DGIdb - LOSARTAN Drug Record

LOSARTAN chembl:CHEMBL191 Approved

Alternate Names:

HGP1405
LOSARTAN
HGP-1405
2-N-BUTYL-4-CHLORO-5-HYDROXYMETHYL-1-[(2'-(1H-TETRAZOL-5-YL)BIPHENYL-4-YL)METHYL]IMIDAZOLE
MK-954
(2-BUTYL-4-CHLORO-1-{[2'-(1H-TETRAZOL-5-YL)BIPHENYL-4-YL]METHYL}-1H-IMIDAZOL-5-YL)METHANOL
DUP 753
COZAAR®
DUP 89
drugbank:00678
rxcui:52175
chembl:CHEMBL191
pubchem.compound:3961
chemidplus:114798-26-4

Drug Info:

FDA Approval	1995
Drug Class	small molecule
Drug Indications	Antihypertensive Agents
Drug Class	antihypertensive agents
Year of Approval	1995
Drug Categories	tetrazoles
Drug Categories	biphenyl compounds
Drug Categories	agents causing angioedema
Drug Categories	agents causing hyperkalemia
Drug Categories	angiotensin 2 receptor blocker
Drug Categories	angiotensin ii receptor blockers (arbs) and calcium channel blockers
Drug Categories	angiotensin ii receptor blockers (arbs) and diuretics
Drug Categories	angiotensin ii receptor blockers (arbs), plain
Drug Categories	angiotensin ii type 2 receptor blockers
Drug Categories	antiarrhythmic agents
Drug Categories	antihypertensive agents indicated for hypertension
Drug Categories	bsep/abcb11 substrates
Drug Categories	cytochrome p-450 cyp2c19 inhibitors (strength unknown)
Drug Categories	cytochrome p-450 cyp2c8 inhibitors (strength unknown)
Drug Categories	cytochrome p-450 cyp3a substrates
Drug Categories	cytochrome p-450 cyp3a4 inhibitors
Drug Categories	cytochrome p-450 cyp3a4 inhibitors (strength unknown)
Drug Categories	cytochrome p-450 enzyme inhibitors
Drug Categories	cytochrome p-450 substrates
Drug Categories	drugs causing inadvertant photosensitivity
Drug Categories	oat1/slc22a6 inhibitors
Drug Categories	p-glycoprotein inhibitors
Drug Categories	p-glycoprotein substrates
Drug Categories	photosensitizing agents
Drug Categories	potential qtc-prolonging agents
Drug Categories	qtc prolonging agents
Drug Categories	ugt1a1 substrates
Drug Categories	ugt1a3 substrates
Drug Categories	ugt2b7 substrates

(4 More Sources)

Publications:

Rocha et al., 2003, Angiotensin AT1 receptor antagonist losartan and the defence reaction in the anaesthetised rat. Effect on the carotid chemoreflex., Exp. Physiol.
Dickstein et al., 1998, Losartan: a selective angiotensin II type 1 (AT1) receptor antagonist for the treatment of heart failure., Expert Opin Investig Drugs
Anand-Srivastava et al., 2003, Angiotensin-II-induced enhanced expression of Gi proteins is attenuated by losartan in A10 vascular smooth muscle cells: role of AT1 receptors., Can. J. Physiol. Pharmacol.
Ismail MA et al., 2006, Design and synthesis of new tetrazolyl- and carboxy-biphenylylmethyl-quinazolin-4-one derivatives as angiotensin II AT1 receptor antagonists., J Med Chem
Sookoian S et al., 2005, A1166C angiotensin II type 1 receptor gene polymorphism may predict hemodynamic response to losartan in patients with cirrhosis and portal hypertension., Am J Gastroenterol
Miller JA et al., 1999, Angiotensin II type 1 receptor gene polymorphism predicts response to losartan and angiotensin II., Kidney Int
Arsenault J et al., 2010, A single-nucleotide polymorphism of alanine to threonine at position 163 of the human angiotensin II type 1 receptor impairs Losartan affinity., Pharmacogenet Genomics
Sardo et al., Effects of AT1 receptor antagonist losartan on sICAM-1 and TNF-alpha levels in uncomplicated hypertensive patients., Angiology
Chen et al., 2002, TTD: Therapeutic Target Database., Nucleic Acids Res.
Guan et al., 2004, [The effects of losartan on pulmonary arterial collagen and AT1 in chronic hypoxic rats]., Sichuan Da Xue Xue Bao Yi Xue Ban
Donner KM et al., 2012, STK39 variation predicts the ambulatory blood pressure response to losartan in hypertensive men., Hypertens Res
Frau F et al., 2014, Genome-wide association study identifies CAMKID variants involved in blood pressure response to losartan: the SOPHIA study., Pharmacogenomics
Rendic S et al., 1997, Human cytochrome P450 enzymes: a status report summarizing their reactions, substrates, inducers, and inhibitors., Drug Metab Rev
Zanger UM et al., 2008, Functional pharmacogenetics/genomics of human cytochromes P450 involved in drug biotransformation., Anal Bioanal Chem
Göktaş MT et al., 2016, Relationship between genetic polymorphisms of drug efflux transporter MDR1 (ABCB1) and response to losartan in hypertension patients., Eur Rev Med Pharmacol Sci

LOSARTAN NPHS1

Interaction Score: 6.31

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
PharmGKB
LOSARTAN STK39

Interaction Score: 6.31

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
21993215

Sources:
PharmGKB
LOSARTAN AGTR1

Interaction Score: 2.1

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Specific Action of the Ligand Antagonist

Endogenous Drug? False

Direct Interaction? True

PMIDs:
12719755 15991937 12710529 16509571 15743363 10594793 20436376 15026875 11752352 15573751

Sources:
TEND DTC PharmGKB TdgClinicalTrial TTD DrugBank GuideToPharmacology
LOSARTAN CAMK1D

Interaction Score: 1.15

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
25410890

Sources:
PharmGKB
LOSARTAN UGT2B7

Interaction Score: 0.3

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
PharmGKB
LOSARTAN UGT1A1

Interaction Score: 0.16

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
PharmGKB
LOSARTAN CYP3A5

Interaction Score: 0.12

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
18695978

Sources:
PharmGKB
LOSARTAN ABCB1

Interaction Score: 0.05

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
27338075

Sources:
PharmGKB
LOSARTAN CYP3A4

Interaction Score: 0.02

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
9187528

Sources:
DTC PharmGKB

DrugBank: DB00678

Version: 5.1.7

Alternate Names:

LOSARTAN DrugBank Drug Name

114798-26-4 CAS Number

Act Losartan Drug Brand

Drug Info:

Drug Type small molecule

Drug Groups approved

Drug Categories agents acting on the renin-angiotensin system

Publications:

Rocha et al., 2003, Angiotensin AT1 receptor antagonist losartan and the defence reaction in the anaesthetised rat. Effect on the carotid chemoreflex., Exp. Physiol.

Dickstein et al., 1998, Losartan: a selective angiotensin II type 1 (AT1) receptor antagonist for the treatment of heart failure., Expert Opin Investig Drugs

Anand-Srivastava et al., 2003, Angiotensin-II-induced enhanced expression of Gi proteins is attenuated by losartan in A10 vascular smooth muscle cells: role of AT1 receptors., Can. J. Physiol. Pharmacol.

TEND: LOSARTAN
- Version: 01-August-2011
Alternate Names:

LOSARTAN Primary Drug Name

Drug Info:

Year of Approval 1995

Drug Class antihypertensive agents

Publications:
TdgClinicalTrial: LOSARTAN
- Version: January-2014
Alternate Names:

Drug Info:

Drug Indications Antihypertensive Agents

Drug Class small molecule

FDA Approval 1995

Publications:
DTC: LOSARTAN
- Version: 02-September-2020
Alternate Names:

CHEMBL191 ChEMBL Drug ID

Drug Info:

Publications:

Ismail MA et al., 2006, Design and synthesis of new tetrazolyl- and carboxy-biphenylylmethyl-quinazolin-4-one derivatives as angiotensin II AT1 receptor antagonists., J Med Chem

PharmGKB: losartan

Version: 18-August-2020

Alternate Names:

Drug Info:

Publications:

Zanger UM et al., 2008, Functional pharmacogenetics/genomics of human cytochromes P450 involved in drug biotransformation., Anal Bioanal Chem

Göktaş MT et al., 2016, Relationship between genetic polymorphisms of drug efflux transporter MDR1 (ABCB1) and response to losartan in hypertension patients., Eur Rev Med Pharmacol Sci

Frau F et al., 2014, Genome-wide association study identifies CAMKID variants involved in blood pressure response to losartan: the SOPHIA study., Pharmacogenomics

GuideToPharmacology: 135650532
- Version: 29-September-2020
Alternate Names:

LOSARTAN GuideToPharmacology Ligand Name

Drug Info:

Publications:
TTD: Losartan
- Version: 2020.06.01
Alternate Names:

D0DD0K TTD Drug ID

Drug Info:

Publications:
ChemblDrugs: chembl:CHEMBL191
- Version: ChEMBL_27
Alternate Names:

Drug Info:

Publications:

Specific Action of the Ligand	Antagonist
Endogenous Drug?	False
Direct Interaction?	True

LOSARTAN	DrugBank Drug Name
114798-26-4	CAS Number
Act Losartan	Drug Brand

Drug Type	small molecule
Drug Groups	approved
Drug Categories	agents acting on the renin-angiotensin system

LOSARTAN Drug Record

LOSARTAN chembl:CHEMBL191 Approved

Alternate Names:

Drug Info:

Publications:

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: PharmGKB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 21993215

Sources: PharmGKB

Interaction Types & Directionality: antagonist (inhibitory)

Interaction Info: Specific Action of the Ligand Antagonist Endogenous Drug? False Direct Interaction? True

PMIDs: 12719755 15991937 12710529 16509571 15743363 10594793 20436376 15026875 11752352 15573751

Sources: TEND DTC PharmGKB TdgClinicalTrial TTD DrugBank GuideToPharmacology

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 25410890

Sources: PharmGKB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: PharmGKB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: PharmGKB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 18695978

Sources: PharmGKB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 27338075

Sources: PharmGKB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 9187528

Sources: DTC PharmGKB

DrugBank: DB00678

Alternate Names: LOSARTAN DrugBank Drug Name 114798-26-4 CAS Number Act Losartan Drug Brand

Drug Info: Drug Type small molecule Drug Groups approved Drug Categories agents acting on the renin-angiotensin system

TEND: LOSARTAN

Alternate Names: LOSARTAN Primary Drug Name

Drug Info: Year of Approval 1995 Drug Class antihypertensive agents

Publications:

TdgClinicalTrial: LOSARTAN

Alternate Names:

Drug Info: Drug Indications Antihypertensive Agents Drug Class small molecule FDA Approval 1995

Publications:

DTC: LOSARTAN

Alternate Names: CHEMBL191 ChEMBL Drug ID

Drug Info:

Publications: Ismail MA et al., 2006, Design and synthesis of new tetrazolyl- and carboxy-biphenylylmethyl-quinazolin-4-one derivatives as angiotensin II AT1 receptor antagonists., J Med Chem

PharmGKB: losartan

Alternate Names:

Drug Info:

GuideToPharmacology: 135650532

Alternate Names: LOSARTAN GuideToPharmacology Ligand Name

Drug Info:

Publications:

TTD: Losartan

Alternate Names: D0DD0K TTD Drug ID

Drug Info:

Publications:

ChemblDrugs: chembl:CHEMBL191

Alternate Names:

Drug Info:

Publications:

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
21993215

Sources:
PharmGKB

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Specific Action of the Ligand Antagonist

Endogenous Drug? False

Direct Interaction? True

PMIDs:
12719755 15991937 12710529 16509571 15743363 10594793 20436376 15026875 11752352 15573751

Sources:
TEND DTC PharmGKB TdgClinicalTrial TTD DrugBank GuideToPharmacology

Interaction Types & Directionality:

n/a

PMIDs:
25410890

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
18695978

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
27338075

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
9187528

Sources:
DTC PharmGKB

Alternate Names:

LOSARTAN DrugBank Drug Name

114798-26-4 CAS Number

Act Losartan Drug Brand

Drug Info:

Drug Type small molecule

Drug Groups approved

Drug Categories agents acting on the renin-angiotensin system

Alternate Names:

LOSARTAN Primary Drug Name

Drug Info:

Year of Approval 1995

Drug Class antihypertensive agents

Drug Info:

Drug Indications Antihypertensive Agents

Drug Class small molecule

FDA Approval 1995

Alternate Names:

CHEMBL191 ChEMBL Drug ID

Publications:

Ismail MA et al., 2006, Design and synthesis of new tetrazolyl- and carboxy-biphenylylmethyl-quinazolin-4-one derivatives as angiotensin II AT1 receptor antagonists., J Med Chem

Alternate Names:

LOSARTAN GuideToPharmacology Ligand Name

Alternate Names:

D0DD0K TTD Drug ID