DGIdb - METHYLPREDNISOLONE Drug Record

METHYLPREDNISOLONE chembl:CHEMBL650 ApprovedAntineoplasticImmunotherapy

Alternate Names:

J3.872E
U-67590A
MEDROL
MEDRONE
METHYLPREDNISOLONE
NSC-19987
(6ALPHA,11BETA)-11,17,21-TRIHYDROXY-6-METHYLPREGNA-1,4-DIENE-3,20-DIONE
METHYLPREDNISOLON
(6Α,11Β)-11,17,21-TRIHYDROXY-6-METHYLPREGNA-1,4-DIENE-3,20-DIONE
6ALPHA-METHYL-11BETA,17ALPHA,21-TRIOL-1,4-PREGNADIENE-3,20-DIONE
MEDRATE
SOLOMET
MEDROL®
DELTA(1)-6ALPHA-METHYLHYDROCORTISONE
URBASON
1-DEHYDRO-6Α-METHYLHYDROCORTISONE
SOLU-MEDROL
1-DEHYDRO-6ALPHA-METHYLHYDROCORTISONE
METILPREDNISOLONA
METHYLPREDNISOLONUM
chembl:CHEMBL650
chemidplus:83-43-2
rxcui:6902
pubchem.compound:6741
drugbank:00959

Drug Info:

FDA Approval	Approved before 1982
Drug Class	small molecule
Drug Indications	Glucocorticoids
Drug Indications	Anti-Inflammatory Agents
Year of Approval	approved before 1982
Drug Class	glucocorticoids
Drug Class	anti-inflammatory agents
Drug Categories	adrenals
Drug Categories	anti-acne preparations
Drug Categories	anti-acne preparations for topical use
Drug Categories	compounds used in a research, industrial, or household setting
Drug Categories	corticosteroid hormone receptor agonists
Drug Categories	corticosteroids
Drug Categories	corticosteroids for systemic use, plain
Drug Categories	corticosteroids, dermatological preparations
Drug Categories	corticosteroids, weak (group i)
Drug Categories	cytochrome p-450 cyp2a6 inducers
Drug Categories	cytochrome p-450 cyp2b6 inducers
Drug Categories	cytochrome p-450 cyp2b6 inducers (strength unknown)
Drug Categories	cytochrome p-450 cyp2c19 inducers
Drug Categories	cytochrome p-450 cyp2c19 inducers (strength unknown)
Drug Categories	cytochrome p-450 cyp2c8 inducers
Drug Categories	cytochrome p-450 cyp2c8 inducers (strength unknown)
Drug Categories	cytochrome p-450 cyp2c9 inducers
Drug Categories	cytochrome p-450 cyp2c9 inducers (strength unknown)
Drug Categories	cytochrome p-450 cyp3a inducers
Drug Categories	cytochrome p-450 cyp3a substrates
Drug Categories	cytochrome p-450 cyp3a4 inducers
Drug Categories	cytochrome p-450 cyp3a4 inducers (strength unknown)
Drug Categories	cytochrome p-450 enzyme inducers
Drug Categories	cytochrome p-450 substrates
Drug Categories	dermatologicals
Drug Categories	experimental unapproved treatments for covid-19
Drug Categories	fused-ring compounds
Drug Categories	ophthalmologicals
Drug Categories	p-glycoprotein inducers
Drug Categories	p-glycoprotein substrates
Drug Categories	sensory organs

(5 More Sources)

Publications:

Serres et al., 1994, Expression of annexin I in freshly isolated human epidermal cells and in cultured keratinocytes., Arch. Dermatol. Res.
Asano T et al., 2003, ABCB1 C3435T and G2677T/A polymorphism decreased the risk for steroid-induced osteonecrosis of the femoral head after kidney transplantation., Pharmacogenetics
Yagi et al., 1997, [Cytokine-secreting cells in relapsing multiple sclerosis patients treated with high-dose intravenous methylprednisolone]., Rinsho Shinkeigaku
Juruena et al., 2006, Different responses to dexamethasone and prednisolone in the same depressed patients., Psychopharmacology (Berl.)
Owen et al., 2007, The growth plate sparing effects of the selective glucocorticoid receptor modulator, AL-438., Mol. Cell. Endocrinol.
Chen et al., 2002, TTD: Therapeutic Target Database., Nucleic Acids Res.
Boivin et al., 2007, Mechanism of glucocorticoid regulation of the intestinal tight junction barrier., Am. J. Physiol. Gastrointest. Liver Physiol.
Quesnell et al., 2007, Glucocorticoids stimulate ENaC upregulation in bovine mammary epithelium., Am. J. Physiol., Cell Physiol.
Kim et al., 2004, Continuous brain-derived neurotrophic factor (BDNF) infusion after methylprednisolone treatment in severe spinal cord injury., J. Korean Med. Sci.
Mantzavinos et al., 1996, Serum markers of immune activation in women undergoing in-vitro fertilization and embryo transfer., Hum. Reprod.
Lavignac et al., 1996, [Immunohistochemical study of lesions in Horton's temporal arteritis before and during corticotherapy]., Rev Med Interne
Michałowska-Wender et al., Effect of methylprednisolone treatment on expression of sPECAM-1 and CXCL10 chemokine in serum of MS patients., Pharmacol Rep
Hallsworth et al., 1992, Glucocorticoids inhibit granulocyte-macrophage colony-stimulating factor-1 and interleukin-5 enhanced in vitro survival of human eosinophils., Immunology
Taniguchi et al., 1999, Activation of lymphocytes and increased interleukin-5 levels in bronchoalveolar lavage fluid in acute eosinophilic pneumonia., Eur. Respir. J.
Morris et al., 1997, Decreased C-MYC and BCL2 expression correlates with methylprednisolone-mediated inhibition of Raji lymphoma growth., Biochem. Mol. Med.
Adişen et al., 2006, The effects of calcipotriol and methylprednisolone aseponate on bcl-2, p53 and ki-67 expression in psoriasis., J Eur Acad Dermatol Venereol
Emir et al., 2005, Beneficial effect of methylprednisolone on cardiac myocytes in a rat model of severe brain injury., Tohoku J. Exp. Med.
Boylan et al., 1999, CD80 (B7-1) and CD86 (B7-2) expression in multiple sclerosis patients: clinical subtype specific variation in peripheral monocytes and B cells and lack of modulation by high dose methylprednisolone., J. Neurol. Sci.

METHYLPREDNISOLONE IL5

Interaction Score: 1.33

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
1551701 10836352

Sources:
NCI
METHYLPREDNISOLONE CD80

Interaction Score: 0.89

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
10521545

Sources:
NCI
METHYLPREDNISOLONE CXCL10

Interaction Score: 0.55

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
17220550

Sources:
NCI
METHYLPREDNISOLONE ITGB2

Interaction Score: 0.37

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
8976974

Sources:
NCI
METHYLPREDNISOLONE IFNG

Interaction Score: 0.37

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
9396353

Sources:
NCI
METHYLPREDNISOLONE ANXA1

Interaction Score: 0.37

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

PMIDs:
8060156

Sources:
TEND DrugBank
METHYLPREDNISOLONE IL2RA

Interaction Score: 0.24

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
8981122

Sources:
NCI
METHYLPREDNISOLONE TRPC5

Interaction Score: 0.24

Interaction Types & Directionality:

activator (activating)

Interaction Info:

Details of the Assay for Interaction Measuring intracellular calcium elevation in HEK293 cells expressing hTRPC5.

Specific Action of the Ligand Activation

Endogenous Drug? False

PMIDs:
None found

Sources:
GuideToPharmacology
METHYLPREDNISOLONE NR3C1

Interaction Score: 0.23

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Trial Name -

Novel drug target Established target

Mechanism of Interaction Glucocorticoid receptor agonist

PMIDs:
17016711 17182172 11752352 17068119 17251323

Sources:
TEND TdgClinicalTrial DrugBank GuideToPharmacology ChemblInteractions
METHYLPREDNISOLONE BCL2

Interaction Score: 0.22

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
16141680 16684279

Sources:
NCI
METHYLPREDNISOLONE MYC

Interaction Score: 0.17

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
9169090

Sources:
NCI
METHYLPREDNISOLONE BDNF

Interaction Score: 0.11

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
14966352

Sources:
NCI
METHYLPREDNISOLONE ABCB1

Interaction Score: 0.03

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
14583680

Sources:
PharmGKB
METHYLPREDNISOLONE TP53

Interaction Score: 0.02

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
16684279

Sources:
NCI
METHYLPREDNISOLONE NFE2L2

Interaction Score: 0.0

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
METHYLPREDNISOLONE AR

Interaction Score: 0.0

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC

DrugBank: DB00959

Version: 5.1.7

Alternate Names:

METHYLPREDNISOLONE DrugBank Drug Name

83-43-2 CAS Number

Depo-Medrol Drug Brand

Drug Info:

Drug Type small molecule

Drug Groups approved

Drug Groups vet_approved

Publications:

Juruena et al., 2006, Different responses to dexamethasone and prednisolone in the same depressed patients., Psychopharmacology (Berl.)

Owen et al., 2007, The growth plate sparing effects of the selective glucocorticoid receptor modulator, AL-438., Mol. Cell. Endocrinol.

Chen et al., 2002, TTD: Therapeutic Target Database., Nucleic Acids Res.

TEND: METHYLPREDNISOLONE
- Version: 01-August-2011
Alternate Names:

METHYLPREDNISOLONE Primary Drug Name

Drug Info:

Drug Class anti-inflammatory agents

Drug Class glucocorticoids

Year of Approval approved before 1982

Publications:
TdgClinicalTrial: METHYLPREDNISOLONE
- Version: January-2014
Alternate Names:

Drug Info:

Drug Indications Anti-Inflammatory Agents

Drug Indications Glucocorticoids

Drug Class small molecule

Publications:

NCI: METHYLPREDNISOLONE

Version: 14-September-2017

Alternate Names:

C647 NCI drug code

Drug Info:

Publications:

Yagi et al., 1997, [Cytokine-secreting cells in relapsing multiple sclerosis patients treated with high-dose intravenous methylprednisolone]., Rinsho Shinkeigaku

Lavignac et al., 1996, [Immunohistochemical study of lesions in Horton's temporal arteritis before and during corticotherapy]., Rev Med Interne

Mantzavinos et al., 1996, Serum markers of immune activation in women undergoing in-vitro fertilization and embryo transfer., Hum. Reprod.

PharmGKB: methylprednisolone
- Version: 18-August-2020
Alternate Names:

Drug Info:

Publications:

Asano T et al., 2003, ABCB1 C3435T and G2677T/A polymorphism decreased the risk for steroid-induced osteonecrosis of the femoral head after kidney transplantation., Pharmacogenetics
GuideToPharmacology: 178103666
- Version: 29-September-2020
Alternate Names:

METHYLPREDNISOLONE GuideToPharmacology Ligand Name

Drug Info:

Publications:
DTC: METHYLPREDNISOLONE
- Version: 02-September-2020
Alternate Names:

CHEMBL650 ChEMBL Drug ID

Drug Info:

Publications:
ChemblDrugs: chembl:CHEMBL650
- Version: ChEMBL_27
Alternate Names:

Drug Info:

Publications:
ChemblInteractions: CHEMBL650
- Version: chembl_23
Alternate Names:

Drug Info:

Publications:

Details of the Assay for Interaction	Measuring intracellular calcium elevation in HEK293 cells expressing hTRPC5.
Specific Action of the Ligand	Activation
Endogenous Drug?	False

Trial Name	-
Novel drug target	Established target
Mechanism of Interaction	Glucocorticoid receptor agonist

METHYLPREDNISOLONE	DrugBank Drug Name
83-43-2	CAS Number
Depo-Medrol	Drug Brand

Drug Type	small molecule
Drug Groups	approved
Drug Groups	vet_approved

METHYLPREDNISOLONE Drug Record

METHYLPREDNISOLONE chembl:CHEMBL650 ApprovedAntineoplasticImmunotherapy

Alternate Names:

Drug Info:

Publications:

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 1551701 10836352

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 10521545

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 17220550

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 8976974

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 9396353

Sources: NCI

Interaction Types & Directionality: agonist (activating)

Interaction Info:

PMIDs: 8060156

Sources: TEND DrugBank

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 8981122

Sources: NCI

Interaction Types & Directionality: activator (activating)

Interaction Info: Details of the Assay for Interaction Measuring intracellular calcium elevation in HEK293 cells expressing hTRPC5. Specific Action of the Ligand Activation Endogenous Drug? False

PMIDs: None found

Sources: GuideToPharmacology

Interaction Types & Directionality: agonist (activating)

Interaction Info: Trial Name - Novel drug target Established target Mechanism of Interaction Glucocorticoid receptor agonist

PMIDs: 17016711 17182172 11752352 17068119 17251323

Sources: TEND TdgClinicalTrial DrugBank GuideToPharmacology ChemblInteractions

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 16141680 16684279

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 9169090

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 14966352

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 14583680

Sources: PharmGKB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 16684279

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

DrugBank: DB00959

Alternate Names: METHYLPREDNISOLONE DrugBank Drug Name 83-43-2 CAS Number Depo-Medrol Drug Brand

Drug Info: Drug Type small molecule Drug Groups approved Drug Groups vet_approved

TEND: METHYLPREDNISOLONE

Alternate Names: METHYLPREDNISOLONE Primary Drug Name

Drug Info: Drug Class anti-inflammatory agents Drug Class glucocorticoids Year of Approval approved before 1982

Publications:

TdgClinicalTrial: METHYLPREDNISOLONE

Alternate Names:

Drug Info: Drug Indications Anti-Inflammatory Agents Drug Indications Glucocorticoids Drug Class small molecule

Publications:

Interaction Types & Directionality:

n/a

PMIDs:
1551701 10836352

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
10521545

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
17220550

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
8976974

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
9396353

Sources:
NCI

Interaction Types & Directionality:

agonist (activating)

PMIDs:
8060156

Sources:
TEND DrugBank

Interaction Types & Directionality:

n/a

PMIDs:
8981122

Sources:
NCI

Interaction Types & Directionality:

activator (activating)

Interaction Info:

Details of the Assay for Interaction Measuring intracellular calcium elevation in HEK293 cells expressing hTRPC5.

Specific Action of the Ligand Activation

Endogenous Drug? False

PMIDs:
None found

Sources:
GuideToPharmacology

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Trial Name -

Novel drug target Established target

Mechanism of Interaction Glucocorticoid receptor agonist

PMIDs:
17016711 17182172 11752352 17068119 17251323

Sources:
TEND TdgClinicalTrial DrugBank GuideToPharmacology ChemblInteractions

Interaction Types & Directionality:

n/a

PMIDs:
16141680 16684279

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
9169090

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
14966352

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
14583680

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
16684279

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Alternate Names:

METHYLPREDNISOLONE DrugBank Drug Name

83-43-2 CAS Number

Depo-Medrol Drug Brand

Drug Info:

Drug Type small molecule

Drug Groups approved

Drug Groups vet_approved

Alternate Names:

METHYLPREDNISOLONE Primary Drug Name

Drug Info:

Drug Class anti-inflammatory agents

Drug Class glucocorticoids

Year of Approval approved before 1982

Drug Info:

Drug Indications Anti-Inflammatory Agents

Drug Indications Glucocorticoids

Drug Class small molecule

Alternate Names:

C647 NCI drug code

Publications:

Asano T et al., 2003, ABCB1 C3435T and G2677T/A polymorphism decreased the risk for steroid-induced osteonecrosis of the femoral head after kidney transplantation., Pharmacogenetics

Alternate Names:

METHYLPREDNISOLONE GuideToPharmacology Ligand Name

Alternate Names:

CHEMBL650 ChEMBL Drug ID