DGIdb - MIFEPRISTONE Drug Record

MIFEPRISTONE chembl:CHEMBL1276308 Approved

Alternate Names:

MIFEPRISTONE
MIFEPREX
RU-38486
KORLYM
MIFEGYNE
RU486
RU-486
11-(4-DIMETHYLAMINO-PHENYL)-17-HYDROXY-13-METHYL-17-PROP-1-YNYL-1,2,6,7,8,11,12,13,14,15,16,17-DODEC AHYDRO-CYCLOPENTA[A]PHENANTHREN-3-ONE
MIFEPREX®
MIFEPRISTONUM
MIFEPRISTON
CORLUX
MIFÉPRISTONE
MIFEPRISTONA
chembl:CHEMBL1276308
rxcui:6964
pubchem.compound:55245
chemidplus:84371-65-3
drugbank:00834

Drug Info:

Year of Approval	2000
Drug Class	abortifacient agents
Drug Indications	antipsychotic,antidepressant
FDA Approval	approved
Drug Class	Small Molecule
Drug Indications	opthalmological agent,for lowering intraocular pressure

(5 More Sources)

Publications:

Galand, 1988, Effect of an antiglucocorticoid (RU-38486) on hydrocortisone induction of maltase-glucosamylase, sucrase-isomaltase and trehalase in brush border membranes of suckling rats., Experientia
Zarghami et al., 1997, Steroid hormone regulation of prostate-specific antigen gene expression in breast cancer., Br. J. Cancer
Kang Z et al., 2004, Coregulator recruitment and histone modifications in transcriptional regulation by the androgen receptor., Mol Endocrinol
Sun et al., 1998, [Effect of mifepristone on the expression of progesterone receptor messenger RNA and protein in uterine leiomyomata]., Zhonghua Fu Chan Ke Za Zhi
Hazra et al., 2000, Synthesis of 11beta-(4-dimethylaminophenyl)-17beta-hydroxy-17alpha- (3-methyl-1-butynyl)-4, 9-estradien-3-one and 11beta-(4-acetophenyl)- 17beta-hydroxy-17alpha-(3-methyl-1-butynyl)-4, 9-estradien-3-one: two new analogs of mifepristone (RU-486)., Steroids
Jiang et al., 2001, [Effects of mifepristone on expression of estrogen receptor and progesterone receptor in cultured human eutopic and ectopic endometria]., Zhonghua Fu Chan Ke Za Zhi
Greb et al., 1999, Disparate actions of mifepristone (RU 486) on glands and stroma in the primate endometrium., Hum. Reprod.
Chen et al., 2002, TTD: Therapeutic Target Database., Nucleic Acids Res.
Gao et al., 1998, [Failure of mifepristone induced interruption of pregnancy: point mutation at genetic codon 722 in human progesterone receptor gene]., Zhonghua Fu Chan Ke Za Zhi
Liu et al., 1999, Mifepristone regulation of leukemia inhibitory factor and uterine receptivity in rabbits., Contraception
LeVan et al., 1999, Pharmacological characterization of glucocorticoid receptors in primary human bronchial epithelial cells., Biochem. Pharmacol.
Gu et al., 2005, Estrogen protects primary osteocytes against glucocorticoid-induced apoptosis., Apoptosis
de Pablos et al., 2006, Stress increases vulnerability to inflammation in the rat prefrontal cortex., J. Neurosci.
Aida et al., 2004, The effects of betamethasone (BM) on endothelial nitric oxide synthase (eNOS) expression in adult baboon femoral arterial endothelial cells., J. Steroid Biochem. Mol. Biol.
Attardi et al., 2004, In vitro antiprogestational/antiglucocorticoid activity and progestin and glucocorticoid receptor binding of the putative metabolites and synthetic derivatives of CDB-2914, CDB-4124, and mifepristone., J. Steroid Biochem. Mol. Biol.
Mackin et al., 2007, Changes in brain-derived neurotrophic factor following treatment with mifepristone in bipolar disorder and schizophrenia., Aust N Z J Psychiatry
Rendic S et al., 1997, Human cytochrome P450 enzymes: a status report summarizing their reactions, substrates, inducers, and inhibitors., Drug Metab Rev

MIFEPRISTONE SI

Interaction Score: 1.3

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
3132399

Sources:
NCI
MIFEPRISTONE LIF

Interaction Score: 0.59

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
10717784

Sources:
NCI
MIFEPRISTONE PGR

Interaction Score: 0.57

Interaction Types & Directionality:

agonist (activating)

antagonist (inhibitory)

Interaction Info:

Mechanism of Interaction Progesterone receptor antagonist

Direct Interaction yes

Trial Name Mifepristone, RU486

PMIDs:
10682471 10699595 11783365 10374120 11752352 10806733

Sources:
TdgClinicalTrial ChemblInteractions TEND
MIFEPRISTONE KLK3

Interaction Score: 0.54

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
9052414 15308689

Sources:
NCI
MIFEPRISTONE NR3C1

Interaction Score: 0.23

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Trial Name Mifepristone, RU486

Novel drug target Established target

Trial Name mifepristone,Corlux

PMIDs:
10796070 15909120 16723527 15336699 15120421

Sources:
DTC TdgClinicalTrial ChemblInteractions TTD
MIFEPRISTONE BDNF

Interaction Score: 0.1

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
17464718

Sources:
NCI
MIFEPRISTONE GNAS

Interaction Score: 0.09

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
MIFEPRISTONE NPSR1

Interaction Score: 0.04

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
MIFEPRISTONE MPHOSPH8

Interaction Score: 0.03

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
MIFEPRISTONE MTOR

Interaction Score: 0.03

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
MIFEPRISTONE DRD1

Interaction Score: 0.02

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
MIFEPRISTONE CBX1

Interaction Score: 0.02

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
MIFEPRISTONE ABCB1

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
PharmGKB
MIFEPRISTONE BAZ2B

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
MIFEPRISTONE KDM4A

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
MIFEPRISTONE CYP3A4

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
9187528

Sources:
PharmGKB
MIFEPRISTONE NFE2L2

Interaction Score: 0.0

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
MIFEPRISTONE AR

Interaction Score: 0.0

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

PMIDs:
None found

Sources:
DTC
MIFEPRISTONE EHMT2

Interaction Score: 0.0

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC

TEND: MIFEPRISTONE
- Version: 01-August-2011
Alternate Names:

MIFEPRISTONE Primary Drug Name

Drug Info:

Drug Class abortifacient agents

Year of Approval 2000

Publications:
TdgClinicalTrial: MIFEPRISTONE
- Version: January-2014
Alternate Names:

Drug Info:

Drug Indications opthalmological agent,for lowering intraocular pressure

Drug Class Small Molecule

FDA Approval approved

Publications:

NCI: MIFEPRISTONE

Version: 14-September-2017

Alternate Names:

C655 NCI drug code

Drug Info:

Publications:

Zarghami et al., 1997, Steroid hormone regulation of prostate-specific antigen gene expression in breast cancer., Br. J. Cancer

Mackin et al., 2007, Changes in brain-derived neurotrophic factor following treatment with mifepristone in bipolar disorder and schizophrenia., Aust N Z J Psychiatry

Liu et al., 1999, Mifepristone regulation of leukemia inhibitory factor and uterine receptivity in rabbits., Contraception

NCI: RU-38486

Version: 14-September-2017

Alternate Names:

C655 NCI drug code

Drug Info:

Publications:

Galand, 1988, Effect of an antiglucocorticoid (RU-38486) on hydrocortisone induction of maltase-glucosamylase, sucrase-isomaltase and trehalase in brush border membranes of suckling rats., Experientia

PharmGKB: mifepristone
- Version: 18-August-2020
Alternate Names:

Drug Info:

Publications:

Rendic S et al., 1997, Human cytochrome P450 enzymes: a status report summarizing their reactions, substrates, inducers, and inhibitors., Drug Metab Rev
DTC: MIFEPRISTONE
- Version: 02-September-2020
Alternate Names:

CHEMBL1276308 ChEMBL Drug ID

Drug Info:

Publications:
TTD: Mifepristone
- Version: 2020.06.01
Alternate Names:

D0Z4EI TTD Drug ID

Drug Info:

Publications:
ChemblDrugs: chembl:CHEMBL1276308
- Version: ChEMBL_27
Alternate Names:

Drug Info:

Publications:
ChemblInteractions: CHEMBL1276308
- Version: chembl_23
Alternate Names:

Drug Info:

Publications:

Mechanism of Interaction	Progesterone receptor antagonist
Direct Interaction	yes
Trial Name	Mifepristone, RU486

Trial Name	Mifepristone, RU486
Novel drug target	Established target
Trial Name	mifepristone,Corlux

agonist (activating)
antagonist (inhibitory)

MIFEPRISTONE Drug Record

MIFEPRISTONE chembl:CHEMBL1276308 Approved

Alternate Names:

Drug Info:

Publications:

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 3132399

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 10717784

Sources: NCI

Interaction Types & Directionality: agonist (activating) antagonist (inhibitory)

Interaction Info: Mechanism of Interaction Progesterone receptor antagonist Direct Interaction yes Trial Name Mifepristone, RU486

PMIDs: 10682471 10699595 11783365 10374120 11752352 10806733

Sources: TdgClinicalTrial ChemblInteractions TEND

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 9052414 15308689

Sources: NCI

Interaction Types & Directionality: antagonist (inhibitory)

Interaction Info: Trial Name Mifepristone, RU486 Novel drug target Established target Trial Name mifepristone,Corlux

PMIDs: 10796070 15909120 16723527 15336699 15120421

Sources: DTC TdgClinicalTrial ChemblInteractions TTD

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 17464718

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: PharmGKB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 9187528

Sources: PharmGKB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: antagonist (inhibitory)

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Interaction Types & Directionality:

n/a

PMIDs:
3132399

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
10717784

Sources:
NCI

Interaction Types & Directionality:

agonist (activating)

antagonist (inhibitory)

Interaction Info:

Mechanism of Interaction Progesterone receptor antagonist

Direct Interaction yes

Trial Name Mifepristone, RU486

PMIDs:
10682471 10699595 11783365 10374120 11752352 10806733

Sources:
TdgClinicalTrial ChemblInteractions TEND

Interaction Types & Directionality:

n/a

PMIDs:
9052414 15308689

Sources:
NCI

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Trial Name Mifepristone, RU486

Novel drug target Established target

Trial Name mifepristone,Corlux

PMIDs:
10796070 15909120 16723527 15336699 15120421

Sources:
DTC TdgClinicalTrial ChemblInteractions TTD

Interaction Types & Directionality:

n/a

PMIDs:
17464718

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
9187528

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

antagonist (inhibitory)

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Alternate Names:

MIFEPRISTONE Primary Drug Name

Drug Info:

Drug Class abortifacient agents

Year of Approval 2000

Drug Info:

Drug Indications opthalmological agent,for lowering intraocular pressure

Drug Class Small Molecule

FDA Approval approved

Alternate Names:

C655 NCI drug code

Alternate Names:

C655 NCI drug code

Publications:

Galand, 1988, Effect of an antiglucocorticoid (RU-38486) on hydrocortisone induction of maltase-glucosamylase, sucrase-isomaltase and trehalase in brush border membranes of suckling rats., Experientia

Publications:

Rendic S et al., 1997, Human cytochrome P450 enzymes: a status report summarizing their reactions, substrates, inducers, and inhibitors., Drug Metab Rev

Alternate Names:

CHEMBL1276308 ChEMBL Drug ID

Alternate Names:

D0Z4EI TTD Drug ID