DGIdb - NIMESULIDE Drug Record

NIMESULIDE chembl:CHEMBL56367 Approved

Alternate Names:

R-805
AULIN
NIMESULIDE
drugbank:04743
chemidplus:51803-78-2
chembl:CHEMBL56367
rxcui:53694
pubchem.compound:4495

Drug Info:

(0 More Sources)

Publications:

Rainsford et al., 2006, Nimesulide -- a multifactorial approach to inflammation and pain: scientific and clinical consensus., Curr Med Res Opin
Chen et al., 2002, TTD: Therapeutic Target Database., Nucleic Acids Res.
Candelario-Jalil et al., 2007, Post-ischaemic treatment with the cyclooxygenase-2 inhibitor nimesulide reduces blood-brain barrier disruption and leukocyte infiltration following transient focal cerebral ischaemia in rats., J. Neurochem.
Wu et al., 1998, Inhibition of prostaglandin production by nimesulide is accompanied by changes in expression of the cassette of uterine labor-related genes in pregnant sheep., Endocrinology
Sakatis MZ et al., 2012, Preclinical strategy to reduce clinical hepatotoxicity using in vitro bioactivation data for >200 compounds., Chem Res Toxicol
Srivatsa et al., 2003, Does nimesulide induce haemolysis in glucose-6-phosphate dehydrogenase deficiency?, Acta Paediatr.
Karmeli et al., 2000, Cyclo-oxygenase-2 inhibitors ameliorate the severity of experimental colitis in rats., Eur J Gastroenterol Hepatol

NIMESULIDE MPO

Interaction Score: 0.54

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
17176264

Sources:
NCI
NIMESULIDE HSPA4

Interaction Score: 0.33

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
9645681

Sources:
NCI
NIMESULIDE NOS1

Interaction Score: 0.27

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
10741939

Sources:
NCI
NIMESULIDE PTGS2

Interaction Score: 0.19

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

PMIDs:
16846549 11752352

Sources:
PharmGKB
NIMESULIDE G6PD

Interaction Score: 0.15

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
12839301

Sources:
NCI
NIMESULIDE TDP1

Interaction Score: 0.08

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
NIMESULIDE APEX1

Interaction Score: 0.03

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
NIMESULIDE CYP2C9

Interaction Score: 0.02

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
22931300

Sources:
DTC
NIMESULIDE CYP2C19

Interaction Score: 0.02

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
22931300

Sources:
DTC
NIMESULIDE CYP1A2

Interaction Score: 0.02

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
22931300

Sources:
DTC
NIMESULIDE CYP2D6

Interaction Score: 0.02

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
22931300

Sources:
DTC
NIMESULIDE EHMT2

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC

DTC: NIMESULIDE
- Version: 02-September-2020
Alternate Names:

CHEMBL56367 ChEMBL Drug ID

Drug Info:

Publications:

Sakatis MZ et al., 2012, Preclinical strategy to reduce clinical hepatotoxicity using in vitro bioactivation data for >200 compounds., Chem Res Toxicol

NCI: NIMESULIDE

Version: 14-September-2017

Alternate Names:

C29842 NCI drug code

Drug Info:

Publications:

Wu et al., 1998, Inhibition of prostaglandin production by nimesulide is accompanied by changes in expression of the cassette of uterine labor-related genes in pregnant sheep., Endocrinology

Srivatsa et al., 2003, Does nimesulide induce haemolysis in glucose-6-phosphate dehydrogenase deficiency?, Acta Paediatr.

Karmeli et al., 2000, Cyclo-oxygenase-2 inhibitors ameliorate the severity of experimental colitis in rats., Eur J Gastroenterol Hepatol

ChemblDrugs: chembl:CHEMBL56367
- Version: ChEMBL_27
Alternate Names:

Drug Info:

Publications:
PharmGKB: nimesulide
- Version: 18-August-2020
Alternate Names:

Drug Info:

Publications:

NIMESULIDE Drug Record

NIMESULIDE chembl:CHEMBL56367 Approved

Alternate Names:

Drug Info:

Publications:

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 17176264

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 9645681

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 10741939

Sources: NCI

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info:

PMIDs: 16846549 11752352

Sources: PharmGKB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 12839301

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 22931300

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 22931300

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 22931300

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 22931300

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

DTC: NIMESULIDE

Alternate Names: CHEMBL56367 ChEMBL Drug ID

Drug Info:

Publications: Sakatis MZ et al., 2012, Preclinical strategy to reduce clinical hepatotoxicity using in vitro bioactivation data for &gt;200 compounds., Chem Res Toxicol

NCI: NIMESULIDE

Alternate Names: C29842 NCI drug code

Drug Info:

ChemblDrugs: chembl:CHEMBL56367

Alternate Names:

Drug Info:

Publications:

PharmGKB: nimesulide

Alternate Names:

Drug Info:

Publications:

Interaction Types & Directionality:

n/a

PMIDs:
17176264

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
9645681

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
10741939

Sources:
NCI

Interaction Types & Directionality:

inhibitor (inhibitory)

PMIDs:
16846549 11752352

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
12839301

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
22931300

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
22931300

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
22931300

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
22931300

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Alternate Names:

CHEMBL56367 ChEMBL Drug ID

Publications:

Sakatis MZ et al., 2012, Preclinical strategy to reduce clinical hepatotoxicity using in vitro bioactivation data for >200 compounds., Chem Res Toxicol

Alternate Names:

C29842 NCI drug code