DGIdb - LUMIRACOXIB Drug Record

LUMIRACOXIB chembl:CHEMBL404108

Alternate Names:

PREXIGE
LUMIRACOXIB
COX-189
PREXIGE®
LUMIRACOXIBUM
COX 189
2-((2-CHLORO-6-FLUOROPHENYL)AMINO)-5-METHYLBENZENEACETIC ACID
COX189
drugbank:01283
pubchem.compound:151166
chembl:CHEMBL404108
chemidplus:220991-20-8

Drug Info:

Year of Approval	not approved by the fda
Drug Class	anti-inflammatory agent, selective cyclooxygenase 2 inhibitors
FDA Approval	not approved
Drug Class	Small Molecule
Drug Indications	NSAID

(1 More Sources)

Publications:

Grosser T, 2009, Variability in the response to cyclooxygenase inhibitors: toward the individualization of nonsteroidal anti-inflammatory drug therapy., J Investig Med
Esser et al., 2005, Preclinical pharmacology of lumiracoxib: a novel selective inhibitor of cyclooxygenase-2., Br. J. Pharmacol.
Atherton et al., 2004, Pharmacology and gastrointestinal safety of lumiracoxib, a novel cyclooxygenase-2 selective inhibitor: An integrated study., Clin. Gastroenterol. Hepatol.
Capone et al., Clinical pharmacology of selective COX-2 inhibitors., Int J Immunopathol Pharmacol
Chen et al., 2002, TTD: Therapeutic Target Database., Nucleic Acids Res.
Kalbag et al., 2004, No influence of moderate hepatic impairment on the pharmacokinetics of lumiracoxib, an oral COX-2 selective inhibitor., Pharmacol. Res.
Tacconelli et al., 2004, Clinical pharmacology of novel selective COX-2 inhibitors., Curr. Pharm. Des.
Singer JB et al., 2010, A genome-wide study identifies HLA alleles associated with lumiracoxib-related liver injury., Nat Genet

LUMIRACOXIB HLA-DQA1

Interaction Score: 7.73

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
20639878

Sources:
PharmGKB
LUMIRACOXIB HLA-DQB1

Interaction Score: 2.58

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
20639878

Sources:
PharmGKB
LUMIRACOXIB PTGS2

Interaction Score: 2.05

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Trial Name lumiracoxib, COX 189,Prexige

Novel drug target Established target

PMIDs:
19602986 15655513 15017615 14552704 11752352 15177307 14965322

Sources:
TdgClinicalTrial TEND PharmGKB TTD
LUMIRACOXIB HLA-DRB1

Interaction Score: 1.0

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
20639878

Sources:
PharmGKB

TEND: LUMIRACOXIB
- Version: 01-August-2011
Alternate Names:

LUMIRACOXIB Primary Drug Name

Drug Info:

Drug Class anti-inflammatory agent, selective cyclooxygenase 2 inhibitors

Year of Approval not approved by the fda

Publications:
TdgClinicalTrial: LUMIRACOXIB
- Version: January-2014
Alternate Names:

Drug Info:

Drug Indications NSAID

Drug Class Small Molecule

FDA Approval not approved

Publications:

PharmGKB: lumiracoxib

Version: 18-August-2020

Alternate Names:

Drug Info:

Publications:

Grosser T, 2009, Variability in the response to cyclooxygenase inhibitors: toward the individualization of nonsteroidal anti-inflammatory drug therapy., J Investig Med

Singer JB et al., 2010, A genome-wide study identifies HLA alleles associated with lumiracoxib-related liver injury., Nat Genet

TTD: Lumiracoxib
- Version: 2020.06.01
Alternate Names:

D04YMH TTD Drug ID

Drug Info:

Publications:
ChemblDrugs: chembl:CHEMBL404108
- Version: ChEMBL_27
Alternate Names:

Drug Info:

Publications:

Trial Name	lumiracoxib, COX 189,Prexige
Novel drug target	Established target

LUMIRACOXIB Drug Record

LUMIRACOXIB chembl:CHEMBL404108

Alternate Names:

Drug Info:

Publications:

LUMIRACOXIB HLA-DQA1

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 20639878

Sources: PharmGKB

LUMIRACOXIB HLA-DQB1

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 20639878

Sources: PharmGKB

LUMIRACOXIB PTGS2

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Trial Name lumiracoxib, COX 189,Prexige Novel drug target Established target

PMIDs: 19602986 15655513 15017615 14552704 11752352 15177307 14965322

Sources: TdgClinicalTrial TEND PharmGKB TTD

LUMIRACOXIB HLA-DRB1

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 20639878

Sources: PharmGKB

TEND: LUMIRACOXIB

Alternate Names: LUMIRACOXIB Primary Drug Name

Drug Info: Drug Class anti-inflammatory agent, selective cyclooxygenase 2 inhibitors Year of Approval not approved by the fda

Publications:

TdgClinicalTrial: LUMIRACOXIB

Alternate Names:

Drug Info: Drug Indications NSAID Drug Class Small Molecule FDA Approval not approved

Publications:

PharmGKB: lumiracoxib

Alternate Names:

Drug Info:

TTD: Lumiracoxib

Alternate Names: D04YMH TTD Drug ID

Drug Info:

Publications:

ChemblDrugs: chembl:CHEMBL404108

Alternate Names:

Drug Info:

Publications:

Interaction Types & Directionality:

n/a

PMIDs:
20639878

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
20639878

Sources:
PharmGKB

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Trial Name lumiracoxib, COX 189,Prexige

Novel drug target Established target

PMIDs:
19602986 15655513 15017615 14552704 11752352 15177307 14965322

Sources:
TdgClinicalTrial TEND PharmGKB TTD

Interaction Types & Directionality:

n/a

PMIDs:
20639878

Sources:
PharmGKB

Alternate Names:

LUMIRACOXIB Primary Drug Name

Drug Info:

Drug Class anti-inflammatory agent, selective cyclooxygenase 2 inhibitors

Year of Approval not approved by the fda

Drug Info:

Drug Indications NSAID

Drug Class Small Molecule

FDA Approval not approved

Alternate Names:

D04YMH TTD Drug ID