DGIdb - LOPERAMIDE Drug Record

LOPERAMIDE chembl:CHEMBL841 Approved

Alternate Names:

IMODIUM
LOPERAMIDE
LOPERAMID
NU-LOPERAMIDE
R-18553
PMS-LOPERAMIDE
LOPERAMIDUM
APO-LOPERAMIDE
IMODIUM A-D CAPLETS
IMODIUM®
KAOPECTATE II
IMODIUM A-D
MAALOX ANTI-DIARRHEAL
LOPERACAP
LOPÉRAMIDE
LOPERAMIDA
RHO-LOPERAMIDE
FORTASEC®
drugbank:00836
rxcui:6468
chemidplus:53179-11-6
pubchem.compound:3955
chembl:CHEMBL841

Drug Info:

FDA Approval	Approved before 1982
Drug Class	small molecule
Drug Indications	Antidiarrheals
Year of Approval	approved before 1982
Drug Class	antidiarrheals

(2 More Sources)

Publications:

DeHaven-Hudkins et al., 1999, Loperamide (ADL 2-1294), an opioid antihyperalgesic agent with peripheral selectivity., J. Pharmacol. Exp. Ther.
di Bosco et al., 2008, Binding site of loperamide: automated docking of loperamide in human mu- and delta-opioid receptors., Chem Biol Drug Des
Giagnoni et al., 1983, Loperamide: evidence of interaction with mu and delta opioid receptors., Life Sci.
Chen et al., 2002, TTD: Therapeutic Target Database., Nucleic Acids Res.
Tan-No et al., 2003, Development of tolerance to the inhibitory effect of loperamide on gastrointestinal transit in mice., Eur J Pharm Sci
Roge et al., 1993, The enkephalinase inhibitor, acetorphan, in acute diarrhoea. A double-blind, controlled clinical trial versus loperamide., Scand. J. Gastroenterol.
Gong et al., 2012, Discovery of loperamide as an antagonist of angiopoietin1 and angiopoietin2 by virtual screening., Bioorg. Med. Chem. Lett.

LOPERAMIDE TEK

Interaction Score: 0.73

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
22406116

Sources:
DTC
LOPERAMIDE OPRD1

Interaction Score: 0.6

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

PMIDs:
6319884 18284554 11752352

Sources:
TTD
LOPERAMIDE OPRM1

Interaction Score: 0.48

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
10087042 18284554 6319884 11752352 14592702 8488368

Sources:
TdgClinicalTrial TEND
LOPERAMIDE TSHR

Interaction Score: 0.07

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
LOPERAMIDE MTOR

Interaction Score: 0.05

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
LOPERAMIDE ABCB1

Interaction Score: 0.03

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
PharmGKB
LOPERAMIDE TP53

Interaction Score: 0.02

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
LOPERAMIDE CYP2D6

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
LOPERAMIDE AR

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
LOPERAMIDE CYP3A4

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC

TEND: LOPERAMIDE
- Version: 01-August-2011
Alternate Names:

LOPERAMIDE Primary Drug Name

Drug Info:

Drug Class antidiarrheals

Year of Approval approved before 1982

Publications:
TdgClinicalTrial: LOPERAMIDE
- Version: January-2014
Alternate Names:

Drug Info:

Drug Indications Antidiarrheals

Drug Class small molecule

FDA Approval Approved before 1982

Publications:
DTC: LOPERAMIDE
- Version: 02-September-2020
Alternate Names:

CHEMBL841 ChEMBL Drug ID

Drug Info:

Publications:

Gong et al., 2012, Discovery of loperamide as an antagonist of angiopoietin1 and angiopoietin2 by virtual screening., Bioorg. Med. Chem. Lett.
TTD: Loperamide
- Version: 2020.06.01
Alternate Names:

D0CS2F TTD Drug ID

Drug Info:

Publications:
ChemblDrugs: chembl:CHEMBL841
- Version: ChEMBL_27
Alternate Names:

Drug Info:

Publications:
PharmGKB: loperamide
- Version: 18-August-2020
Alternate Names:

Drug Info:

Publications:

Trial Name	-
Novel drug target	Established target

LOPERAMIDE Drug Record

LOPERAMIDE chembl:CHEMBL841 Approved

Alternate Names:

Drug Info:

Publications:

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 22406116

Sources: DTC

Interaction Types & Directionality: agonist (activating)

Interaction Info:

PMIDs: 6319884 18284554 11752352

Sources: TTD

Interaction Types & Directionality: agonist (activating)

Interaction Info: Trial Name - Novel drug target Established target

PMIDs: 10087042 18284554 6319884 11752352 14592702 8488368

Sources: TdgClinicalTrial TEND

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: PharmGKB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

TEND: LOPERAMIDE

Alternate Names: LOPERAMIDE Primary Drug Name

Drug Info: Drug Class antidiarrheals Year of Approval approved before 1982

Publications:

TdgClinicalTrial: LOPERAMIDE

Alternate Names:

Drug Info: Drug Indications Antidiarrheals Drug Class small molecule FDA Approval Approved before 1982

Publications:

DTC: LOPERAMIDE

Alternate Names: CHEMBL841 ChEMBL Drug ID

Drug Info:

Publications: Gong et al., 2012, Discovery of loperamide as an antagonist of angiopoietin1 and angiopoietin2 by virtual screening., Bioorg. Med. Chem. Lett.

TTD: Loperamide

Alternate Names: D0CS2F TTD Drug ID

Drug Info:

Publications:

ChemblDrugs: chembl:CHEMBL841

Alternate Names:

Drug Info:

Publications:

PharmGKB: loperamide

Alternate Names:

Drug Info:

Publications:

Interaction Types & Directionality:

n/a

PMIDs:
22406116

Sources:
DTC

Interaction Types & Directionality:

agonist (activating)

PMIDs:
6319884 18284554 11752352

Sources:
TTD

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
10087042 18284554 6319884 11752352 14592702 8488368

Sources:
TdgClinicalTrial TEND

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Alternate Names:

LOPERAMIDE Primary Drug Name

Drug Info:

Drug Class antidiarrheals

Year of Approval approved before 1982

Drug Info:

Drug Indications Antidiarrheals

Drug Class small molecule

FDA Approval Approved before 1982

Alternate Names:

CHEMBL841 ChEMBL Drug ID

Publications:

Gong et al., 2012, Discovery of loperamide as an antagonist of angiopoietin1 and angiopoietin2 by virtual screening., Bioorg. Med. Chem. Lett.

Alternate Names:

D0CS2F TTD Drug ID