DGIdb - MEDROXYPROGESTERONE ACETATE Drug Record

MEDROXYPROGESTERONE ACETATE chembl:CHEMBL717 Approved

Alternate Names:

FARLUTAL 250
SAYANA PRESS
DEPO-PROVERA
DEPO-PROGEVERA
FARLUTAL
CLIMANOR
CURRETAB
FARLUTAL 200
MEDROXYPROGESTERONE 17-ACETATE
TV-46046
ADGYN MEDRO
AMEN
MEDROXYPROGESTERONE ACETATE
FARLUTAL 500
MEDROXIPROGESTERONE ACETATE
NSC-26386
CYCRIN
LUNELLE
DEPO-SUBQ PROVERA 104
MEDROXYPROGESTERONE
DEPO-PROVERA ONCOLOGY
PROVERA
FARLUTAL 100
PREMPRO
NSC-21171
6Α-METHYL-17Α-HYDROXYPROGESTERONE ACETATE
6ALPHA-METHYL-4-PREGNENE-3,20-DION-17ALPHA-OL ACETATE
MEDROXYACETATE PROGESTERONE
MPA
METIGESTRONA
6ALPHA-METHYL-17ALPHA-HYDROXYPROGESTERONE ACETATE
17ALPHA-HYDROXY-6ALPHA-METHYLPROGESTERONE ACETATE
6-ALPHA-METHYL-17-ALPHA-HYDROXYPROGESTERONE ACETATE
17-ACETOXY-6ALPHA-METHYLPROGESTERONE
6-ALPHA-METHYL-17-ALPHA-ACETOXYPROGESTERONE
6Α-METHYL-17-ACETOXY PROGESTERONE
6ALPHA-METHYL-17-ACETOXY PROGESTERONE
(6ALPHA)-17-(ACETYLOXY)-6-METHYLPREG-4-ENE-3,20-DIONE
17-ACETOXY-6Α-METHYLPROGESTERONE
17Α-HYDROXY-6Α-METHYLPROGESTERONE ACETATE
METHYLACETOXYPROGESTERONE
chemidplus:71-58-9
chembl:CHEMBL717
rxcui:1000112
drugbank:00603
pubchem.compound:6279

Drug Info:

(2 More Sources)

Publications:

Helguero et al., 2003, Progesterone receptor expression in medroxyprogesterone acetate-induced murine mammary carcinomas and response to endocrine treatment., Breast Cancer Res. Treat.
Vereide et al., 2005, Bcl-2, BAX, and apoptosis in endometrial hyperplasia after high dose gestagen therapy: a comparison of responses in patients treated with intrauterine levonorgestrel and systemic medroxyprogesterone., Gynecol. Oncol.
Zanger UM et al., 2008, Functional pharmacogenetics/genomics of human cytochromes P450 involved in drug biotransformation., Anal Bioanal Chem
Deng HW et al., 1998, Change of bone mass in postmenopausal Caucasian women with and without hormone replacement therapy is associated with vitamin D receptor and estrogen receptor genotypes., Hum Genet
Fitton et al., 1998, Assessment of anticollagenase treatments after insertion of a keratoprosthetic material in the rabbit cornea., Cornea
Bulun et al., 2000, Expression of dioxin-related transactivating factors and target genes in human eutopic endometrial and endometriotic tissues., Am. J. Obstet. Gynecol.

MEDROXYPROGESTERONE ACETATE MMP1

Interaction Score: 0.52

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
9436888

Sources:
NCI
MEDROXYPROGESTERONE ACETATE PGR

Interaction Score: 0.35

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Progesterone receptor agonist

PMIDs:
12846422

Sources:
ChemblInteractions NCI TTD
MEDROXYPROGESTERONE ACETATE CYP1B1

Interaction Score: 0.32

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
10764452

Sources:
NCI
MEDROXYPROGESTERONE ACETATE ERG

Interaction Score: 0.21

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
MEDROXYPROGESTERONE ACETATE BAX

Interaction Score: 0.18

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
15885761

Sources:
NCI
MEDROXYPROGESTERONE ACETATE CYP3A5

Interaction Score: 0.09

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
18695978

Sources:
PharmGKB
MEDROXYPROGESTERONE ACETATE NPSR1

Interaction Score: 0.05

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
MEDROXYPROGESTERONE ACETATE RORC

Interaction Score: 0.05

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
MEDROXYPROGESTERONE ACETATE ESR1

Interaction Score: 0.05

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
9860300

Sources:
PharmGKB
MEDROXYPROGESTERONE ACETATE VDR

Interaction Score: 0.02

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
9860300

Sources:
PharmGKB
MEDROXYPROGESTERONE ACETATE ALDH1A1

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
MEDROXYPROGESTERONE ACETATE NFE2L2

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
MEDROXYPROGESTERONE ACETATE AR

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
MEDROXYPROGESTERONE ACETATE CYP3A4

Interaction Score: 0.0

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC

NCI: MEDROXYPROGESTERONE

Version: 14-September-2017

Alternate Names:

C629 NCI drug code

Drug Info:

Publications:

Vereide et al., 2005, Bcl-2, BAX, and apoptosis in endometrial hyperplasia after high dose gestagen therapy: a comparison of responses in patients treated with intrauterine levonorgestrel and systemic medroxyprogesterone., Gynecol. Oncol.

Bulun et al., 2000, Expression of dioxin-related transactivating factors and target genes in human eutopic endometrial and endometriotic tissues., Am. J. Obstet. Gynecol.

Fitton et al., 1998, Assessment of anticollagenase treatments after insertion of a keratoprosthetic material in the rabbit cornea., Cornea

PharmGKB: medroxyprogesterone

Version: 18-August-2020

Alternate Names:

Drug Info:

Publications:

Zanger UM et al., 2008, Functional pharmacogenetics/genomics of human cytochromes P450 involved in drug biotransformation., Anal Bioanal Chem

Deng HW et al., 1998, Change of bone mass in postmenopausal Caucasian women with and without hormone replacement therapy is associated with vitamin D receptor and estrogen receptor genotypes., Hum Genet

DTC: MEDROXYPROGESTERONE ACETATE
- Version: 02-September-2020
Alternate Names:

CHEMBL717 ChEMBL Drug ID

Drug Info:

Publications:
TTD: Medroxyprogesterone
- Version: 2020.06.01
Alternate Names:

D0I2SD TTD Drug ID

Drug Info:

Publications:
ChemblDrugs: chembl:CHEMBL717
- Version: ChEMBL_27
Alternate Names:

Drug Info:

Publications:
ChemblInteractions: CHEMBL717
- Version: chembl_23
Alternate Names:

Drug Info:

Publications:

Direct Interaction	yes
Mechanism of Interaction	Progesterone receptor agonist

MEDROXYPROGESTERONE ACETATE Drug Record

MEDROXYPROGESTERONE ACETATE chembl:CHEMBL717 Approved

Alternate Names:

Drug Info:

Publications:

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 9436888

Sources: NCI

Interaction Types & Directionality: agonist (activating)

Interaction Info: Direct Interaction yes Mechanism of Interaction Progesterone receptor agonist

PMIDs: 12846422

Sources: ChemblInteractions NCI TTD

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 10764452

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 15885761

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 18695978

Sources: PharmGKB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 9860300

Sources: PharmGKB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 9860300

Sources: PharmGKB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

NCI: MEDROXYPROGESTERONE

Alternate Names: C629 NCI drug code

Drug Info:

PharmGKB: medroxyprogesterone

Alternate Names:

Drug Info:

DTC: MEDROXYPROGESTERONE ACETATE

Alternate Names: CHEMBL717 ChEMBL Drug ID

Drug Info:

Publications:

TTD: Medroxyprogesterone

Alternate Names: D0I2SD TTD Drug ID

Drug Info:

Publications:

ChemblDrugs: chembl:CHEMBL717

Alternate Names:

Drug Info:

Publications:

ChemblInteractions: CHEMBL717

Interaction Types & Directionality:

n/a

PMIDs:
9436888

Sources:
NCI

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Progesterone receptor agonist

PMIDs:
12846422

Sources:
ChemblInteractions NCI TTD

Interaction Types & Directionality:

n/a

PMIDs:
10764452

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
15885761

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
18695978

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
9860300

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
9860300

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Alternate Names:

C629 NCI drug code

Alternate Names:

CHEMBL717 ChEMBL Drug ID

Alternate Names:

D0I2SD TTD Drug ID