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NICARDIPINE Drug Record

  • Summary
  • Interactions
  • Claims
  • NICARDIPINE chembl:CHEMBL1484 Approved

    Alternate Names:

    NICARDIPINE
    NICARDIPINO
    (R,S)-NICARDIPINE
    CARDENE®
    NICARDIPINUM
    LOX725
    pubchem.compound:4474
    chemidplus:55985-32-5
    drugbank:00622
    chembl:CHEMBL1484
    rxcui:7396

    Drug Info:

    FDA Approval 1988
    Drug Class small molecule
    Drug Indications Antihypertensive Agents
    Drug Indications Anti-Arrhythmia Agents
    Drug Class anti-arrhythmia agents
    Year of Approval 1988
    Drug Class antihypertensive agents
    Drug Categories calcium channel blockers (dihydropyridine)
    Drug Groups investigational
    Drug Categories adrenergic alpha-1 receptor antagonists
    Drug Categories adrenergic alpha-antagonists
    Drug Categories adrenergic antagonists
    Drug Categories agents causing hyperkalemia
    Drug Categories agents producing tachycardia
    Drug Categories antiarrhythmic agents
    Drug Categories anticholinergic agents
    Drug Categories antihypertensive agents indicated for hypertension
    Drug Categories bradycardia-causing agents
    Drug Categories bsep/abcb11 substrates
    Drug Categories calcium-regulating hormones and agents
    Drug Categories cytochrome p-450 cyp2b6 inducers (strength unknown)
    Drug Categories cytochrome p-450 cyp2c19 inhibitors (strength unknown)
    Drug Categories cytochrome p-450 cyp2c8 inhibitors (moderate)
    Drug Categories cytochrome p-450 cyp2c9 inhibitors (strength unknown)
    Drug Categories cytochrome p-450 cyp3a substrates
    Drug Categories cytochrome p-450 cyp3a4 inhibitors
    Drug Categories cytochrome p-450 cyp3a4 inhibitors (moderate)
    Drug Categories cytochrome p-450 cyp3a5 inhibitors
    Drug Categories cytochrome p-450 cyp3a5 inhibitors (strength unknown)
    Drug Categories cytochrome p-450 enzyme inducers
    Drug Categories cytochrome p-450 enzyme inhibitors
    Drug Categories cytochrome p-450 substrates
    Drug Categories muscarinic antagonists
    Drug Categories oatp1b1/slco1b1 inhibitors
    Drug Categories p-glycoprotein inhibitors
    Drug Categories p-glycoprotein substrates
    Drug Categories potential qtc-prolonging agents
    Drug Categories qtc prolonging agents
    Drug Categories vasodilating agents
    (5 More Sources)

    Publications:

    Chen et al., 2002, TTD: Therapeutic Target Database., Nucleic Acids Res.
    Thayer et al., 1983, The interaction of dihydropyridine calcium channel blockers with calmodulin and calmodulin inhibitors., Mol. Pharmacol.
    Thayer et al., 1985, Effects of dihydropyridine calcium channel blocking drugs on rat brain muscarinic and alpha-adrenergic receptors., Biochem. Pharmacol.
    Tabuchi et al., 2000, Differential activation of brain-derived neurotrophic factor gene promoters I and III by Ca2+ signals evoked via L-type voltage-dependent and N-methyl-D-aspartate receptor Ca2+ channels., J. Biol. Chem.
    Kabuto et al., 1991, [Effect of calcium channel antagonist (nicardipine) on growth hormone and prolactin secretion in pituitary adenomas]., No To Shinkei
    Bell et al., 2001, Biophysical properties, pharmacology, and modulation of human, neuronal L-type (alpha(1D), Ca(V)1.3) voltage-dependent calcium currents., J. Neurophysiol.
    Ikeda et al., 1991, Interleukin-1 suppresses mesangial cell growth via inhibition of Ca2+ entry., Cytokine
    Rendic S et al., 1997, Human cytochrome P450 enzymes: a status report summarizing their reactions, substrates, inducers, and inhibitors., Drug Metab Rev
    Sharma et al., 1997, Mechanisms of inhibition of calmodulin-stimulated cyclic nucleotide phosphodiesterase by dihydropyridine calcium antagonists., J. Neurochem.
  • NICARDIPINE   PDE1B

    Interaction Score: 0.65

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:

    PMIDs:
    9231746


    Sources:
    DrugBank

  • NICARDIPINE   PDE1A

    Interaction Score: 0.44

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:

    PMIDs:
    9231746


    Sources:
    DrugBank

  • NICARDIPINE   CACNB2

    Interaction Score: 0.21

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:

    PMIDs:
    11752352


    Sources:
    DrugBank

  • NICARDIPINE   CACNA2D1

    Interaction Score: 0.18

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:

    PMIDs:
    11752352


    Sources:
    DrugBank

  • NICARDIPINE   CALM1

    Interaction Score: 0.15

    Interaction Types & Directionality:
    other/unknown

    Interaction Info:

    PMIDs:
    6865927


    Sources:
    DrugBank

  • NICARDIPINE   CACNA1C

    Interaction Score: 0.14

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Trial Name -
    Novel drug target Established target

    PMIDs:
    11752352


    Sources:
    TEND TdgClinicalTrial DrugBank

  • NICARDIPINE   PRL

    Interaction Score: 0.12

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    1910948


    Sources:
    NCI

  • NICARDIPINE   CACNA1D

    Interaction Score: 0.12

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:

    PMIDs:
    11160515


    Sources:
    DrugBank

  • NICARDIPINE   IL1B

    Interaction Score: 0.08

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    1888883


    Sources:
    NCI

  • NICARDIPINE   BDNF

    Interaction Score: 0.06

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    10748141


    Sources:
    NCI

  • NICARDIPINE   ADRA1D

    Interaction Score: 0.06

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:

    PMIDs:
    2981533


    Sources:
    DrugBank

  • NICARDIPINE   CHRM4

    Interaction Score: 0.05

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:

    PMIDs:
    2981533


    Sources:
    DrugBank

  • NICARDIPINE   CHRM5

    Interaction Score: 0.05

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:

    PMIDs:
    2981533


    Sources:
    DrugBank

  • NICARDIPINE   ADORA3

    Interaction Score: 0.05

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Specific Action of the Ligand Antagonist
    Endogenous Drug? False

    PMIDs:
    None found


    Sources:
    GuideToPharmacology

  • NICARDIPINE   ADRA1B

    Interaction Score: 0.04

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:

    PMIDs:
    2981533


    Sources:
    DrugBank

  • NICARDIPINE   CHRM2

    Interaction Score: 0.03

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:

    PMIDs:
    2981533


    Sources:
    DrugBank

  • NICARDIPINE   CHRM3

    Interaction Score: 0.03

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:

    PMIDs:
    2981533


    Sources:
    DrugBank

  • NICARDIPINE   CHRM1

    Interaction Score: 0.03

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:

    PMIDs:
    2981533


    Sources:
    DrugBank

  • NICARDIPINE   ADRA1A

    Interaction Score: 0.02

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:

    PMIDs:
    2981533


    Sources:
    DrugBank

  • NICARDIPINE   MTOR

    Interaction Score: 0.01

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • NICARDIPINE   NR1I2

    Interaction Score: 0.01

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    PharmGKB

  • NICARDIPINE   DRD1

    Interaction Score: 0.01

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • NICARDIPINE   CBX1

    Interaction Score: 0.01

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • NICARDIPINE   ATXN2

    Interaction Score: 0.01

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • NICARDIPINE   ABCB1

    Interaction Score: 0.01

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    PharmGKB

  • NICARDIPINE   ATAD5

    Interaction Score: 0.01

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • NICARDIPINE   CYP3A4

    Interaction Score: 0.0

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    9187528


    Sources:
    PharmGKB

  • NICARDIPINE   EHMT2

    Interaction Score: 0.0

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • NICARDIPINE   AR

    Interaction Score: 0.0

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • DrugBank: DB00622

    • Version: 5.1.7

    Alternate Names:
    NICARDIPINE DrugBank Drug Name
    55985-32-5 CAS Number
    Cardene Drug Brand

    Drug Info:
    Drug Type small molecule
    Drug Groups approved
    Drug Groups investigational

    Publications:
    Thayer et al., 1985, Effects of dihydropyridine calcium channel blocking drugs on rat brain muscarinic and alpha-adrenergic receptors., Biochem. Pharmacol.
    Chen et al., 2002, TTD: Therapeutic Target Database., Nucleic Acids Res.
    Sharma et al., 1997, Mechanisms of inhibition of calmodulin-stimulated cyclic nucleotide phosphodiesterase by dihydropyridine calcium antagonists., J. Neurochem.

  • TEND: NICARDIPINE

    • Version: 01-August-2011

    Alternate Names:
    NICARDIPINE Primary Drug Name

    Drug Info:
    Drug Class antihypertensive agents
    Year of Approval 1988
    Drug Class anti-arrhythmia agents

    Publications:

  • TdgClinicalTrial: NICARDIPINE

    • Version: January-2014

    Alternate Names:

    Drug Info:
    Drug Indications Anti-Arrhythmia Agents
    Drug Indications Antihypertensive Agents
    Drug Class small molecule

    Publications:

  • NCI: NICARDIPINE

    • Version: 14-September-2017

    Alternate Names:
    C29840 NCI drug code

    Drug Info:

    Publications:
    Tabuchi et al., 2000, Differential activation of brain-derived neurotrophic factor gene promoters I and III by Ca2+ signals evoked via L-type voltage-dependent and N-methyl-D-aspartate receptor Ca2+ channels., J. Biol. Chem.
    Kabuto et al., 1991, [Effect of calcium channel antagonist (nicardipine) on growth hormone and prolactin secretion in pituitary adenomas]., No To Shinkei
    Ikeda et al., 1991, Interleukin-1 suppresses mesangial cell growth via inhibition of Ca2+ entry., Cytokine

  • PharmGKB: nicardipine

    • Version: 18-August-2020

    Alternate Names:

    Drug Info:

    Publications:
    Rendic S et al., 1997, Human cytochrome P450 enzymes: a status report summarizing their reactions, substrates, inducers, and inhibitors., Drug Metab Rev

  • DTC: NICARDIPINE

    • Version: 02-September-2020

    Alternate Names:
    CHEMBL1484 ChEMBL Drug ID

    Drug Info:

    Publications:

  • TTD: Nicardipine

    • Version: 2020.06.01

    Alternate Names:
    D0T0KA TTD Drug ID

    Drug Info:

    Publications:

  • GuideToPharmacology: 135650714

    • Version: 29-September-2020

    Alternate Names:
    NICARDIPINE GuideToPharmacology Ligand Name

    Drug Info:

    Publications:

  • ChemblDrugs: chembl:CHEMBL1484

    • Version: ChEMBL_27

    Alternate Names:

    Drug Info:

    Publications:

Disclaimer: This resource is intended for purely research purposes. It should not be used for emergencies or medical or professional advice.

A finding of a drug-gene interaction or potentially druggable category does not necessarily indicate effectiveness (or lack thereof) of any drug or treatment regimen. A finding of no interaction or no potentially druggable category does not necessarily indicate lack of effectiveness of any drug or treatment regimen. Drug-gene interactions or potentially druggable categories are not presented in ranked order of potential or predicted efficacy.

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DGIdb (v4.2.0 - sha1 afd9f30b) • Last updated 2020-10-21