DGIdb - MIRTAZAPINE Drug Record

MIRTAZAPINE chembl:CHEMBL654 Approved

Alternate Names:

MIRTAZAPINE
REMERON
REMERON SOLTAB
ORG-3770
ZISPIN
1,2,3,4,10,14B-HEXAHYDRO-2-METHYLPYRAZINO(2,1-A)PYRIDO(2,3-C)BENZAZEPINE
6-AZAMIANSERIN
MEPIRZAPINE
MIRTAZAPINA
MIRTAZAPIN
REMERON®
MIRTAZAPINUM
2-METHYL-1,2,3,4,10,14B-HEXAHYDROPYRAZINO[2,1-A]PYRIDO[2,3-C][2]BENZAZEPINE
chemidplus:85650-52-8
pubchem.compound:4205
chemidplus:61337-67-5
chembl:CHEMBL654
rxcui:15996
drugbank:00370

Drug Info:

FDA Approval	approved
Drug Class	Small Molecule
Drug Indications	antidepressant
Drug Class	antidepressive agents, tricyclic
Year of Approval	1996

(4 More Sources)

Publications:

Kraus et al., 2002, Body weight, the tumor necrosis factor system, and leptin production during treatment with mirtazapine or venlafaxine., Pharmacopsychiatry
Anttila et al., 2001, A review of the pharmacological and clinical profile of mirtazapine., CNS Drug Rev
Kast et al., 2007, Cancer chemotherapy and cachexia: mirtazapine and olanzapine are 5-HT3 antagonists with good antinausea effects., Eur J Cancer Care (Engl)
Westenberg, 1999, Pharmacology of antidepressants: selectivity or multiplicity?, J Clin Psychiatry
Gorman, 1999, Mirtazapine: clinical overview., J Clin Psychiatry
de Boer, 1995, The effects of mirtazapine on central noradrenergic and serotonergic neurotransmission., Int Clin Psychopharmacol
Chen et al., 2002, TTD: Therapeutic Target Database., Nucleic Acids Res.
Rogoz et al., 2002, Effect of repeated treatment with mirtazapine on the central alpha1-adrenergic receptors., J. Physiol. Pharmacol.
Besson et al., 2000, Effects of the co-administration of mirtazapine and paroxetine on serotonergic neurotransmission in the rat brain., Eur Neuropsychopharmacol
Rogóz et al., Effect of repeated treatment with mirtazapine on the central dopaminergic D2/D3 receptors., Pol J Pharmacol
Schreiber et al., Venlafaxine and mirtazapine: different mechanisms of antidepressant action, common opioid-mediated antinociceptive effects--a possible opioid involvement in severe depression?, J. Mol. Neurosci.
García-Sevilla et al., 2004, Regulation of platelet alpha 2A-adrenoceptors, Gi proteins and receptor kinases in major depression: effects of mirtazapine treatment., Neuropsychopharmacology
Haddjeri N et al., 1997, Effects of long-term treatment with the alpha 2-adrenoceptor antagonist mirtazapine on 5-HT neurotransmission., Naunyn Schmiedebergs Arch Pharmacol
Lee HY et al., 2009, Association of the adrenergic alpha 2a receptor--1291C/G polymorphism with weight change and treatment response to mirtazapine in patients with major depressive disorder., Brain Res
Laakmann et al., 1999, Effects of mirtazapine on growth hormone, prolactin, and cortisol secretion in healthy male subjects., Psychoneuroendocrinology
Waldinger et al., 2000, Treatment of hot flushes with mirtazapine: four case reports., Maturitas
Nutt, 1999, Care of depressed patients with anxiety symptoms., J Clin Psychiatry
Celada P et al., 2004, The therapeutic role of 5-HT1A and 5-HT2A receptors in depression., J Psychiatry Neurosci
Pawlyk AC et al., 2006, Effects of the 5-HT2A antagonist mirtazapine in rat models of thermoregulation., Brain Res
Benelli et al., 2004, Influence of mirtazapine on the sexual behavior of male rats., Psychopharmacology (Berl.)
Millan, Serotonin 5-HT2C receptors as a target for the treatment of depressive and anxious states: focus on novel therapeutic strategies., Therapie
Millan et al., 2000, Mirtazapine enhances frontocortical dopaminergic and corticolimbic adrenergic, but not serotonergic, transmission by blockade of alpha2-adrenergic and serotonin2C receptors: a comparison with citalopram., Eur. J. Neurosci.
Meert et al., 1997, Antagonism of meta-chlorophenylpiperazine-induced inhibition of exploratory activity in an emergence procedure, the open field test, in rats., Behav Pharmacol
Dekeyne et al., 2001, Following long-term training with citalopram, both mirtazapine and mianserin block its discriminative stimulus properties in rats., Psychopharmacology (Berl.)
de Boer et al., 1988, Neurochemical and autonomic pharmacological profiles of the 6-aza-analogue of mianserin, Org 3770 and its enantiomers., Neuropharmacology
Fernández et al., 2005, Discovery of new tetracyclic tetrahydrofuran derivatives as potential broad-spectrum psychotropic agents., J. Med. Chem.
Zanger UM et al., 2008, Functional pharmacogenetics/genomics of human cytochromes P450 involved in drug biotransformation., Anal Bioanal Chem
Delacrétaz A et al., 2017, Association of variants in SH2B1 and RABEP1 with worsening of low-density lipoprotein and glucose parameters in patients treated with psychotropic drugs., Gene
Tzvetkov MV et al., 2008, Common genetic variations in human brain-specific tryptophan hydroxylase-2 and response to antidepressant treatment., Pharmacogenet Genomics
Jaquenoud Sirot E et al., 2012, Multicenter study on the clinical effectiveness, pharmacokinetics, and pharmacogenetics of mirtazapine in depression., J Clin Psychopharmacol
Zou YF et al., 2010, Meta-analysis of FKBP5 gene polymorphisms association with treatment response in patients with mood disorders., Neurosci Lett
Binder EB et al., 2004, Polymorphisms in FKBP5 are associated with increased recurrence of depressive episodes and rapid response to antidepressant treatment., Nat Genet
Heiser et al., 2006, Effects of different antipsychotics and the antidepressant mirtazapine on glucose transporter mRNA levels in human blood cells., J Psychiatr Res

MIRTAZAPINE TPH2

Interaction Score: 1.3

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
18496129

Sources:
PharmGKB
MIRTAZAPINE FKBP5

Interaction Score: 0.81

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
20709156 15565110

Sources:
PharmGKB
MIRTAZAPINE RABEP1

Interaction Score: 0.72

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
28694205

Sources:
PharmGKB
MIRTAZAPINE SH2B1

Interaction Score: 0.72

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
28694205

Sources:
PharmGKB
MIRTAZAPINE GAL

Interaction Score: 0.65

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
PharmGKB
MIRTAZAPINE HTR3A

Interaction Score: 0.59

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Trial Name mirtazapine,Remeron, Remeron SolTab, Reflex

Novel drug target Established target

PMIDs:
11607047 17587360 10446734 10446735 8930006 11752352

Sources:
TdgClinicalTrial TEND
MIRTAZAPINE HTR2C

Interaction Score: 0.59

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Mechanism of Interaction Serotonin 2c (5-HT2c) receptor antagonist

Direct Interaction yes

PMIDs:
14615872 16433010 10762339 9832994 11271412 11752352

Sources:
ChemblInteractions TEND TTD
MIRTAZAPINE ADRA2A

Interaction Score: 0.55

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Mechanism of Interaction Adrenergic receptor alpha-2 antagonist

Direct Interaction yes

Trial Name mirtazapine,Remeron, Remeron SolTab, Reflex

PMIDs:
11607047 11939713 10793320 12523492 11931344 14628003 9007838 19401164 8930006

Sources:
TdgClinicalTrial ChemblInteractions TEND
MIRTAZAPINE LEP

Interaction Score: 0.43

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
12518269

Sources:
NCI
MIRTAZAPINE HTR2A

Interaction Score: 0.35

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Mechanism of Interaction Serotonin 2a (5-HT2a) receptor antagonist

Direct Interaction yes

Trial Name mirtazapine,Remeron, Remeron SolTab, Reflex

PMIDs:
11607047 10446734 10446735 10451911 11063897 10446738 15309042 17067560

Sources:
TdgClinicalTrial ChemblInteractions TEND
MIRTAZAPINE ADRA2C

Interaction Score: 0.16

Interaction Types & Directionality:

binder

antagonist (inhibitory)

Interaction Info:

Mechanism of Interaction Adrenergic receptor alpha-2 antagonist

Direct Interaction yes

PMIDs:
3419539 15771415

Sources:
ChemblInteractions
MIRTAZAPINE SLC2A4

Interaction Score: 0.15

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
16002093

Sources:
NCI
MIRTAZAPINE CYP2B6

Interaction Score: 0.14

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
22926595

Sources:
PharmGKB
MIRTAZAPINE ADRA2B

Interaction Score: 0.07

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Mechanism of Interaction Adrenergic receptor alpha-2 antagonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
MIRTAZAPINE CYP3A5

Interaction Score: 0.06

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
18695978

Sources:
PharmGKB
MIRTAZAPINE HTR1A

Interaction Score: 0.06

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
TEND
MIRTAZAPINE CYP2C9

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
MIRTAZAPINE CYP2C19

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
MIRTAZAPINE CYP2D6

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC

TEND: MIRTAZAPINE
- Version: 01-August-2011
Alternate Names:

MIRTAZAPINE Primary Drug Name

Drug Info:

Year of Approval 1996

Drug Class antidepressive agents, tricyclic

Publications:
TdgClinicalTrial: MIRTAZAPINE
- Version: January-2014
Alternate Names:

Drug Info:

Drug Indications antidepressant

Drug Class Small Molecule

FDA Approval approved

Publications:

NCI: MIRTAZAPINE

Version: 14-September-2017

Alternate Names:

C29265 NCI drug code

Drug Info:

Publications:

Kraus et al., 2002, Body weight, the tumor necrosis factor system, and leptin production during treatment with mirtazapine or venlafaxine., Pharmacopsychiatry

Heiser et al., 2006, Effects of different antipsychotics and the antidepressant mirtazapine on glucose transporter mRNA levels in human blood cells., J Psychiatr Res

PharmGKB: mirtazapine

Version: 18-August-2020

Alternate Names:

Drug Info:

Publications:

Delacrétaz A et al., 2017, Association of variants in SH2B1 and RABEP1 with worsening of low-density lipoprotein and glucose parameters in patients treated with psychotropic drugs., Gene

Tzvetkov MV et al., 2008, Common genetic variations in human brain-specific tryptophan hydroxylase-2 and response to antidepressant treatment., Pharmacogenet Genomics

Zanger UM et al., 2008, Functional pharmacogenetics/genomics of human cytochromes P450 involved in drug biotransformation., Anal Bioanal Chem

DTC: MIRTAZAPINE
- Version: 02-September-2020
Alternate Names:

CHEMBL654 ChEMBL Drug ID

Drug Info:

Publications:
TTD: Mirtazapine
- Version: 2020.06.01
Alternate Names:

D05ZIK TTD Drug ID

Drug Info:

Publications:
ChemblDrugs: chembl:CHEMBL654
- Version: ChEMBL_27
Alternate Names:

Drug Info:

Publications:
ChemblInteractions: CHEMBL654
- Version: chembl_23
Alternate Names:

Drug Info:

Publications:

Trial Name	mirtazapine,Remeron, Remeron SolTab, Reflex
Novel drug target	Established target

Mechanism of Interaction	Serotonin 2c (5-HT2c) receptor antagonist
Direct Interaction	yes

Mechanism of Interaction	Adrenergic receptor alpha-2 antagonist
Direct Interaction	yes
Trial Name	mirtazapine,Remeron, Remeron SolTab, Reflex

Mechanism of Interaction	Serotonin 2a (5-HT2a) receptor antagonist
Direct Interaction	yes
Trial Name	mirtazapine,Remeron, Remeron SolTab, Reflex

binder
antagonist (inhibitory)

MIRTAZAPINE Drug Record

MIRTAZAPINE chembl:CHEMBL654 Approved

Alternate Names:

Drug Info:

Publications:

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 18496129

Sources: PharmGKB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 20709156 15565110

Sources: PharmGKB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 28694205

Sources: PharmGKB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 28694205

Sources: PharmGKB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: PharmGKB

Interaction Types & Directionality: antagonist (inhibitory)

Interaction Info: Trial Name mirtazapine,Remeron, Remeron SolTab, Reflex Novel drug target Established target

PMIDs: 11607047 17587360 10446734 10446735 8930006 11752352

Sources: TdgClinicalTrial TEND

Interaction Types & Directionality: antagonist (inhibitory)

Interaction Info: Mechanism of Interaction Serotonin 2c (5-HT2c) receptor antagonist Direct Interaction yes

PMIDs: 14615872 16433010 10762339 9832994 11271412 11752352

Sources: ChemblInteractions TEND TTD

Interaction Types & Directionality: antagonist (inhibitory)

Interaction Info: Mechanism of Interaction Adrenergic receptor alpha-2 antagonist Direct Interaction yes Trial Name mirtazapine,Remeron, Remeron SolTab, Reflex

PMIDs: 11607047 11939713 10793320 12523492 11931344 14628003 9007838 19401164 8930006

Sources: TdgClinicalTrial ChemblInteractions TEND

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 12518269

Sources: NCI

Interaction Types & Directionality: antagonist (inhibitory)

Interaction Info: Mechanism of Interaction Serotonin 2a (5-HT2a) receptor antagonist Direct Interaction yes Trial Name mirtazapine,Remeron, Remeron SolTab, Reflex

PMIDs: 11607047 10446734 10446735 10451911 11063897 10446738 15309042 17067560

Sources: TdgClinicalTrial ChemblInteractions TEND

Interaction Types & Directionality: binder antagonist (inhibitory)

Interaction Info: Mechanism of Interaction Adrenergic receptor alpha-2 antagonist Direct Interaction yes

PMIDs: 3419539 15771415

Sources: ChemblInteractions

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 16002093

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 22926595

Sources: PharmGKB

Interaction Types & Directionality: antagonist (inhibitory)

Interaction Info: Mechanism of Interaction Adrenergic receptor alpha-2 antagonist Direct Interaction yes

PMIDs: None found

Sources: ChemblInteractions

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 18695978

Sources: PharmGKB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: TEND

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Interaction Types & Directionality:

n/a

PMIDs:
18496129

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
20709156 15565110

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
28694205

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
28694205

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
PharmGKB

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Trial Name mirtazapine,Remeron, Remeron SolTab, Reflex

Novel drug target Established target

PMIDs:
11607047 17587360 10446734 10446735 8930006 11752352

Sources:
TdgClinicalTrial TEND

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Mechanism of Interaction Serotonin 2c (5-HT2c) receptor antagonist

Direct Interaction yes

PMIDs:
14615872 16433010 10762339 9832994 11271412 11752352

Sources:
ChemblInteractions TEND TTD

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Mechanism of Interaction Adrenergic receptor alpha-2 antagonist

Direct Interaction yes

Trial Name mirtazapine,Remeron, Remeron SolTab, Reflex

PMIDs:
11607047 11939713 10793320 12523492 11931344 14628003 9007838 19401164 8930006

Sources:
TdgClinicalTrial ChemblInteractions TEND

Interaction Types & Directionality:

n/a

PMIDs:
12518269

Sources:
NCI

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Mechanism of Interaction Serotonin 2a (5-HT2a) receptor antagonist

Direct Interaction yes

Trial Name mirtazapine,Remeron, Remeron SolTab, Reflex

PMIDs:
11607047 10446734 10446735 10451911 11063897 10446738 15309042 17067560

Sources:
TdgClinicalTrial ChemblInteractions TEND

Interaction Types & Directionality:

binder

antagonist (inhibitory)

Interaction Info:

Mechanism of Interaction Adrenergic receptor alpha-2 antagonist

Direct Interaction yes

PMIDs:
3419539 15771415

Sources:
ChemblInteractions

Interaction Types & Directionality:

n/a

PMIDs:
16002093

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
22926595

Sources:
PharmGKB

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Mechanism of Interaction Adrenergic receptor alpha-2 antagonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

n/a

PMIDs:
18695978

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
TEND

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Alternate Names:

MIRTAZAPINE Primary Drug Name

Drug Info:

Year of Approval 1996

Drug Class antidepressive agents, tricyclic

Drug Info:

Drug Indications antidepressant

Drug Class Small Molecule

FDA Approval approved

Alternate Names:

C29265 NCI drug code

Alternate Names:

CHEMBL654 ChEMBL Drug ID

Alternate Names:

D05ZIK TTD Drug ID