DGIdb - MESALAMINE Drug Record

MESALAMINE chembl:CHEMBL704 Approved

Alternate Names:

NSC-38877
LIALDA
SFROWASA
IPOCOL
ROWASA
MESALAZINE
FISALAMINE
APRISO
MEZAVANT XL
DELZICOL
SALOFALK
CANASA
PENTASA
MESALAZINE
MESREN MR
MESALAMINE
ASACOL HD
PENTASA SR
ASACOL
MAX-002
OCTASA
COLTEC EC
P-AMINOSALICYLSAEURE
3-CARBOXY-4-HYDROXYANILINE
MESALAZINA
M-AMINOSALICYLIC ACID
PENTASA®
5-ASA
5-AMINOSALICYLATE
MESALAZINUM
5-AMINOSALICYLIC ACID
MÉSALAZINE
chembl:CHEMBL704
chemidplus:89-57-6
pubchem.compound:4075
drugbank:00244
rxcui:52582

Drug Info:

FDA Approval	approved
Drug Class	Small Molecule
Drug Indications	for treatment of ulcerative proctitis
Year of Approval	1987
Drug Class	anti-inflammatory agents, non-steroidal
Drug Indications	for treatment of ulcerative colitis
Drug Indications	antiinflammatory agent

(5 More Sources)

Publications:

Allgayer, 2003, Review article: mechanisms of action of mesalazine in preventing colorectal carcinoma in inflammatory bowel disease., Aliment. Pharmacol. Ther.
Chen et al., 2002, TTD: Therapeutic Target Database., Nucleic Acids Res.
Allgayer et al., 1984, Soybean lipoxygenase inhibition: studies with the sulphasalazine metabolites N-acetylaminosalicylic acid, 5-aminosalicylic acid and sulphapyridine., Eur. J. Clin. Pharmacol.
Nielsen et al., 1987, Inhibition of 5-lipoxygenase pathway of arachidonic acid metabolism in human neutrophils by sulfasalazine and 5-aminosalicylic acid., Dig. Dis. Sci.
Sircar et al., 1983, Inhibition of soybean lipoxygenase by sulfasalazine and 5-aminosalicylic acid: a possible mode of action in ulcerative colitis., Biochem. Pharmacol.
Rousseaux et al., 2005, Intestinal antiinflammatory effect of 5-aminosalicylic acid is dependent on peroxisome proliferator-activated receptor-gamma., J. Exp. Med.
Linard et al., 2008, Reduction of peroxisome proliferation-activated receptor gamma expression by gamma-irradiation as a mechanism contributing to inflammatory response in rat colon: modulation by the 5-aminosalicylic acid agonist., J. Pharmacol. Exp. Ther.
Desreumaux et al., 2006, Review article: mode of action and delivery of 5-aminosalicylic acid - new evidence., Aliment. Pharmacol. Ther.
Schwab et al., 2008, PPARgamma is involved in mesalazine-mediated induction of apoptosis and inhibition of cell growth in colon cancer cells., Carcinogenesis
Distrutti et al., 2006, 5-Amino-2-hydroxybenzoic acid 4-(5-thioxo-5H-[1,2]dithiol-3yl)-phenyl ester (ATB-429), a hydrogen sulfide-releasing derivative of mesalamine, exerts antinociceptive effects in a model of postinflammatory hypersensitivity., J. Pharmacol. Exp. Ther.
Mifflin et al., 2004, Aspirin-mediated COX-2 transcript stabilization via sustained p38 activation in human intestinal myofibroblasts., Mol. Pharmacol.
Generini et al., Therapy of spondylarthropathy in inflammatory bowel disease., Clin. Exp. Rheumatol.
Pruzanski et al., 1997, Inhibition of extracellular release of proinflammatory secretory phospholipase A2 (sPLA2) by sulfasalazine: a novel mechanism of anti-inflammatory activity., Biochem. Pharmacol.
Cipolla et al., 2002, Nonsteroidal anti-inflammatory drugs and inflammatory bowel disease: current perspectives., Pharmacol. Res.
Santucci et al., 2005, Different sensitivity of lamina propria T-cell subsets to nitric oxide-induced apoptosis explains immunomodulatory activity of a nitric oxide-releasing derivative of mesalamine in rodent colitis., Gastroenterology
Bantel et al., 2000, Mesalazine inhibits activation of transcription factor NF-kappaB in inflamed mucosa of patients with ulcerative colitis., Am. J. Gastroenterol.
Weber et al., 2000, Suppression of NF-kappaB activity by sulfasalazine is mediated by direct inhibition of IkappaB kinases alpha and beta., Gastroenterology

MESALAMINE CHUK

Interaction Score: 1.55

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Trial Name SPD476,Lialda

Novel drug target Established target

PMIDs:
12950415 11151876 11054378

Sources:
TdgClinicalTrial
MESALAMINE ALOX5

Interaction Score: 0.62

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Trial Name MAX-002

Novel drug target Established target

Mechanism of Interaction Arachidonate 5-lipoxygenase inhibitor

PMIDs:
6428914 2882965 6131674

Sources:
TdgClinicalTrial ChemblInteractions
MESALAMINE IKBKB

Interaction Score: 0.59

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Trial Name SPD476,Lialda

Novel drug target Established target

PMIDs:
12950415 11151876 11054378

Sources:
TdgClinicalTrial
MESALAMINE IL10

Interaction Score: 0.36

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
15887108

Sources:
NCI
MESALAMINE PTGS1

Interaction Score: 0.3

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Trial Name MAX-002

Novel drug target Established target

Trial Name mesalamine,Pentasa, Canasa, Asacol

PMIDs:
12950415 11752352

Sources:
TdgClinicalTrial ChemblInteractions TEND TTD
MESALAMINE PTGS2

Interaction Score: 0.3

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Trial Name MAX-002

Novel drug target Established target

Trial Name mesalamine,Pentasa, Canasa, Asacol

PMIDs:
16855178 14742690 12463455 9256165 12208114

Sources:
TdgClinicalTrial ChemblInteractions TEND
MESALAMINE PPARG

Interaction Score: 0.15

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Novel drug target Established target

Trial Name MAX-002

Mechanism of Interaction Peroxisome proliferator-activated receptor gamma agonist

PMIDs:
15824083 18077625 16939423 18544567

Sources:
TdgClinicalTrial ChemblInteractions
MESALAMINE CASP1

Interaction Score: 0.13

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
MESALAMINE NAT1

Interaction Score: 0.05

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
PharmGKB
MESALAMINE GLS

Interaction Score: 0.05

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
MESALAMINE RECQL

Interaction Score: 0.02

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
MESALAMINE APEX1

Interaction Score: 0.02

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
MESALAMINE USP1

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
MESALAMINE HPGD

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
MESALAMINE POLK

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
MESALAMINE HSD17B10

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
MESALAMINE VDR

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
MESALAMINE CYP2C19

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
MESALAMINE EHMT2

Interaction Score: 0.0

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
MESALAMINE CYP3A4

Interaction Score: 0.0

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC

TEND: MESALAZINE
- Version: 01-August-2011
Alternate Names:

MESALAZINE Primary Drug Name

Drug Info:

Drug Class anti-inflammatory agents, non-steroidal

Year of Approval 1987

Publications:
TdgClinicalTrial: MESALAMINE
- Version: January-2014
Alternate Names:

Drug Info:

Drug Indications antiinflammatory agent

Drug Class Small molecule

FDA Approval approved

Publications:
TdgClinicalTrial: MESALAZINE
- Version: January-2014
Alternate Names:

Drug Info:

Drug Indications for treatment of ulcerative proctitis

Drug Class Small Molecule

FDA Approval approved

Publications:

NCI: MESALAMINE

Version: 14-September-2017

Alternate Names:

C29249 NCI drug code

Drug Info:

Publications:

Santucci et al., 2005, Different sensitivity of lamina propria T-cell subsets to nitric oxide-induced apoptosis explains immunomodulatory activity of a nitric oxide-releasing derivative of mesalamine in rodent colitis., Gastroenterology

DTC: MESALAMINE
- Version: 02-September-2020
Alternate Names:

CHEMBL704 ChEMBL Drug ID

Drug Info:

Publications:
TTD: Mesalazine
- Version: 2020.06.01
Alternate Names:

D0C4YC TTD Drug ID

Drug Info:

Publications:
ChemblDrugs: chembl:CHEMBL704
- Version: ChEMBL_27
Alternate Names:

Drug Info:

Publications:
PharmGKB: mesalazine
- Version: 18-August-2020
Alternate Names:

Drug Info:

Publications:
ChemblInteractions: CHEMBL704
- Version: chembl_23
Alternate Names:

Drug Info:

Publications:

Trial Name	MAX-002
Novel drug target	Established target
Mechanism of Interaction	Arachidonate 5-lipoxygenase inhibitor

MESALAMINE Drug Record

MESALAMINE chembl:CHEMBL704 Approved

Alternate Names:

Drug Info:

Publications:

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Trial Name SPD476,Lialda Novel drug target Established target

PMIDs: 12950415 11151876 11054378

Sources: TdgClinicalTrial

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Trial Name MAX-002 Novel drug target Established target Mechanism of Interaction Arachidonate 5-lipoxygenase inhibitor

PMIDs: 6428914 2882965 6131674

Sources: TdgClinicalTrial ChemblInteractions

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Trial Name SPD476,Lialda Novel drug target Established target

PMIDs: 12950415 11151876 11054378

Sources: TdgClinicalTrial

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 15887108

Sources: NCI

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Trial Name MAX-002 Novel drug target Established target Trial Name mesalamine,Pentasa, Canasa, Asacol

PMIDs: 12950415 11752352

Sources: TdgClinicalTrial ChemblInteractions TEND TTD

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Trial Name MAX-002 Novel drug target Established target Trial Name mesalamine,Pentasa, Canasa, Asacol

PMIDs: 16855178 14742690 12463455 9256165 12208114

Sources: TdgClinicalTrial ChemblInteractions TEND

Interaction Types & Directionality: agonist (activating)

Interaction Info: Novel drug target Established target Trial Name MAX-002 Mechanism of Interaction Peroxisome proliferator-activated receptor gamma agonist

PMIDs: 15824083 18077625 16939423 18544567

Sources: TdgClinicalTrial ChemblInteractions

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: PharmGKB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Trial Name SPD476,Lialda

Novel drug target Established target

PMIDs:
12950415 11151876 11054378

Sources:
TdgClinicalTrial

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Trial Name MAX-002

Novel drug target Established target

Mechanism of Interaction Arachidonate 5-lipoxygenase inhibitor

PMIDs:
6428914 2882965 6131674

Sources:
TdgClinicalTrial ChemblInteractions

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Trial Name SPD476,Lialda

Novel drug target Established target

PMIDs:
12950415 11151876 11054378

Sources:
TdgClinicalTrial

Interaction Types & Directionality:

n/a

PMIDs:
15887108

Sources:
NCI

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Trial Name MAX-002

Novel drug target Established target

Trial Name mesalamine,Pentasa, Canasa, Asacol

PMIDs:
12950415 11752352

Sources:
TdgClinicalTrial ChemblInteractions TEND TTD

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Trial Name MAX-002

Novel drug target Established target

Trial Name mesalamine,Pentasa, Canasa, Asacol

PMIDs:
16855178 14742690 12463455 9256165 12208114

Sources:
TdgClinicalTrial ChemblInteractions TEND

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Novel drug target Established target

Trial Name MAX-002

Mechanism of Interaction Peroxisome proliferator-activated receptor gamma agonist

PMIDs:
15824083 18077625 16939423 18544567

Sources:
TdgClinicalTrial ChemblInteractions

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Alternate Names:

MESALAZINE Primary Drug Name

Drug Info:

Drug Class anti-inflammatory agents, non-steroidal

Year of Approval 1987

Drug Info:

Drug Indications antiinflammatory agent

Drug Class Small molecule

FDA Approval approved

Drug Info:

Drug Indications for treatment of ulcerative proctitis

Drug Class Small Molecule

FDA Approval approved

Alternate Names:

C29249 NCI drug code

Publications:

Santucci et al., 2005, Different sensitivity of lamina propria T-cell subsets to nitric oxide-induced apoptosis explains immunomodulatory activity of a nitric oxide-releasing derivative of mesalamine in rodent colitis., Gastroenterology

Alternate Names:

CHEMBL704 ChEMBL Drug ID

Alternate Names:

D0C4YC TTD Drug ID