DGIdb - MIGLITOL Drug Record

MIGLITOL chembl:CHEMBL1561 Approved

Alternate Names:

GLYSET
MIGLITOL
DIASTABOL
BAY-M-1099
MIGLITOLUM
N-HYDROXYLETHYL-1-DEOXYNOJIRIMYCIN
GLYSET®
chembl:CHEMBL1561
drugbank:00491
chemidplus:72432-03-2
pubchem.compound:441314
rxcui:30009

Drug Info:

FDA Approval	1996
Drug Class	small molecule
Drug Indications	Hypoglycemic Agents
Drug Categories	piperidines
Drug Categories	physiological effects of drugs
Drug Categories	pharmacologic actions
Drug Categories	organic chemicals
Drug Categories	monosaccharides
Drug Categories	molecular mechanisms of pharmacological action
Drug Categories	imino sugars
Drug Categories	imino pyranoses
Drug Categories	imines
Drug Categories	hypoglycemic agents
Drug Categories	heterocyclic compounds, 1-ring
Drug Categories	heterocyclic compounds
Drug Categories	glycoside hydrolase inhibitors
Drug Categories	enzyme inhibitors
Drug Categories	drugs used in diabetes
Drug Categories	chemical actions and uses
Drug Categories	carbohydrates
Drug Categories	blood glucose lowering drugs, excl. insulins
Drug Categories	blood glucose lowering agents
Drug Categories	anti-bacterial agents
Drug Categories	alkaloids
Drug Categories	alimentary tract and metabolism
Drug Groups	approved
Drug Type	small molecule
Year of Approval	1996
Drug Class	hypoglycemic agents
Drug Categories	hypoglycemia-associated agents

(4 More Sources)

Publications:

Chen et al., 2002, TTD: Therapeutic Target Database., Nucleic Acids Res.
Rossi et al., 2006, Inhibition of recombinant human maltase glucoamylase by salacinol and derivatives., FEBS J.
Fukaya et al., 2009, The alpha-glucosidase inhibitor miglitol delays the development of diabetes and dysfunctional insulin secretion in pancreatic beta-cells in OLETF rats., Eur. J. Pharmacol.
Mooradian et al., 1999, Drug therapy of postprandial hyperglycaemia., Drugs
Kato A et al., 2012, α-1-C-butyl-1,4-dideoxy-1,4-imino-l-arabinitol as a second-generation iminosugar-based oral α-glucosidase inhibitor for improving postprandial hyperglycemia., J Med Chem
Hirata et al., 2009, Effect of miglitol, an alpha-glucosidase inhibitor, on atherogenic outcomes in balloon-injured diabetic rats., Horm. Metab. Res.

MIGLITOL MGA

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Maltase-glucoamylase inhibitor

Publications:

MIGLITOL MGAM

Interaction Types & Directionality:

inhibitor (inhibitory)

antagonist (inhibitory)

Interaction Info:

Trial Name -

Novel drug target Established target

Details of the Assay for Interaction Inhibition of human recombinant N-terminal subunit of maltase-glucoamylase after 60 mins by glucose oxidase assay

Publications:

Chen et al., 2002, TTD: Therapeutic Target Database., Nucleic Acids Res.

Rossi et al., 2006, Inhibition of recombinant human maltase glucoamylase by salacinol and derivatives., FEBS J.

Fukaya et al., 2009, The alpha-glucosidase inhibitor miglitol delays the development of diabetes and dysfunctional insulin secretion in pancreatic beta-cells in OLETF rats., Eur. J. Pharmacol.

MIGLITOL GAA

Interaction Types & Directionality:

inhibitor (inhibitory)

antagonist (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Lysosomal alpha-glucosidase inhibitor

Specific Action of the Ligand Inhibition

Publications:

Kato A et al., 2012, α-1-C-butyl-1,4-dideoxy-1,4-imino-l-arabinitol as a second-generation iminosugar-based oral α-glucosidase inhibitor for improving postprandial hyperglycemia., J Med Chem

Hirata et al., 2009, Effect of miglitol, an alpha-glucosidase inhibitor, on atherogenic outcomes in balloon-injured diabetic rats., Horm. Metab. Res.

Fukaya et al., 2009, The alpha-glucosidase inhibitor miglitol delays the development of diabetes and dysfunctional insulin secretion in pancreatic beta-cells in OLETF rats., Eur. J. Pharmacol.

MIGLITOL GANC

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Publications:

Hirata et al., 2009, Effect of miglitol, an alpha-glucosidase inhibitor, on atherogenic outcomes in balloon-injured diabetic rats., Horm. Metab. Res.

Fukaya et al., 2009, The alpha-glucosidase inhibitor miglitol delays the development of diabetes and dysfunctional insulin secretion in pancreatic beta-cells in OLETF rats., Eur. J. Pharmacol.

MIGLITOL GANAB

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Publications:

Hirata et al., 2009, Effect of miglitol, an alpha-glucosidase inhibitor, on atherogenic outcomes in balloon-injured diabetic rats., Horm. Metab. Res.

Fukaya et al., 2009, The alpha-glucosidase inhibitor miglitol delays the development of diabetes and dysfunctional insulin secretion in pancreatic beta-cells in OLETF rats., Eur. J. Pharmacol.

DrugBank: DB00491

Version: 5.1.7

Alternate Names:

MIGLITOL DrugBank Drug Name

72432-03-2 CAS Number

Diaban Drug Brand

Drug Info:

Drug Type small molecule

Drug Groups approved

Drug Categories alimentary tract and metabolism

Publications:

Fukaya et al., 2009, The alpha-glucosidase inhibitor miglitol delays the development of diabetes and dysfunctional insulin secretion in pancreatic beta-cells in OLETF rats., Eur. J. Pharmacol.

Rossi et al., 2006, Inhibition of recombinant human maltase glucoamylase by salacinol and derivatives., FEBS J.

Mooradian et al., 1999, Drug therapy of postprandial hyperglycaemia., Drugs

TEND: MIGLITOL
- Version: 01-August-2011
Alternate Names:

MIGLITOL Primary Drug Name

Drug Info:

Drug Class hypoglycemic agents

Year of Approval 1996

Publications:
TdgClinicalTrial: MIGLITOL
- Version: January-2014
Alternate Names:

Drug Info:

Drug Indications Hypoglycemic Agents

Drug Class small molecule

FDA Approval 1996

Publications:
DTC: MIGLITOL
- Version: 02-September-2020
Alternate Names:

CHEMBL1561 ChEMBL Drug ID

Drug Info:

Publications:

Kato A et al., 2012, α-1-C-butyl-1,4-dideoxy-1,4-imino-l-arabinitol as a second-generation iminosugar-based oral α-glucosidase inhibitor for improving postprandial hyperglycemia., J Med Chem
GuideToPharmacologyInteractions: 178101544
- Version: 20-July-2020
Alternate Names:

MIGLITOL GuideToPharmacology Ligand Name

Drug Info:

Publications:
TTD: Miglitol
- Version: 2020.06.01
Alternate Names:

D0D0ZD TTD Drug ID

Drug Info:

Publications:
ChemblDrugs: chembl:CHEMBL1561
- Version: ChEMBL_27
Alternate Names:

Drug Info:

Publications:
ChemblInteractions: CHEMBL1561
- Version: chembl_23
Alternate Names:

Drug Info:

Publications:

Direct Interaction	yes
Mechanism of Interaction	Maltase-glucoamylase inhibitor

Trial Name	-
Novel drug target	Established target
Details of the Assay for Interaction	Inhibition of human recombinant N-terminal subunit of maltase-glucoamylase after 60 mins by glucose oxidase assay

Direct Interaction	yes
Mechanism of Interaction	Lysosomal alpha-glucosidase inhibitor
Specific Action of the Ligand	Inhibition

MIGLITOL	DrugBank Drug Name
72432-03-2	CAS Number
Diaban	Drug Brand

MIGLITOL Drug Record

MIGLITOL chembl:CHEMBL1561 Approved

Alternate Names:

Drug Info:

Publications:

MIGLITOL MGA

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Direct Interaction yes Mechanism of Interaction Maltase-glucoamylase inhibitor

Publications:

MIGLITOL MGAM

Interaction Types & Directionality: inhibitor (inhibitory) antagonist (inhibitory)

Interaction Info: Trial Name - Novel drug target Established target Details of the Assay for Interaction Inhibition of human recombinant N-terminal subunit of maltase-glucoamylase after 60 mins by glucose oxidase assay

MIGLITOL GAA

Interaction Types & Directionality: inhibitor (inhibitory) antagonist (inhibitory)

Interaction Info: Direct Interaction yes Mechanism of Interaction Lysosomal alpha-glucosidase inhibitor Specific Action of the Ligand Inhibition

MIGLITOL GANC

Interaction Types & Directionality: antagonist (inhibitory)

Interaction Info:

MIGLITOL GANAB

Interaction Types & Directionality: antagonist (inhibitory)

Interaction Info:

DrugBank: DB00491

Alternate Names: MIGLITOL DrugBank Drug Name 72432-03-2 CAS Number Diaban Drug Brand

Drug Info: Drug Type small molecule Drug Groups approved Drug Categories alimentary tract and metabolism

TEND: MIGLITOL

Alternate Names: MIGLITOL Primary Drug Name

Drug Info: Drug Class hypoglycemic agents Year of Approval 1996

Publications:

TdgClinicalTrial: MIGLITOL

Alternate Names:

Drug Info: Drug Indications Hypoglycemic Agents Drug Class small molecule FDA Approval 1996

Publications:

DTC: MIGLITOL

Alternate Names: CHEMBL1561 ChEMBL Drug ID

Drug Info:

Publications: Kato A et al., 2012, α-1-C-butyl-1,4-dideoxy-1,4-imino-l-arabinitol as a second-generation iminosugar-based oral α-glucosidase inhibitor for improving postprandial hyperglycemia., J Med Chem

GuideToPharmacologyInteractions: 178101544

Alternate Names: MIGLITOL GuideToPharmacology Ligand Name

Drug Info:

Publications:

TTD: Miglitol

Alternate Names: D0D0ZD TTD Drug ID

Drug Info:

Publications:

ChemblDrugs: chembl:CHEMBL1561

Alternate Names:

Drug Info:

Publications:

ChemblInteractions: CHEMBL1561

Alternate Names:

Drug Info:

Publications:

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Maltase-glucoamylase inhibitor

Interaction Types & Directionality:

inhibitor (inhibitory)

antagonist (inhibitory)

Interaction Info:

Trial Name -

Novel drug target Established target

Details of the Assay for Interaction Inhibition of human recombinant N-terminal subunit of maltase-glucoamylase after 60 mins by glucose oxidase assay

Interaction Types & Directionality:

inhibitor (inhibitory)

antagonist (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Lysosomal alpha-glucosidase inhibitor

Specific Action of the Ligand Inhibition

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Types & Directionality:

antagonist (inhibitory)

Alternate Names:

MIGLITOL DrugBank Drug Name

72432-03-2 CAS Number

Diaban Drug Brand

Drug Info:

Drug Type small molecule

Drug Groups approved

Drug Categories alimentary tract and metabolism

Alternate Names:

MIGLITOL Primary Drug Name

Drug Info:

Drug Class hypoglycemic agents

Year of Approval 1996

Drug Info:

Drug Indications Hypoglycemic Agents

Drug Class small molecule

FDA Approval 1996

Alternate Names:

CHEMBL1561 ChEMBL Drug ID

Publications:

Kato A et al., 2012, α-1-C-butyl-1,4-dideoxy-1,4-imino-l-arabinitol as a second-generation iminosugar-based oral α-glucosidase inhibitor for improving postprandial hyperglycemia., J Med Chem

Alternate Names:

MIGLITOL GuideToPharmacology Ligand Name

Alternate Names:

D0D0ZD TTD Drug ID