDs:
2567267 2858133 2877081 11752352 2895808 1843561

Sources:
TdgClinicalTrial ChemblInteractions TEND TTD
NIZATIDINE TAC1

Interaction Score: 2.81

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
12495560

Sources:
NCI

TEND: NIZATIDINE
- Version: 01-August-2011
Alternate Names:

NIZATIDINE Primary Drug Name

Drug Info:

Drug Class gi anti-ulcer agents, antihistamines

Year of Approval 1988

Publications:
TdgClinicalTrial: NIZATIDINE
- Version: January-2014
Alternate Names:

Drug Info:

Drug Indications GI Anti-Ulcer Agents, antihistamines

Drug Class small molecule

FDA Approval 1988

Publications:

NCI: NIZATIDINE

Version: 14-September-2017

Alternate Names:

C29295 NCI drug code

Drug Info:

Publications:

Itoh et al., 2002, Effects of histamine H(2)-receptor antagonists on human plasma levels of calcitonin gene-related peptide, substance P and vasoactive intestinal peptide., J. Pharm. Pharmacol.

TTD: Nizatidine
- Version: 2020.06.01
Alternate Names:

D0Q9DK TTD Drug ID

Drug Info:

Publications:
ChemblDrugs: chembl:CHEMBL3183075
- Version: ChEMBL_27
Alternate Names:

Drug Info:

Publications:
ChemblInteractions: CHEMBL653
- Version: chembl_23
Alternate Names:

Drug Info:

Publications:

Mechanism of Interaction	Histamine H2 receptor antagonist
Direct Interaction	yes
Trial Name	-

NIZATIDINE Drug Record

NIZATIDINE chembl:CHEMBL3183075 Approved

Alternate Names:

Drug Info:

Publications:

NIZATIDINE HRH2

Interaction Types & Directionality: antagonist (inhibitory)

Interaction Info: Mechanism of Interaction Histamine H2 receptor antagonist Direct Interaction yes Trial Name -

PMIDs: 2567267 2858133 2877081 11752352 2895808 1843561

Sources: TdgClinicalTrial ChemblInteractions TEND TTD

NIZATIDINE TAC1

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 12495560

Sources: NCI

TEND: NIZATIDINE

Alternate Names: NIZATIDINE Primary Drug Name

Drug Info: Drug Class gi anti-ulcer agents, antihistamines Year of Approval 1988

Publications:

TdgClinicalTrial: NIZATIDINE

Alternate Names:

Drug Info: Drug Indications GI Anti-Ulcer Agents, antihistamines Drug Class small molecule FDA Approval 1988

Publications:

NCI: NIZATIDINE

Alternate Names: C29295 NCI drug code

Drug Info:

Publications: Itoh et al., 2002, Effects of histamine H(2)-receptor antagonists on human plasma levels of calcitonin gene-related peptide, substance P and vasoactive intestinal peptide., J. Pharm. Pharmacol.

TTD: Nizatidine

Alternate Names: D0Q9DK TTD Drug ID

Drug Info:

Publications:

ChemblDrugs: chembl:CHEMBL3183075

Alternate Names:

Drug Info:

Publications:

ChemblInteractions: CHEMBL653

Alternate Names:

Drug Info:

Publications:

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Mechanism of Interaction Histamine H2 receptor antagonist

Direct Interaction yes

Trial Name -

PMIDs:
2567267 2858133 2877081 11752352 2895808 1843561

Sources:
TdgClinicalTrial ChemblInteractions TEND TTD

Interaction Types & Directionality:

n/a

PMIDs:
12495560

Sources:
NCI

Alternate Names:

NIZATIDINE Primary Drug Name

Drug Info:

Drug Class gi anti-ulcer agents, antihistamines

Year of Approval 1988

Drug Info:

Drug Indications GI Anti-Ulcer Agents, antihistamines

Drug Class small molecule

FDA Approval 1988

Alternate Names:

C29295 NCI drug code

Publications:

Itoh et al., 2002, Effects of histamine H(2)-receptor antagonists on human plasma levels of calcitonin gene-related peptide, substance P and vasoactive intestinal peptide., J. Pharm. Pharmacol.

Alternate Names:

D0Q9DK TTD Drug ID