DGIdb - MELATONIN Drug Record

MELATONIN chembl:CHEMBL45 Approved

Alternate Names:

LIFE EXT
J5.258B
HEALTH AID
BCI-049
NATURE'S BLEND
VESPRO
VYTALONIN
HEIDADOUPPI
MELATONIN
TRAVELAG
QUALITY HEALTH
GENERAL NUTRIT
NSC-113928
N-(2-(5-METHOXY-1H-INDOL-3-YL)ETHYL)ACETAMIDE
N-ACETYL-5-METHOXYTRYPTAMINE
MELAPURE
CIRCADIN
NSC-56423
NATURES BOUNTY
NATROL
ICENIA
S.GARD
{N-[2-(5-METHOXY-1H-INDOL-3-YL)ETHYL]-} ACETAMIDE
N-[2-(5-METHOXY-1H-INDOL-3-YL)ETHYL]ACETAMIDE
N-[2-(5-METHOXYINDOL-3-YL)ETHYL]-ACETAMIDE
MLT
REGULIN
MELATONIN (SYNTH.) STANDARD-GRADE
{N-[2-(5-METHOXYINDOL-3-YL)ETHYL]-} ACETAMIDE
MELATONIN (SYNTH.) ULTRA-PURE
N-(2-(5-METHOXYINDOL-3-YL)ETHYL)ACETAMIDE
N-ACETYL-5-METHOXY-TRYPTAMINE MELATONINE
MT6
MELOVINE
N-(2-(5-METHOXYINDOL-3-YL)ETHYL)-ACETAMIDE
MELATOL
N-[2-(5-METHOXY-1H-INDOL-3-YL)ETHYL]-ACETAMIDE
5-METHOXY-N-ACETYLTRYPTAMINE
N-ACETYL-5-METHOXY-TRYPTAMINE
N-[2-(5-METHOXYINDOL-3-YL)ETHYL]ACETAMIDE
N-[2-(5-METHOXY-1H-INDOL-3-YL)ETHYL)ACETAMIDE
chemidplus:73-31-4
rxcui:6711
drugbank:01065
chembl:CHEMBL45
pubchem.compound:896

Drug Info:

Drug Categories	tryptamines
Drug Categories	therapeutic uses
Drug Categories	specialty uses of chemicals
Drug Categories	psycholeptics
Drug Categories	protective agents
Drug Categories	physiological effects of drugs
Drug Categories	pharmacologic actions
Drug Categories	organic chemicals
Drug Categories	nervous system
Drug Categories	molecular mechanisms of pharmacological action
Drug Categories	melatonin receptor agonists
Drug Categories	indoles
Drug Categories	hypnotics and sedatives
Drug Categories	hormones, hormone substitutes, and hormone antagonists
Drug Categories	hormones
Drug Categories	heterocyclic compounds, 2-ring
Drug Categories	heterocyclic compounds
Drug Categories	cytochrome p-450 cyp2c9 substrates
Drug Categories	cytochrome p-450 cyp2c19 substrates
Drug Categories	cytochrome p-450 cyp1a2 substrates
Drug Categories	cytochrome p-450 cyp1a2 inhibitors
Drug Categories	chemical actions and uses
Drug Categories	central nervous system depressants
Drug Categories	central nervous system agents
Drug Categories	biogenic monoamines
Drug Categories	biogenic amines
Drug Categories	antioxidants
Drug Categories	amines
Drug Groups	vet_approved
Drug Groups	approved
Drug Groups	nutraceutical
Drug Type	small molecule
Drug Class	hypnotics and sedatives
Year of Approval	not approved by the fda
FDA Approval	not approved by the FDA
Drug Class	small molecule
Drug Indications	Hypnotics and Sedatives
Drug Categories	oat3/slc22a8 inhibitors
Drug Categories	melatonin, antagonists & inhibitors
Drug Categories	melatonin, agonists
Drug Categories	heterocyclic compounds, fused-ring
Drug Categories	cytochrome p-450 substrates
Drug Categories	compounds used in a research, industrial, or household setting

(4 More Sources)

Publications:

Klinger et al., Interactions of melatonin with the liver microsomal cytochrome P450 system of rats and humans in vitro and effects on the P450 system and the antioxidative status in rat liver after acute treatment., Eur J Drug Metab Pharmacokinet
Radogna et al., 2009, Rapid and transient stimulation of intracellular reactive oxygen species by melatonin in normal and tumor leukocytes., Toxicol. Appl. Pharmacol.
Srinivasan et al., 2010, Jet lag, circadian rhythm sleep disturbances, and depression: the role of melatonin and its analogs., Adv Ther
Carocci et al., 2010, Design, synthesis, and pharmacological effects of structurally simple ligands for MT(1) and MT(2) melatonin receptors., Bioorg. Med. Chem.
Hardeland, Melatonin: signaling mechanisms of a pleiotropic agent., Biofactors
Prendergast, 2010, MT1 melatonin receptors mediate somatic, behavioral, and reproductive neuroendocrine responses to photoperiod and melatonin in Siberian hamsters (Phodopus sungorus)., Endocrinology
Boutin et al., 2005, Molecular tools to study melatonin pathways and actions., Trends Pharmacol. Sci.
Onur et al., 2004, The effects of melatonin and the antioxidant defence system on apoptosis regulator proteins (Bax and Bcl-2) in experimentally induced varicocele., Urol. Res.
Meléndez et al., 1996, Effect of melatonin on beta-tubulin and MAP2 expression in NIE-115 cells., Neurochem. Res.
Chen et al., 2002, TTD: Therapeutic Target Database., Nucleic Acids Res.
Di Stefano et al., 1994, Inhibitory effect of melatonin on production of IFN gamma or TNF alpha in peripheral blood mononuclear cells of some blood donors., J. Pineal Res.
Kiefer et al., 2005, Differential regulation of estrogen receptor alpha, glucocorticoid receptor and retinoic acid receptor alpha transcriptional activity by melatonin is mediated via different G proteins., J. Pineal Res.
Valcavi et al., 1993, Melatonin stimulates growth hormone secretion through pathways other than the growth hormone-releasing hormone., Clin. Endocrinol. (Oxf)
Awney et al., 2002, Effect of melatonin on the production of microsomal hydrogen peroxide and cytochrome P-450 content in rat treated with aflatoxin B(1)., Toxicology
Minneman et al., 1976, The pharmacology of the pineal gland., Annu. Rev. Pharmacol. Toxicol.
del Río et al., 2004, Melatonin, an endogenous-specific inhibitor of estrogen receptor alpha via calmodulin., J. Biol. Chem.
Johnston et al., 2005, Photoperiod regulates multiple gene expression in the suprachiasmatic nuclei and pars tuberalis of the Siberian hamster (Phodopus sungorus)., Eur. J. Neurosci.
Poirel et al., 2003, Contrary to other non-photic cues, acute melatonin injection does not induce immediate changes of clock gene mRNA expression in the rat suprachiasmatic nuclei., Neuroscience
Galijasevic et al., 2008, Melatonin is a potent inhibitor for myeloperoxidase., Biochemistry
Lu et al., 2008, Analysis of the mechanism by which melatonin inhibits human eosinophil peroxidase., Br. J. Pharmacol.
Itoh et al., 1995, Melatonin and arylalkylamine N-acetyltransferase activity in the silkworm, Bombyx mori., Mol. Cell. Endocrinol.
Ganguly et al., 2005, Melatonin synthesis: 14-3-3-dependent activation and inhibition of arylalkylamine N-acetyltransferase mediated by phosphoserine-205., Proc. Natl. Acad. Sci. U.S.A.
Johnston et al., 2004, Rhythmic melatonin secretion does not correlate with the expression of arylalkylamine N-acetyltransferase, inducible cyclic amp early repressor, period1 or cryptochrome1 mRNA in the sheep pineal., Neuroscience
Satomura et al., 2007, Melatonin at pharmacological doses enhances human osteoblastic differentiation in vitro and promotes mouse cortical bone formation in vivo., J. Pineal Res.
Urata et al., 1999, Melatonin induces gamma-glutamylcysteine synthetase mediated by activator protein-1 in human vascular endothelial cells., Free Radic. Biol. Med.
Eck et al., 1998, A sequential treatment regimen with melatonin and all-trans retinoic acid induces apoptosis in MCF-7 tumour cells., Br. J. Cancer
Lee et al., 2006, Sustained activation of Akt by melatonin contributes to the protection against kainic acid-induced neuronal death in hippocampus., J. Pineal Res.
Yoo et al., 2009, Melatonin-induced estrogen receptor alpha-mediated calbindin-D9k expression plays a role in H2O2-mediated cell death in rat pituitary GH3 cells., J. Pineal Res.
Manev et al., 1999, Primary cultures of rat cerebellar granule cells as a model to study neuronal 5-lipoxygenase and FLAP gene expression., Ann. N. Y. Acad. Sci.
Molis et al., 1995, Melatonin modulation of estrogen-regulated proteins, growth factors, and proto-oncogenes in human breast cancer., J. Pineal Res.
Tang et al., 1998, Enhanced glial cell line-derived neurotrophic factor mRNA expression upon (-)-deprenyl and melatonin treatments., J. Neurosci. Res.
Borlongan et al., 2000, Glial cell survival is enhanced during melatonin-induced neuroprotection against cerebral ischemia., FASEB J.
Morrey et al., 1994, Activation of human monocytes by the pineal hormone melatonin., J. Immunol.
Becker-André et al., 1994, Pineal gland hormone melatonin binds and activates an orphan of the nuclear receptor superfamily., J. Biol. Chem.
Capelli et al., 2002, Evaluation of gene expression in human lymphocytes activated in the presence of melatonin., Int. Immunopharmacol.
Macías et al., 2003, Calreticulin-melatonin. An unexpected relationship., Eur. J. Biochem.
Viguié et al., 1997, Characterization of the short day-induced decrease in median eminence tyrosine hydroxylase activity in the ewe: temporal relationship to the changes in luteinizing hormone and prolactin secretion and short day-like effect of melatonin., Endocrinology
Schräder et al., 1996, Identification of natural monomeric response elements of the nuclear receptor RZR/ROR. They also bind COUP-TF homodimers., J. Biol. Chem.
Winczyk et al., Possible involvement of the nuclear RZR/ROR-alpha receptor in the antitumor action of melatonin on murine Colon 38 cancer., Tumour Biol.

MELATONIN HTR2B

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Endogenous Drug? False

Specific Action of the Ligand Antagonist

Publications:

MELATONIN MTNR1B

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Specific Action of the Ligand Full agonist

Endogenous Drug? True

Direct Interaction? True

Publications:

Srinivasan et al., 2010, Jet lag, circadian rhythm sleep disturbances, and depression: the role of melatonin and its analogs., Adv Ther

Carocci et al., 2010, Design, synthesis, and pharmacological effects of structurally simple ligands for MT(1) and MT(2) melatonin receptors., Bioorg. Med. Chem.

Hardeland, Melatonin: signaling mechanisms of a pleiotropic agent., Biofactors

MELATONIN MTNR1A

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Novel drug target Established target

Trial Name -

Specific Action of the Ligand Full agonist

Publications:

Srinivasan et al., 2010, Jet lag, circadian rhythm sleep disturbances, and depression: the role of melatonin and its analogs., Adv Ther

Carocci et al., 2010, Design, synthesis, and pharmacological effects of structurally simple ligands for MT(1) and MT(2) melatonin receptors., Bioorg. Med. Chem.

Hardeland, Melatonin: signaling mechanisms of a pleiotropic agent., Biofactors

MELATONIN MPO

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Publications:

Galijasevic et al., 2008, Melatonin is a potent inhibitor for myeloperoxidase., Biochemistry
MELATONIN EPX

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Publications:

Lu et al., 2008, Analysis of the mechanism by which melatonin inhibits human eosinophil peroxidase., Br. J. Pharmacol.

MELATONIN ESR1

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Publications:

del Río et al., 2004, Melatonin, an endogenous-specific inhibitor of estrogen receptor alpha via calmodulin., J. Biol. Chem.

Yoo et al., 2009, Melatonin-induced estrogen receptor alpha-mediated calbindin-D9k expression plays a role in H2O2-mediated cell death in rat pituitary GH3 cells., J. Pineal Res.

MELATONIN RORB

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Publications:

Becker-André et al., 1994, Pineal gland hormone melatonin binds and activates an orphan of the nuclear receptor superfamily., J. Biol. Chem.

MELATONIN CYP3A43

Interaction Types & Directionality:

n/a

Interaction Info:

Publications:

Klinger et al., Interactions of melatonin with the liver microsomal cytochrome P450 system of rats and humans in vitro and effects on the P450 system and the antioxidative status in rat liver after acute treatment., Eur J Drug Metab Pharmacokinet

MELATONIN NQO2

Interaction Types & Directionality:

n/a

Interaction Info:

Publications:

Radogna et al., 2009, Rapid and transient stimulation of intracellular reactive oxygen species by melatonin in normal and tumor leukocytes., Toxicol. Appl. Pharmacol.
MELATONIN BAX

Interaction Types & Directionality:

n/a

Interaction Info:

Publications:

Onur et al., 2004, The effects of melatonin and the antioxidant defence system on apoptosis regulator proteins (Bax and Bcl-2) in experimentally induced varicocele., Urol. Res.
MELATONIN MAP2

Interaction Types & Directionality:

n/a

Interaction Info:

Publications:

Meléndez et al., 1996, Effect of melatonin on beta-tubulin and MAP2 expression in NIE-115 cells., Neurochem. Res.
MELATONIN IFNG

Interaction Types & Directionality:

n/a

Interaction Info:

Publications:

Di Stefano et al., 1994, Inhibitory effect of melatonin on production of IFN gamma or TNF alpha in peripheral blood mononuclear cells of some blood donors., J. Pineal Res.

MELATONIN RARA

Interaction Types & Directionality:

n/a

Interaction Info:

Publications:

Kiefer et al., 2005, Differential regulation of estrogen receptor alpha, glucocorticoid receptor and retinoic acid receptor alpha transcriptional activity by melatonin is mediated via different G proteins., J. Pineal Res.

MELATONIN GHRH

Interaction Types & Directionality:

n/a

Interaction Info:

Publications:

Valcavi et al., 1993, Melatonin stimulates growth hormone secretion through pathways other than the growth hormone-releasing hormone., Clin. Endocrinol. (Oxf)
MELATONIN CYP3A7

Interaction Types & Directionality:

n/a

Interaction Info:

Publications:

Awney et al., 2002, Effect of melatonin on the production of microsomal hydrogen peroxide and cytochrome P-450 content in rat treated with aflatoxin B(1)., Toxicology
MELATONIN ASMT

Interaction Types & Directionality:

n/a

Interaction Info:

Publications:

Minneman et al., 1976, The pharmacology of the pineal gland., Annu. Rev. Pharmacol. Toxicol.

MELATONIN CALM1

Interaction Types & Directionality:

n/a

Interaction Info:

Publications:

del Río et al., 2004, Melatonin, an endogenous-specific inhibitor of estrogen receptor alpha via calmodulin., J. Biol. Chem.

Radogna et al., 2009, Rapid and transient stimulation of intracellular reactive oxygen species by melatonin in normal and tumor leukocytes., Toxicol. Appl. Pharmacol.

MELATONIN PER1

Interaction Types & Directionality:

n/a

Interaction Info:

Publications:

Johnston et al., 2005, Photoperiod regulates multiple gene expression in the suprachiasmatic nuclei and pars tuberalis of the Siberian hamster (Phodopus sungorus)., Eur. J. Neurosci.

Poirel et al., 2003, Contrary to other non-photic cues, acute melatonin injection does not induce immediate changes of clock gene mRNA expression in the rat suprachiasmatic nuclei., Neuroscience

MELATONIN AANAT

Interaction Types & Directionality:

n/a

Interaction Info:

Publications:

Itoh et al., 1995, Melatonin and arylalkylamine N-acetyltransferase activity in the silkworm, Bombyx mori., Mol. Cell. Endocrinol.

Ganguly et al., 2005, Melatonin synthesis: 14-3-3-dependent activation and inhibition of arylalkylamine N-acetyltransferase mediated by phosphoserine-205., Proc. Natl. Acad. Sci. U.S.A.

Johnston et al., 2004, Rhythmic melatonin secretion does not correlate with the expression of arylalkylamine N-acetyltransferase, inducible cyclic amp early repressor, period1 or cryptochrome1 mRNA in the sheep pineal., Neuroscience

MELATONIN BGLAP

Interaction Types & Directionality:

n/a

Interaction Info:

Publications:

Satomura et al., 2007, Melatonin at pharmacological doses enhances human osteoblastic differentiation in vitro and promotes mouse cortical bone formation in vivo., J. Pineal Res.
MELATONIN GCLM

Interaction Types & Directionality:

n/a

Interaction Info:

Publications:

Urata et al., 1999, Melatonin induces gamma-glutamylcysteine synthetase mediated by activator protein-1 in human vascular endothelial cells., Free Radic. Biol. Med.
MELATONIN TGFB1

Interaction Types & Directionality:

n/a

Interaction Info:

Publications:

Eck et al., 1998, A sequential treatment regimen with melatonin and all-trans retinoic acid induces apoptosis in MCF-7 tumour cells., Br. J. Cancer
MELATONIN PIK3CG

Interaction Types & Directionality:

n/a

Interaction Info:

Publications:

Lee et al., 2006, Sustained activation of Akt by melatonin contributes to the protection against kainic acid-induced neuronal death in hippocampus., J. Pineal Res.
MELATONIN ALOX5

Interaction Types & Directionality:

n/a

Interaction Info:

Publications:

Manev et al., 1999, Primary cultures of rat cerebellar granule cells as a model to study neuronal 5-lipoxygenase and FLAP gene expression., Ann. N. Y. Acad. Sci.
MELATONIN MYC

Interaction Types & Directionality:

n/a

Interaction Info:

Publications:

Molis et al., 1995, Melatonin modulation of estrogen-regulated proteins, growth factors, and proto-oncogenes in human breast cancer., J. Pineal Res.
MELATONIN MAOB

Interaction Types & Directionality:

n/a

Interaction Info:

Publications:

Tang et al., 1998, Enhanced glial cell line-derived neurotrophic factor mRNA expression upon (-)-deprenyl and melatonin treatments., J. Neurosci. Res.
MELATONIN GFAP

Interaction Types & Directionality:

n/a

Interaction Info:

Publications:

Borlongan et al., 2000, Glial cell survival is enhanced during melatonin-induced neuroprotection against cerebral ischemia., FASEB J.
MELATONIN IL1B

Interaction Types & Directionality:

n/a

Interaction Info:

Publications:

Morrey et al., 1994, Activation of human monocytes by the pineal hormone melatonin., J. Immunol.
MELATONIN TMSB10

Interaction Types & Directionality:

n/a

Interaction Info:

Publications:

Capelli et al., 2002, Evaluation of gene expression in human lymphocytes activated in the presence of melatonin., Int. Immunopharmacol.
MELATONIN CALR

Interaction Types & Directionality:

n/a

Interaction Info:

Publications:

Hardeland, Melatonin: signaling mechanisms of a pleiotropic agent., Biofactors

Macías et al., 2003, Calreticulin-melatonin. An unexpected relationship., Eur. J. Biochem.

MELATONIN PRL

Interaction Types & Directionality:

n/a

Interaction Info:

Publications:

Viguié et al., 1997, Characterization of the short day-induced decrease in median eminence tyrosine hydroxylase activity in the ewe: temporal relationship to the changes in luteinizing hormone and prolactin secretion and short day-like effect of melatonin., Endocrinology

MELATONIN RORA

Interaction Types & Directionality:

n/a

Interaction Info:

Publications:

Schräder et al., 1996, Identification of natural monomeric response elements of the nuclear receptor RZR/ROR. They also bind COUP-TF homodimers., J. Biol. Chem.

Winczyk et al., Possible involvement of the nuclear RZR/ROR-alpha receptor in the antitumor action of melatonin on murine Colon 38 cancer., Tumour Biol.

MELATONIN CYP3A4

Interaction Types & Directionality:

n/a

Interaction Info:

Publications:
MELATONIN CYP1A2

Interaction Types & Directionality:

n/a

Interaction Info:

Publications:

DrugBank: DB01065

Version: 5.1.7

Alternate Names:

MELATONIN DrugBank Drug Name

73-31-4 CAS Number

Amerix Melatonin Drug Brand

Drug Info:

Drug Type small molecule

Drug Groups approved

Drug Groups nutraceutical

Publications:

Becker-André et al., 1994, Pineal gland hormone melatonin binds and activates an orphan of the nuclear receptor superfamily., J. Biol. Chem.

Radogna et al., 2009, Rapid and transient stimulation of intracellular reactive oxygen species by melatonin in normal and tumor leukocytes., Toxicol. Appl. Pharmacol.

del Río et al., 2004, Melatonin, an endogenous-specific inhibitor of estrogen receptor alpha via calmodulin., J. Biol. Chem.

TEND: MELATONIN
- Version: 01-August-2011
Alternate Names:

MELATONIN Primary Drug Name

Drug Info:

Year of Approval not approved by the fda

Drug Class hypnotics and sedatives

Publications:
TdgClinicalTrial: MELATONIN
- Version: January-2014
Alternate Names:

Drug Info:

Drug Indications Hypnotics and Sedatives

Drug Class small molecule

FDA Approval not approved by the FDA

Publications:

NCI: MELATONIN

Version: 14-September-2017

Alternate Names:

C632 NCI drug code

Drug Info:

Publications:

Meléndez et al., 1996, Effect of melatonin on beta-tubulin and MAP2 expression in NIE-115 cells., Neurochem. Res.

Eck et al., 1998, A sequential treatment regimen with melatonin and all-trans retinoic acid induces apoptosis in MCF-7 tumour cells., Br. J. Cancer

Capelli et al., 2002, Evaluation of gene expression in human lymphocytes activated in the presence of melatonin., Int. Immunopharmacol.

GuideToPharmacologyInteractions: 135651518
- Version: 20-July-2020
Alternate Names:

MELATONIN GuideToPharmacology Ligand Name

Drug Info:

Publications:
TTD: Melatonin
- Version: 2020.06.01
Alternate Names:

D0AN7B TTD Drug ID

Drug Info:

Publications:
DTC: MELATONIN
- Version: 02-September-2020
Alternate Names:

CHEMBL45 ChEMBL Drug ID

Drug Info:

Publications:
ChemblDrugs: chembl:CHEMBL45
- Version: ChEMBL_27
Alternate Names:

Drug Info:

Publications:

Endogenous Drug?	False
Specific Action of the Ligand	Antagonist

Specific Action of the Ligand	Full agonist
Endogenous Drug?	True
Direct Interaction?	True

Novel drug target	Established target
Trial Name	-
Specific Action of the Ligand	Full agonist

MELATONIN	DrugBank Drug Name
73-31-4	CAS Number
Amerix Melatonin	Drug Brand

MELATONIN Drug Record

MELATONIN chembl:CHEMBL45 Approved

Alternate Names:

Drug Info:

Publications:

Interaction Types & Directionality: antagonist (inhibitory)

Interaction Info: Endogenous Drug? False Specific Action of the Ligand Antagonist

Publications:

Interaction Types & Directionality: agonist (activating)

Interaction Info: Specific Action of the Ligand Full agonist Endogenous Drug? True Direct Interaction? True

Interaction Types & Directionality: agonist (activating)

Interaction Info: Novel drug target Established target Trial Name - Specific Action of the Ligand Full agonist

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info:

Publications: Galijasevic et al., 2008, Melatonin is a potent inhibitor for myeloperoxidase., Biochemistry

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info:

Publications: Lu et al., 2008, Analysis of the mechanism by which melatonin inhibits human eosinophil peroxidase., Br. J. Pharmacol.

Interaction Types & Directionality: antagonist (inhibitory)

Interaction Info:

Interaction Types & Directionality: agonist (activating)

Interaction Info:

Publications: Becker-André et al., 1994, Pineal gland hormone melatonin binds and activates an orphan of the nuclear receptor superfamily., J. Biol. Chem.

Interaction Types & Directionality: n/a

Interaction Info:

Publications: Klinger et al., Interactions of melatonin with the liver microsomal cytochrome P450 system of rats and humans in vitro and effects on the P450 system and the antioxidative status in rat liver after acute treatment., Eur J Drug Metab Pharmacokinet

Interaction Types & Directionality: n/a

Interaction Info:

Publications: Radogna et al., 2009, Rapid and transient stimulation of intracellular reactive oxygen species by melatonin in normal and tumor leukocytes., Toxicol. Appl. Pharmacol.

Interaction Types & Directionality: n/a

Interaction Info:

Publications: Onur et al., 2004, The effects of melatonin and the antioxidant defence system on apoptosis regulator proteins (Bax and Bcl-2) in experimentally induced varicocele., Urol. Res.

Interaction Types & Directionality: n/a

Interaction Info:

Publications: Meléndez et al., 1996, Effect of melatonin on beta-tubulin and MAP2 expression in NIE-115 cells., Neurochem. Res.

Interaction Types & Directionality: n/a

Interaction Info:

Publications: Di Stefano et al., 1994, Inhibitory effect of melatonin on production of IFN gamma or TNF alpha in peripheral blood mononuclear cells of some blood donors., J. Pineal Res.

Interaction Types & Directionality: n/a

Interaction Info:

Publications: Kiefer et al., 2005, Differential regulation of estrogen receptor alpha, glucocorticoid receptor and retinoic acid receptor alpha transcriptional activity by melatonin is mediated via different G proteins., J. Pineal Res.

Interaction Types & Directionality: n/a

Interaction Info:

Publications: Valcavi et al., 1993, Melatonin stimulates growth hormone secretion through pathways other than the growth hormone-releasing hormone., Clin. Endocrinol. (Oxf)

Interaction Types & Directionality: n/a

Interaction Info:

Publications: Awney et al., 2002, Effect of melatonin on the production of microsomal hydrogen peroxide and cytochrome P-450 content in rat treated with aflatoxin B(1)., Toxicology

Interaction Types & Directionality: n/a

Interaction Info:

Publications: Minneman et al., 1976, The pharmacology of the pineal gland., Annu. Rev. Pharmacol. Toxicol.

Interaction Types & Directionality: n/a

Interaction Info:

Interaction Types & Directionality: n/a

Interaction Info:

Interaction Types & Directionality: n/a

Interaction Info:

Interaction Types & Directionality: n/a

Interaction Info:

Publications: Satomura et al., 2007, Melatonin at pharmacological doses enhances human osteoblastic differentiation in vitro and promotes mouse cortical bone formation in vivo., J. Pineal Res.

Interaction Types & Directionality: n/a

Interaction Info:

Publications: Urata et al., 1999, Melatonin induces gamma-glutamylcysteine synthetase mediated by activator protein-1 in human vascular endothelial cells., Free Radic. Biol. Med.

Interaction Types & Directionality: n/a

Interaction Info:

Publications: Eck et al., 1998, A sequential treatment regimen with melatonin and all-trans retinoic acid induces apoptosis in MCF-7 tumour cells., Br. J. Cancer

Interaction Types & Directionality: n/a

Interaction Info:

Publications: Lee et al., 2006, Sustained activation of Akt by melatonin contributes to the protection against kainic acid-induced neuronal death in hippocampus., J. Pineal Res.

Interaction Types & Directionality: n/a

Interaction Info:

Publications: Manev et al., 1999, Primary cultures of rat cerebellar granule cells as a model to study neuronal 5-lipoxygenase and FLAP gene expression., Ann. N. Y. Acad. Sci.

Interaction Types & Directionality: n/a

Interaction Info:

Publications: Molis et al., 1995, Melatonin modulation of estrogen-regulated proteins, growth factors, and proto-oncogenes in human breast cancer., J. Pineal Res.

Interaction Types & Directionality: n/a

Interaction Info:

Publications: Tang et al., 1998, Enhanced glial cell line-derived neurotrophic factor mRNA expression upon (-)-deprenyl and melatonin treatments., J. Neurosci. Res.

Interaction Types & Directionality: n/a

Interaction Info:

Publications: Borlongan et al., 2000, Glial cell survival is enhanced during melatonin-induced neuroprotection against cerebral ischemia., FASEB J.

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Endogenous Drug? False

Specific Action of the Ligand Antagonist

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Specific Action of the Ligand Full agonist

Endogenous Drug? True

Direct Interaction? True

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Novel drug target Established target

Trial Name -

Specific Action of the Ligand Full agonist

Interaction Types & Directionality:

inhibitor (inhibitory)

Publications:

Galijasevic et al., 2008, Melatonin is a potent inhibitor for myeloperoxidase., Biochemistry

Interaction Types & Directionality:

inhibitor (inhibitory)

Publications:

Lu et al., 2008, Analysis of the mechanism by which melatonin inhibits human eosinophil peroxidase., Br. J. Pharmacol.

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Types & Directionality:

agonist (activating)

Publications:

Becker-André et al., 1994, Pineal gland hormone melatonin binds and activates an orphan of the nuclear receptor superfamily., J. Biol. Chem.

Interaction Types & Directionality:

n/a

Publications:

Klinger et al., Interactions of melatonin with the liver microsomal cytochrome P450 system of rats and humans in vitro and effects on the P450 system and the antioxidative status in rat liver after acute treatment., Eur J Drug Metab Pharmacokinet

Interaction Types & Directionality:

n/a

Publications:

Radogna et al., 2009, Rapid and transient stimulation of intracellular reactive oxygen species by melatonin in normal and tumor leukocytes., Toxicol. Appl. Pharmacol.

Interaction Types & Directionality:

n/a

Publications:

Onur et al., 2004, The effects of melatonin and the antioxidant defence system on apoptosis regulator proteins (Bax and Bcl-2) in experimentally induced varicocele., Urol. Res.

Interaction Types & Directionality:

n/a

Publications:

Meléndez et al., 1996, Effect of melatonin on beta-tubulin and MAP2 expression in NIE-115 cells., Neurochem. Res.

Interaction Types & Directionality:

n/a

Publications:

Di Stefano et al., 1994, Inhibitory effect of melatonin on production of IFN gamma or TNF alpha in peripheral blood mononuclear cells of some blood donors., J. Pineal Res.

Interaction Types & Directionality:

n/a

Publications:

Kiefer et al., 2005, Differential regulation of estrogen receptor alpha, glucocorticoid receptor and retinoic acid receptor alpha transcriptional activity by melatonin is mediated via different G proteins., J. Pineal Res.

Interaction Types & Directionality:

n/a

Publications:

Valcavi et al., 1993, Melatonin stimulates growth hormone secretion through pathways other than the growth hormone-releasing hormone., Clin. Endocrinol. (Oxf)

Interaction Types & Directionality:

n/a

Publications:

Awney et al., 2002, Effect of melatonin on the production of microsomal hydrogen peroxide and cytochrome P-450 content in rat treated with aflatoxin B(1)., Toxicology

Interaction Types & Directionality:

n/a

Publications:

Minneman et al., 1976, The pharmacology of the pineal gland., Annu. Rev. Pharmacol. Toxicol.

Interaction Types & Directionality:

n/a

Interaction Types & Directionality:

n/a

Interaction Types & Directionality:

n/a

Interaction Types & Directionality:

n/a

Publications:

Satomura et al., 2007, Melatonin at pharmacological doses enhances human osteoblastic differentiation in vitro and promotes mouse cortical bone formation in vivo., J. Pineal Res.

Interaction Types & Directionality:

n/a

Publications:

Urata et al., 1999, Melatonin induces gamma-glutamylcysteine synthetase mediated by activator protein-1 in human vascular endothelial cells., Free Radic. Biol. Med.

Interaction Types & Directionality:

n/a

Publications:

Eck et al., 1998, A sequential treatment regimen with melatonin and all-trans retinoic acid induces apoptosis in MCF-7 tumour cells., Br. J. Cancer

Interaction Types & Directionality:

n/a

Publications:

Lee et al., 2006, Sustained activation of Akt by melatonin contributes to the protection against kainic acid-induced neuronal death in hippocampus., J. Pineal Res.

Interaction Types & Directionality:

n/a

Publications:

Manev et al., 1999, Primary cultures of rat cerebellar granule cells as a model to study neuronal 5-lipoxygenase and FLAP gene expression., Ann. N. Y. Acad. Sci.

Interaction Types & Directionality:

n/a

Publications:

Molis et al., 1995, Melatonin modulation of estrogen-regulated proteins, growth factors, and proto-oncogenes in human breast cancer., J. Pineal Res.

Interaction Types & Directionality:

n/a

Publications:

Tang et al., 1998, Enhanced glial cell line-derived neurotrophic factor mRNA expression upon (-)-deprenyl and melatonin treatments., J. Neurosci. Res.

Interaction Types & Directionality:

n/a

Publications:

Borlongan et al., 2000, Glial cell survival is enhanced during melatonin-induced neuroprotection against cerebral ischemia., FASEB J.

Interaction Types & Directionality:

n/a

Publications:

Morrey et al., 1994, Activation of human monocytes by the pineal hormone melatonin., J. Immunol.

Interaction Types & Directionality:

n/a

Publications:

Capelli et al., 2002, Evaluation of gene expression in human lymphocytes activated in the presence of melatonin., Int. Immunopharmacol.

Interaction Types & Directionality:

n/a

Publications:

Hardeland, Melatonin: signaling mechanisms of a pleiotropic agent., Biofactors

Macías et al., 2003, Calreticulin-melatonin. An unexpected relationship., Eur. J. Biochem.

Interaction Types & Directionality:

n/a

Publications:

Viguié et al., 1997, Characterization of the short day-induced decrease in median eminence tyrosine hydroxylase activity in the ewe: temporal relationship to the changes in luteinizing hormone and prolactin secretion and short day-like effect of melatonin., Endocrinology

Interaction Types & Directionality:

n/a

Interaction Types & Directionality:

n/a

Interaction Types & Directionality:

n/a

Alternate Names:

MELATONIN DrugBank Drug Name

73-31-4 CAS Number

Amerix Melatonin Drug Brand

Drug Info:

Drug Type small molecule

Drug Groups approved

Drug Groups nutraceutical

Alternate Names:

MELATONIN Primary Drug Name

Drug Info:

Year of Approval not approved by the fda

Drug Class hypnotics and sedatives