DGIdb - METYROSINE Drug Record

METYROSINE chembl:CHEMBL1200862 Approved

Alternate Names:

METYROSINE
L-588357-0
MK-781
METIROSINE
DEMSER
METHYLTYROSINE
METIROSINUM
METIROSIN
(-)-ALPHA-METHYL-L-TYROSINE
DEMSER®
ALPHA-METHYL-P-TYROSINE
Α-MPT
Α-METHYL-L-P-TYROSINE
ALPHA-METHYLTYROSINE
ALPHA-METHYL-PARA-TYROSINE
MÉTIROSINE
ALPHA-METHYL-L-P-TYROSINE
Α-METHYL-PARA-TYROSINE
(–)-Α-METHYL-L-TYROSINE
L-ALPHA-METHYLTYROSINE
(S)-ALPHA-METHYLTYROSINE
METIROSINA
Α-METHYL-P-TYROSINE
rxcui:266604
drugbank:00765
chemidplus:672-87-7
chembl:CHEMBL1200862
pubchem.compound:441350

Drug Info:

Drug Class	catecholamine synthesis inhibitors
Year of Approval	1979
Drug Categories	tyrosine hydroxylase inhibitors
Drug Categories	methyltyrosines
FDA Approval	1979
Drug Class	small molecule
Drug Indications	Catecholamine synthesis inhibitors
Drug Categories	catecholamine synthesis inhibitor

(7 More Sources)

Publications:

Yoshimoto et al., 2005, L-dopa and dopamine enhance the formation of aggregates under proteasome inhibition in PC12 cells., FEBS Lett.
Shore et al., 1975, On a prime role for newly synthesized dopamine in striatal function., Eur. J. Pharmacol.
Nasrallah et al., 1977, Inhibition of dopamine synthesis in chronic schizophrenia. Clinical ineffectiveness of metyrosine., Arch. Gen. Psychiatry
Chen et al., 2002, TTD: Therapeutic Target Database., Nucleic Acids Res.
Moore et al., 1980, Influence of prolactin on dopaminergic neuronal systems in the hypothalamus., Fed. Proc.
Peng et al., 2004, Effect of catecholamines on IL-2 production and NK cytotoxicity of rats in vitro., Acta Pharmacol. Sin.
Won et al., 1993, Alpha-methyl-p-tyrosine reduces poly I:C-induced augmenting interferon production and splenic natural killer cell activity in mice., Pharmacology
Sakatis MZ et al., 2012, Preclinical strategy to reduce clinical hepatotoxicity using in vitro bioactivation data for >200 compounds., Chem Res Toxicol
Sivitz et al., 1999, Sympathetic inhibition, leptin, and uncoupling protein subtype expression in normal fasting rats., Am. J. Physiol.
Han et al., 1999, D2 autoreceptors are not involved in the down-regulation of the striatal dopamine transporter caused by alpha-methyl-p-tyrosine., Res. Commun. Mol. Pathol. Pharmacol.
Wang et al., 2006, Secretion of brain-derived neurotrophic factor from PC12 cells in response to oxidative stress requires autocrine dopamine signaling., J. Neurochem.

METYROSINE TH

Interaction Score: 4.13

Interaction Types & Directionality:

inhibitor (inhibitory)

binder

Interaction Info:

Mechanism of Interaction Tyrosine 3-hydroxylase inhibitor

Direct Interaction yes

Trial Name -

PMIDs:
15710413 1168577 17374 11752352 7409209

Sources:
DrugBank TdgClinicalTrial ChemblInteractions TEND GuideToPharmacology PharmGKB TTD
METYROSINE UCP1

Interaction Score: 3.44

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
10516126

Sources:
NCI
METYROSINE IFNA1

Interaction Score: 2.58

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
7685917

Sources:
NCI
METYROSINE IL2

Interaction Score: 0.26

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
15456539

Sources:
NCI
METYROSINE BDNF

Interaction Score: 0.15

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
16390493

Sources:
NCI
METYROSINE SLC6A3

Interaction Score: 0.13

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
10741383

Sources:
NCI
METYROSINE CYP2C9

Interaction Score: 0.02

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
22931300

Sources:
DTC
METYROSINE CYP2C19

Interaction Score: 0.02

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
22931300

Sources:
DTC
METYROSINE CYP1A2

Interaction Score: 0.02

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
22931300

Sources:
DTC
METYROSINE CYP2D6

Interaction Score: 0.02

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
22931300

Sources:
DTC
METYROSINE CYP3A4

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
22931300

Sources:
DTC

DrugBank: DB00765

Version: 5.1.7

Alternate Names:

METYROSINE DrugBank Drug Name

672-87-7 CAS Number

Demser Drug Brand

Drug Info:

Drug Type small molecule

Drug Groups approved

Drug Categories amino acids

Publications:

Shore et al., 1975, On a prime role for newly synthesized dopamine in striatal function., Eur. J. Pharmacol.

Nasrallah et al., 1977, Inhibition of dopamine synthesis in chronic schizophrenia. Clinical ineffectiveness of metyrosine., Arch. Gen. Psychiatry

Yoshimoto et al., 2005, L-dopa and dopamine enhance the formation of aggregates under proteasome inhibition in PC12 cells., FEBS Lett.

TEND: METYROSINE
- Version: 01-August-2011
Alternate Names:

METYROSINE Primary Drug Name

Drug Info:

Year of Approval 1979

Drug Class catecholamine synthesis inhibitors

Publications:
TdgClinicalTrial: METYROSINE
- Version: January-2014
Alternate Names:

Drug Info:

Drug Indications Catecholamine synthesis inhibitors

Drug Class small molecule

FDA Approval 1979

Publications:

NCI: ALPHA-METHYL-P-TYROSINE

Version: 14-September-2017

Alternate Names:

C998 NCI drug code

Drug Info:

Publications:

Han et al., 1999, D2 autoreceptors are not involved in the down-regulation of the striatal dopamine transporter caused by alpha-methyl-p-tyrosine., Res. Commun. Mol. Pathol. Pharmacol.

Wang et al., 2006, Secretion of brain-derived neurotrophic factor from PC12 cells in response to oxidative stress requires autocrine dopamine signaling., J. Neurochem.

Won et al., 1993, Alpha-methyl-p-tyrosine reduces poly I:C-induced augmenting interferon production and splenic natural killer cell activity in mice., Pharmacology

DTC: METYROSINE
- Version: 02-September-2020
Alternate Names:

CHEMBL1200862 ChEMBL Drug ID

Drug Info:

Publications:

Sakatis MZ et al., 2012, Preclinical strategy to reduce clinical hepatotoxicity using in vitro bioactivation data for >200 compounds., Chem Res Toxicol
TTD: Metyrosine
- Version: 2020.06.01
Alternate Names:

D0B3QM TTD Drug ID

Drug Info:

Publications:
GuideToPharmacology: 178103538
- Version: 29-September-2020
Alternate Names:

ALPHA-METHYLTYROSINE GuideToPharmacology Ligand Name

Drug Info:

Publications:
GuideToPharmacology: 178101787
- Version: 29-September-2020
Alternate Names:

METHYLTYROSINE GuideToPharmacology Ligand Name

Drug Info:

Publications:
ChemblDrugs: chembl:CHEMBL1200862
- Version: ChEMBL_27
Alternate Names:

Drug Info:

Publications:
ChemblInteractions: CHEMBL1200862
- Version: chembl_23
Alternate Names:

Drug Info:

Publications:
PharmGKB: metyrosine
- Version: 18-August-2020
Alternate Names:

Drug Info:

Publications:

Mechanism of Interaction	Tyrosine 3-hydroxylase inhibitor
Direct Interaction	yes
Trial Name	-

METYROSINE	DrugBank Drug Name
672-87-7	CAS Number
Demser	Drug Brand

Drug Type	small molecule
Drug Groups	approved
Drug Categories	amino acids

inhibitor (inhibitory)
binder

METYROSINE Drug Record

METYROSINE chembl:CHEMBL1200862 Approved

Alternate Names:

Drug Info:

Publications:

Interaction Types & Directionality: inhibitor (inhibitory) binder

Interaction Info: Mechanism of Interaction Tyrosine 3-hydroxylase inhibitor Direct Interaction yes Trial Name -

PMIDs: 15710413 1168577 17374 11752352 7409209

Sources: DrugBank TdgClinicalTrial ChemblInteractions TEND GuideToPharmacology PharmGKB TTD

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 10516126

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 7685917

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 15456539

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 16390493

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 10741383

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 22931300

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 22931300

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 22931300

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 22931300

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 22931300

Sources: DTC

DrugBank: DB00765

Alternate Names: METYROSINE DrugBank Drug Name 672-87-7 CAS Number Demser Drug Brand

Drug Info: Drug Type small molecule Drug Groups approved Drug Categories amino acids

TEND: METYROSINE

Alternate Names: METYROSINE Primary Drug Name

Drug Info: Year of Approval 1979 Drug Class catecholamine synthesis inhibitors

Publications:

TdgClinicalTrial: METYROSINE

Alternate Names:

Drug Info: Drug Indications Catecholamine synthesis inhibitors Drug Class small molecule FDA Approval 1979

Publications:

NCI: ALPHA-METHYL-P-TYROSINE

Alternate Names: C998 NCI drug code

Drug Info:

DTC: METYROSINE

Alternate Names: CHEMBL1200862 ChEMBL Drug ID

Drug Info:

Publications: Sakatis MZ et al., 2012, Preclinical strategy to reduce clinical hepatotoxicity using in vitro bioactivation data for &gt;200 compounds., Chem Res Toxicol

TTD: Metyrosine

Alternate Names: D0B3QM TTD Drug ID

Drug Info:

Publications:

GuideToPharmacology: 178103538

Alternate Names: ALPHA-METHYLTYROSINE GuideToPharmacology Ligand Name

Drug Info:

Publications:

GuideToPharmacology: 178101787

Alternate Names: METHYLTYROSINE GuideToPharmacology Ligand Name

Drug Info:

Publications:

ChemblDrugs: chembl:CHEMBL1200862

Interaction Types & Directionality:

inhibitor (inhibitory)

binder

Interaction Info:

Mechanism of Interaction Tyrosine 3-hydroxylase inhibitor

Direct Interaction yes

Trial Name -

PMIDs:
15710413 1168577 17374 11752352 7409209

Sources:
DrugBank TdgClinicalTrial ChemblInteractions TEND GuideToPharmacology PharmGKB TTD

Interaction Types & Directionality:

n/a

PMIDs:
10516126

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
7685917

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
15456539

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
16390493

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
10741383

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
22931300

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
22931300

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
22931300

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
22931300

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
22931300

Sources:
DTC

Alternate Names:

METYROSINE DrugBank Drug Name

672-87-7 CAS Number

Demser Drug Brand

Drug Info:

Drug Type small molecule

Drug Groups approved

Drug Categories amino acids

Alternate Names:

METYROSINE Primary Drug Name

Drug Info:

Year of Approval 1979

Drug Class catecholamine synthesis inhibitors

Drug Info:

Drug Indications Catecholamine synthesis inhibitors

Drug Class small molecule

FDA Approval 1979

Alternate Names:

C998 NCI drug code

Alternate Names:

CHEMBL1200862 ChEMBL Drug ID

Publications:

Sakatis MZ et al., 2012, Preclinical strategy to reduce clinical hepatotoxicity using in vitro bioactivation data for >200 compounds., Chem Res Toxicol

Alternate Names:

D0B3QM TTD Drug ID

Alternate Names:

ALPHA-METHYLTYROSINE GuideToPharmacology Ligand Name

Alternate Names:

METHYLTYROSINE GuideToPharmacology Ligand Name