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MIRTAZAPINE Drug Record

  • Summary
  • Interactions
  • Claims
  • MIRTAZAPINE chembl:CHEMBL654 Approved

    Alternate Names:

    MIRTAZAPINE
    REMERON
    REMERON SOLTAB
    ORG-3770
    ZISPIN
    1,2,3,4,10,14B-HEXAHYDRO-2-METHYLPYRAZINO(2,1-A)PYRIDO(2,3-C)BENZAZEPINE
    6-AZAMIANSERIN
    MEPIRZAPINE
    MIRTAZAPINA
    MIRTAZAPIN
    REMERON®
    MIRTAZAPINUM
    2-METHYL-1,2,3,4,10,14B-HEXAHYDROPYRAZINO[2,1-A]PYRIDO[2,3-C][2]BENZAZEPINE
    chemidplus:85650-52-8
    pubchem.compound:4205
    chemidplus:61337-67-5
    chembl:CHEMBL654
    rxcui:15996
    drugbank:00370

    Drug Info:

    FDA Approval approved
    Drug Class Small Molecule
    Drug Indications antidepressant
    Drug Class antidepressive agents, tricyclic
    Year of Approval 1996
    Drug Categories adrenergic alpha-2 receptor antagonists
    Drug Categories agents that produce hypertension
    Drug Categories anti-anxiety agents
    Drug Categories antidepressive agents, tetracyclic
    Drug Categories cytochrome p-450 cyp3a substrates
    Drug Categories cytochrome p-450 cyp3a4 inhibitors
    Drug Categories cytochrome p-450 cyp3a4 inhibitors (weak)
    Drug Categories cytochrome p-450 enzyme inhibitors
    Drug Categories cytochrome p-450 substrates
    Drug Categories heterocyclic compounds, fused-ring
    Drug Categories miscellaneous antidepressants
    Drug Categories potential qtc-prolonging agents
    Drug Categories qtc prolonging agents
    Drug Categories serotonergic drugs shown to increase risk of serotonin syndrome
    Drug Categories serotonin 5-ht2 receptor antagonists
    Drug Categories serotonin 5-ht3 receptor antagonists
    Drug Categories serotonin agents
    Drug Categories serotonin receptor antagonists
    Drug Categories tranquilizing agents
    (6 More Sources)

    Publications:

    Kraus et al., 2002, Body weight, the tumor necrosis factor system, and leptin production during treatment with mirtazapine or venlafaxine., Pharmacopsychiatry
    Millan et al., 2000, Mirtazapine enhances frontocortical dopaminergic and corticolimbic adrenergic, but not serotonergic, transmission by blockade of alpha2-adrenergic and serotonin2C receptors: a comparison with citalopram., Eur. J. Neurosci.
    Nutt D, 1997, Mirtazapine: pharmacology in relation to adverse effects., Acta Psychiatr Scand Suppl
    Fernández et al., 2005, Discovery of new tetracyclic tetrahydrofuran derivatives as potential broad-spectrum psychotropic agents., J. Med. Chem.
    Wikström et al., 2002, Synthesis and pharmacological testing of 1,2,3,4,10,14b-hexahydro-6-methoxy-2-methyldibenzo[c,f]pyrazino[1,2-a]azepin and its enantiomers in comparison with the two antidepressants mianserin and mirtazapine., J. Med. Chem.
    de Boer et al., 1988, Neurochemical and autonomic pharmacological profiles of the 6-aza-analogue of mianserin, Org 3770 and its enantiomers., Neuropharmacology
    Kast et al., 2007, Cancer chemotherapy and cachexia: mirtazapine and olanzapine are 5-HT3 antagonists with good antinausea effects., Eur J Cancer Care (Engl)
    Anttila et al., 2001, A review of the pharmacological and clinical profile of mirtazapine., CNS Drug Rev
    Gorman, 1999, Mirtazapine: clinical overview., J Clin Psychiatry
    de Boer, 1995, The effects of mirtazapine on central noradrenergic and serotonergic neurotransmission., Int Clin Psychopharmacol
    Chen et al., 2002, TTD: Therapeutic Target Database., Nucleic Acids Res.
    Westenberg, 1999, Pharmacology of antidepressants: selectivity or multiplicity?, J Clin Psychiatry
    Schreiber et al., Venlafaxine and mirtazapine: different mechanisms of antidepressant action, common opioid-mediated antinociceptive effects--a possible opioid involvement in severe depression?, J. Mol. Neurosci.
    Haddjeri N et al., 1997, Effects of long-term treatment with the alpha 2-adrenoceptor antagonist mirtazapine on 5-HT neurotransmission., Naunyn Schmiedebergs Arch Pharmacol
    Rogóz et al., Effect of repeated treatment with mirtazapine on the central dopaminergic D2/D3 receptors., Pol J Pharmacol
    García-Sevilla et al., 2004, Regulation of platelet alpha 2A-adrenoceptors, Gi proteins and receptor kinases in major depression: effects of mirtazapine treatment., Neuropsychopharmacology
    Lee HY et al., 2009, Association of the adrenergic alpha 2a receptor--1291C/G polymorphism with weight change and treatment response to mirtazapine in patients with major depressive disorder., Brain Res
    Rogoz et al., 2002, Effect of repeated treatment with mirtazapine on the central alpha1-adrenergic receptors., J. Physiol. Pharmacol.
    Besson et al., 2000, Effects of the co-administration of mirtazapine and paroxetine on serotonergic neurotransmission in the rat brain., Eur Neuropsychopharmacol
    Pawlyk AC et al., 2006, Effects of the 5-HT2A antagonist mirtazapine in rat models of thermoregulation., Brain Res
    Celada P et al., 2004, The therapeutic role of 5-HT1A and 5-HT2A receptors in depression., J Psychiatry Neurosci
    Nutt, 1999, Care of depressed patients with anxiety symptoms., J Clin Psychiatry
    Waldinger et al., 2000, Treatment of hot flushes with mirtazapine: four case reports., Maturitas
    Laakmann et al., 1999, Effects of mirtazapine on growth hormone, prolactin, and cortisol secretion in healthy male subjects., Psychoneuroendocrinology
    Millan, Serotonin 5-HT2C receptors as a target for the treatment of depressive and anxious states: focus on novel therapeutic strategies., Therapie
    Dekeyne et al., 2001, Following long-term training with citalopram, both mirtazapine and mianserin block its discriminative stimulus properties in rats., Psychopharmacology (Berl.)
    Meert et al., 1997, Antagonism of meta-chlorophenylpiperazine-induced inhibition of exploratory activity in an emergence procedure, the open field test, in rats., Behav Pharmacol
    Benelli et al., 2004, Influence of mirtazapine on the sexual behavior of male rats., Psychopharmacology (Berl.)
    Zanger UM et al., 2008, Functional pharmacogenetics/genomics of human cytochromes P450 involved in drug biotransformation., Anal Bioanal Chem
    Delacrétaz A et al., 2017, Association of variants in SH2B1 and RABEP1 with worsening of low-density lipoprotein and glucose parameters in patients treated with psychotropic drugs., Gene
    Tzvetkov MV et al., 2008, Common genetic variations in human brain-specific tryptophan hydroxylase-2 and response to antidepressant treatment., Pharmacogenet Genomics
    Olianas et al., 2012, The atypical antidepressant mianserin exhibits agonist activity at κ-opioid receptors., Br. J. Pharmacol.
    Peckham AM et al., 2018, Kappa opioid receptor antagonism: Are opioids the answer for treatment resistant depression?, Ment Health Clin
    Schreiber et al., 2002, The antinociceptive effect of mirtazapine in mice is mediated through serotonergic, noradrenergic and opioid mechanisms., Brain Res. Bull.
    Sato H et al., 2013, Histamine H₁ receptor occupancy by the new-generation antidepressants fluvoxamine and mirtazapine: a positron emission tomography study in healthy volunteers., Psychopharmacology (Berl)
    Salvi V et al., 2016, H1-histamine receptor affinity predicts weight gain with antidepressants., Eur Neuropsychopharmacol
    Vande Griend JP et al., 2012, Histamine-1 receptor antagonism for treatment of insomnia., J Am Pharm Assoc (2003)
    Jaquenoud Sirot E et al., 2012, Multicenter study on the clinical effectiveness, pharmacokinetics, and pharmacogenetics of mirtazapine in depression., J Clin Psychopharmacol
    Zou YF et al., 2010, Meta-analysis of FKBP5 gene polymorphisms association with treatment response in patients with mood disorders., Neurosci Lett
    Binder EB et al., 2004, Polymorphisms in FKBP5 are associated with increased recurrence of depressive episodes and rapid response to antidepressant treatment., Nat Genet
    Heiser et al., 2006, Effects of different antipsychotics and the antidepressant mirtazapine on glucose transporter mRNA levels in human blood cells., J Psychiatr Res
  • MIRTAZAPINE   FKBP5

    Interaction Score: 0.65

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    20709156 15565110


    Sources:
    PharmGKB

  • MIRTAZAPINE   TPH2

    Interaction Score: 0.65

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    18496129


    Sources:
    PharmGKB

  • MIRTAZAPINE   RABEP1

    Interaction Score: 0.57

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    28694205


    Sources:
    PharmGKB

  • MIRTAZAPINE   SH2B1

    Interaction Score: 0.57

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    28694205


    Sources:
    PharmGKB

  • MIRTAZAPINE   GAL

    Interaction Score: 0.52

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    PharmGKB

  • MIRTAZAPINE   LEP

    Interaction Score: 0.34

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    12518269


    Sources:
    NCI

  • MIRTAZAPINE   HTR3A

    Interaction Score: 0.33

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Trial Name mirtazapine,Remeron, Remeron SolTab, Reflex
    Novel drug target Established target

    PMIDs:
    17587360 11607047 10446735 8930006 11752352 10446734


    Sources:
    TEND TdgClinicalTrial

  • MIRTAZAPINE   ADRA2A

    Interaction Score: 0.27

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Mechanism of Interaction Adrenergic receptor alpha-2 antagonist
    Direct Interaction yes
    Specific Action of the Ligand Antagonist

    PMIDs:
    11931344 9007838 12523492 14628003 11607047 8930006 19401164 11939713 10793320


    Sources:
    TEND TdgClinicalTrial DrugBank GuideToPharmacology ChemblInteractions

  • MIRTAZAPINE   HTR2C

    Interaction Score: 0.22

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Specific Action of the Ligand Antagonist
    Endogenous Drug? False
    Direct Interaction? True

    PMIDs:
    16433010 11271412 10762339 9832994 11752352 14615872


    Sources:
    TEND TTD DrugBank GuideToPharmacology ChemblInteractions

  • MIRTAZAPINE   HTR2A

    Interaction Score: 0.18

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Mechanism of Interaction Serotonin 2a (5-HT2a) receptor antagonist
    Direct Interaction yes
    Trial Name mirtazapine,Remeron, Remeron SolTab, Reflex

    PMIDs:
    17067560 15309042 10446738 11607047 11063897 10446735 10446734 10451911


    Sources:
    TEND TdgClinicalTrial DrugBank GuideToPharmacology ChemblInteractions

  • MIRTAZAPINE   SLC2A4

    Interaction Score: 0.12

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    16002093


    Sources:
    NCI

  • MIRTAZAPINE   CYP2B6

    Interaction Score: 0.1

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    22926595


    Sources:
    PharmGKB

  • MIRTAZAPINE   ADRA2C

    Interaction Score: 0.1

    Interaction Types & Directionality:
    binder
    antagonist (inhibitory)

    Interaction Info:
    Mechanism of Interaction Adrenergic receptor alpha-2 antagonist
    Direct Interaction yes
    Specific Action of the Ligand Antagonist

    PMIDs:
    15771415 3419539


    Sources:
    GuideToPharmacology ChemblInteractions

  • MIRTAZAPINE   OPRK1

    Interaction Score: 0.09

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:

    PMIDs:
    22708686 30155392 12372565


    Sources:
    DrugBank

  • MIRTAZAPINE   ADRA1A

    Interaction Score: 0.09

    Interaction Types & Directionality:
    binder
    antagonist (inhibitory)

    Interaction Info:

    PMIDs:
    10762339 9265949 15771415 12109911 3419539


    Sources:
    DrugBank

  • MIRTAZAPINE   HRH1

    Interaction Score: 0.07

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:

    PMIDs:
    23728612 27593622 23229983 11752352


    Sources:
    DrugBank

  • MIRTAZAPINE   ADRA2B

    Interaction Score: 0.06

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Direct Interaction? True
    Endogenous Drug? False
    Specific Action of the Ligand Antagonist

    PMIDs:
    None found


    Sources:
    GuideToPharmacology ChemblInteractions

  • MIRTAZAPINE   CYP3A5

    Interaction Score: 0.05

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    18695978


    Sources:
    PharmGKB

  • MIRTAZAPINE   HTR1A

    Interaction Score: 0.02

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    TEND

  • MIRTAZAPINE   CYP2C9

    Interaction Score: 0.01

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • MIRTAZAPINE   CYP2C19

    Interaction Score: 0.01

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • MIRTAZAPINE   CYP2D6

    Interaction Score: 0.0

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • DrugBank: DB00370

    • Version: 5.1.7

    Alternate Names:
    MIRTAZAPINE DrugBank Drug Name
    85650-52-8 CAS Number
    Apo-mirtazapine Drug Brand

    Drug Info:
    Drug Type small molecule
    Drug Groups approved
    Drug Categories adrenergic agents

    Publications:
    Davis R et al., 1996, Mirtazapine : A Review of its Pharmacology and Therapeutic Potential in the Management of Major Depression., CNS Drugs
    Thompson AJ et al., 2007, The 5-HT3 receptor as a therapeutic target., Expert Opin Ther Targets
    Bell SN et al., 1985, Tibia vara caused by focal fibrocartilaginous dysplasia. Three case reports., J Bone Joint Surg Br

  • TEND: MIRTAZAPINE

    • Version: 01-August-2011

    Alternate Names:
    MIRTAZAPINE Primary Drug Name

    Drug Info:
    Year of Approval 1996
    Drug Class antidepressive agents, tricyclic

    Publications:

  • TdgClinicalTrial: MIRTAZAPINE

    • Version: January-2014

    Alternate Names:

    Drug Info:
    Drug Indications antidepressant
    Drug Class Small Molecule
    FDA Approval approved

    Publications:

  • NCI: MIRTAZAPINE

    • Version: 14-September-2017

    Alternate Names:
    C29265 NCI drug code

    Drug Info:

    Publications:
    Kraus et al., 2002, Body weight, the tumor necrosis factor system, and leptin production during treatment with mirtazapine or venlafaxine., Pharmacopsychiatry
    Heiser et al., 2006, Effects of different antipsychotics and the antidepressant mirtazapine on glucose transporter mRNA levels in human blood cells., J Psychiatr Res

  • PharmGKB: mirtazapine

    • Version: 18-August-2020

    Alternate Names:

    Drug Info:

    Publications:
    Delacrétaz A et al., 2017, Association of variants in SH2B1 and RABEP1 with worsening of low-density lipoprotein and glucose parameters in patients treated with psychotropic drugs., Gene
    Tzvetkov MV et al., 2008, Common genetic variations in human brain-specific tryptophan hydroxylase-2 and response to antidepressant treatment., Pharmacogenet Genomics
    Zanger UM et al., 2008, Functional pharmacogenetics/genomics of human cytochromes P450 involved in drug biotransformation., Anal Bioanal Chem

  • GuideToPharmacology: 178103815

    • Version: 29-September-2020

    Alternate Names:
    MIRTAZAPINE GuideToPharmacology Ligand Name

    Drug Info:

    Publications:

  • DTC: MIRTAZAPINE

    • Version: 02-September-2020

    Alternate Names:
    CHEMBL654 ChEMBL Drug ID

    Drug Info:

    Publications:

  • TTD: Mirtazapine

    • Version: 2020.06.01

    Alternate Names:
    D05ZIK TTD Drug ID

    Drug Info:

    Publications:

  • ChemblDrugs: chembl:CHEMBL654

    • Version: ChEMBL_27

    Alternate Names:

    Drug Info:

    Publications:

  • ChemblInteractions: CHEMBL654

    • Version: chembl_23

    Alternate Names:

    Drug Info:

    Publications:

Disclaimer: This resource is intended for purely research purposes. It should not be used for emergencies or medical or professional advice.

A finding of a drug-gene interaction or potentially druggable category does not necessarily indicate effectiveness (or lack thereof) of any drug or treatment regimen. A finding of no interaction or no potentially druggable category does not necessarily indicate lack of effectiveness of any drug or treatment regimen. Drug-gene interactions or potentially druggable categories are not presented in ranked order of potential or predicted efficacy.

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DGIdb (v4.2.0 - sha1 afd9f30b) • Last updated 2021-04-13