DGIdb - MAPROTILINE Drug Record

MAPROTILINE chembl:CHEMBL21731 Approved

Alternate Names:

MAPROTILINE
BA-34276 FREE BASE
BA-34276 [AS HYDROCHLORIDE]
BA-34,276 FREE BASE
MAPROTYLINA
LUD276
MAPROTILINE HYDROCHLORIDE
MAPROTILINUM
MAPROTILINA
chemidplus:10262-69-8
chembl:CHEMBL21731
pubchem.compound:4011
rxcui:6646
drugbank:00934

Drug Info:

Drug Class	antidepressive agents, second-generation
Year of Approval	1980
Drug Class	small molecule
Drug Indications	Antidepressive Agents, Second-Generation
FDA Approval	1980

(2 More Sources)

Publications:

Saba et al., 2007, [11C]LBT-999: a suitable radioligand for investigation of extra-striatal dopamine transporter with PET., Synapse
Arai et al., 2003, Chronic inhibition of the norepinephrine transporter in the brain participates in seizure sensitization to cocaine and local anesthetics., Brain Res.
Cloonan et al., 2010, The antidepressants maprotiline and fluoxetine have potent selective antiproliferative effects against Burkitt lymphoma independently of the norepinephrine and serotonin transporters., Leuk. Lymphoma
Dronjak et al., 2007, Effects of noradrenaline and serotonin reuptake inhibitors on pituitary-adrenocortical and sympatho-adrenomedullar system of adult rats., Neuro Endocrinol. Lett.
Mochizucki, 2004, Serotonin and noradrenaline reuptake inhibitors in animal models of pain., Hum Psychopharmacol
Sakatis MZ et al., 2012, Preclinical strategy to reduce clinical hepatotoxicity using in vitro bioactivation data for >200 compounds., Chem Res Toxicol

MAPROTILINE SLC6A2

Interaction Score: 1.01

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
17068778 12573515 20141432 17984940 15378668

Sources:
TdgClinicalTrial TEND
MAPROTILINE TSHR

Interaction Score: 0.06

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
MAPROTILINE MTOR

Interaction Score: 0.04

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
MAPROTILINE DRD1

Interaction Score: 0.04

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
MAPROTILINE CYP2C9

Interaction Score: 0.03

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
22931300

Sources:
DTC
MAPROTILINE ABCB1

Interaction Score: 0.02

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
PharmGKB
MAPROTILINE ATXN2

Interaction Score: 0.02

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
MAPROTILINE CYP1A2

Interaction Score: 0.02

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
22931300

Sources:
DTC
MAPROTILINE CYP2D6

Interaction Score: 0.02

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
22931300

Sources:
DTC
MAPROTILINE TP53

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
MAPROTILINE CYP3A4

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC

TEND: MAPROTILINE
- Version: 01-August-2011
Alternate Names:

MAPROTILINE Primary Drug Name

Drug Info:

Year of Approval 1980

Drug Class antidepressive agents, second-generation

Publications:
TdgClinicalTrial: MAPROTILINE
- Version: January-2014
Alternate Names:

Drug Info:

FDA Approval 1980

Drug Indications Antidepressive Agents, Second-Generation

Drug Class small molecule

Publications:
DTC: MAPROTILINE
- Version: 02-September-2020
Alternate Names:

CHEMBL21731 ChEMBL Drug ID

Drug Info:

Publications:

Sakatis MZ et al., 2012, Preclinical strategy to reduce clinical hepatotoxicity using in vitro bioactivation data for >200 compounds., Chem Res Toxicol
TTD: Maprotiline
- Version: 2020.06.01
Alternate Names:

D03KQF TTD Drug ID

Drug Info:

Publications:
ChemblDrugs: chembl:CHEMBL21731
- Version: ChEMBL_27
Alternate Names:

Drug Info:

Publications:
PharmGKB: maprotiline
- Version: 18-August-2020
Alternate Names:

Drug Info:

Publications:

Trial Name	-
Novel drug target	Established target

MAPROTILINE Drug Record

MAPROTILINE chembl:CHEMBL21731 Approved

Alternate Names:

Drug Info:

Publications:

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Trial Name - Novel drug target Established target

PMIDs: 17068778 12573515 20141432 17984940 15378668

Sources: TdgClinicalTrial TEND

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 22931300

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: PharmGKB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 22931300

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 22931300

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

TEND: MAPROTILINE

Alternate Names: MAPROTILINE Primary Drug Name

Drug Info: Year of Approval 1980 Drug Class antidepressive agents, second-generation

Publications:

TdgClinicalTrial: MAPROTILINE

Alternate Names:

Drug Info: FDA Approval 1980 Drug Indications Antidepressive Agents, Second-Generation Drug Class small molecule

Publications:

DTC: MAPROTILINE

Alternate Names: CHEMBL21731 ChEMBL Drug ID

Drug Info:

Publications: Sakatis MZ et al., 2012, Preclinical strategy to reduce clinical hepatotoxicity using in vitro bioactivation data for &gt;200 compounds., Chem Res Toxicol

TTD: Maprotiline

Alternate Names: D03KQF TTD Drug ID

Drug Info:

Publications:

ChemblDrugs: chembl:CHEMBL21731

Alternate Names:

Drug Info:

Publications:

PharmGKB: maprotiline

Alternate Names:

Drug Info:

Publications:

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
17068778 12573515 20141432 17984940 15378668

Sources:
TdgClinicalTrial TEND

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
22931300

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
22931300

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
22931300

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Alternate Names:

MAPROTILINE Primary Drug Name

Drug Info:

Year of Approval 1980

Drug Class antidepressive agents, second-generation

Drug Info:

FDA Approval 1980

Drug Indications Antidepressive Agents, Second-Generation

Drug Class small molecule

Alternate Names:

CHEMBL21731 ChEMBL Drug ID

Publications:

Sakatis MZ et al., 2012, Preclinical strategy to reduce clinical hepatotoxicity using in vitro bioactivation data for >200 compounds., Chem Res Toxicol

Alternate Names:

D03KQF TTD Drug ID