DGIdb - LITHIUM Drug Record

LITHIUM chembl:CHEMBL2146126

Alternate Names:

LITHIUM

Drug Info:

Drug Categories	tricarboxylic acids
Drug Categories	metals, alkali
Drug Categories	metals
Drug Categories	lithium compounds
Drug Categories	antimanic agents
Drug Categories	drugs that are mainly renally excreted
Drug Categories	mood stabilizer
Drug Categories	nephrotoxic agents
Drug Categories	neurotoxic agents
Drug Categories	qtc prolonging agents
Drug Categories	serotonergic drugs shown to increase risk of serotonin syndrome
Drug Categories	serotonin agents

(0 More Sources)

Publications:

Delacrétaz A et al., 2017, Association of variants in SH2B1 and RABEP1 with worsening of low-density lipoprotein and glucose parameters in patients treated with psychotropic drugs., Gene
Rantamäki et al., 2006, The effects of acute and long-term lithium treatments on trkB neurotrophin receptor activation in the mouse hippocampus and anterior cingulate cortex., Neuropharmacology
McCarthy MJ et al., 2010, Pharmacogenetics of lithium response in bipolar disorder., Pharmacogenomics
Salloum NC et al., 2014, Towards the clinical implementation of pharmacogenetics in bipolar disorder., BMC Med
Squassina A et al., 2011, Evidence for association of an ACCN1 gene variant with response to lithium treatment in Sardinian patients with bipolar disorder., Pharmacogenomics
Serretti et al., Serotonin receptor 2A, 2C, 1A genes and response to lithium prophylaxis in mood disorders., J Psychiatr Res
Rojo et al., 2008, Functional interference between glycogen synthase kinase-3 beta and the transcription factor Nrf2 in protection against kainate-induced hippocampal cell death., Mol. Cell. Neurosci.
Tanizawa et al., 2006, Inositol monophosphatase regulates localization of synaptic components and behavior in the mature nervous system of C. elegans., Genes Dev.
Ohnishi et al., 2007, Spatial expression patterns and biochemical properties distinguish a second myo-inositol monophosphatase IMPA2 from IMPA1., J. Biol. Chem.
Sarkar et al., Inositol and IP3 levels regulate autophagy: biology and therapeutic speculations., Autophagy
Trinquet et al., 2006, D-myo-inositol 1-phosphate as a surrogate of D-myo-inositol 1,4,5-tris phosphate to monitor G protein-coupled receptor activation., Anal. Biochem.
Ohnishi et al., 2007, A promoter haplotype of the inositol monophosphatase 2 gene (IMPA2) at 18p11.2 confers a possible risk for bipolar disorder by enhancing transcription., Neuropsychopharmacology
Li et al., 2010, Mobile loop mutations in an archaeal inositol monophosphatase: modulating three-metal ion assisted catalysis and lithium inhibition., Protein Sci.
International Consortium on Lithium Genetics (ConLi+Gen). et al., 2018, Association of Polygenic Score for Schizophrenia and HLA Antigen and Inflammation Genes With Response to Lithium in Bipolar Affective Disorder: A Genome-Wide Association Study., JAMA Psychiatry
Hunter et al., 1989, Luteinizing hormone responses to luteinizing hormone releasing hormone (LHRH) in acute mania and the effects of lithium on LHRH and thyrotrophin releasing hormone tests in volunteers., Psychol Med
Beurel et al., 2004, GSK-3beta inhibition by lithium confers resistance to chemotherapy-induced apoptosis through the repression of CD95 (Fas/APO-1) expression., Exp. Cell Res.
Celano et al., 2003, Selective regulation of presynaptic calcium/calmodulin-dependent protein kinase II by psychotropic drugs., Biol. Psychiatry
Chen et al., 2003, Regulation of c-Jun N-terminal kinase, p38 kinase and AP-1 DNA binding in cultured brain neurons: roles in glutamate excitotoxicity and lithium neuroprotection., J. Neurochem.
McCarthy MJ et al., 2011, Functional genetic variation in the Rev-Erbα pathway and lithium response in the treatment of bipolar disorder., Genes Brain Behav
Lin YF et al., 2013, Glycogen synthase kinase 3β gene polymorphisms may be associated with bipolar I disorder and the therapeutic response to lithium., J Affect Disord
O'Brien et al., 2009, Validating GSK3 as an in vivo target of lithium action., Biochem. Soc. Trans.
Borsotto et al., 2007, PP2A-Bgamma subunit and KCNQ2 K+ channels in bipolar disorder., Pharmacogenomics J.
Adli et al., 2007, Response to lithium augmentation in depression is associated with the glycogen synthase kinase 3-beta -50T/C single nucleotide polymorphism., Biol. Psychiatry
Michelon et al., 2006, Association study of the INPP1, 5HTT, BDNF, AP-2beta and GSK-3beta GENE variants and restrospectively scored response to lithium prophylaxis in bipolar disorder., Neurosci. Lett.
Campos-de-Sousa S et al., 2010, Nuclear receptor rev-erb-{alpha} circadian gene variants and lithium carbonate prophylaxis in bipolar affective disorder., J Biol Rhythms
Perroud N et al., 2011, Clinical and genetic correlates of suicidal ideation during antidepressant treatment in a depressed outpatient sample., Pharmacogenomics
Clement et al., 1994, Effects of haloperidol, quinelorane, and lithium on regional neurotensin/neuromedin N concentrations: further evidence for neurotensin/neuromedin N-dopamine interactions., Synapse
Gao et al., 1997, Characterization and cytokine-stimulating activities of acidic heteroglycans from Tremella fuciformis., Planta Med.
Rice et al., 2004, Analysis of the relationship between Scl transcription factor complex protein expression patterns and the effects of LiCl on ATRA-induced differentiation in blast cells from patients with acute myeloid leukemia., Leuk. Res.
Himmerich et al., 2005, Plasma levels of leptin and endogenous immune modulators during treatment with carbamazepine or lithium., Psychopharmacology (Berl.)
Türközkan et al., 1993, Biochemical investigation of leukocyte functions during lithium therapy., Int. J. Biochem.
Berrettini et al., 1987, CSF neuropeptides in euthymic bipolar patients and controls., Br J Psychiatry
Domínguez-Cáceres et al., 2004, Prolactin induces c-Myc expression and cell survival through activation of Src/Akt pathway in lymphoid cells., Oncogene
Karkanias et al., 1999, Lithium modulates desensitization of the glutamate receptor subtype gluR3 in Xenopus oocytes., Neurosci. Lett.
Dziedzicka-Wasylewska et al., 1996, The effect of prolonged administration of lithium on the level of dopamine D2 receptor mRNA in the rat striatum and nucleus accumbens., Acta Neurobiol Exp (Wars)
Kim et al., 2004, Lithium selectively increases neuronal differentiation of hippocampal neural progenitor cells both in vitro and in vivo., J. Neurochem.
Silberberg G et al., 2008, Stargazin involvement with bipolar disorder and response to lithium treatment., Pharmacogenet Genomics
Kirchheiner J et al., 2008, Genetic variants in FKBP5 affecting response to antidepressant drug treatment., Pharmacogenomics
Zou YF et al., 2010, Meta-analysis of FKBP5 gene polymorphisms association with treatment response in patients with mood disorders., Neurosci Lett
Sarginson JE et al., 2010, FKBP5 polymorphisms and antidepressant response in geriatric depression., Am J Med Genet B Neuropsychiatr Genet
Binder EB et al., 2004, Polymorphisms in FKBP5 are associated with increased recurrence of depressive episodes and rapid response to antidepressant treatment., Nat Genet
Niitsu T et al., 2013, Pharmacogenetics in major depression: a comprehensive meta-analysis., Prog Neuropsychopharmacol Biol Psychiatry
Papiol S et al., 2007, Genetic variability at HPA axis in major depression and clinical response to antidepressant treatment., J Affect Disord
Cryns et al., 2007, Lack of lithium-like behavioral and molecular effects in IMPA2 knockout mice., Neuropsychopharmacology
Ren et al., 2003, Postinsult treatment with lithium reduces brain damage and facilitates neurological recovery in a rat ischemia/reperfusion model., Proc. Natl. Acad. Sci. U.S.A.
Chuang, 2005, The antiapoptotic actions of mood stabilizers: molecular mechanisms and therapeutic potentials., Ann. N. Y. Acad. Sci.
Xu et al., 2006, Enhancement of neuroprotection and heat shock protein induction by combined prostaglandin A1 and lithium in rodent models of focal ischemia., Brain Res.

LITHIUM MYO1H

Interaction Score: 2.32

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
29121268

Sources:
PharmGKB
LITHIUM ZNF804A

Interaction Score: 2.32

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
29121268

Sources:
PharmGKB
LITHIUM LMO2

Interaction Score: 2.32

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
15380350

Sources:
NCI
LITHIUM GRAMD1B

Interaction Score: 2.32

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
29121268

Sources:
PharmGKB
LITHIUM FAM177A1

Interaction Score: 2.32

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
29121268

Sources:
PharmGKB
LITHIUM OR52J3

Interaction Score: 2.32

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
21961650

Sources:
PharmGKB
LITHIUM INPP1

Interaction Score: 2.32

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
16787706

Sources:
NCI
LITHIUM OR52J2P

Interaction Score: 2.32

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
21961650

Sources:
PharmGKB
LITHIUM FAM178B

Interaction Score: 2.32

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
29121268

Sources:
PharmGKB
LITHIUM OR52E2

Interaction Score: 2.32

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
21961650

Sources:
PharmGKB
LITHIUM IMPA1

Interaction Score: 1.62

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

PMIDs:
17158747 17068342 16874097 16965760 17251911 20027624

Sources:
DrugBank
LITHIUM IMPA2

Interaction Score: 1.55

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

PMIDs:
16841073 17068342 17251911

Sources:
DrugBank
LITHIUM CLOCK

Interaction Score: 1.16

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
21047205

Sources:
PharmGKB
LITHIUM CRY1

Interaction Score: 1.16

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
PharmGKB
LITHIUM FKBP5

Interaction Score: 0.77

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
18597649 21449676 20709156 19676097 15565110 23733030 17467808

Sources:
PharmGKB
LITHIUM NR1D1

Interaction Score: 0.58

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
20348464

Sources:
PharmGKB
LITHIUM ADCY1

Interaction Score: 0.46

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
29121268

Sources:
PharmGKB
LITHIUM ASIC2

Interaction Score: 0.46

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
21961650

Sources:
PharmGKB
LITHIUM CACNG2

Interaction Score: 0.43

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
18408563 21047205

Sources:
PharmGKB
LITHIUM CREB1

Interaction Score: 0.39

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
24885933

Sources:
PharmGKB
LITHIUM SST

Interaction Score: 0.33

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
2888503

Sources:
NCI
LITHIUM TNFRSF1B

Interaction Score: 0.33

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
15565432

Sources:
NCI
LITHIUM NTS

Interaction Score: 0.29

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
7992199

Sources:
NCI
LITHIUM RABEP1

Interaction Score: 0.26

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
28694205

Sources:
PharmGKB
LITHIUM SH2B1

Interaction Score: 0.26

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
28694205

Sources:
PharmGKB
LITHIUM GNRH1

Interaction Score: 0.21

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
2498919

Sources:
NCI
LITHIUM TPH1

Interaction Score: 0.18

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
21047205

Sources:
PharmGKB
LITHIUM GSK3B

Interaction Score: 0.16

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

PMIDs:
21781277 23021822 19754466 16733521 21047205 17628506 24885933

Sources:
PharmGKB DrugBank
LITHIUM THRA

Interaction Score: 0.15

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
20348464

Sources:
PharmGKB
LITHIUM EPHX2

Interaction Score: 0.15

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
29121268

Sources:
PharmGKB
LITHIUM HSPA4

Interaction Score: 0.14

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
12732732 16179524 16797496

Sources:
NCI
LITHIUM FAS

Interaction Score: 0.12

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
15475000

Sources:
NCI
LITHIUM NTRK2

Interaction Score: 0.12

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
16300803 21047205 24885933

Sources:
NCI PharmGKB
LITHIUM CAMK2G

Interaction Score: 0.11

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
12614997

Sources:
NCI
LITHIUM GFAP

Interaction Score: 0.09

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
15056276

Sources:
NCI
LITHIUM MPO

Interaction Score: 0.09

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
8224362

Sources:
NCI
LITHIUM GRIA3

Interaction Score: 0.08

Interaction Types & Directionality:

potentiator

Interaction Info:

PMIDs:
10626836

Sources:
DrugBank
LITHIUM BDNF

Interaction Score: 0.07

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
16300803 24885933

Sources:
NCI PharmGKB
LITHIUM MYC

Interaction Score: 0.06

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
15286700

Sources:
NCI
LITHIUM IL1B

Interaction Score: 0.05

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
9342951

Sources:
NCI
LITHIUM COMT

Interaction Score: 0.03

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
PharmGKB
LITHIUM HTR1B

Interaction Score: 0.03

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
21449676

Sources:
PharmGKB
LITHIUM MAPK14

Interaction Score: 0.02

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
12558976

Sources:
NCI
LITHIUM DRD1

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
21047205

Sources:
PharmGKB
LITHIUM SCN5A

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
PharmGKB
LITHIUM HTR2A

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
10758249

Sources:
NCI
LITHIUM DRD2

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
8787189

Sources:
NCI
LITHIUM ABCB1

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
21449676

Sources:
PharmGKB
LITHIUM NFE2L2

Interaction Score: 0.0

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
18619545

Sources:
NCI

DrugBank: DB14507

Version: 5.1.7

Alternate Names:

LITHIUM CITRATE DrugBank Drug Name

919-16-4 CAS Number

Lithium Drug Brand

Drug Info:

Drug Type small molecule

Drug Groups approved

Drug Categories acids, acyclic

Publications:

Cryns et al., 2007, Lack of lithium-like behavioral and molecular effects in IMPA2 knockout mice., Neuropsychopharmacology

Ohnishi et al., 2007, Spatial expression patterns and biochemical properties distinguish a second myo-inositol monophosphatase IMPA2 from IMPA1., J. Biol. Chem.

Ohnishi et al., 2007, A promoter haplotype of the inositol monophosphatase 2 gene (IMPA2) at 18p11.2 confers a possible risk for bipolar disorder by enhancing transcription., Neuropsychopharmacology

NCI: LITHIUM

Version: 14-September-2017

Alternate Names:

C1318 NCI drug code

Drug Info:

Publications:

Serretti et al., Serotonin receptor 2A, 2C, 1A genes and response to lithium prophylaxis in mood disorders., J Psychiatr Res

Celano et al., 2003, Selective regulation of presynaptic calcium/calmodulin-dependent protein kinase II by psychotropic drugs., Biol. Psychiatry

Clement et al., 1994, Effects of haloperidol, quinelorane, and lithium on regional neurotensin/neuromedin N concentrations: further evidence for neurotensin/neuromedin N-dopamine interactions., Synapse

PharmGKB: lithium

Version: 18-August-2020

Alternate Names:

Drug Info:

Publications:

Squassina A et al., 2011, Evidence for association of an ACCN1 gene variant with response to lithium treatment in Sardinian patients with bipolar disorder., Pharmacogenomics

McCarthy MJ et al., 2010, Pharmacogenetics of lithium response in bipolar disorder., Pharmacogenomics

Salloum NC et al., 2014, Towards the clinical implementation of pharmacogenetics in bipolar disorder., BMC Med

ChemblDrugs: chembl:CHEMBL2146126
- Version: ChEMBL_27
Alternate Names:

Drug Info:

Publications:

LITHIUM CITRATE	DrugBank Drug Name
919-16-4	CAS Number
Lithium	Drug Brand

Drug Type	small molecule
Drug Groups	approved
Drug Categories	acids, acyclic

LITHIUM Drug Record

LITHIUM chembl:CHEMBL2146126

Alternate Names:

Drug Info:

Publications:

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 29121268

Sources: PharmGKB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 29121268

Sources: PharmGKB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 15380350

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 29121268

Sources: PharmGKB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 29121268

Sources: PharmGKB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 21961650

Sources: PharmGKB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 16787706

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 21961650

Sources: PharmGKB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 29121268

Sources: PharmGKB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 21961650

Sources: PharmGKB

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info:

PMIDs: 17158747 17068342 16874097 16965760 17251911 20027624

Sources: DrugBank

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info:

PMIDs: 16841073 17068342 17251911

Sources: DrugBank

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 21047205

Sources: PharmGKB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: PharmGKB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 18597649 21449676 20709156 19676097 15565110 23733030 17467808

Sources: PharmGKB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 20348464

Sources: PharmGKB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 29121268

Sources: PharmGKB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 21961650

Sources: PharmGKB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 18408563 21047205

Interaction Types & Directionality:

n/a

PMIDs:
29121268

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
29121268

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
15380350

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
29121268

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
29121268

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
21961650

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
16787706

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
21961650

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
29121268

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
21961650

Sources:
PharmGKB

Interaction Types & Directionality:

inhibitor (inhibitory)

PMIDs:
17158747 17068342 16874097 16965760 17251911 20027624

Sources:
DrugBank

Interaction Types & Directionality:

inhibitor (inhibitory)

PMIDs:
16841073 17068342 17251911

Sources:
DrugBank

Interaction Types & Directionality:

n/a

PMIDs:
21047205

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
18597649 21449676 20709156 19676097 15565110 23733030 17467808

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
20348464

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
29121268

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
21961650

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
18408563 21047205

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
24885933

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
2888503

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
15565432

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
7992199

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
28694205

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
28694205

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
2498919

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
21047205