DGIdb - MECAMYLAMINE Drug Record

MECAMYLAMINE chembl:CHEMBL267936 Approved

Alternate Names:

MECAMYLAMINE

Drug Info:

Year of Approval	1956
Drug Class	antihypertensive agents
Drug Indications	for treatment of ADHD
FDA Approval	approved
Drug Class	Small Molecule
Drug Indications	motilitant

(1 More Sources)

Publications:

Sakatis MZ et al., 2012, Preclinical strategy to reduce clinical hepatotoxicity using in vitro bioactivation data for >200 compounds., Chem Res Toxicol
Shytle et al., 2002, Mecamylamine (Inversine): an old antihypertensive with new research directions., J Hum Hypertens
Imming et al., 2006, Drugs, their targets and the nature and number of drug targets., Nat Rev Drug Discov
Overington et al., 2006, How many drug targets are there?, Nat Rev Drug Discov
Chen et al., 2002, TTD: Therapeutic Target Database., Nucleic Acids Res.
Struthers et al., 2009, Mecamylamine, dihydro-beta-erythroidine, and dextromethorphan block conditioned responding evoked by the conditional stimulus effects of nicotine., Pharmacol. Biochem. Behav.
Eaton JB et al., 2003, Characterization of human alpha 4 beta 2-nicotinic acetylcholine receptors stably and heterologously expressed in native nicotinic receptor-null SH-EP1 human epithelial cells., Mol Pharmacol

MECAMYLAMINE CHRNA2

Interaction Score: 4.01

Interaction Types & Directionality:

antagonist (inhibitory)

blocker (inhibitory)

inhibitor (inhibitory)

Interaction Info:

Trial Name AGI-004, mecamylamine transdermal patch, CR

Novel drug target Established target

Trial Name mecamylamine HCl , TC-5231

PMIDs:
12080428 17016423 17139284 11752352 19778551

Sources:
TdgClinicalTrial TEND
MECAMYLAMINE CHRNA4

Interaction Score: 0.54

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

PMIDs:
14645658

Sources:
TTD
MECAMYLAMINE CYP2C9

Interaction Score: 0.05

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
22931300

Sources:
DTC
MECAMYLAMINE CYP1A2

Interaction Score: 0.04

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
22931300

Sources:
DTC
MECAMYLAMINE CYP2D6

Interaction Score: 0.03

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
22931300

Sources:
DTC
MECAMYLAMINE CYP3A4

Interaction Score: 0.02

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
22931300

Sources:
DTC

TEND: MECAMYLAMINE
- Version: 01-August-2011
Alternate Names:

Drug Info:

Drug Class antihypertensive agents

Year of Approval 1956

Publications:
TdgClinicalTrial: MECAMYLAMINE
- Version: January-2014
Alternate Names:

Drug Info:

Drug Indications motilitant

Drug Class Small Molecule

FDA Approval approved

Publications:
DTC: MECAMYLAMINE
- Version: 02-September-2020
Alternate Names:

CHEMBL1398031 ChEMBL Drug ID

Drug Info:

Publications:

Sakatis MZ et al., 2012, Preclinical strategy to reduce clinical hepatotoxicity using in vitro bioactivation data for >200 compounds., Chem Res Toxicol
TTD: Mecamylamine
- Version: 2020.06.01
Alternate Names:

D0V8HA TTD Drug ID

Drug Info:

Publications:
ChemblDrugs: chembl:CHEMBL267936
- Version: ChEMBL_27
Alternate Names:

Drug Info:

Publications:

Trial Name	AGI-004, mecamylamine transdermal patch, CR
Novel drug target	Established target
Trial Name	mecamylamine HCl , TC-5231

antagonist (inhibitory)
blocker (inhibitory)
inhibitor (inhibitory)

MECAMYLAMINE Drug Record

MECAMYLAMINE chembl:CHEMBL267936 Approved

Alternate Names:

Drug Info:

Publications:

MECAMYLAMINE CHRNA2

Interaction Types & Directionality: antagonist (inhibitory) blocker (inhibitory) inhibitor (inhibitory)

Interaction Info: Trial Name AGI-004, mecamylamine transdermal patch, CR Novel drug target Established target Trial Name mecamylamine HCl , TC-5231

PMIDs: 12080428 17016423 17139284 11752352 19778551

Sources: TdgClinicalTrial TEND

MECAMYLAMINE CHRNA4

Interaction Types & Directionality: blocker (inhibitory)

Interaction Info:

PMIDs: 14645658

Sources: TTD

MECAMYLAMINE CYP2C9

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 22931300

Sources: DTC

MECAMYLAMINE CYP1A2

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 22931300

Sources: DTC

MECAMYLAMINE CYP2D6

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 22931300

Sources: DTC

MECAMYLAMINE CYP3A4

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 22931300

Sources: DTC

TEND: MECAMYLAMINE

Alternate Names:

Drug Info: Drug Class antihypertensive agents Year of Approval 1956

Publications:

TdgClinicalTrial: MECAMYLAMINE

Alternate Names:

Drug Info: Drug Indications motilitant Drug Class Small Molecule FDA Approval approved

Publications:

DTC: MECAMYLAMINE

Alternate Names: CHEMBL1398031 ChEMBL Drug ID

Drug Info:

Publications: Sakatis MZ et al., 2012, Preclinical strategy to reduce clinical hepatotoxicity using in vitro bioactivation data for &gt;200 compounds., Chem Res Toxicol

TTD: Mecamylamine

Alternate Names: D0V8HA TTD Drug ID

Drug Info:

Publications:

ChemblDrugs: chembl:CHEMBL267936

Alternate Names:

Drug Info:

Publications:

Interaction Types & Directionality:

antagonist (inhibitory)

blocker (inhibitory)

inhibitor (inhibitory)

Interaction Info:

Trial Name AGI-004, mecamylamine transdermal patch, CR

Novel drug target Established target

Trial Name mecamylamine HCl , TC-5231

PMIDs:
12080428 17016423 17139284 11752352 19778551

Sources:
TdgClinicalTrial TEND

Interaction Types & Directionality:

blocker (inhibitory)

PMIDs:
14645658

Sources:
TTD

Interaction Types & Directionality:

n/a

PMIDs:
22931300

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
22931300

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
22931300

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
22931300

Sources:
DTC

Drug Info:

Drug Class antihypertensive agents

Year of Approval 1956

Drug Info:

Drug Indications motilitant

Drug Class Small Molecule

FDA Approval approved

Alternate Names:

CHEMBL1398031 ChEMBL Drug ID

Publications:

Sakatis MZ et al., 2012, Preclinical strategy to reduce clinical hepatotoxicity using in vitro bioactivation data for >200 compounds., Chem Res Toxicol

Alternate Names:

D0V8HA TTD Drug ID