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LITHIUM Drug Record

  • Summary
  • Interactions
  • Claims
  • LITHIUM chembl:CHEMBL2146126

    Alternate Names:

    LITHIUM

    Drug Info:

    Drug Categories tricarboxylic acids
    Drug Categories metals, alkali
    Drug Categories metals
    Drug Categories lithium compounds
    Drug Categories antimanic agents
    Drug Categories drugs that are mainly renally excreted
    Drug Categories mood stabilizer
    Drug Categories nephrotoxic agents
    Drug Categories neurotoxic agents
    Drug Categories qtc prolonging agents
    Drug Categories serotonergic drugs shown to increase risk of serotonin syndrome
    Drug Categories serotonin agents
    (0 More Sources)

    Publications:

    Delacrétaz A et al., 2017, Association of variants in SH2B1 and RABEP1 with worsening of low-density lipoprotein and glucose parameters in patients treated with psychotropic drugs., Gene
    Rantamäki et al., 2006, The effects of acute and long-term lithium treatments on trkB neurotrophin receptor activation in the mouse hippocampus and anterior cingulate cortex., Neuropharmacology
    McCarthy MJ et al., 2010, Pharmacogenetics of lithium response in bipolar disorder., Pharmacogenomics
    Salloum NC et al., 2014, Towards the clinical implementation of pharmacogenetics in bipolar disorder., BMC Med
    Squassina A et al., 2011, Evidence for association of an ACCN1 gene variant with response to lithium treatment in Sardinian patients with bipolar disorder., Pharmacogenomics
    Serretti et al., Serotonin receptor 2A, 2C, 1A genes and response to lithium prophylaxis in mood disorders., J Psychiatr Res
    Rojo et al., 2008, Functional interference between glycogen synthase kinase-3 beta and the transcription factor Nrf2 in protection against kainate-induced hippocampal cell death., Mol. Cell. Neurosci.
    Tanizawa et al., 2006, Inositol monophosphatase regulates localization of synaptic components and behavior in the mature nervous system of C. elegans., Genes Dev.
    Ohnishi et al., 2007, Spatial expression patterns and biochemical properties distinguish a second myo-inositol monophosphatase IMPA2 from IMPA1., J. Biol. Chem.
    Sarkar et al., Inositol and IP3 levels regulate autophagy: biology and therapeutic speculations., Autophagy
    Trinquet et al., 2006, D-myo-inositol 1-phosphate as a surrogate of D-myo-inositol 1,4,5-tris phosphate to monitor G protein-coupled receptor activation., Anal. Biochem.
    Ohnishi et al., 2007, A promoter haplotype of the inositol monophosphatase 2 gene (IMPA2) at 18p11.2 confers a possible risk for bipolar disorder by enhancing transcription., Neuropsychopharmacology
    Li et al., 2010, Mobile loop mutations in an archaeal inositol monophosphatase: modulating three-metal ion assisted catalysis and lithium inhibition., Protein Sci.
    International Consortium on Lithium Genetics (ConLi+Gen). et al., 2018, Association of Polygenic Score for Schizophrenia and HLA Antigen and Inflammation Genes With Response to Lithium in Bipolar Affective Disorder: A Genome-Wide Association Study., JAMA Psychiatry
    Hunter et al., 1989, Luteinizing hormone responses to luteinizing hormone releasing hormone (LHRH) in acute mania and the effects of lithium on LHRH and thyrotrophin releasing hormone tests in volunteers., Psychol Med
    Beurel et al., 2004, GSK-3beta inhibition by lithium confers resistance to chemotherapy-induced apoptosis through the repression of CD95 (Fas/APO-1) expression., Exp. Cell Res.
    Celano et al., 2003, Selective regulation of presynaptic calcium/calmodulin-dependent protein kinase II by psychotropic drugs., Biol. Psychiatry
    Chen et al., 2003, Regulation of c-Jun N-terminal kinase, p38 kinase and AP-1 DNA binding in cultured brain neurons: roles in glutamate excitotoxicity and lithium neuroprotection., J. Neurochem.
    McCarthy MJ et al., 2011, Functional genetic variation in the Rev-Erbα pathway and lithium response in the treatment of bipolar disorder., Genes Brain Behav
    Lin YF et al., 2013, Glycogen synthase kinase 3β gene polymorphisms may be associated with bipolar I disorder and the therapeutic response to lithium., J Affect Disord
    O'Brien et al., 2009, Validating GSK3 as an in vivo target of lithium action., Biochem. Soc. Trans.
    Borsotto et al., 2007, PP2A-Bgamma subunit and KCNQ2 K+ channels in bipolar disorder., Pharmacogenomics J.
    Adli et al., 2007, Response to lithium augmentation in depression is associated with the glycogen synthase kinase 3-beta -50T/C single nucleotide polymorphism., Biol. Psychiatry
    Michelon et al., 2006, Association study of the INPP1, 5HTT, BDNF, AP-2beta and GSK-3beta GENE variants and restrospectively scored response to lithium prophylaxis in bipolar disorder., Neurosci. Lett.
    Campos-de-Sousa S et al., 2010, Nuclear receptor rev-erb-{alpha} circadian gene variants and lithium carbonate prophylaxis in bipolar affective disorder., J Biol Rhythms
    Perroud N et al., 2011, Clinical and genetic correlates of suicidal ideation during antidepressant treatment in a depressed outpatient sample., Pharmacogenomics
    Clement et al., 1994, Effects of haloperidol, quinelorane, and lithium on regional neurotensin/neuromedin N concentrations: further evidence for neurotensin/neuromedin N-dopamine interactions., Synapse
    Gao et al., 1997, Characterization and cytokine-stimulating activities of acidic heteroglycans from Tremella fuciformis., Planta Med.
    Rice et al., 2004, Analysis of the relationship between Scl transcription factor complex protein expression patterns and the effects of LiCl on ATRA-induced differentiation in blast cells from patients with acute myeloid leukemia., Leuk. Res.
    Himmerich et al., 2005, Plasma levels of leptin and endogenous immune modulators during treatment with carbamazepine or lithium., Psychopharmacology (Berl.)
    Türközkan et al., 1993, Biochemical investigation of leukocyte functions during lithium therapy., Int. J. Biochem.
    Berrettini et al., 1987, CSF neuropeptides in euthymic bipolar patients and controls., Br J Psychiatry
    Domínguez-Cáceres et al., 2004, Prolactin induces c-Myc expression and cell survival through activation of Src/Akt pathway in lymphoid cells., Oncogene
    Karkanias et al., 1999, Lithium modulates desensitization of the glutamate receptor subtype gluR3 in Xenopus oocytes., Neurosci. Lett.
    Dziedzicka-Wasylewska et al., 1996, The effect of prolonged administration of lithium on the level of dopamine D2 receptor mRNA in the rat striatum and nucleus accumbens., Acta Neurobiol Exp (Wars)
    Kim et al., 2004, Lithium selectively increases neuronal differentiation of hippocampal neural progenitor cells both in vitro and in vivo., J. Neurochem.
    Silberberg G et al., 2008, Stargazin involvement with bipolar disorder and response to lithium treatment., Pharmacogenet Genomics
    Kirchheiner J et al., 2008, Genetic variants in FKBP5 affecting response to antidepressant drug treatment., Pharmacogenomics
    Zou YF et al., 2010, Meta-analysis of FKBP5 gene polymorphisms association with treatment response in patients with mood disorders., Neurosci Lett
    Sarginson JE et al., 2010, FKBP5 polymorphisms and antidepressant response in geriatric depression., Am J Med Genet B Neuropsychiatr Genet
    Binder EB et al., 2004, Polymorphisms in FKBP5 are associated with increased recurrence of depressive episodes and rapid response to antidepressant treatment., Nat Genet
    Niitsu T et al., 2013, Pharmacogenetics in major depression: a comprehensive meta-analysis., Prog Neuropsychopharmacol Biol Psychiatry
    Papiol S et al., 2007, Genetic variability at HPA axis in major depression and clinical response to antidepressant treatment., J Affect Disord
    Cryns et al., 2007, Lack of lithium-like behavioral and molecular effects in IMPA2 knockout mice., Neuropsychopharmacology
    Ren et al., 2003, Postinsult treatment with lithium reduces brain damage and facilitates neurological recovery in a rat ischemia/reperfusion model., Proc. Natl. Acad. Sci. U.S.A.
    Chuang, 2005, The antiapoptotic actions of mood stabilizers: molecular mechanisms and therapeutic potentials., Ann. N. Y. Acad. Sci.
    Xu et al., 2006, Enhancement of neuroprotection and heat shock protein induction by combined prostaglandin A1 and lithium in rodent models of focal ischemia., Brain Res.
  • LITHIUM   MYO1H

    Interaction Score: 2.32

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    29121268


    Sources:
    PharmGKB

  • LITHIUM   ZNF804A

    Interaction Score: 2.32

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    29121268


    Sources:
    PharmGKB

  • LITHIUM   LMO2

    Interaction Score: 2.32

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    15380350


    Sources:
    NCI

  • LITHIUM   GRAMD1B

    Interaction Score: 2.32

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    29121268


    Sources:
    PharmGKB

  • LITHIUM   FAM177A1

    Interaction Score: 2.32

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    29121268


    Sources:
    PharmGKB

  • LITHIUM   OR52J3

    Interaction Score: 2.32

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    21961650


    Sources:
    PharmGKB

  • LITHIUM   INPP1

    Interaction Score: 2.32

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    16787706


    Sources:
    NCI

  • LITHIUM   OR52J2P

    Interaction Score: 2.32

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    21961650


    Sources:
    PharmGKB

  • LITHIUM   FAM178B

    Interaction Score: 2.32

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    29121268


    Sources:
    PharmGKB

  • LITHIUM   OR52E2

    Interaction Score: 2.32

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    21961650


    Sources:
    PharmGKB

  • LITHIUM   IMPA1

    Interaction Score: 1.62

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:

    PMIDs:
    17158747 17068342 16874097 16965760 17251911 20027624


    Sources:
    DrugBank

  • LITHIUM   IMPA2

    Interaction Score: 1.55

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:

    PMIDs:
    16841073 17068342 17251911


    Sources:
    DrugBank

  • LITHIUM   CLOCK

    Interaction Score: 1.16

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    21047205


    Sources:
    PharmGKB

  • LITHIUM   CRY1

    Interaction Score: 1.16

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    PharmGKB

  • LITHIUM   FKBP5

    Interaction Score: 0.77

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    18597649 21449676 20709156 19676097 15565110 23733030 17467808


    Sources:
    PharmGKB

  • LITHIUM   NR1D1

    Interaction Score: 0.58

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    20348464


    Sources:
    PharmGKB

  • LITHIUM   ADCY1

    Interaction Score: 0.46

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    29121268


    Sources:
    PharmGKB

  • LITHIUM   ASIC2

    Interaction Score: 0.46

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    21961650


    Sources:
    PharmGKB

  • LITHIUM   CACNG2

    Interaction Score: 0.43

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    18408563 21047205


    Sources:
    PharmGKB

  • LITHIUM   CREB1

    Interaction Score: 0.39

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    24885933


    Sources:
    PharmGKB

  • LITHIUM   SST

    Interaction Score: 0.33

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    2888503


    Sources:
    NCI

  • LITHIUM   TNFRSF1B

    Interaction Score: 0.33

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    15565432


    Sources:
    NCI

  • LITHIUM   NTS

    Interaction Score: 0.29

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    7992199


    Sources:
    NCI

  • LITHIUM   RABEP1

    Interaction Score: 0.26

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    28694205


    Sources:
    PharmGKB

  • LITHIUM   SH2B1

    Interaction Score: 0.26

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    28694205


    Sources:
    PharmGKB

  • LITHIUM   GNRH1

    Interaction Score: 0.21

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    2498919


    Sources:
    NCI

  • LITHIUM   TPH1

    Interaction Score: 0.18

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    21047205


    Sources:
    PharmGKB

  • LITHIUM   GSK3B

    Interaction Score: 0.16

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:

    PMIDs:
    21781277 23021822 19754466 16733521 21047205 17628506 24885933


    Sources:
    PharmGKB DrugBank

  • LITHIUM   THRA

    Interaction Score: 0.15

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    20348464


    Sources:
    PharmGKB

  • LITHIUM   EPHX2

    Interaction Score: 0.15

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    29121268


    Sources:
    PharmGKB

  • LITHIUM   HSPA4

    Interaction Score: 0.14

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    12732732 16179524 16797496


    Sources:
    NCI

  • LITHIUM   FAS

    Interaction Score: 0.12

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    15475000


    Sources:
    NCI

  • LITHIUM   NTRK2

    Interaction Score: 0.12

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    16300803 21047205 24885933


    Sources:
    NCI PharmGKB

  • LITHIUM   CAMK2G

    Interaction Score: 0.11

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    12614997


    Sources:
    NCI

  • LITHIUM   GFAP

    Interaction Score: 0.09

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    15056276


    Sources:
    NCI

  • LITHIUM   MPO

    Interaction Score: 0.09

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    8224362


    Sources:
    NCI

  • LITHIUM   GRIA3

    Interaction Score: 0.08

    Interaction Types & Directionality:
    potentiator

    Interaction Info:

    PMIDs:
    10626836


    Sources:
    DrugBank

  • LITHIUM   BDNF

    Interaction Score: 0.07

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    16300803 24885933


    Sources:
    NCI PharmGKB

  • LITHIUM   MYC

    Interaction Score: 0.06

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    15286700


    Sources:
    NCI

  • LITHIUM   IL1B

    Interaction Score: 0.05

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    9342951


    Sources:
    NCI

  • LITHIUM   COMT

    Interaction Score: 0.03

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    PharmGKB

  • LITHIUM   HTR1B

    Interaction Score: 0.03

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    21449676


    Sources:
    PharmGKB

  • LITHIUM   MAPK14

    Interaction Score: 0.02

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    12558976


    Sources:
    NCI

  • LITHIUM   DRD1

    Interaction Score: 0.01

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    21047205


    Sources:
    PharmGKB

  • LITHIUM   SCN5A

    Interaction Score: 0.01

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    PharmGKB

  • LITHIUM   HTR2A

    Interaction Score: 0.01

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    10758249


    Sources:
    NCI

  • LITHIUM   DRD2

    Interaction Score: 0.01

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    8787189


    Sources:
    NCI

  • LITHIUM   ABCB1

    Interaction Score: 0.01

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    21449676


    Sources:
    PharmGKB

  • LITHIUM   NFE2L2

    Interaction Score: 0.0

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    18619545


    Sources:
    NCI

  • DrugBank: DB14507

    • Version: 5.1.7

    Alternate Names:
    LITHIUM CITRATE DrugBank Drug Name
    919-16-4 CAS Number
    Lithium Drug Brand

    Drug Info:
    Drug Type small molecule
    Drug Groups approved
    Drug Categories acids, acyclic

    Publications:
    Cryns et al., 2007, Lack of lithium-like behavioral and molecular effects in IMPA2 knockout mice., Neuropsychopharmacology
    Ohnishi et al., 2007, Spatial expression patterns and biochemical properties distinguish a second myo-inositol monophosphatase IMPA2 from IMPA1., J. Biol. Chem.
    Ohnishi et al., 2007, A promoter haplotype of the inositol monophosphatase 2 gene (IMPA2) at 18p11.2 confers a possible risk for bipolar disorder by enhancing transcription., Neuropsychopharmacology

  • NCI: LITHIUM

    • Version: 14-September-2017

    Alternate Names:
    C1318 NCI drug code

    Drug Info:

    Publications:
    Serretti et al., Serotonin receptor 2A, 2C, 1A genes and response to lithium prophylaxis in mood disorders., J Psychiatr Res
    Celano et al., 2003, Selective regulation of presynaptic calcium/calmodulin-dependent protein kinase II by psychotropic drugs., Biol. Psychiatry
    Clement et al., 1994, Effects of haloperidol, quinelorane, and lithium on regional neurotensin/neuromedin N concentrations: further evidence for neurotensin/neuromedin N-dopamine interactions., Synapse

  • PharmGKB: lithium

    • Version: 18-August-2020

    Alternate Names:

    Drug Info:

    Publications:
    Squassina A et al., 2011, Evidence for association of an ACCN1 gene variant with response to lithium treatment in Sardinian patients with bipolar disorder., Pharmacogenomics
    McCarthy MJ et al., 2010, Pharmacogenetics of lithium response in bipolar disorder., Pharmacogenomics
    Salloum NC et al., 2014, Towards the clinical implementation of pharmacogenetics in bipolar disorder., BMC Med

  • ChemblDrugs: chembl:CHEMBL2146126

    • Version: ChEMBL_27

    Alternate Names:

    Drug Info:

    Publications:

Disclaimer: This resource is intended for purely research purposes. It should not be used for emergencies or medical or professional advice.

A finding of a drug-gene interaction or potentially druggable category does not necessarily indicate effectiveness (or lack thereof) of any drug or treatment regimen. A finding of no interaction or no potentially druggable category does not necessarily indicate lack of effectiveness of any drug or treatment regimen. Drug-gene interactions or potentially druggable categories are not presented in ranked order of potential or predicted efficacy.

The dgidb.org website does not provide any medical or healthcare products, services or advice, and is not for medical emergencies or urgent situations. IF YOU THINK YOU MAY HAVE A MEDICAL EMERGENCY, CALL YOUR DOCTOR OR 911 IMMEDIATELY. Information contained on this website is not a substitute for a doctor's medical judgment or advice. We recommend that you discuss your specific, individual health concerns with your doctor or health care professional.

DGIdb (v4.2.0 - sha1 afd9f30b) • Last updated 2020-10-21