DGIdb - LYPRESSIN Drug Record

LYPRESSIN chembl:CHEMBL1200690 Approved

Alternate Names:

DIAPID
L-8
LYPRESSIN

Drug Info:

(0 More Sources)

Publications:

Aoyagi et al., 2007, Alteration of glucose homeostasis in V1a vasopressin receptor-deficient mice., Endocrinology
Adikesavan et al., 2005, A C-terminal segment of the V1R vasopressin receptor is unstructured in the crystal structure of its chimera with the maltose-binding protein., Acta Crystallogr. Sect. F Struct. Biol. Cryst. Commun.
Liedman et al., 2006, Intrauterine pressure, ischemia markers, and experienced pain during administration of a vasopressin V1a receptor antagonist in spontaneous and vasopressin-induced dysmenorrhea., Acta Obstet Gynecol Scand
Hammock et al., 2005, Association of vasopressin 1a receptor levels with a regulatory microsatellite and behavior., Genes Brain Behav.
Hiroyama et al., 2007, Vasopressin promotes cardiomyocyte hypertrophy via the vasopressin V1A receptor in neonatal mice., Eur. J. Pharmacol.
Wersinger et al., 2007, Disruption of the vasopressin 1b receptor gene impairs the attack component of aggressive behavior in mice., Genes Brain Behav.
Young et al., 2006, The vasopressin 1b receptor is prominent in the hippocampal area CA2 where it is unaffected by restraint stress or adrenalectomy., Neuroscience
Volpi et al., 2006, Vasopressin increases GAGA binding activity to the V1b receptor promoter through transactivation of the MAP kinase pathway., J. Mol. Endocrinol.
Slusarz et al., 2006, Analysis of interactions responsible for vasopressin binding to human neurohypophyseal hormone receptors-molecular dynamics study of the activated receptor-vasopressin-G(alpha) systems., J. Pept. Sci.
Jurkevich et al., 2005, Characterization and immunohistochemical visualization of the vasotocin VT2 receptor in the pituitary gland of the chicken, Gallus gallus., Gen. Comp. Endocrinol.
Slusarz et al., 2006, Investigation of mechanism of desmopressin binding in vasopressin V2 receptor versus vasopressin V1a and oxytocin receptors: molecular dynamics simulation of the agonist-bound state in the membrane-aqueous system., Biopolymers
Boson et al., 2006, Novel vasopressin type 2 (AVPR2) gene mutations in Brazilian nephrogenic diabetes insipidus patients., Genet. Test.
Yi et al., 2007, Alix (AIP1) is a vasopressin receptor (V2R)-interacting protein that increases lysosomal degradation of the V2R., Am. J. Physiol. Renal Physiol.
Chen et al., 2002, TTD: Therapeutic Target Database., Nucleic Acids Res.
Bouley et al., 2006, Aquaporin 2 (AQP2) and vasopressin type 2 receptor (V2R) endocytosis in kidney epithelial cells: AQP2 is located in 'endocytosis-resistant' membrane domains after vasopressin treatment., Biol. Cell

LYPRESSIN AVPR1B

Interaction Score: 8.24

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Mechanism of Interaction Vasopressin receptor agonist

Direct Interaction yes

PMIDs:
17284170 17027167 16720725 16114100 15993108

Sources:
ChemblInteractions
LYPRESSIN AVPR1A

Interaction Score: 7.27

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Vasopressin receptor agonist

PMIDs:
17303660 16511036 16532916 16011575 17275806

Sources:
ChemblInteractions
LYPRESSIN AVPR2

Interaction Score: 6.51

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Mechanism of Interaction Vasopressin receptor agonist

Direct Interaction yes

PMIDs:
16333859 17020465 17287200 11752352 16563128

Sources:
ChemblInteractions

TTD: Lypressin
- Version: 2020.06.01
Alternate Names:

D09PZZ TTD Drug ID

Drug Info:

Publications:
ChemblDrugs: chembl:CHEMBL1200690
- Version: ChEMBL_27
Alternate Names:

Drug Info:

Publications:
ChemblInteractions: CHEMBL1200690
- Version: chembl_23
Alternate Names:

Drug Info:

Publications:

Mechanism of Interaction	Vasopressin receptor agonist
Direct Interaction	yes

LYPRESSIN Drug Record

LYPRESSIN chembl:CHEMBL1200690 Approved

Alternate Names:

Drug Info:

Publications:

LYPRESSIN AVPR1B

Interaction Types & Directionality: agonist (activating)

Interaction Info: Mechanism of Interaction Vasopressin receptor agonist Direct Interaction yes

PMIDs: 17284170 17027167 16720725 16114100 15993108

Sources: ChemblInteractions

LYPRESSIN AVPR1A

Interaction Types & Directionality: agonist (activating)

Interaction Info: Direct Interaction yes Mechanism of Interaction Vasopressin receptor agonist

PMIDs: 17303660 16511036 16532916 16011575 17275806

Sources: ChemblInteractions

LYPRESSIN AVPR2

Interaction Types & Directionality: agonist (activating)

Interaction Info: Mechanism of Interaction Vasopressin receptor agonist Direct Interaction yes

PMIDs: 16333859 17020465 17287200 11752352 16563128

Sources: ChemblInteractions

TTD: Lypressin

Alternate Names: D09PZZ TTD Drug ID

Drug Info:

Publications:

ChemblDrugs: chembl:CHEMBL1200690

Alternate Names:

Drug Info:

Publications:

ChemblInteractions: CHEMBL1200690

Alternate Names:

Drug Info:

Publications:

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Mechanism of Interaction Vasopressin receptor agonist

Direct Interaction yes

PMIDs:
17284170 17027167 16720725 16114100 15993108

Sources:
ChemblInteractions

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Vasopressin receptor agonist

PMIDs:
17303660 16511036 16532916 16011575 17275806

Sources:
ChemblInteractions

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Mechanism of Interaction Vasopressin receptor agonist

Direct Interaction yes

PMIDs:
16333859 17020465 17287200 11752352 16563128

Sources:
ChemblInteractions

Alternate Names:

D09PZZ TTD Drug ID