DGIdb - MIVACURIUM Drug Record

MIVACURIUM chembl:CHEMBL1182833 Approved

Alternate Names:

BW B109OU
BW-B109OU
MIVACURIUM
BWB109OU
MIVACRON®
chemidplus:133814-19-4
pubchem.compound:5281042
rxcui:30077
drugbank:01226
chembl:CHEMBL1182833

Drug Info:

Year of Approval	1992
Drug Class	muscle relaxants
FDA Approval	1992
Drug Class	small molecule
Drug Indications	Muscle Relaxants

(2 More Sources)

Publications:

Jonsson Fagerlund et al., 2009, Pharmacological characteristics of the inhibition of nondepolarizing neuromuscular blocking agents at human adult muscle nicotinic acetylcholine receptor., Anesthesiology
Ihmsen et al., 2009, Influence of disease progression on the neuromuscular blocking effect of mivacurium in children and adolescents with Duchenne muscular dystrophy., Anesthesiology
Jonsson et al., 2006, Distinct pharmacologic properties of neuromuscular blocking agents on human neuronal nicotinic acetylcholine receptors: a possible explanation for the train-of-four fade., Anesthesiology
Chen et al., 2002, TTD: Therapeutic Target Database., Nucleic Acids Res.
Imming et al., 2006, Drugs, their targets and the nature and number of drug targets., Nat Rev Drug Discov
Overington et al., 2006, How many drug targets are there?, Nat Rev Drug Discov
Wichmann S et al., 2016, Patients with prolonged effect of succinylcholine or mivacurium had novel mutations in the butyrylcholinesterase gene., Pharmacogenet Genomics
Kao et al., 1996, The reversal of profound mivacurium-induced neuromuscular blockade., Can J Anaesth
Hou et al., 1998, Neuromuscular relaxants as antagonists for M2 and M3 muscarinic receptors., Anesthesiology

MIVACURIUM CHRNA2

Interaction Score: 10.3

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
19417616 19352159 16931985 11752352 17016423 17139284

Sources:
TdgClinicalTrial TEND TTD
MIVACURIUM BCHE

Interaction Score: 4.85

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
27031121 8922768

Sources:
PharmGKB FDA
MIVACURIUM CHRM2

Interaction Score: 2.02

Interaction Types & Directionality:

partial agonist (activating)

antagonist (inhibitory)

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
17016423 17139284 9523819

Sources:
TdgClinicalTrial TEND

TEND: MIVACURIUM
- Version: 01-August-2011
Alternate Names:

MIVACURIUM Primary Drug Name

Drug Info:

Drug Class muscle relaxants

Year of Approval 1992

Publications:
TdgClinicalTrial: MIVACURIUM
- Version: January-2014
Alternate Names:

Drug Info:

Drug Indications Muscle Relaxants

Drug Class small molecule

FDA Approval 1992

Publications:
PharmGKB: mivacurium
- Version: 18-August-2020
Alternate Names:

Drug Info:

Publications:

Wichmann S et al., 2016, Patients with prolonged effect of succinylcholine or mivacurium had novel mutations in the butyrylcholinesterase gene., Pharmacogenet Genomics
TTD: Mivacurium
- Version: 2020.06.01
Alternate Names:

D0OB2M TTD Drug ID

Drug Info:

Publications:
ChemblDrugs: chembl:CHEMBL1182833
- Version: ChEMBL_27
Alternate Names:

Drug Info:

Publications:
FDA: Mivacurium
- Version: 04-September-2020
Alternate Names:

Drug Info:

Publications:

Trial Name	-
Novel drug target	Established target

partial agonist (activating)
antagonist (inhibitory)

Trial Name	-
Novel drug target	Established target

MIVACURIUM Drug Record

MIVACURIUM chembl:CHEMBL1182833 Approved

Alternate Names:

Drug Info:

Publications:

MIVACURIUM CHRNA2

Interaction Types & Directionality: antagonist (inhibitory)

Interaction Info: Trial Name - Novel drug target Established target

PMIDs: 19417616 19352159 16931985 11752352 17016423 17139284

Sources: TdgClinicalTrial TEND TTD

MIVACURIUM BCHE

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 27031121 8922768

Sources: PharmGKB FDA

MIVACURIUM CHRM2

Interaction Types & Directionality: partial agonist (activating) antagonist (inhibitory)

Interaction Info: Trial Name - Novel drug target Established target

PMIDs: 17016423 17139284 9523819

Sources: TdgClinicalTrial TEND

TEND: MIVACURIUM

Alternate Names: MIVACURIUM Primary Drug Name

Drug Info: Drug Class muscle relaxants Year of Approval 1992

Publications:

TdgClinicalTrial: MIVACURIUM

Alternate Names:

Drug Info: Drug Indications Muscle Relaxants Drug Class small molecule FDA Approval 1992

Publications:

PharmGKB: mivacurium

Alternate Names:

Drug Info:

Publications: Wichmann S et al., 2016, Patients with prolonged effect of succinylcholine or mivacurium had novel mutations in the butyrylcholinesterase gene., Pharmacogenet Genomics

TTD: Mivacurium

Alternate Names: D0OB2M TTD Drug ID

Drug Info:

Publications:

ChemblDrugs: chembl:CHEMBL1182833

Alternate Names:

Drug Info:

Publications:

FDA: Mivacurium

Alternate Names:

Drug Info:

Publications:

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
19417616 19352159 16931985 11752352 17016423 17139284

Sources:
TdgClinicalTrial TEND TTD

Interaction Types & Directionality:

n/a

PMIDs:
27031121 8922768

Sources:
PharmGKB FDA

Interaction Types & Directionality:

partial agonist (activating)

antagonist (inhibitory)

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
17016423 17139284 9523819

Sources:
TdgClinicalTrial TEND

Alternate Names:

MIVACURIUM Primary Drug Name

Drug Info:

Drug Class muscle relaxants

Year of Approval 1992

Drug Info:

Drug Indications Muscle Relaxants

Drug Class small molecule

FDA Approval 1992

Publications:

Wichmann S et al., 2016, Patients with prolonged effect of succinylcholine or mivacurium had novel mutations in the butyrylcholinesterase gene., Pharmacogenet Genomics

Alternate Names:

D0OB2M TTD Drug ID