DGIdb - NICARDIPINE Drug Record

NICARDIPINE chembl:CHEMBL1484 Approved

Alternate Names:

NICARDIPINE
NICARDIPINO
(R,S)-NICARDIPINE
CARDENE®
NICARDIPINUM
LOX725
pubchem.compound:4474
chemidplus:55985-32-5
drugbank:00622
chembl:CHEMBL1484
rxcui:7396

Drug Info:

FDA Approval	1988
Drug Class	small molecule
Drug Indications	Antihypertensive Agents
Drug Indications	Anti-Arrhythmia Agents
Drug Class	anti-arrhythmia agents
Year of Approval	1988
Drug Class	antihypertensive agents

(4 More Sources)

Publications:

Chen et al., 2002, TTD: Therapeutic Target Database., Nucleic Acids Res.
Tabuchi et al., 2000, Differential activation of brain-derived neurotrophic factor gene promoters I and III by Ca2+ signals evoked via L-type voltage-dependent and N-methyl-D-aspartate receptor Ca2+ channels., J. Biol. Chem.
Kabuto et al., 1991, [Effect of calcium channel antagonist (nicardipine) on growth hormone and prolactin secretion in pituitary adenomas]., No To Shinkei
Ikeda et al., 1991, Interleukin-1 suppresses mesangial cell growth via inhibition of Ca2+ entry., Cytokine
Rendic S et al., 1997, Human cytochrome P450 enzymes: a status report summarizing their reactions, substrates, inducers, and inhibitors., Drug Metab Rev

NICARDIPINE CACNA1C

Interaction Score: 0.38

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
11752352

Sources:
TdgClinicalTrial TEND
NICARDIPINE PRL

Interaction Score: 0.26

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
1910948

Sources:
NCI
NICARDIPINE IL1B

Interaction Score: 0.23

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
1888883

Sources:
NCI
NICARDIPINE BDNF

Interaction Score: 0.13

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
10748141

Sources:
NCI
NICARDIPINE ADORA3

Interaction Score: 0.11

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Specific Action of the Ligand Antagonist

Endogenous Drug? False

PMIDs:
None found

Sources:
GuideToPharmacology
NICARDIPINE NR1I2

Interaction Score: 0.04

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
PharmGKB
NICARDIPINE MTOR

Interaction Score: 0.03

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
NICARDIPINE DRD1

Interaction Score: 0.03

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
NICARDIPINE CBX1

Interaction Score: 0.02

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
NICARDIPINE ABCB1

Interaction Score: 0.02

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
PharmGKB
NICARDIPINE ATXN2

Interaction Score: 0.02

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
NICARDIPINE ATAD5

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
NICARDIPINE CYP3A4

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
9187528

Sources:
PharmGKB
NICARDIPINE EHMT2

Interaction Score: 0.0

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
NICARDIPINE AR

Interaction Score: 0.0

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC

TEND: NICARDIPINE
- Version: 01-August-2011
Alternate Names:

NICARDIPINE Primary Drug Name

Drug Info:

Drug Class antihypertensive agents

Year of Approval 1988

Drug Class anti-arrhythmia agents

Publications:
TdgClinicalTrial: NICARDIPINE
- Version: January-2014
Alternate Names:

Drug Info:

Drug Indications Anti-Arrhythmia Agents

Drug Indications Antihypertensive Agents

Drug Class small molecule

Publications:

NCI: NICARDIPINE

Version: 14-September-2017

Alternate Names:

C29840 NCI drug code

Drug Info:

Publications:

Tabuchi et al., 2000, Differential activation of brain-derived neurotrophic factor gene promoters I and III by Ca2+ signals evoked via L-type voltage-dependent and N-methyl-D-aspartate receptor Ca2+ channels., J. Biol. Chem.

Kabuto et al., 1991, [Effect of calcium channel antagonist (nicardipine) on growth hormone and prolactin secretion in pituitary adenomas]., No To Shinkei

Ikeda et al., 1991, Interleukin-1 suppresses mesangial cell growth via inhibition of Ca2+ entry., Cytokine

PharmGKB: nicardipine
- Version: 18-August-2020
Alternate Names:

Drug Info:

Publications:

Rendic S et al., 1997, Human cytochrome P450 enzymes: a status report summarizing their reactions, substrates, inducers, and inhibitors., Drug Metab Rev
DTC: NICARDIPINE
- Version: 02-September-2020
Alternate Names:

CHEMBL1484 ChEMBL Drug ID

Drug Info:

Publications:
TTD: Nicardipine
- Version: 2020.06.01
Alternate Names:

D0T0KA TTD Drug ID

Drug Info:

Publications:
GuideToPharmacology: 135650714
- Version: 29-September-2020
Alternate Names:

NICARDIPINE GuideToPharmacology Ligand Name

Drug Info:

Publications:
ChemblDrugs: chembl:CHEMBL1484
- Version: ChEMBL_27
Alternate Names:

Drug Info:

Publications:

Specific Action of the Ligand	Antagonist
Endogenous Drug?	False

Trial Name	-
Novel drug target	Established target

NICARDIPINE Drug Record

NICARDIPINE chembl:CHEMBL1484 Approved

Alternate Names:

Drug Info:

Publications:

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Trial Name - Novel drug target Established target

PMIDs: 11752352

Sources: TdgClinicalTrial TEND

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 1910948

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 1888883

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 10748141

Sources: NCI

Interaction Types & Directionality: antagonist (inhibitory)

Interaction Info: Specific Action of the Ligand Antagonist Endogenous Drug? False

PMIDs: None found

Sources: GuideToPharmacology

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: PharmGKB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: PharmGKB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 9187528

Sources: PharmGKB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

TEND: NICARDIPINE

Alternate Names: NICARDIPINE Primary Drug Name

Drug Info: Drug Class antihypertensive agents Year of Approval 1988 Drug Class anti-arrhythmia agents

Publications:

TdgClinicalTrial: NICARDIPINE

Alternate Names:

Drug Info: Drug Indications Anti-Arrhythmia Agents Drug Indications Antihypertensive Agents Drug Class small molecule

Publications:

NCI: NICARDIPINE

Alternate Names: C29840 NCI drug code

Drug Info:

PharmGKB: nicardipine

Alternate Names:

Drug Info:

Publications: Rendic S et al., 1997, Human cytochrome P450 enzymes: a status report summarizing their reactions, substrates, inducers, and inhibitors., Drug Metab Rev

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
11752352

Sources:
TdgClinicalTrial TEND

Interaction Types & Directionality:

n/a

PMIDs:
1910948

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
1888883

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
10748141

Sources:
NCI

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Specific Action of the Ligand Antagonist

Endogenous Drug? False

PMIDs:
None found

Sources:
GuideToPharmacology

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
9187528

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Alternate Names:

NICARDIPINE Primary Drug Name

Drug Info:

Drug Class antihypertensive agents

Year of Approval 1988

Drug Class anti-arrhythmia agents

Drug Info:

Drug Indications Anti-Arrhythmia Agents

Drug Indications Antihypertensive Agents

Drug Class small molecule

Alternate Names:

C29840 NCI drug code

Publications:

Rendic S et al., 1997, Human cytochrome P450 enzymes: a status report summarizing their reactions, substrates, inducers, and inhibitors., Drug Metab Rev

Alternate Names:

CHEMBL1484 ChEMBL Drug ID

Alternate Names:

D0T0KA TTD Drug ID

Alternate Names:

NICARDIPINE GuideToPharmacology Ligand Name