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MAPROTILINE Drug Record

  • Summary
  • Interactions
  • Claims
  • MAPROTILINE chembl:CHEMBL21731 Approved

    Alternate Names:

    MAPROTILINE
    BA-34276 FREE BASE
    BA-34276 [AS HYDROCHLORIDE]
    BA-34,276 FREE BASE
    MAPROTYLINA
    LUD276
    MAPROTILINE HYDROCHLORIDE
    MAPROTILINUM
    MAPROTILINA
    chemidplus:10262-69-8
    chembl:CHEMBL21731
    pubchem.compound:4011
    rxcui:6646
    drugbank:00934

    Drug Info:

    Drug Class antidepressive agents, second-generation
    Year of Approval 1980
    Drug Class small molecule
    Drug Indications Antidepressive Agents, Second-Generation
    FDA Approval 1980
    (2 More Sources)

    Publications:

    Saba et al., 2007, [11C]LBT-999: a suitable radioligand for investigation of extra-striatal dopamine transporter with PET., Synapse
    Arai et al., 2003, Chronic inhibition of the norepinephrine transporter in the brain participates in seizure sensitization to cocaine and local anesthetics., Brain Res.
    Cloonan et al., 2010, The antidepressants maprotiline and fluoxetine have potent selective antiproliferative effects against Burkitt lymphoma independently of the norepinephrine and serotonin transporters., Leuk. Lymphoma
    Dronjak et al., 2007, Effects of noradrenaline and serotonin reuptake inhibitors on pituitary-adrenocortical and sympatho-adrenomedullar system of adult rats., Neuro Endocrinol. Lett.
    Mochizucki, 2004, Serotonin and noradrenaline reuptake inhibitors in animal models of pain., Hum Psychopharmacol
    Sakatis MZ et al., 2012, Preclinical strategy to reduce clinical hepatotoxicity using in vitro bioactivation data for >200 compounds., Chem Res Toxicol
  • MAPROTILINE   SLC6A2

    Interaction Score: 1.01

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Trial Name -
    Novel drug target Established target

    PMIDs:
    17068778 12573515 20141432 17984940 15378668


    Sources:
    TdgClinicalTrial TEND

  • MAPROTILINE   TSHR

    Interaction Score: 0.06

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • MAPROTILINE   MTOR

    Interaction Score: 0.04

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • MAPROTILINE   DRD1

    Interaction Score: 0.04

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • MAPROTILINE   CYP2C9

    Interaction Score: 0.03

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    22931300


    Sources:
    DTC

  • MAPROTILINE   ABCB1

    Interaction Score: 0.02

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    PharmGKB

  • MAPROTILINE   ATXN2

    Interaction Score: 0.02

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • MAPROTILINE   CYP1A2

    Interaction Score: 0.02

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    22931300


    Sources:
    DTC

  • MAPROTILINE   CYP2D6

    Interaction Score: 0.02

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    22931300


    Sources:
    DTC

  • MAPROTILINE   TP53

    Interaction Score: 0.01

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • MAPROTILINE   CYP3A4

    Interaction Score: 0.01

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • TEND: MAPROTILINE

    • Version: 01-August-2011

    Alternate Names:
    MAPROTILINE Primary Drug Name

    Drug Info:
    Year of Approval 1980
    Drug Class antidepressive agents, second-generation

    Publications:

  • TdgClinicalTrial: MAPROTILINE

    • Version: January-2014

    Alternate Names:

    Drug Info:
    FDA Approval 1980
    Drug Indications Antidepressive Agents, Second-Generation
    Drug Class small molecule

    Publications:

  • DTC: MAPROTILINE

    • Version: 02-September-2020

    Alternate Names:
    CHEMBL21731 ChEMBL Drug ID

    Drug Info:

    Publications:
    Sakatis MZ et al., 2012, Preclinical strategy to reduce clinical hepatotoxicity using in vitro bioactivation data for >200 compounds., Chem Res Toxicol

  • TTD: Maprotiline

    • Version: 2020.06.01

    Alternate Names:
    D03KQF TTD Drug ID

    Drug Info:

    Publications:

  • ChemblDrugs: chembl:CHEMBL21731

    • Version: ChEMBL_27

    Alternate Names:

    Drug Info:

    Publications:

  • PharmGKB: maprotiline

    • Version: 18-August-2020

    Alternate Names:

    Drug Info:

    Publications:

Disclaimer: This resource is intended for purely research purposes. It should not be used for emergencies or medical or professional advice.

A finding of a drug-gene interaction or potentially druggable category does not necessarily indicate effectiveness (or lack thereof) of any drug or treatment regimen. A finding of no interaction or no potentially druggable category does not necessarily indicate lack of effectiveness of any drug or treatment regimen. Drug-gene interactions or potentially druggable categories are not presented in ranked order of potential or predicted efficacy.

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DGIdb (v4.2.0 - sha1 afd9f30b) • Last updated 2020-10-21