DGIdb - LOMETREXOL Drug Record

LOMETREXOL chembl:CHEMBL34412

Alternate Names:

LOMETREXOL
LY264618

Drug Info:

(0 More Sources)

Publications:

Li B et al., 2015, Negative feedback-defective PRPS1 mutants drive thiopurine resistance in relapsed childhood ALL., Nat Med
Wang L et al., 2010, Synthesis and antitumor activity of a novel series of 6-substituted pyrrolo[2,3-d]pyrimidine thienoyl antifolate inhibitors of purine biosynthesis with selectivity for high affinity folate receptors and the proton-coupled folate transporter over the reduced folate carrier for cellular entry., J Med Chem
Wang L et al., 2011, Synthesis, biological, and antitumor activity of a highly potent 6-substituted pyrrolo[2,3-d]pyrimidine thienoyl antifolate inhibitor with proton-coupled folate transporter and folate receptor selectivity over the reduced folate carrier that inhibits β-glycinamide ribonucleotide formyltransferase., J Med Chem
Wang L et al., 2012, Synthesis and biological activity of 6-substituted pyrrolo[2,3-d]pyrimidine thienoyl regioisomers as inhibitors of de novo purine biosynthesis with selectivity for cellular uptake by high affinity folate receptors and the proton-coupled folate transporter over the reduced folate carrier., J Med Chem

LOMETREXOL FOLR2

Interaction Score: 12.37

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
20085328

Sources:
DTC
LOMETREXOL GART

Interaction Score: 8.24

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
22243528

Sources:
DTC
LOMETREXOL PRPS1

Interaction Score: 8.24

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
25962120

Sources:
CIViC
LOMETREXOL FOLR1

Interaction Score: 2.47

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
20085328

Sources:
DTC
LOMETREXOL SLC19A1

Interaction Score: 2.25

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
21879757

Sources:
DTC

DTC: LOMETREXOL

Version: 02-September-2020

Alternate Names:

CHEMBL34412 ChEMBL Drug ID

Drug Info:

Publications:

Wang L et al., 2011, Synthesis, biological, and antitumor activity of a highly potent 6-substituted pyrrolo[2,3-d]pyrimidine thienoyl antifolate inhibitor with proton-coupled folate transporter and folate receptor selectivity over the reduced folate carrier that inhibits β-glycinamide ribonucleotide formyltransferase., J Med Chem

Wang L et al., 2012, Synthesis and biological activity of 6-substituted pyrrolo[2,3-d]pyrimidine thienoyl regioisomers as inhibitors of de novo purine biosynthesis with selectivity for cellular uptake by high affinity folate receptors and the proton-coupled folate transporter over the reduced folate carrier., J Med Chem

Wang L et al., 2010, Synthesis and antitumor activity of a novel series of 6-substituted pyrrolo[2,3-d]pyrimidine thienoyl antifolate inhibitors of purine biosynthesis with selectivity for high affinity folate receptors and the proton-coupled folate transporter over the reduced folate carrier for cellular entry., J Med Chem

CIViC: LOMETREXOL
- Version: 14-September-2020
Alternate Names:

Drug Info:

Publications:

Li B et al., 2015, Negative feedback-defective PRPS1 mutants drive thiopurine resistance in relapsed childhood ALL., Nat Med
ChemblDrugs: chembl:CHEMBL34412
- Version: ChEMBL_27
Alternate Names:

Drug Info:

Publications:

LOMETREXOL Drug Record

LOMETREXOL chembl:CHEMBL34412

Alternate Names:

Drug Info:

Publications:

LOMETREXOL FOLR2

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 20085328

Sources: DTC

LOMETREXOL GART

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 22243528

Sources: DTC

LOMETREXOL PRPS1

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 25962120

Sources: CIViC

LOMETREXOL FOLR1

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 20085328

Sources: DTC

LOMETREXOL SLC19A1

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 21879757

Sources: DTC

DTC: LOMETREXOL

Alternate Names: CHEMBL34412 ChEMBL Drug ID

Drug Info:

CIViC: LOMETREXOL

Alternate Names:

Drug Info:

Publications: Li B et al., 2015, Negative feedback-defective PRPS1 mutants drive thiopurine resistance in relapsed childhood ALL., Nat Med

ChemblDrugs: chembl:CHEMBL34412

Alternate Names:

Drug Info:

Publications:

Interaction Types & Directionality:

n/a

PMIDs:
20085328

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
22243528

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
25962120

Sources:
CIViC

Interaction Types & Directionality:

n/a

PMIDs:
20085328

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
21879757

Sources:
DTC

Alternate Names:

CHEMBL34412 ChEMBL Drug ID

Publications:

Li B et al., 2015, Negative feedback-defective PRPS1 mutants drive thiopurine resistance in relapsed childhood ALL., Nat Med