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MEXILETINE Drug Record

  • Summary
  • Interactions
  • Claims
  • MEXILETINE chembl:CHEMBL558 Approved

    Alternate Names:

    MEXILETINE

    Drug Info:

    Year of Approval 1985
    Drug Class anti-arrhythmia agents
    FDA Approval 1985
    Drug Class small molecule
    Drug Indications Anti-Arrhythmia Agents
    (2 More Sources)

    Publications:

    Wang et al., 2003, Effect of mexiletine on long QT syndrome model., Acta Pharmacol. Sin.
    Valdivia et al., 2002, A novel SCN5A arrhythmia mutation, M1766L, with expression defect rescued by mexiletine., Cardiovasc. Res.
    Fabritz et al., 2003, Effect of pacing and mexiletine on dispersion of repolarisation and arrhythmias in DeltaKPQ SCN5A (long QT3) mice., Cardiovasc. Res.
    Chinushi et al., 2003, Ventricular tachyarrhythmias in a canine model of LQT3: arrhythmogenic effects of sympathetic activity and therapeutic effects of mexiletine., Circ. J.
    Napolitano et al., 2006, Gene-specific therapy for inherited arrhythmogenic diseases., Pharmacol. Ther.
    Chen et al., 2002, TTD: Therapeutic Target Database., Nucleic Acids Res.
    Shimizu et al., 2000, Effect of sodium channel blockers on ST segment, QRS duration, and corrected QT interval in patients with Brugada syndrome., J. Cardiovasc. Electrophysiol.
    Jarvis et al., 1998, Mexiletine. A review of its therapeutic use in painful diabetic neuropathy., Drugs
    Kamei et al., 1993, Effects of mexiletine on formalin-induced nociceptive responses in mice., Res. Commun. Chem. Pathol. Pharmacol.
  • MEXILETINE   SCN5A

    Interaction Score: 2.67

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Trial Name -
    Novel drug target Established target

    PMIDs:
    12676070 12123767 12650887 12604879 16168489 11752352 11196553


    Sources:
    TdgClinicalTrial TEND PharmGKB TTD

  • MEXILETINE   TAC1

    Interaction Score: 1.87

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    7686682


    Sources:
    NCI

  • MEXILETINE   CYP2D6

    Interaction Score: 0.1

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    9806111


    Sources:
    NCI PharmGKB

  • TEND: MEXILETINE

    • Version: 01-August-2011

    Alternate Names:
    MEXILETINE Primary Drug Name

    Drug Info:
    Drug Class anti-arrhythmia agents
    Year of Approval 1985

    Publications:

  • TdgClinicalTrial: MEXILETINE

    • Version: January-2014

    Alternate Names:

    Drug Info:
    Drug Indications Anti-Arrhythmia Agents
    Drug Class small molecule
    FDA Approval 1985

    Publications:

  • NCI: MEXILETINE

    • Version: 14-September-2017

    Alternate Names:
    C652 NCI drug code

    Drug Info:

    Publications:
    Kamei et al., 1993, Effects of mexiletine on formalin-induced nociceptive responses in mice., Res. Commun. Chem. Pathol. Pharmacol.
    Jarvis et al., 1998, Mexiletine. A review of its therapeutic use in painful diabetic neuropathy., Drugs

  • TTD: Mexiletine

    • Version: 2020.06.01

    Alternate Names:
    D0X0RI TTD Drug ID

    Drug Info:

    Publications:

  • ChemblDrugs: chembl:CHEMBL558

    • Version: ChEMBL_27

    Alternate Names:

    Drug Info:

    Publications:

  • PharmGKB: mexiletine

    • Version: 18-August-2020

    Alternate Names:

    Drug Info:

    Publications:

Disclaimer: This resource is intended for purely research purposes. It should not be used for emergencies or medical or professional advice.

A finding of a drug-gene interaction or potentially druggable category does not necessarily indicate effectiveness (or lack thereof) of any drug or treatment regimen. A finding of no interaction or no potentially druggable category does not necessarily indicate lack of effectiveness of any drug or treatment regimen. Drug-gene interactions or potentially druggable categories are not presented in ranked order of potential or predicted efficacy.

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DGIdb (v4.2.0 - sha1 afd9f30b) • Last updated 2020-10-21