• Search
      • Search Interactions Search Categories
    • Browse
      • Browse Categories Browse Sources
    • Information
      • About Publications Interaction Types & Directionalities Interaction Score & Query Score API Documentation FAQ Known Data Clients News Contact
    • Downloads
      • Data Source Code

MESALAMINE Drug Record

  • Summary
  • Interactions
  • Claims
  • MESALAMINE chembl:CHEMBL704 Approved

    Alternate Names:

    NSC-38877
    LIALDA
    SFROWASA
    IPOCOL
    ROWASA
    MESALAZINE
    FISALAMINE
    APRISO
    MEZAVANT XL
    DELZICOL
    SALOFALK
    CANASA
    PENTASA
    MESALAZINE
    MESREN MR
    MESALAMINE
    ASACOL HD
    PENTASA SR
    ASACOL
    MAX-002
    OCTASA
    COLTEC EC
    P-AMINOSALICYLSAEURE
    3-CARBOXY-4-HYDROXYANILINE
    MESALAZINA
    M-AMINOSALICYLIC ACID
    PENTASA®
    5-ASA
    5-AMINOSALICYLATE
    MESALAZINUM
    5-AMINOSALICYLIC ACID
    MÉSALAZINE
    chembl:CHEMBL704
    chemidplus:89-57-6
    pubchem.compound:4075
    drugbank:00244
    rxcui:52582

    Drug Info:

    FDA Approval approved
    Drug Class Small Molecule
    Drug Indications for treatment of ulcerative proctitis
    Year of Approval 1987
    Drug Class anti-inflammatory agents, non-steroidal
    Drug Indications for treatment of ulcerative colitis
    Drug Indications antiinflammatory agent
    (5 More Sources)

    Publications:

    Allgayer, 2003, Review article: mechanisms of action of mesalazine in preventing colorectal carcinoma in inflammatory bowel disease., Aliment. Pharmacol. Ther.
    Chen et al., 2002, TTD: Therapeutic Target Database., Nucleic Acids Res.
    Allgayer et al., 1984, Soybean lipoxygenase inhibition: studies with the sulphasalazine metabolites N-acetylaminosalicylic acid, 5-aminosalicylic acid and sulphapyridine., Eur. J. Clin. Pharmacol.
    Nielsen et al., 1987, Inhibition of 5-lipoxygenase pathway of arachidonic acid metabolism in human neutrophils by sulfasalazine and 5-aminosalicylic acid., Dig. Dis. Sci.
    Sircar et al., 1983, Inhibition of soybean lipoxygenase by sulfasalazine and 5-aminosalicylic acid: a possible mode of action in ulcerative colitis., Biochem. Pharmacol.
    Rousseaux et al., 2005, Intestinal antiinflammatory effect of 5-aminosalicylic acid is dependent on peroxisome proliferator-activated receptor-gamma., J. Exp. Med.
    Linard et al., 2008, Reduction of peroxisome proliferation-activated receptor gamma expression by gamma-irradiation as a mechanism contributing to inflammatory response in rat colon: modulation by the 5-aminosalicylic acid agonist., J. Pharmacol. Exp. Ther.
    Desreumaux et al., 2006, Review article: mode of action and delivery of 5-aminosalicylic acid - new evidence., Aliment. Pharmacol. Ther.
    Schwab et al., 2008, PPARgamma is involved in mesalazine-mediated induction of apoptosis and inhibition of cell growth in colon cancer cells., Carcinogenesis
    Distrutti et al., 2006, 5-Amino-2-hydroxybenzoic acid 4-(5-thioxo-5H-[1,2]dithiol-3yl)-phenyl ester (ATB-429), a hydrogen sulfide-releasing derivative of mesalamine, exerts antinociceptive effects in a model of postinflammatory hypersensitivity., J. Pharmacol. Exp. Ther.
    Mifflin et al., 2004, Aspirin-mediated COX-2 transcript stabilization via sustained p38 activation in human intestinal myofibroblasts., Mol. Pharmacol.
    Generini et al., Therapy of spondylarthropathy in inflammatory bowel disease., Clin. Exp. Rheumatol.
    Pruzanski et al., 1997, Inhibition of extracellular release of proinflammatory secretory phospholipase A2 (sPLA2) by sulfasalazine: a novel mechanism of anti-inflammatory activity., Biochem. Pharmacol.
    Cipolla et al., 2002, Nonsteroidal anti-inflammatory drugs and inflammatory bowel disease: current perspectives., Pharmacol. Res.
    Santucci et al., 2005, Different sensitivity of lamina propria T-cell subsets to nitric oxide-induced apoptosis explains immunomodulatory activity of a nitric oxide-releasing derivative of mesalamine in rodent colitis., Gastroenterology
    Bantel et al., 2000, Mesalazine inhibits activation of transcription factor NF-kappaB in inflamed mucosa of patients with ulcerative colitis., Am. J. Gastroenterol.
    Weber et al., 2000, Suppression of NF-kappaB activity by sulfasalazine is mediated by direct inhibition of IkappaB kinases alpha and beta., Gastroenterology
  • MESALAMINE   CHUK

    Interaction Score: 1.55

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Trial Name SPD476,Lialda
    Novel drug target Established target

    PMIDs:
    12950415 11151876 11054378


    Sources:
    TdgClinicalTrial

  • MESALAMINE   ALOX5

    Interaction Score: 0.62

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Trial Name MAX-002
    Novel drug target Established target
    Mechanism of Interaction Arachidonate 5-lipoxygenase inhibitor

    PMIDs:
    6428914 2882965 6131674


    Sources:
    TdgClinicalTrial ChemblInteractions

  • MESALAMINE   IKBKB

    Interaction Score: 0.59

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Trial Name SPD476,Lialda
    Novel drug target Established target

    PMIDs:
    12950415 11151876 11054378


    Sources:
    TdgClinicalTrial

  • MESALAMINE   IL10

    Interaction Score: 0.36

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    15887108


    Sources:
    NCI

  • MESALAMINE   PTGS1

    Interaction Score: 0.3

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Trial Name MAX-002
    Novel drug target Established target
    Trial Name mesalamine,Pentasa, Canasa, Asacol

    PMIDs:
    12950415 11752352


    Sources:
    TdgClinicalTrial ChemblInteractions TEND TTD

  • MESALAMINE   PTGS2

    Interaction Score: 0.3

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Trial Name MAX-002
    Novel drug target Established target
    Trial Name mesalamine,Pentasa, Canasa, Asacol

    PMIDs:
    16855178 14742690 12463455 9256165 12208114


    Sources:
    TdgClinicalTrial ChemblInteractions TEND

  • MESALAMINE   PPARG

    Interaction Score: 0.15

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Novel drug target Established target
    Trial Name MAX-002
    Mechanism of Interaction Peroxisome proliferator-activated receptor gamma agonist

    PMIDs:
    15824083 18077625 16939423 18544567


    Sources:
    TdgClinicalTrial ChemblInteractions

  • MESALAMINE   CASP1

    Interaction Score: 0.13

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • MESALAMINE   NAT1

    Interaction Score: 0.05

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    PharmGKB

  • MESALAMINE   GLS

    Interaction Score: 0.05

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • MESALAMINE   RECQL

    Interaction Score: 0.02

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • MESALAMINE   APEX1

    Interaction Score: 0.02

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • MESALAMINE   USP1

    Interaction Score: 0.01

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • MESALAMINE   HPGD

    Interaction Score: 0.01

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • MESALAMINE   POLK

    Interaction Score: 0.01

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • MESALAMINE   HSD17B10

    Interaction Score: 0.01

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • MESALAMINE   VDR

    Interaction Score: 0.01

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • MESALAMINE   CYP2C19

    Interaction Score: 0.01

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • MESALAMINE   EHMT2

    Interaction Score: 0.0

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • MESALAMINE   CYP3A4

    Interaction Score: 0.0

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • TEND: MESALAZINE

    • Version: 01-August-2011

    Alternate Names:
    MESALAZINE Primary Drug Name

    Drug Info:
    Drug Class anti-inflammatory agents, non-steroidal
    Year of Approval 1987

    Publications:

  • TdgClinicalTrial: MESALAMINE

    • Version: January-2014

    Alternate Names:

    Drug Info:
    Drug Indications antiinflammatory agent
    Drug Class Small molecule
    FDA Approval approved

    Publications:

  • TdgClinicalTrial: MESALAZINE

    • Version: January-2014

    Alternate Names:

    Drug Info:
    Drug Indications for treatment of ulcerative proctitis
    Drug Class Small Molecule
    FDA Approval approved

    Publications:

  • NCI: MESALAMINE

    • Version: 14-September-2017

    Alternate Names:
    C29249 NCI drug code

    Drug Info:

    Publications:
    Santucci et al., 2005, Different sensitivity of lamina propria T-cell subsets to nitric oxide-induced apoptosis explains immunomodulatory activity of a nitric oxide-releasing derivative of mesalamine in rodent colitis., Gastroenterology

  • DTC: MESALAMINE

    • Version: 02-September-2020

    Alternate Names:
    CHEMBL704 ChEMBL Drug ID

    Drug Info:

    Publications:

  • TTD: Mesalazine

    • Version: 2020.06.01

    Alternate Names:
    D0C4YC TTD Drug ID

    Drug Info:

    Publications:

  • ChemblDrugs: chembl:CHEMBL704

    • Version: ChEMBL_27

    Alternate Names:

    Drug Info:

    Publications:

  • PharmGKB: mesalazine

    • Version: 18-August-2020

    Alternate Names:

    Drug Info:

    Publications:

  • ChemblInteractions: CHEMBL704

    • Version: chembl_23

    Alternate Names:

    Drug Info:

    Publications:

Disclaimer: This resource is intended for purely research purposes. It should not be used for emergencies or medical or professional advice.

A finding of a drug-gene interaction or potentially druggable category does not necessarily indicate effectiveness (or lack thereof) of any drug or treatment regimen. A finding of no interaction or no potentially druggable category does not necessarily indicate lack of effectiveness of any drug or treatment regimen. Drug-gene interactions or potentially druggable categories are not presented in ranked order of potential or predicted efficacy.

The dgidb.org website does not provide any medical or healthcare products, services or advice, and is not for medical emergencies or urgent situations. IF YOU THINK YOU MAY HAVE A MEDICAL EMERGENCY, CALL YOUR DOCTOR OR 911 IMMEDIATELY. Information contained on this website is not a substitute for a doctor's medical judgment or advice. We recommend that you discuss your specific, individual health concerns with your doctor or health care professional.

DGIdb (v4.2.0 - sha1 afd9f30b) • Last updated 2020-10-21