DGIdb - NIMODIPINE Drug Record

NIMODIPINE chembl:CHEMBL1428 Approved

Alternate Names:

NYMALIZE
NIMOTOP
NIMODIPINE
BAY-E-9736
ISOPROPYL 2-METHOXYETHYL 1,4-DIHYDRO-2,6-DIMETHYL-4-(3-NITROPHENYL)-3,5-PYRIDINEDICARBOXYLATE
NIMODIPINUM
2,6-DIMETHYL-4-(3'-NITROPHENYL)-1,4-DIHYDROPYRIDINE-3,5-DICARBOXYLIC ACID 3-BETA-METHOXYETHYL ESTER 5-ISOPROPYL ESTER
NIMODIPINO
2,6-DIMETHYL-4-(3'-NITROPHENYL)-1,4-DIHYDROPYRIDINE-3,5-DICARBOXYLIC ACID 3-Β-METHOXYETHYL ESTER 5-ISOPROPYL ESTER
BAY E 9736
ISOPROPYL 2-METHOXYETHYL 1,4-DIHYDRO-2,6-DIMETHYL-4-(M-NITROPHENYL)-3,5-PYRIDINEDICARBOXYLATE
NIMOTOP®
chemidplus:66085-59-4
rxcui:7426
drugbank:00393
pubchem.compound:4497
chembl:CHEMBL1428

Drug Info:

FDA Approval	1988
Drug Class	small molecule
Drug Indications	Vasodilator Agents
Drug Indications	Antihypertensive Agents
Year of Approval	1988
Drug Class	vasodilator agents
Drug Class	antihypertensive agents

(4 More Sources)

Publications:

Kim et al., 2009, Intraarterial nimodipine infusion to treat symptomatic cerebral vasospasm after aneurysmal subarachnoid hemorrhage., J Korean Neurosurg Soc
Peterson et al., 2006, Allosteric interactions required for high-affinity binding of dihydropyridine antagonists to Ca(V)1.1 Channels are modulated by calcium in the pore., Mol. Pharmacol.
Weant et al., 2010, Role of intraarterial therapy for cerebral vasospasm secondary to aneurysmal subarachnoid hemorrhage., Pharmacotherapy
Keyrouz et al., 2007, Clinical review: Prevention and therapy of vasospasm in subarachnoid hemorrhage., Crit Care
Dong et al., 2010, Nimodipine enhancement of alpha2 adrenergic modulation of NMDA receptor via a mechanism independent of Ca2+ channel blocking., Invest. Ophthalmol. Vis. Sci.
Kumar et al., 2010, L-type calcium channel blockers, morphine and pain: Newer insights., Indian J Anaesth
Zhao Y et al., 2009, Effects of CYP3A5, MDR1 and CACNA1C polymorphisms on the oral disposition and response of nimodipine in a Chinese cohort., Eur J Clin Pharmacol
Marchetti et al., 1996, High affinity block by nimodipine of the internal calcium elevation in chronically depolarized rat cerebellar granule neurons., Neurosci. Lett.
Chen et al., 2002, TTD: Therapeutic Target Database., Nucleic Acids Res.
Guntinas-Lichius et al., 1997, Nimodipine maintains in vivo the increase in GFAP and enhances the astroglial ensheathment of surviving motoneurons in the rat following permanent target deprivation., J. Neurocytol.
Koh et al., 1995, Potentiated necrosis of cultured cortical neurons by neurotrophins., Science
Dietz et al., 2008, A number of marketed dihydropyridine calcium channel blockers have mineralocorticoid receptor antagonist activity., Hypertension
Roos et al., 2001, Nimodipine increases fibrinolytic activity in patients with aneurysmal subarachnoid hemorrhage., Stroke
Gahm et al., 2005, Neuronal degeneration and iNOS expression in experimental brain contusion following treatment with colchicine, dexamethasone, tirilazad mesylate and nimodipine., Acta Neurochir (Wien)
Sinnegger-Brauns et al., 2009, Expression and 1,4-dihydropyridine-binding properties of brain L-type calcium channel isoforms., Mol. Pharmacol.
Liu et al., Effect of P-glycoprotein inhibitors erythromycin and cyclosporin A on brain pharmacokinetics of nimodipine in rats., Eur J Drug Metab Pharmacokinet
Yu DD et al., 2013, Development of time resolved fluorescence resonance energy transfer-based assay for FXR antagonist discovery., Bioorg Med Chem
Ko et al., 1993, Action of dihydropyridine calcium antagonists on early growth response gene expression and cell growth in vascular smooth muscle cells., J. Hypertens.

NIMODIPINE CACNA1C

Interaction Score: 1.33

Interaction Types & Directionality:

blocker (inhibitory)

inhibitor (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Voltage-gated L-type calcium channel blocker

PMIDs:
19205682 19844625 20334460 17705883 8731425 11752352 20335610 20661350

Sources:
ChemblInteractions PharmGKB
NIMODIPINE CACNA1D

Interaction Score: 1.2

Interaction Types & Directionality:

blocker (inhibitory)

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Voltage-gated L-type calcium channel blocker

Direct Interaction yes

PMIDs:
19844625 20334460 17705883 20335610 19029287 20661350

Sources:
ChemblInteractions
NIMODIPINE CACNA1S

Interaction Score: 0.93

Interaction Types & Directionality:

blocker (inhibitory)

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Voltage-gated L-type calcium channel blocker

Direct Interaction yes

PMIDs:
19844625 16675661 20334460 17705883 20335610 20661350

Sources:
ChemblInteractions
NIMODIPINE CACNA1F

Interaction Score: 0.9

Interaction Types & Directionality:

blocker (inhibitory)

inhibitor (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Voltage-gated L-type calcium channel blocker

PMIDs:
20334460 20661350 19844625 20335610

Sources:
ChemblInteractions
NIMODIPINE FOS

Interaction Score: 0.82

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
8301097

Sources:
NCI
NIMODIPINE CACNG1

Interaction Score: 0.63

Interaction Types & Directionality:

n/a

Interaction Info:

Novel drug target Established target

Trial Name -

PMIDs:
None found

Sources:
TdgClinicalTrial TEND
NIMODIPINE NTF3

Interaction Score: 0.52

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
7725105

Sources:
NCI
NIMODIPINE NR3C2

Interaction Score: 0.46

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Mechanism of Interaction Mineralocorticoid receptor antagonist

Direct Interaction yes

PMIDs:
18250364

Sources:
ChemblInteractions
NIMODIPINE SERPINE1

Interaction Score: 0.41

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
11486117

Sources:
NCI
NIMODIPINE NOS2

Interaction Score: 0.39

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
16044358

Sources:
NCI
NIMODIPINE GFAP

Interaction Score: 0.33

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
9192289

Sources:
NCI
NIMODIPINE NR1H4

Interaction Score: 0.13

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
23688559

Sources:
DTC
NIMODIPINE CYP3A5

Interaction Score: 0.08

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
19205682

Sources:
PharmGKB
NIMODIPINE ABCB1

Interaction Score: 0.03

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
14743973

Sources:
NCI
NIMODIPINE ATAD5

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC

TEND: NIMODIPINE
- Version: 01-August-2011
Alternate Names:

NIMODIPINE Primary Drug Name

Drug Info:

Drug Class antihypertensive agents

Drug Class vasodilator agents

Year of Approval 1988

Publications:
TdgClinicalTrial: NIMODIPINE
- Version: January-2014
Alternate Names:

Drug Info:

Drug Indications Antihypertensive Agents

Drug Indications Vasodilator Agents

Drug Class small molecule

Publications:
DTC: NIMODIPINE
- Version: 02-September-2020
Alternate Names:

CHEMBL1428 ChEMBL Drug ID

Drug Info:

Publications:

Yu DD et al., 2013, Development of time resolved fluorescence resonance energy transfer-based assay for FXR antagonist discovery., Bioorg Med Chem

NCI: NIMODIPINE

Version: 14-September-2017

Alternate Names:

C692 NCI drug code

Drug Info:

Publications:

Koh et al., 1995, Potentiated necrosis of cultured cortical neurons by neurotrophins., Science

Roos et al., 2001, Nimodipine increases fibrinolytic activity in patients with aneurysmal subarachnoid hemorrhage., Stroke

Ko et al., 1993, Action of dihydropyridine calcium antagonists on early growth response gene expression and cell growth in vascular smooth muscle cells., J. Hypertens.

PharmGKB: nimodipine
- Version: 18-August-2020
Alternate Names:

Drug Info:

Publications:

Zhao Y et al., 2009, Effects of CYP3A5, MDR1 and CACNA1C polymorphisms on the oral disposition and response of nimodipine in a Chinese cohort., Eur J Clin Pharmacol
TTD: Nimodipine
- Version: 2020.06.01
Alternate Names:

D0XN1F TTD Drug ID

Drug Info:

Publications:
ChemblDrugs: chembl:CHEMBL1428
- Version: ChEMBL_27
Alternate Names:

Drug Info:

Publications:
ChemblInteractions: CHEMBL1428
- Version: chembl_23
Alternate Names:

Drug Info:

Publications:

Direct Interaction	yes
Mechanism of Interaction	Voltage-gated L-type calcium channel blocker

Mechanism of Interaction	Mineralocorticoid receptor antagonist
Direct Interaction	yes

blocker (inhibitory)
inhibitor (inhibitory)

blocker (inhibitory)
inhibitor (inhibitory)

blocker (inhibitory)
inhibitor (inhibitory)

blocker (inhibitory)
inhibitor (inhibitory)

NIMODIPINE Drug Record

NIMODIPINE chembl:CHEMBL1428 Approved

Alternate Names:

Drug Info:

Publications:

Interaction Types & Directionality: blocker (inhibitory) inhibitor (inhibitory)

Interaction Info: Direct Interaction yes Mechanism of Interaction Voltage-gated L-type calcium channel blocker

PMIDs: 19205682 19844625 20334460 17705883 8731425 11752352 20335610 20661350

Sources: ChemblInteractions PharmGKB

Interaction Types & Directionality: blocker (inhibitory) inhibitor (inhibitory)

Interaction Info: Mechanism of Interaction Voltage-gated L-type calcium channel blocker Direct Interaction yes

PMIDs: 19844625 20334460 17705883 20335610 19029287 20661350

Sources: ChemblInteractions

Interaction Types & Directionality: blocker (inhibitory) inhibitor (inhibitory)

Interaction Info: Mechanism of Interaction Voltage-gated L-type calcium channel blocker Direct Interaction yes

PMIDs: 19844625 16675661 20334460 17705883 20335610 20661350

Sources: ChemblInteractions

Interaction Types & Directionality: blocker (inhibitory) inhibitor (inhibitory)

Interaction Info: Direct Interaction yes Mechanism of Interaction Voltage-gated L-type calcium channel blocker

PMIDs: 20334460 20661350 19844625 20335610

Sources: ChemblInteractions

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 8301097

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info: Novel drug target Established target Trial Name -

PMIDs: None found

Sources: TdgClinicalTrial TEND

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 7725105

Sources: NCI

Interaction Types & Directionality: antagonist (inhibitory)

Interaction Info: Mechanism of Interaction Mineralocorticoid receptor antagonist Direct Interaction yes

PMIDs: 18250364

Sources: ChemblInteractions

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 11486117

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 16044358

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 9192289

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 23688559

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 19205682

Sources: PharmGKB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 14743973

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

TEND: NIMODIPINE

Alternate Names: NIMODIPINE Primary Drug Name

Drug Info: Drug Class antihypertensive agents Drug Class vasodilator agents Year of Approval 1988

Publications:

TdgClinicalTrial: NIMODIPINE

Alternate Names:

Drug Info: Drug Indications Antihypertensive Agents Drug Indications Vasodilator Agents Drug Class small molecule

Publications:

DTC: NIMODIPINE

Alternate Names: CHEMBL1428 ChEMBL Drug ID

Drug Info:

Publications: Yu DD et al., 2013, Development of time resolved fluorescence resonance energy transfer-based assay for FXR antagonist discovery., Bioorg Med Chem

NCI: NIMODIPINE

Alternate Names: C692 NCI drug code

Drug Info:

Interaction Types & Directionality:

blocker (inhibitory)

inhibitor (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Voltage-gated L-type calcium channel blocker

PMIDs:
19205682 19844625 20334460 17705883 8731425 11752352 20335610 20661350

Sources:
ChemblInteractions PharmGKB

Interaction Types & Directionality:

blocker (inhibitory)

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Voltage-gated L-type calcium channel blocker

Direct Interaction yes

PMIDs:
19844625 20334460 17705883 20335610 19029287 20661350

Sources:
ChemblInteractions

Interaction Types & Directionality:

blocker (inhibitory)

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Voltage-gated L-type calcium channel blocker

Direct Interaction yes

PMIDs:
19844625 16675661 20334460 17705883 20335610 20661350

Sources:
ChemblInteractions

Interaction Types & Directionality:

blocker (inhibitory)

inhibitor (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Voltage-gated L-type calcium channel blocker

PMIDs:
20334460 20661350 19844625 20335610

Sources:
ChemblInteractions

Interaction Types & Directionality:

n/a

PMIDs:
8301097

Sources:
NCI

Interaction Types & Directionality:

n/a

Interaction Info:

Novel drug target Established target

Trial Name -

PMIDs:
None found

Sources:
TdgClinicalTrial TEND

Interaction Types & Directionality:

n/a

PMIDs:
7725105

Sources:
NCI

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Mechanism of Interaction Mineralocorticoid receptor antagonist

Direct Interaction yes

PMIDs:
18250364

Sources:
ChemblInteractions

Interaction Types & Directionality:

n/a

PMIDs:
11486117

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
16044358

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
9192289

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
23688559

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
19205682

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
14743973

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Alternate Names:

NIMODIPINE Primary Drug Name

Drug Info:

Drug Class antihypertensive agents

Drug Class vasodilator agents

Year of Approval 1988

Drug Info:

Drug Indications Antihypertensive Agents

Drug Indications Vasodilator Agents

Drug Class small molecule

Alternate Names:

CHEMBL1428 ChEMBL Drug ID

Publications:

Yu DD et al., 2013, Development of time resolved fluorescence resonance energy transfer-based assay for FXR antagonist discovery., Bioorg Med Chem

Alternate Names:

C692 NCI drug code

Publications:

Zhao Y et al., 2009, Effects of CYP3A5, MDR1 and CACNA1C polymorphisms on the oral disposition and response of nimodipine in a Chinese cohort., Eur J Clin Pharmacol

Alternate Names:

D0XN1F TTD Drug ID