• Search
      • Search Interactions Search Categories
    • Browse
      • Browse Categories Browse Sources
    • Information
      • About Publications Interaction Types & Directionalities Interaction Score & Query Score API Documentation FAQ Known Data Clients News Contact
    • Downloads
      • Data Source Code

NIZATIDINE Drug Record

  • Summary
  • Interactions
  • Claims
  • NIZATIDINE chembl:CHEMBL3183075 Approved

    Alternate Names:

    AXID AR
    NIZATIDINE
    LY-139037
    LY 139037
    ZINGA 150
    ZINGA 300
    AXID

    Drug Info:

    Year of Approval 1988
    Drug Class gi anti-ulcer agents, antihistamines
    FDA Approval 1988
    Drug Class small molecule
    Drug Indications GI Anti-Ulcer Agents, antihistamines
    (2 More Sources)

    Publications:

    Okabe et al., 1989, [Effects of nizatidine, a new histamine H2-receptor antagonist, on gastric acid secretion and various gastric and duodenal lesions in rats: comparison with cimetidine]., Nippon Yakurigaku Zasshi
    Meredith et al., 1985, Nizatidine, a new histamine H2-receptor antagonist, and hepatic oxidative drug metabolism in the rat: a comparison with structurally related compounds., Toxicol. Appl. Pharmacol.
    Lin et al., 1986, Actions of nizatidine, a selective histamine H2-receptor antagonist, on gastric acid secretion in dogs, rats and frogs., J. Pharmacol. Exp. Ther.
    Chen et al., 2002, TTD: Therapeutic Target Database., Nucleic Acids Res.
    Kounenis et al., 1987, The excitatory effect of the new histamine H2-receptor antagonist nizatidine (LY 139037) on the guinea pig ileum., J. Pharmacobio-dyn.
    Enriz et al., 1991, [Theoretical conformation study of tiotidine and nizatidine, two strong histamine H2-receptor antagonists]., Acta Cient. Venez.
    Itoh et al., 2002, Effects of histamine H(2)-receptor antagonists on human plasma levels of calcitonin gene-related peptide, substance P and vasoactive intestinal peptide., J. Pharm. Pharmacol.
  • NIZATIDINE   HRH2

    Interaction Score: 20.61

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Mechanism of Interaction Histamine H2 receptor antagonist
    Direct Interaction yes
    Trial Name -

    PMIDs:
    2567267 2858133 2877081 11752352 2895808 1843561


    Sources:
    TdgClinicalTrial ChemblInteractions TEND TTD

  • NIZATIDINE   TAC1

    Interaction Score: 2.81

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    12495560


    Sources:
    NCI

  • TEND: NIZATIDINE

    • Version: 01-August-2011

    Alternate Names:
    NIZATIDINE Primary Drug Name

    Drug Info:
    Drug Class gi anti-ulcer agents, antihistamines
    Year of Approval 1988

    Publications:

  • TdgClinicalTrial: NIZATIDINE

    • Version: January-2014

    Alternate Names:

    Drug Info:
    Drug Indications GI Anti-Ulcer Agents, antihistamines
    Drug Class small molecule
    FDA Approval 1988

    Publications:

  • NCI: NIZATIDINE

    • Version: 14-September-2017

    Alternate Names:
    C29295 NCI drug code

    Drug Info:

    Publications:
    Itoh et al., 2002, Effects of histamine H(2)-receptor antagonists on human plasma levels of calcitonin gene-related peptide, substance P and vasoactive intestinal peptide., J. Pharm. Pharmacol.

  • TTD: Nizatidine

    • Version: 2020.06.01

    Alternate Names:
    D0Q9DK TTD Drug ID

    Drug Info:

    Publications:

  • ChemblDrugs: chembl:CHEMBL3183075

    • Version: ChEMBL_27

    Alternate Names:

    Drug Info:

    Publications:

  • ChemblInteractions: CHEMBL653

    • Version: chembl_23

    Alternate Names:

    Drug Info:

    Publications:

Disclaimer: This resource is intended for purely research purposes. It should not be used for emergencies or medical or professional advice.

A finding of a drug-gene interaction or potentially druggable category does not necessarily indicate effectiveness (or lack thereof) of any drug or treatment regimen. A finding of no interaction or no potentially druggable category does not necessarily indicate lack of effectiveness of any drug or treatment regimen. Drug-gene interactions or potentially druggable categories are not presented in ranked order of potential or predicted efficacy.

The dgidb.org website does not provide any medical or healthcare products, services or advice, and is not for medical emergencies or urgent situations. IF YOU THINK YOU MAY HAVE A MEDICAL EMERGENCY, CALL YOUR DOCTOR OR 911 IMMEDIATELY. Information contained on this website is not a substitute for a doctor's medical judgment or advice. We recommend that you discuss your specific, individual health concerns with your doctor or health care professional.

DGIdb (v4.2.0 - sha1 afd9f30b) • Last updated 2020-10-21