DGIdb - NICARDIPINE Drug Record

NICARDIPINE chembl:CHEMBL1484 Approved

Alternate Names:

NICARDIPINE
NICARDIPINO
(R,S)-NICARDIPINE
CARDENE®
NICARDIPINUM
LOX725
pubchem.compound:4474
chemidplus:55985-32-5
drugbank:00622
chembl:CHEMBL1484
rxcui:7396

Drug Info:

FDA Approval	1988
Drug Class	small molecule
Drug Indications	Antihypertensive Agents
Drug Indications	Anti-Arrhythmia Agents
Drug Class	anti-arrhythmia agents
Year of Approval	1988
Drug Class	antihypertensive agents
Drug Categories	calcium channel blockers (dihydropyridine)
Drug Groups	investigational
Drug Categories	adrenergic alpha-1 receptor antagonists
Drug Categories	adrenergic alpha-antagonists
Drug Categories	adrenergic antagonists
Drug Categories	agents causing hyperkalemia
Drug Categories	agents producing tachycardia
Drug Categories	antiarrhythmic agents
Drug Categories	anticholinergic agents
Drug Categories	antihypertensive agents indicated for hypertension
Drug Categories	bradycardia-causing agents
Drug Categories	bsep/abcb11 substrates
Drug Categories	calcium-regulating hormones and agents
Drug Categories	cytochrome p-450 cyp2b6 inducers (strength unknown)
Drug Categories	cytochrome p-450 cyp2c19 inhibitors (strength unknown)
Drug Categories	cytochrome p-450 cyp2c8 inhibitors (moderate)
Drug Categories	cytochrome p-450 cyp2c9 inhibitors (strength unknown)
Drug Categories	cytochrome p-450 cyp3a substrates
Drug Categories	cytochrome p-450 cyp3a4 inhibitors
Drug Categories	cytochrome p-450 cyp3a4 inhibitors (moderate)
Drug Categories	cytochrome p-450 cyp3a5 inhibitors
Drug Categories	cytochrome p-450 cyp3a5 inhibitors (strength unknown)
Drug Categories	cytochrome p-450 enzyme inducers
Drug Categories	cytochrome p-450 enzyme inhibitors
Drug Categories	cytochrome p-450 substrates
Drug Categories	muscarinic antagonists
Drug Categories	oatp1b1/slco1b1 inhibitors
Drug Categories	p-glycoprotein inhibitors
Drug Categories	p-glycoprotein substrates
Drug Categories	potential qtc-prolonging agents
Drug Categories	qtc prolonging agents
Drug Categories	vasodilating agents

(5 More Sources)

Publications:

Chen et al., 2002, TTD: Therapeutic Target Database., Nucleic Acids Res.
Thayer et al., 1983, The interaction of dihydropyridine calcium channel blockers with calmodulin and calmodulin inhibitors., Mol. Pharmacol.
Thayer et al., 1985, Effects of dihydropyridine calcium channel blocking drugs on rat brain muscarinic and alpha-adrenergic receptors., Biochem. Pharmacol.
Tabuchi et al., 2000, Differential activation of brain-derived neurotrophic factor gene promoters I and III by Ca2+ signals evoked via L-type voltage-dependent and N-methyl-D-aspartate receptor Ca2+ channels., J. Biol. Chem.
Kabuto et al., 1991, [Effect of calcium channel antagonist (nicardipine) on growth hormone and prolactin secretion in pituitary adenomas]., No To Shinkei
Bell et al., 2001, Biophysical properties, pharmacology, and modulation of human, neuronal L-type (alpha(1D), Ca(V)1.3) voltage-dependent calcium currents., J. Neurophysiol.
Ikeda et al., 1991, Interleukin-1 suppresses mesangial cell growth via inhibition of Ca2+ entry., Cytokine
Rendic S et al., 1997, Human cytochrome P450 enzymes: a status report summarizing their reactions, substrates, inducers, and inhibitors., Drug Metab Rev
Sharma et al., 1997, Mechanisms of inhibition of calmodulin-stimulated cyclic nucleotide phosphodiesterase by dihydropyridine calcium antagonists., J. Neurochem.

NICARDIPINE PDE1B

Interaction Score: 0.65

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

PMIDs:
9231746

Sources:
DrugBank
NICARDIPINE PDE1A

Interaction Score: 0.44

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

PMIDs:
9231746

Sources:
DrugBank
NICARDIPINE CACNB2

Interaction Score: 0.21

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

PMIDs:
11752352

Sources:
DrugBank
NICARDIPINE CACNA2D1

Interaction Score: 0.18

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

PMIDs:
11752352

Sources:
DrugBank
NICARDIPINE CALM1

Interaction Score: 0.15

Interaction Types & Directionality:

other/unknown

Interaction Info:

PMIDs:
6865927

Sources:
DrugBank
NICARDIPINE CACNA1C

Interaction Score: 0.14

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
11752352

Sources:
TEND TdgClinicalTrial DrugBank
NICARDIPINE PRL

Interaction Score: 0.12

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
1910948

Sources:
NCI
NICARDIPINE CACNA1D

Interaction Score: 0.12

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

PMIDs:
11160515

Sources:
DrugBank
NICARDIPINE IL1B

Interaction Score: 0.08

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
1888883

Sources:
NCI
NICARDIPINE BDNF

Interaction Score: 0.06

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
10748141

Sources:
NCI
NICARDIPINE ADRA1D

Interaction Score: 0.06

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

PMIDs:
2981533

Sources:
DrugBank
NICARDIPINE CHRM4

Interaction Score: 0.05

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

PMIDs:
2981533

Sources:
DrugBank
NICARDIPINE CHRM5

Interaction Score: 0.05

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

PMIDs:
2981533

Sources:
DrugBank
NICARDIPINE ADORA3

Interaction Score: 0.05

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Specific Action of the Ligand Antagonist

Endogenous Drug? False

PMIDs:
None found

Sources:
GuideToPharmacology
NICARDIPINE ADRA1B

Interaction Score: 0.04

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

PMIDs:
2981533

Sources:
DrugBank
NICARDIPINE CHRM2

Interaction Score: 0.03

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

PMIDs:
2981533

Sources:
DrugBank
NICARDIPINE CHRM3

Interaction Score: 0.03

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

PMIDs:
2981533

Sources:
DrugBank
NICARDIPINE CHRM1

Interaction Score: 0.03

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

PMIDs:
2981533

Sources:
DrugBank
NICARDIPINE ADRA1A

Interaction Score: 0.02

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

PMIDs:
2981533

Sources:
DrugBank
NICARDIPINE MTOR

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
NICARDIPINE NR1I2

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
PharmGKB
NICARDIPINE DRD1

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
NICARDIPINE CBX1

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
NICARDIPINE ATXN2

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
NICARDIPINE ABCB1

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
PharmGKB
NICARDIPINE ATAD5

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
NICARDIPINE CYP3A4

Interaction Score: 0.0

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
9187528

Sources:
PharmGKB
NICARDIPINE EHMT2

Interaction Score: 0.0

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
NICARDIPINE AR

Interaction Score: 0.0

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC

DrugBank: DB00622

Version: 5.1.7

Alternate Names:

NICARDIPINE DrugBank Drug Name

55985-32-5 CAS Number

Cardene Drug Brand

Drug Info:

Drug Type small molecule

Drug Groups approved

Drug Groups investigational

Publications:

Thayer et al., 1985, Effects of dihydropyridine calcium channel blocking drugs on rat brain muscarinic and alpha-adrenergic receptors., Biochem. Pharmacol.

Chen et al., 2002, TTD: Therapeutic Target Database., Nucleic Acids Res.

Sharma et al., 1997, Mechanisms of inhibition of calmodulin-stimulated cyclic nucleotide phosphodiesterase by dihydropyridine calcium antagonists., J. Neurochem.

TEND: NICARDIPINE
- Version: 01-August-2011
Alternate Names:

NICARDIPINE Primary Drug Name

Drug Info:

Drug Class antihypertensive agents

Year of Approval 1988

Drug Class anti-arrhythmia agents

Publications:
TdgClinicalTrial: NICARDIPINE
- Version: January-2014
Alternate Names:

Drug Info:

Drug Indications Anti-Arrhythmia Agents

Drug Indications Antihypertensive Agents

Drug Class small molecule

Publications:

NCI: NICARDIPINE

Version: 14-September-2017

Alternate Names:

C29840 NCI drug code

Drug Info:

Publications:

Tabuchi et al., 2000, Differential activation of brain-derived neurotrophic factor gene promoters I and III by Ca2+ signals evoked via L-type voltage-dependent and N-methyl-D-aspartate receptor Ca2+ channels., J. Biol. Chem.

Kabuto et al., 1991, [Effect of calcium channel antagonist (nicardipine) on growth hormone and prolactin secretion in pituitary adenomas]., No To Shinkei

Ikeda et al., 1991, Interleukin-1 suppresses mesangial cell growth via inhibition of Ca2+ entry., Cytokine

PharmGKB: nicardipine
- Version: 18-August-2020
Alternate Names:

Drug Info:

Publications:

Rendic S et al., 1997, Human cytochrome P450 enzymes: a status report summarizing their reactions, substrates, inducers, and inhibitors., Drug Metab Rev
DTC: NICARDIPINE
- Version: 02-September-2020
Alternate Names:

CHEMBL1484 ChEMBL Drug ID

Drug Info:

Publications:
TTD: Nicardipine
- Version: 2020.06.01
Alternate Names:

D0T0KA TTD Drug ID

Drug Info:

Publications:
GuideToPharmacology: 135650714
- Version: 29-September-2020
Alternate Names:

NICARDIPINE GuideToPharmacology Ligand Name

Drug Info:

Publications:
ChemblDrugs: chembl:CHEMBL1484
- Version: ChEMBL_27
Alternate Names:

Drug Info:

Publications:

Specific Action of the Ligand	Antagonist
Endogenous Drug?	False

NICARDIPINE	DrugBank Drug Name
55985-32-5	CAS Number
Cardene	Drug Brand

Drug Type	small molecule
Drug Groups	approved
Drug Groups	investigational

Trial Name	-
Novel drug target	Established target

NICARDIPINE Drug Record

NICARDIPINE chembl:CHEMBL1484 Approved

Alternate Names:

Drug Info:

Publications:

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info:

PMIDs: 9231746

Sources: DrugBank

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info:

PMIDs: 9231746

Sources: DrugBank

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info:

PMIDs: 11752352

Sources: DrugBank

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info:

PMIDs: 11752352

Sources: DrugBank

Interaction Types & Directionality: other/unknown

Interaction Info:

PMIDs: 6865927

Sources: DrugBank

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Trial Name - Novel drug target Established target

PMIDs: 11752352

Sources: TEND TdgClinicalTrial DrugBank

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 1910948

Sources: NCI

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info:

PMIDs: 11160515

Sources: DrugBank

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 1888883

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 10748141

Sources: NCI

Interaction Types & Directionality: antagonist (inhibitory)

Interaction Info:

PMIDs: 2981533

Sources: DrugBank

Interaction Types & Directionality: antagonist (inhibitory)

Interaction Info:

PMIDs: 2981533

Sources: DrugBank

Interaction Types & Directionality: antagonist (inhibitory)

Interaction Info:

PMIDs: 2981533

Sources: DrugBank

Interaction Types & Directionality: antagonist (inhibitory)

Interaction Info: Specific Action of the Ligand Antagonist Endogenous Drug? False

PMIDs: None found

Sources: GuideToPharmacology

Interaction Types & Directionality: antagonist (inhibitory)

Interaction Info:

PMIDs: 2981533

Sources: DrugBank

Interaction Types & Directionality: antagonist (inhibitory)

Interaction Info:

PMIDs: 2981533

Sources: DrugBank

Interaction Types & Directionality: antagonist (inhibitory)

Interaction Info:

PMIDs: 2981533

Sources: DrugBank

Interaction Types & Directionality: antagonist (inhibitory)

Interaction Info:

PMIDs: 2981533

Sources: DrugBank

Interaction Types & Directionality: antagonist (inhibitory)

Interaction Info:

PMIDs: 2981533

Interaction Types & Directionality:

inhibitor (inhibitory)

PMIDs:
9231746

Sources:
DrugBank

Interaction Types & Directionality:

inhibitor (inhibitory)

PMIDs:
9231746

Sources:
DrugBank

Interaction Types & Directionality:

inhibitor (inhibitory)

PMIDs:
11752352

Sources:
DrugBank

Interaction Types & Directionality:

inhibitor (inhibitory)

PMIDs:
11752352

Sources:
DrugBank

Interaction Types & Directionality:

other/unknown

PMIDs:
6865927

Sources:
DrugBank

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
11752352

Sources:
TEND TdgClinicalTrial DrugBank

Interaction Types & Directionality:

n/a

PMIDs:
1910948

Sources:
NCI

Interaction Types & Directionality:

inhibitor (inhibitory)

PMIDs:
11160515

Sources:
DrugBank

Interaction Types & Directionality:

n/a

PMIDs:
1888883

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
10748141

Sources:
NCI

Interaction Types & Directionality:

antagonist (inhibitory)

PMIDs:
2981533

Sources:
DrugBank

Interaction Types & Directionality:

antagonist (inhibitory)

PMIDs:
2981533

Sources:
DrugBank

Interaction Types & Directionality:

antagonist (inhibitory)

PMIDs:
2981533

Sources:
DrugBank

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Specific Action of the Ligand Antagonist

Endogenous Drug? False

PMIDs:
None found

Sources:
GuideToPharmacology

Interaction Types & Directionality:

antagonist (inhibitory)

PMIDs:
2981533

Sources:
DrugBank

Interaction Types & Directionality:

antagonist (inhibitory)

PMIDs:
2981533

Sources:
DrugBank

Interaction Types & Directionality:

antagonist (inhibitory)

PMIDs:
2981533

Sources:
DrugBank

Interaction Types & Directionality:

antagonist (inhibitory)

PMIDs:
2981533

Sources:
DrugBank

Interaction Types & Directionality:

antagonist (inhibitory)

PMIDs:
2981533

Sources:
DrugBank

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC