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LOPERAMIDE Drug Record

  • Summary
  • Interactions
  • Claims
  • LOPERAMIDE chembl:CHEMBL841 Approved

    Alternate Names:

    IMODIUM
    LOPERAMIDE
    LOPERAMID
    NU-LOPERAMIDE
    R-18553
    PMS-LOPERAMIDE
    LOPERAMIDUM
    APO-LOPERAMIDE
    IMODIUM A-D CAPLETS
    IMODIUM®
    KAOPECTATE II
    IMODIUM A-D
    MAALOX ANTI-DIARRHEAL
    LOPERACAP
    LOPÉRAMIDE
    LOPERAMIDA
    RHO-LOPERAMIDE
    FORTASEC®
    drugbank:00836
    rxcui:6468
    chemidplus:53179-11-6
    pubchem.compound:3955
    chembl:CHEMBL841

    Drug Info:

    FDA Approval Approved before 1982
    Drug Class small molecule
    Drug Indications Antidiarrheals
    Year of Approval approved before 1982
    Drug Class antidiarrheals
    (2 More Sources)

    Publications:

    DeHaven-Hudkins et al., 1999, Loperamide (ADL 2-1294), an opioid antihyperalgesic agent with peripheral selectivity., J. Pharmacol. Exp. Ther.
    di Bosco et al., 2008, Binding site of loperamide: automated docking of loperamide in human mu- and delta-opioid receptors., Chem Biol Drug Des
    Giagnoni et al., 1983, Loperamide: evidence of interaction with mu and delta opioid receptors., Life Sci.
    Chen et al., 2002, TTD: Therapeutic Target Database., Nucleic Acids Res.
    Tan-No et al., 2003, Development of tolerance to the inhibitory effect of loperamide on gastrointestinal transit in mice., Eur J Pharm Sci
    Roge et al., 1993, The enkephalinase inhibitor, acetorphan, in acute diarrhoea. A double-blind, controlled clinical trial versus loperamide., Scand. J. Gastroenterol.
    Gong et al., 2012, Discovery of loperamide as an antagonist of angiopoietin1 and angiopoietin2 by virtual screening., Bioorg. Med. Chem. Lett.
  • LOPERAMIDE   TEK

    Interaction Score: 0.73

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    22406116


    Sources:
    DTC

  • LOPERAMIDE   OPRD1

    Interaction Score: 0.6

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:

    PMIDs:
    6319884 18284554 11752352


    Sources:
    TTD

  • LOPERAMIDE   OPRM1

    Interaction Score: 0.48

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Trial Name -
    Novel drug target Established target

    PMIDs:
    10087042 18284554 6319884 11752352 14592702 8488368


    Sources:
    TdgClinicalTrial TEND

  • LOPERAMIDE   TSHR

    Interaction Score: 0.07

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • LOPERAMIDE   MTOR

    Interaction Score: 0.05

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • LOPERAMIDE   ABCB1

    Interaction Score: 0.03

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    PharmGKB

  • LOPERAMIDE   TP53

    Interaction Score: 0.02

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • LOPERAMIDE   CYP2D6

    Interaction Score: 0.01

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • LOPERAMIDE   AR

    Interaction Score: 0.01

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • LOPERAMIDE   CYP3A4

    Interaction Score: 0.01

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • TEND: LOPERAMIDE

    • Version: 01-August-2011

    Alternate Names:
    LOPERAMIDE Primary Drug Name

    Drug Info:
    Drug Class antidiarrheals
    Year of Approval approved before 1982

    Publications:

  • TdgClinicalTrial: LOPERAMIDE

    • Version: January-2014

    Alternate Names:

    Drug Info:
    Drug Indications Antidiarrheals
    Drug Class small molecule
    FDA Approval Approved before 1982

    Publications:

  • DTC: LOPERAMIDE

    • Version: 02-September-2020

    Alternate Names:
    CHEMBL841 ChEMBL Drug ID

    Drug Info:

    Publications:
    Gong et al., 2012, Discovery of loperamide as an antagonist of angiopoietin1 and angiopoietin2 by virtual screening., Bioorg. Med. Chem. Lett.

  • TTD: Loperamide

    • Version: 2020.06.01

    Alternate Names:
    D0CS2F TTD Drug ID

    Drug Info:

    Publications:

  • ChemblDrugs: chembl:CHEMBL841

    • Version: ChEMBL_27

    Alternate Names:

    Drug Info:

    Publications:

  • PharmGKB: loperamide

    • Version: 18-August-2020

    Alternate Names:

    Drug Info:

    Publications:

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A finding of a drug-gene interaction or potentially druggable category does not necessarily indicate effectiveness (or lack thereof) of any drug or treatment regimen. A finding of no interaction or no potentially druggable category does not necessarily indicate lack of effectiveness of any drug or treatment regimen. Drug-gene interactions or potentially druggable categories are not presented in ranked order of potential or predicted efficacy.

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DGIdb (v4.2.0 - sha1 afd9f30b) • Last updated 2020-10-21