• Search
      • Search Interactions Search Categories
    • Browse
      • Browse Categories Browse Sources
    • Information
      • About Publications Interaction Types & Directionalities Interaction Score & Query Score API Documentation FAQ Known Data Clients News Contact
    • Downloads
      • Data Source Code

LYPRESSIN Drug Record

  • Summary
  • Interactions
  • Claims
  • LYPRESSIN chembl:CHEMBL1200690 Approved

    Alternate Names:

    DIAPID
    L-8
    LYPRESSIN

    Drug Info:

    (0 More Sources)

    Publications:

    Aoyagi et al., 2007, Alteration of glucose homeostasis in V1a vasopressin receptor-deficient mice., Endocrinology
    Adikesavan et al., 2005, A C-terminal segment of the V1R vasopressin receptor is unstructured in the crystal structure of its chimera with the maltose-binding protein., Acta Crystallogr. Sect. F Struct. Biol. Cryst. Commun.
    Liedman et al., 2006, Intrauterine pressure, ischemia markers, and experienced pain during administration of a vasopressin V1a receptor antagonist in spontaneous and vasopressin-induced dysmenorrhea., Acta Obstet Gynecol Scand
    Hammock et al., 2005, Association of vasopressin 1a receptor levels with a regulatory microsatellite and behavior., Genes Brain Behav.
    Hiroyama et al., 2007, Vasopressin promotes cardiomyocyte hypertrophy via the vasopressin V1A receptor in neonatal mice., Eur. J. Pharmacol.
    Wersinger et al., 2007, Disruption of the vasopressin 1b receptor gene impairs the attack component of aggressive behavior in mice., Genes Brain Behav.
    Young et al., 2006, The vasopressin 1b receptor is prominent in the hippocampal area CA2 where it is unaffected by restraint stress or adrenalectomy., Neuroscience
    Volpi et al., 2006, Vasopressin increases GAGA binding activity to the V1b receptor promoter through transactivation of the MAP kinase pathway., J. Mol. Endocrinol.
    Slusarz et al., 2006, Analysis of interactions responsible for vasopressin binding to human neurohypophyseal hormone receptors-molecular dynamics study of the activated receptor-vasopressin-G(alpha) systems., J. Pept. Sci.
    Jurkevich et al., 2005, Characterization and immunohistochemical visualization of the vasotocin VT2 receptor in the pituitary gland of the chicken, Gallus gallus., Gen. Comp. Endocrinol.
    Slusarz et al., 2006, Investigation of mechanism of desmopressin binding in vasopressin V2 receptor versus vasopressin V1a and oxytocin receptors: molecular dynamics simulation of the agonist-bound state in the membrane-aqueous system., Biopolymers
    Boson et al., 2006, Novel vasopressin type 2 (AVPR2) gene mutations in Brazilian nephrogenic diabetes insipidus patients., Genet. Test.
    Yi et al., 2007, Alix (AIP1) is a vasopressin receptor (V2R)-interacting protein that increases lysosomal degradation of the V2R., Am. J. Physiol. Renal Physiol.
    Chen et al., 2002, TTD: Therapeutic Target Database., Nucleic Acids Res.
    Bouley et al., 2006, Aquaporin 2 (AQP2) and vasopressin type 2 receptor (V2R) endocytosis in kidney epithelial cells: AQP2 is located in 'endocytosis-resistant' membrane domains after vasopressin treatment., Biol. Cell
  • LYPRESSIN   AVPR1B

    Interaction Score: 8.24

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Mechanism of Interaction Vasopressin receptor agonist
    Direct Interaction yes

    PMIDs:
    17284170 17027167 16720725 16114100 15993108


    Sources:
    ChemblInteractions

  • LYPRESSIN   AVPR1A

    Interaction Score: 7.27

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Direct Interaction yes
    Mechanism of Interaction Vasopressin receptor agonist

    PMIDs:
    17303660 16511036 16532916 16011575 17275806


    Sources:
    ChemblInteractions

  • LYPRESSIN   AVPR2

    Interaction Score: 6.51

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Mechanism of Interaction Vasopressin receptor agonist
    Direct Interaction yes

    PMIDs:
    16333859 17020465 17287200 11752352 16563128


    Sources:
    ChemblInteractions

  • TTD: Lypressin

    • Version: 2020.06.01

    Alternate Names:
    D09PZZ TTD Drug ID

    Drug Info:

    Publications:

  • ChemblDrugs: chembl:CHEMBL1200690

    • Version: ChEMBL_27

    Alternate Names:

    Drug Info:

    Publications:

  • ChemblInteractions: CHEMBL1200690

    • Version: chembl_23

    Alternate Names:

    Drug Info:

    Publications:

Disclaimer: This resource is intended for purely research purposes. It should not be used for emergencies or medical or professional advice.

A finding of a drug-gene interaction or potentially druggable category does not necessarily indicate effectiveness (or lack thereof) of any drug or treatment regimen. A finding of no interaction or no potentially druggable category does not necessarily indicate lack of effectiveness of any drug or treatment regimen. Drug-gene interactions or potentially druggable categories are not presented in ranked order of potential or predicted efficacy.

The dgidb.org website does not provide any medical or healthcare products, services or advice, and is not for medical emergencies or urgent situations. IF YOU THINK YOU MAY HAVE A MEDICAL EMERGENCY, CALL YOUR DOCTOR OR 911 IMMEDIATELY. Information contained on this website is not a substitute for a doctor's medical judgment or advice. We recommend that you discuss your specific, individual health concerns with your doctor or health care professional.

DGIdb (v4.2.0 - sha1 afd9f30b) • Last updated 2020-10-21