DGIdb - METIPRANOLOL Drug Record

METIPRANOLOL chembl:CHEMBL1291

Alternate Names:

VUAB-6453
METIPRANOLOL
VUAB6453 (SPOFA)
OPTIPRANOLOL
BM-01004
GLAULINE

Drug Info:

FDA Approval	1989
Drug Class	small molecule
Drug Indications	Anti-glaucoma agent
Drug Indications	Antihypertensive Agents
Drug Indications	Anti-Arrhythmia Agents
Drug Class	antihypertensive agents
Drug Class	anti-arrhythmia agents
Drug Class	anti-glaucoma agent
Year of Approval	1989
Drug Categories	agents causing hyperkalemia
Drug Categories	antiarrhythmic agents
Drug Categories	beta blocking agents and thiazides
Drug Categories	beta blocking agents, non-selective, and thiazides
Drug Categories	cytochrome p-450 cyp2d6 substrates
Drug Categories	cytochrome p-450 substrates

(2 More Sources)

Publications:

Noack, 1986, [Antiglaucomatous effectiveness of beta receptor blockers with special reference to metipranolol]., Klin Monbl Augenheilkd
Bilcíková et al., 1987, The action of adrenoceptor agonists and antagonists on the guinea pig and dog trachea., Gen. Physiol. Biophys.
Arai et al., 2003, Beta-adrenergic receptor agonists and antagonists counteract LPS-induced neuronal death in retinal cultures by different mechanisms., Brain Res.
Drímal et al., 1987, External transport of beta-adrenergic binding sites in ischemic myocardium., Gen. Physiol. Biophys.
Overington et al., 2006, How many drug targets are there?, Nat Rev Drug Discov
Imming et al., 2006, Drugs, their targets and the nature and number of drug targets., Nat Rev Drug Discov

METIPRANOLOL ADRB1

Interaction Score: 1.35

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
2885244 12967722 2895037 17139284 17016423

Sources:
TEND TdgClinicalTrial TTD DrugBank
METIPRANOLOL ADRB2

Interaction Score: 1.04

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Novel drug target Established target

Trial Name -

PMIDs:
2876128 2885244 12967722 2895037 17139284 17016423

Sources:
TEND TdgClinicalTrial DrugBank
METIPRANOLOL AR

Interaction Score: 0.02

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC

DrugBank: DB01214

Version: 5.1.7

Alternate Names:

METIPRANOLOL DrugBank Drug Name

22664-55-7 CAS Number

Betanol Drug Brand

Drug Info:

Drug Type small molecule

Drug Groups approved

Drug Categories adrenergic agents

Publications:

Noack, 1986, [Antiglaucomatous effectiveness of beta receptor blockers with special reference to metipranolol]., Klin Monbl Augenheilkd

Bilcíková et al., 1987, The action of adrenoceptor agonists and antagonists on the guinea pig and dog trachea., Gen. Physiol. Biophys.

Arai et al., 2003, Beta-adrenergic receptor agonists and antagonists counteract LPS-induced neuronal death in retinal cultures by different mechanisms., Brain Res.

TEND: METIPRANOLOL
- Version: 01-August-2011
Alternate Names:

METIPRANOLOL Primary Drug Name

Drug Info:

Year of Approval 1989

Drug Class anti-glaucoma agent

Drug Class anti-arrhythmia agents

Publications:
TdgClinicalTrial: METIPRANOLOL
- Version: January-2014
Alternate Names:

Drug Info:

Drug Indications Anti-Arrhythmia Agents

Drug Indications Antihypertensive Agents

Drug Indications Anti-glaucoma agent

Publications:
TTD: Metipranolol
- Version: 2020.06.01
Alternate Names:

D0L5FY TTD Drug ID

Drug Info:

Publications:
DTC: METIPRANOLOL
- Version: 02-September-2020
Alternate Names:

CHEMBL1291 ChEMBL Drug ID

Drug Info:

Publications:
ChemblDrugs: chembl:CHEMBL1291
- Version: ChEMBL_27
Alternate Names:

Drug Info:

Publications:

METIPRANOLOL	DrugBank Drug Name
22664-55-7	CAS Number
Betanol	Drug Brand

Drug Type	small molecule
Drug Groups	approved
Drug Categories	adrenergic agents

Trial Name	-
Novel drug target	Established target

Novel drug target	Established target
Trial Name	-

METIPRANOLOL Drug Record

METIPRANOLOL chembl:CHEMBL1291

Alternate Names:

Drug Info:

Publications:

METIPRANOLOL ADRB1

Interaction Types & Directionality: antagonist (inhibitory)

Interaction Info: Trial Name - Novel drug target Established target

PMIDs: 2885244 12967722 2895037 17139284 17016423

Sources: TEND TdgClinicalTrial TTD DrugBank

METIPRANOLOL ADRB2

Interaction Types & Directionality: antagonist (inhibitory)

Interaction Info: Novel drug target Established target Trial Name -

PMIDs: 2876128 2885244 12967722 2895037 17139284 17016423

Sources: TEND TdgClinicalTrial DrugBank

METIPRANOLOL AR

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

DrugBank: DB01214

Alternate Names: METIPRANOLOL DrugBank Drug Name 22664-55-7 CAS Number Betanol Drug Brand

Drug Info: Drug Type small molecule Drug Groups approved Drug Categories adrenergic agents

TEND: METIPRANOLOL

Alternate Names: METIPRANOLOL Primary Drug Name

Drug Info: Year of Approval 1989 Drug Class anti-glaucoma agent Drug Class anti-arrhythmia agents

Publications:

TdgClinicalTrial: METIPRANOLOL

Alternate Names:

Drug Info: Drug Indications Anti-Arrhythmia Agents Drug Indications Antihypertensive Agents Drug Indications Anti-glaucoma agent

Publications:

TTD: Metipranolol

Alternate Names: D0L5FY TTD Drug ID

Drug Info:

Publications:

DTC: METIPRANOLOL

Alternate Names: CHEMBL1291 ChEMBL Drug ID

Drug Info:

Publications:

ChemblDrugs: chembl:CHEMBL1291

Alternate Names:

Drug Info:

Publications:

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
2885244 12967722 2895037 17139284 17016423

Sources:
TEND TdgClinicalTrial TTD DrugBank

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Novel drug target Established target

Trial Name -

PMIDs:
2876128 2885244 12967722 2895037 17139284 17016423

Sources:
TEND TdgClinicalTrial DrugBank

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Alternate Names:

METIPRANOLOL DrugBank Drug Name

22664-55-7 CAS Number

Betanol Drug Brand

Drug Info:

Drug Type small molecule

Drug Groups approved

Drug Categories adrenergic agents

Alternate Names:

METIPRANOLOL Primary Drug Name

Drug Info:

Year of Approval 1989

Drug Class anti-glaucoma agent

Drug Class anti-arrhythmia agents

Drug Info:

Drug Indications Anti-Arrhythmia Agents

Drug Indications Antihypertensive Agents

Drug Indications Anti-glaucoma agent

Alternate Names:

D0L5FY TTD Drug ID

Alternate Names:

CHEMBL1291 ChEMBL Drug ID