DGIdb - MEPERIDINE Drug Record

MEPERIDINE chembl:CHEMBL607 Approved

Alternate Names:

PETHIDINE
MEPERIDINE
IDS-NP-001
PÉTHIDINE
PETYDYNA
ISONIPECAÏNE
MEPADIN
LYDOL
PETHIDINUM
DEMEROL®
DEMEROL
PETIDINA
DOLANTIN
PETHIDIN
ALODAN
pubchem.compound:4058
rxcui:6754
drugbank:00454
chemidplus:57-42-1
chembl:CHEMBL607

Drug Info:

Year of Approval	1942
Drug Class	analgesics, opioid
FDA Approval	1942
Drug Class	small molecule
Drug Indications	Analgesics, Opioid
Drug Categories	agents that reduce seizure threshold
Drug Categories	antidepressive agents
Drug Categories	cytochrome p-450 cyp1a2 inducers
Drug Categories	cytochrome p-450 cyp1a2 inducers (strength unknown)
Drug Categories	cytochrome p-450 cyp3a inducers
Drug Categories	cytochrome p-450 cyp3a substrates
Drug Categories	cytochrome p-450 cyp3a4 inducers
Drug Categories	cytochrome p-450 cyp3a4 inducers (strength unknown)
Drug Categories	cytochrome p-450 cyp3a4 substrates (strength unknown)
Drug Categories	cytochrome p-450 enzyme inducers
Drug Categories	cytochrome p-450 substrates
Drug Categories	drugs that are mainly renally excreted
Drug Categories	high-risk opioids
Drug Categories	nmda receptor antagonists
Drug Categories	opiate agonists
Drug Categories	opioid agonist
Drug Categories	opioids
Drug Categories	p-glycoprotein substrates
Drug Categories	phenylpiperidine opioids
Drug Categories	serotonergic drugs shown to increase risk of serotonin syndrome
Drug Categories	serotonin agents

(3 More Sources)

Publications:

Kurz M et al., 1993, Naloxone, meperidine, and shivering., Anesthesiology
Ikeda T et al., 1997, The effect of opioids on thermoregulatory responses in humans and the special antishivering action of meperidine., Ann N Y Acad Sci
Yasaei R et al., 2020, Meperidine,
Overington et al., 2006, How many drug targets are there?, Nat Rev Drug Discov
Imming et al., 2006, Drugs, their targets and the nature and number of drug targets., Nat Rev Drug Discov
Cruz Pardos P et al., 2000, [Usefulness of meperidine in anesthesiology]., Rev Esp Anestesiol Reanim
Zanger UM et al., 2008, Functional pharmacogenetics/genomics of human cytochromes P450 involved in drug biotransformation., Anal Bioanal Chem
Hustveit, 1994, Binding of fentanyl and pethidine to muscarinic receptors in rat brain., Jpn. J. Pharmacol.
Poulain et al., 2001, From hit to lead. Combining two complementary methods for focused library design. Application to mu opiate ligands., J. Med. Chem.
Yamakura et al., 2000, N-methyl-D-aspartate receptor channel block by meperidine is dependent on extracellular pH., Anesth. Analg.
Gu et al., 2010, Synthesis and structure-activity studies of benzyl ester meperidine and normeperidine derivatives as selective serotonin transporter ligands., Bioorg. Med. Chem.
Lomenzo et al., 2005, Synthesis and biological evaluation of meperidine analogues at monoamine transporters., J. Med. Chem.
Lomenzo et al., 1999, Synthesis, dopamine and serotonin transporter binding affinities of novel analogues of meperidine., Bioorg. Med. Chem. Lett.
Zanger UM et al., 2007, Polymorphic CYP2B6: molecular mechanisms and emerging clinical significance., Pharmacogenomics
Lang T et al., 2001, Extensive genetic polymorphism in the human CYP2B6 gene with impact on expression and function in human liver., Pharmacogenetics
Zhang J et al., 1999, Binding and hydrolysis of meperidine by human liver carboxylesterase hCE-1., J Pharmacol Exp Ther

MEPERIDINE OPRK1

Interaction Score: 0.32

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Direct Interaction? False

Endogenous Drug? False

Specific Action of the Ligand Agonist

PMIDs:
8267194 9100971 29261967 17139284 17016423 10846914

Sources:
TEND TdgClinicalTrial DrugBank GuideToPharmacology
MEPERIDINE CES1

Interaction Score: 0.3

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
10381793

Sources:
DrugBank
MEPERIDINE CYP2B6

Interaction Score: 0.2

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
17638512 11470993

Sources:
PharmGKB
MEPERIDINE GRIN2D

Interaction Score: 0.19

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

PMIDs:
10735801

Sources:
DrugBank
MEPERIDINE GRIN2C

Interaction Score: 0.19

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

PMIDs:
10735801

Sources:
DrugBank
MEPERIDINE GRIN2A

Interaction Score: 0.18

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

PMIDs:
10735801

Sources:
DrugBank
MEPERIDINE SLC6A3

Interaction Score: 0.17

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

PMIDs:
10612583 20980153 15743177

Sources:
DrugBank
MEPERIDINE SLC6A2

Interaction Score: 0.14

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

PMIDs:
20980153 15743177

Sources:
DrugBank
MEPERIDINE GRIN2B

Interaction Score: 0.13

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

PMIDs:
10735801

Sources:
DrugBank
MEPERIDINE SLC6A4

Interaction Score: 0.12

Interaction Types & Directionality:

binder

Interaction Info:

PMIDs:
20980153 15743177

Sources:
DrugBank
MEPERIDINE GRIN1

Interaction Score: 0.11

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

PMIDs:
10735801

Sources:
DrugBank
MEPERIDINE OPRM1

Interaction Score: 0.07

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Specific Action of the Ligand Agonist

Endogenous Drug? False

Direct Interaction? True

PMIDs:
11585443

Sources:
DrugBank GuideToPharmacology
MEPERIDINE CYP3A5

Interaction Score: 0.07

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
18695978

Sources:
PharmGKB
MEPERIDINE CHRM1

Interaction Score: 0.05

Interaction Types & Directionality:

binder

Interaction Info:

PMIDs:
8164394

Sources:
DrugBank
MEPERIDINE OPRD1

Interaction Score: 0.04

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Specific Action of the Ligand Agonist

Endogenous Drug? False

Direct Interaction? False

PMIDs:
None found

Sources:
GuideToPharmacology
MEPERIDINE ADRA2A

Interaction Score: 0.03

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
TTD

DrugBank: DB00454

Version: 5.1.7

Alternate Names:

MEPERIDINE DrugBank Drug Name

57-42-1 CAS Number

Demerol Drug Brand

Drug Info:

Drug Type small molecule

Drug Groups approved

Drug Categories adjuvants

Publications:

Yamakura et al., 2000, N-methyl-D-aspartate receptor channel block by meperidine is dependent on extracellular pH., Anesth. Analg.

Kurz M et al., 1993, Naloxone, meperidine, and shivering., Anesthesiology

Ikeda T et al., 1997, The effect of opioids on thermoregulatory responses in humans and the special antishivering action of meperidine., Ann N Y Acad Sci

TEND: MEPERIDINE
- Version: 01-August-2011
Alternate Names:

MEPERIDINE Primary Drug Name

Drug Info:

Drug Class analgesics, opioid

Year of Approval 1942

Publications:
TdgClinicalTrial: MEPERIDINE
- Version: January-2014
Alternate Names:

Drug Info:

Drug Indications Analgesics, Opioid

Drug Class small molecule

FDA Approval 1942

Publications:

PharmGKB: meperidine

Version: 18-August-2020

Alternate Names:

Drug Info:

Publications:

Zanger UM et al., 2008, Functional pharmacogenetics/genomics of human cytochromes P450 involved in drug biotransformation., Anal Bioanal Chem

Zanger UM et al., 2007, Polymorphic CYP2B6: molecular mechanisms and emerging clinical significance., Pharmacogenomics

Lang T et al., 2001, Extensive genetic polymorphism in the human CYP2B6 gene with impact on expression and function in human liver., Pharmacogenetics

GuideToPharmacology: 178103795
- Version: 29-September-2020
Alternate Names:

PETHIDINE GuideToPharmacology Ligand Name

Drug Info:

Publications:
TTD: Meperidine
- Version: 2020.06.01
Alternate Names:

D00UYE TTD Drug ID

Drug Info:

Publications:
ChemblDrugs: chembl:CHEMBL607
- Version: ChEMBL_27
Alternate Names:

Drug Info:

Publications:

Direct Interaction?	False
Endogenous Drug?	False
Specific Action of the Ligand	Agonist

MEPERIDINE	DrugBank Drug Name
57-42-1	CAS Number
Demerol	Drug Brand

Drug Type	small molecule
Drug Groups	approved
Drug Categories	adjuvants

MEPERIDINE Drug Record

MEPERIDINE chembl:CHEMBL607 Approved

Alternate Names:

Drug Info:

Publications:

Interaction Types & Directionality: agonist (activating)

Interaction Info: Direct Interaction? False Endogenous Drug? False Specific Action of the Ligand Agonist

PMIDs: 8267194 9100971 29261967 17139284 17016423 10846914

Sources: TEND TdgClinicalTrial DrugBank GuideToPharmacology

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 10381793

Sources: DrugBank

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 17638512 11470993

Sources: PharmGKB

Interaction Types & Directionality: antagonist (inhibitory)

Interaction Info:

PMIDs: 10735801

Sources: DrugBank

Interaction Types & Directionality: antagonist (inhibitory)

Interaction Info:

PMIDs: 10735801

Sources: DrugBank

Interaction Types & Directionality: antagonist (inhibitory)

Interaction Info:

PMIDs: 10735801

Sources: DrugBank

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info:

PMIDs: 10612583 20980153 15743177

Sources: DrugBank

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info:

PMIDs: 20980153 15743177

Sources: DrugBank

Interaction Types & Directionality: antagonist (inhibitory)

Interaction Info:

PMIDs: 10735801

Sources: DrugBank

Interaction Types & Directionality: binder

Interaction Info:

PMIDs: 20980153 15743177

Sources: DrugBank

Interaction Types & Directionality: antagonist (inhibitory)

Interaction Info:

PMIDs: 10735801

Sources: DrugBank

Interaction Types & Directionality: agonist (activating)

Interaction Info: Specific Action of the Ligand Agonist Endogenous Drug? False Direct Interaction? True

PMIDs: 11585443

Sources: DrugBank GuideToPharmacology

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 18695978

Sources: PharmGKB

Interaction Types & Directionality: binder

Interaction Info:

PMIDs: 8164394

Sources: DrugBank

Interaction Types & Directionality: agonist (activating)

Interaction Info: Specific Action of the Ligand Agonist Endogenous Drug? False Direct Interaction? False

PMIDs: None found

Sources: GuideToPharmacology

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: TTD

DrugBank: DB00454

Alternate Names: MEPERIDINE DrugBank Drug Name 57-42-1 CAS Number Demerol Drug Brand

Drug Info: Drug Type small molecule Drug Groups approved Drug Categories adjuvants

TEND: MEPERIDINE

Alternate Names: MEPERIDINE Primary Drug Name

Drug Info: Drug Class analgesics, opioid Year of Approval 1942

Publications:

TdgClinicalTrial: MEPERIDINE

Alternate Names:

Drug Info: Drug Indications Analgesics, Opioid Drug Class small molecule FDA Approval 1942

Publications:

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Direct Interaction? False

Endogenous Drug? False

Specific Action of the Ligand Agonist

PMIDs:
8267194 9100971 29261967 17139284 17016423 10846914

Sources:
TEND TdgClinicalTrial DrugBank GuideToPharmacology

Interaction Types & Directionality:

n/a

PMIDs:
10381793

Sources:
DrugBank

Interaction Types & Directionality:

n/a

PMIDs:
17638512 11470993

Sources:
PharmGKB

Interaction Types & Directionality:

antagonist (inhibitory)

PMIDs:
10735801

Sources:
DrugBank

Interaction Types & Directionality:

antagonist (inhibitory)

PMIDs:
10735801

Sources:
DrugBank

Interaction Types & Directionality:

antagonist (inhibitory)

PMIDs:
10735801

Sources:
DrugBank

Interaction Types & Directionality:

inhibitor (inhibitory)

PMIDs:
10612583 20980153 15743177

Sources:
DrugBank

Interaction Types & Directionality:

inhibitor (inhibitory)

PMIDs:
20980153 15743177

Sources:
DrugBank

Interaction Types & Directionality:

antagonist (inhibitory)

PMIDs:
10735801

Sources:
DrugBank

Interaction Types & Directionality:

binder

PMIDs:
20980153 15743177

Sources:
DrugBank

Interaction Types & Directionality:

antagonist (inhibitory)

PMIDs:
10735801

Sources:
DrugBank

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Specific Action of the Ligand Agonist

Endogenous Drug? False

Direct Interaction? True

PMIDs:
11585443

Sources:
DrugBank GuideToPharmacology

Interaction Types & Directionality:

n/a

PMIDs:
18695978

Sources:
PharmGKB

Interaction Types & Directionality:

binder

PMIDs:
8164394

Sources:
DrugBank

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Specific Action of the Ligand Agonist

Endogenous Drug? False

Direct Interaction? False

PMIDs:
None found

Sources:
GuideToPharmacology

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
TTD

Alternate Names:

MEPERIDINE DrugBank Drug Name

57-42-1 CAS Number

Demerol Drug Brand

Drug Info:

Drug Type small molecule

Drug Groups approved

Drug Categories adjuvants

Alternate Names:

MEPERIDINE Primary Drug Name

Drug Info:

Drug Class analgesics, opioid

Year of Approval 1942

Drug Info:

Drug Indications Analgesics, Opioid

Drug Class small molecule

FDA Approval 1942

Alternate Names:

PETHIDINE GuideToPharmacology Ligand Name

Alternate Names:

D00UYE TTD Drug ID