DGIdb - MEXILETINE Drug Record

MEXILETINE chembl:CHEMBL558 Approved

Alternate Names:

MEXILETINE

Drug Info:

Year of Approval	1985
Drug Class	anti-arrhythmia agents
FDA Approval	1985
Drug Class	small molecule
Drug Indications	Anti-Arrhythmia Agents

(2 More Sources)

Publications:

Wang et al., 2003, Effect of mexiletine on long QT syndrome model., Acta Pharmacol. Sin.
Valdivia et al., 2002, A novel SCN5A arrhythmia mutation, M1766L, with expression defect rescued by mexiletine., Cardiovasc. Res.
Fabritz et al., 2003, Effect of pacing and mexiletine on dispersion of repolarisation and arrhythmias in DeltaKPQ SCN5A (long QT3) mice., Cardiovasc. Res.
Chinushi et al., 2003, Ventricular tachyarrhythmias in a canine model of LQT3: arrhythmogenic effects of sympathetic activity and therapeutic effects of mexiletine., Circ. J.
Napolitano et al., 2006, Gene-specific therapy for inherited arrhythmogenic diseases., Pharmacol. Ther.
Chen et al., 2002, TTD: Therapeutic Target Database., Nucleic Acids Res.
Shimizu et al., 2000, Effect of sodium channel blockers on ST segment, QRS duration, and corrected QT interval in patients with Brugada syndrome., J. Cardiovasc. Electrophysiol.
Jarvis et al., 1998, Mexiletine. A review of its therapeutic use in painful diabetic neuropathy., Drugs
Kamei et al., 1993, Effects of mexiletine on formalin-induced nociceptive responses in mice., Res. Commun. Chem. Pathol. Pharmacol.

MEXILETINE SCN5A

Interaction Score: 2.67

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
12676070 12123767 12650887 12604879 16168489 11752352 11196553

Sources:
TdgClinicalTrial TEND PharmGKB TTD
MEXILETINE TAC1

Interaction Score: 1.87

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
7686682

Sources:
NCI
MEXILETINE CYP2D6

Interaction Score: 0.1

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
9806111

Sources:
NCI PharmGKB

TEND: MEXILETINE
- Version: 01-August-2011
Alternate Names:

MEXILETINE Primary Drug Name

Drug Info:

Drug Class anti-arrhythmia agents

Year of Approval 1985

Publications:
TdgClinicalTrial: MEXILETINE
- Version: January-2014
Alternate Names:

Drug Info:

Drug Indications Anti-Arrhythmia Agents

Drug Class small molecule

FDA Approval 1985

Publications:

NCI: MEXILETINE

Version: 14-September-2017

Alternate Names:

C652 NCI drug code

Drug Info:

Publications:

Kamei et al., 1993, Effects of mexiletine on formalin-induced nociceptive responses in mice., Res. Commun. Chem. Pathol. Pharmacol.

Jarvis et al., 1998, Mexiletine. A review of its therapeutic use in painful diabetic neuropathy., Drugs

TTD: Mexiletine
- Version: 2020.06.01
Alternate Names:

D0X0RI TTD Drug ID

Drug Info:

Publications:
ChemblDrugs: chembl:CHEMBL558
- Version: ChEMBL_27
Alternate Names:

Drug Info:

Publications:
PharmGKB: mexiletine
- Version: 18-August-2020
Alternate Names:

Drug Info:

Publications:

Trial Name	-
Novel drug target	Established target

MEXILETINE Drug Record

MEXILETINE chembl:CHEMBL558 Approved

Alternate Names:

Drug Info:

Publications:

MEXILETINE SCN5A

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Trial Name - Novel drug target Established target

PMIDs: 12676070 12123767 12650887 12604879 16168489 11752352 11196553

Sources: TdgClinicalTrial TEND PharmGKB TTD

MEXILETINE TAC1

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 7686682

Sources: NCI

MEXILETINE CYP2D6

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 9806111

Sources: NCI PharmGKB

TEND: MEXILETINE

Alternate Names: MEXILETINE Primary Drug Name

Drug Info: Drug Class anti-arrhythmia agents Year of Approval 1985

Publications:

TdgClinicalTrial: MEXILETINE

Alternate Names:

Drug Info: Drug Indications Anti-Arrhythmia Agents Drug Class small molecule FDA Approval 1985

Publications:

NCI: MEXILETINE

Alternate Names: C652 NCI drug code

Drug Info:

Publications: Kamei et al., 1993, Effects of mexiletine on formalin-induced nociceptive responses in mice., Res. Commun. Chem. Pathol. Pharmacol. Jarvis et al., 1998, Mexiletine. A review of its therapeutic use in painful diabetic neuropathy., Drugs

TTD: Mexiletine

Alternate Names: D0X0RI TTD Drug ID

Drug Info:

Publications:

ChemblDrugs: chembl:CHEMBL558

Alternate Names:

Drug Info:

Publications:

PharmGKB: mexiletine

Alternate Names:

Drug Info:

Publications:

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
12676070 12123767 12650887 12604879 16168489 11752352 11196553

Sources:
TdgClinicalTrial TEND PharmGKB TTD

Interaction Types & Directionality:

n/a

PMIDs:
7686682

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
9806111

Sources:
NCI PharmGKB

Alternate Names:

MEXILETINE Primary Drug Name

Drug Info:

Drug Class anti-arrhythmia agents

Year of Approval 1985

Drug Info:

Drug Indications Anti-Arrhythmia Agents

Drug Class small molecule

FDA Approval 1985

Alternate Names:

C652 NCI drug code

Publications:

Kamei et al., 1993, Effects of mexiletine on formalin-induced nociceptive responses in mice., Res. Commun. Chem. Pathol. Pharmacol.

Jarvis et al., 1998, Mexiletine. A review of its therapeutic use in painful diabetic neuropathy., Drugs

Alternate Names:

D0X0RI TTD Drug ID