DGIdb - LISURIDE Drug Record

LISURIDE chembl:CHEMBL157138 Approved

Alternate Names:

LISURIDE MALEATE
LISURIDE
LYSURIDE
REVANIL 200
(+)-LISURIDE
N'-((8ALPHA)-9,10-DIDEHYDRO-6-METHYLERGOLIN-8-YL)-N,N-DIETHYLUREA
DOPERGIN®
LISURIDA
LISURID
LISURIDUM
rxcui:6446
pubchem.compound:28864
chemidplus:18016-80-3
chembl:CHEMBL157138
drugbank:00589

Drug Info:

FDA Approval	not approved by the FDA
Drug Class	small molecule
Drug Indications	Antiparkinson Agents
Drug Class	antiparkinson agents
Year of Approval	not approved by the fda

(1 More Sources)

Publications:

Kvernmo et al., 2008, Receptor-binding and pharmacokinetic properties of dopaminergic agonists., Curr Top Med Chem
Imming et al., 2006, Drugs, their targets and the nature and number of drug targets., Nat Rev Drug Discov
Overington et al., 2006, How many drug targets are there?, Nat Rev Drug Discov
Chen et al., 2002, TTD: Therapeutic Target Database., Nucleic Acids Res.
Egan et al., 1998, Agonist activity of LSD and lisuride at cloned 5HT2A and 5HT2C receptors., Psychopharmacology (Berl.)
Akai et al., 1991, [Anxiolytic effects of lisuride and its agonistic action to central 5-HT1A receptors]., Nippon Yakurigaku Zasshi
Cunningham et al., 1987, Discriminative stimulus properties of 8-hydroxy-2-(di-n-propylamino)tetralin (8-OHDPAT): implications for understanding the actions of novel anxiolytics., Eur. J. Pharmacol.
Kimura et al., 1991, Dual activation by lisuride of central serotonin 5-HT(1A) and dopamine D(2) receptor sites: drug discrimination and receptor binding studies., Behav Pharmacol
Marona-Lewicka et al., 2002, Re-evaluation of lisuride pharmacology: 5-hydroxytryptamine1A receptor-mediated behavioral effects overlap its other properties in rats., Psychopharmacology (Berl.)
Miyazawa et al., 1991, [Effect of lisuride on experimental cerebral infarction in rats]., Nippon Yakurigaku Zasshi

LISURIDE HTR1A

Interaction Score: 0.34

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Specific Action of the Ligand Full agonist

Endogenous Drug? False

Trial Name -

PMIDs:
1678728 2887435 11224054 12373423 18691132 1783326

Sources:
TdgClinicalTrial TEND GuideToPharmacology
LISURIDE DRD5

Interaction Score: 0.25

Interaction Types & Directionality:

agonist (activating)

antagonist (inhibitory)

Interaction Info:

Endogenous Drug? False

Specific Action of the Ligand Partial agonist

PMIDs:
18691132

Sources:
GuideToPharmacology
LISURIDE DRD1

Interaction Score: 0.15

Interaction Types & Directionality:

agonist (activating)

antagonist (inhibitory)

Interaction Info:

Trial Name -

Novel drug target Established target

Specific Action of the Ligand Partial agonist

PMIDs:
18691132 17016423 17139284

Sources:
TdgClinicalTrial TEND GuideToPharmacology
LISURIDE DRD2

Interaction Score: 0.14

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Endogenous Drug? False

Specific Action of the Ligand Partial agonist

Trial Name -

PMIDs:
18691132 11752352

Sources:
TdgClinicalTrial TEND GuideToPharmacology TTD
LISURIDE HTR1D

Interaction Score: 0.13

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Endogenous Drug? False

Specific Action of the Ligand Partial agonist

PMIDs:
18691132

Sources:
GuideToPharmacology
LISURIDE DRD4

Interaction Score: 0.12

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Specific Action of the Ligand Partial agonist

Endogenous Drug? False

PMIDs:
18691132

Sources:
GuideToPharmacology
LISURIDE HTR2C

Interaction Score: 0.12

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Endogenous Drug? False

Specific Action of the Ligand Partial agonist

PMIDs:
9600588 18691132

Sources:
GuideToPharmacology
LISURIDE HTR1B

Interaction Score: 0.12

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Specific Action of the Ligand Partial agonist

Endogenous Drug? False

PMIDs:
18691132

Sources:
GuideToPharmacology
LISURIDE HTR2B

Interaction Score: 0.12

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Endogenous Drug? False

Specific Action of the Ligand Antagonist

PMIDs:
18691132

Sources:
GuideToPharmacology
LISURIDE ADRA2B

Interaction Score: 0.11

Interaction Types & Directionality:

other/unknown

antagonist (inhibitory)

Interaction Info:

Specific Action of the Ligand Antagonist

Endogenous Drug? False

PMIDs:
18691132

Sources:
GuideToPharmacology
LISURIDE ADRA2C

Interaction Score: 0.1

Interaction Types & Directionality:

other/unknown

antagonist (inhibitory)

Interaction Info:

Specific Action of the Ligand Antagonist

Endogenous Drug? False

PMIDs:
18691132

Sources:
GuideToPharmacology
LISURIDE HTR6

Interaction Score: 0.09

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Specific Action of the Ligand Partial agonist

Endogenous Drug? False

PMIDs:
None found

Sources:
GuideToPharmacology
LISURIDE ADRA2A

Interaction Score: 0.09

Interaction Types & Directionality:

other/unknown

antagonist (inhibitory)

Interaction Info:

Specific Action of the Ligand Antagonist

Endogenous Drug? False

PMIDs:
18691132

Sources:
GuideToPharmacology
LISURIDE DRD3

Interaction Score: 0.09

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Specific Action of the Ligand Partial agonist

Endogenous Drug? False

PMIDs:
18691132

Sources:
GuideToPharmacology
LISURIDE HTR2A

Interaction Score: 0.08

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Specific Action of the Ligand Partial agonist

Endogenous Drug? False

PMIDs:
9600588 18691132

Sources:
GuideToPharmacology
LISURIDE ADRA1A

Interaction Score: 0.04

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Specific Action of the Ligand Antagonist

Endogenous Drug? False

PMIDs:
None found

Sources:
GuideToPharmacology

TEND: LISURIDE
- Version: 01-August-2011
Alternate Names:

LISURIDE Primary Drug Name

Drug Info:

Year of Approval not approved by the fda

Drug Class antiparkinson agents

Publications:
TdgClinicalTrial: LISURIDE
- Version: January-2014
Alternate Names:

Drug Info:

Drug Indications Antiparkinson Agents

Drug Class small molecule

FDA Approval not approved by the FDA

Publications:
TTD: Lisuride
- Version: 2020.06.01
Alternate Names:

D0X7KB TTD Drug ID

Drug Info:

Publications:
GuideToPharmacology: 135650525
- Version: 29-September-2020
Alternate Names:

LISURIDE GuideToPharmacology Ligand Name

Drug Info:

Publications:
ChemblDrugs: chembl:CHEMBL157138
- Version: ChEMBL_27
Alternate Names:

Drug Info:

Publications:

Specific Action of the Ligand	Full agonist
Endogenous Drug?	False
Trial Name	-

Trial Name	-
Novel drug target	Established target
Specific Action of the Ligand	Partial agonist

Specific Action of the Ligand	Antagonist
Endogenous Drug?	False

agonist (activating)
antagonist (inhibitory)

agonist (activating)
antagonist (inhibitory)

other/unknown
antagonist (inhibitory)

other/unknown
antagonist (inhibitory)

LISURIDE Drug Record

LISURIDE chembl:CHEMBL157138 Approved

Alternate Names:

Drug Info:

Publications:

Interaction Types & Directionality: agonist (activating)

Interaction Info: Specific Action of the Ligand Full agonist Endogenous Drug? False Trial Name -

PMIDs: 1678728 2887435 11224054 12373423 18691132 1783326

Sources: TdgClinicalTrial TEND GuideToPharmacology

Interaction Types & Directionality: agonist (activating) antagonist (inhibitory)

Interaction Info: Endogenous Drug? False Specific Action of the Ligand Partial agonist

PMIDs: 18691132

Sources: GuideToPharmacology

Interaction Types & Directionality: agonist (activating) antagonist (inhibitory)

Interaction Info: Trial Name - Novel drug target Established target Specific Action of the Ligand Partial agonist

PMIDs: 18691132 17016423 17139284

Sources: TdgClinicalTrial TEND GuideToPharmacology

Interaction Types & Directionality: agonist (activating)

Interaction Info: Endogenous Drug? False Specific Action of the Ligand Partial agonist Trial Name -

PMIDs: 18691132 11752352

Sources: TdgClinicalTrial TEND GuideToPharmacology TTD

Interaction Types & Directionality: agonist (activating)

Interaction Info: Endogenous Drug? False Specific Action of the Ligand Partial agonist

PMIDs: 18691132

Sources: GuideToPharmacology

Interaction Types & Directionality: agonist (activating)

Interaction Info: Specific Action of the Ligand Partial agonist Endogenous Drug? False

PMIDs: 18691132

Sources: GuideToPharmacology

Interaction Types & Directionality: agonist (activating)

Interaction Info: Endogenous Drug? False Specific Action of the Ligand Partial agonist

PMIDs: 9600588 18691132

Sources: GuideToPharmacology

Interaction Types & Directionality: agonist (activating)

Interaction Info: Specific Action of the Ligand Partial agonist Endogenous Drug? False

PMIDs: 18691132

Sources: GuideToPharmacology

Interaction Types & Directionality: antagonist (inhibitory)

Interaction Info: Endogenous Drug? False Specific Action of the Ligand Antagonist

PMIDs: 18691132

Sources: GuideToPharmacology

Interaction Types & Directionality: other/unknown antagonist (inhibitory)

Interaction Info: Specific Action of the Ligand Antagonist Endogenous Drug? False

PMIDs: 18691132

Sources: GuideToPharmacology

Interaction Types & Directionality: other/unknown antagonist (inhibitory)

Interaction Info: Specific Action of the Ligand Antagonist Endogenous Drug? False

PMIDs: 18691132

Sources: GuideToPharmacology

Interaction Types & Directionality: agonist (activating)

Interaction Info: Specific Action of the Ligand Partial agonist Endogenous Drug? False

PMIDs: None found

Sources: GuideToPharmacology

Interaction Types & Directionality: other/unknown antagonist (inhibitory)

Interaction Info: Specific Action of the Ligand Antagonist Endogenous Drug? False

PMIDs: 18691132

Sources: GuideToPharmacology

Interaction Types & Directionality: agonist (activating)

Interaction Info: Specific Action of the Ligand Partial agonist Endogenous Drug? False

PMIDs: 18691132

Sources: GuideToPharmacology

Interaction Types & Directionality: agonist (activating)

Interaction Info: Specific Action of the Ligand Partial agonist Endogenous Drug? False

PMIDs: 9600588 18691132

Sources: GuideToPharmacology

Interaction Types & Directionality: antagonist (inhibitory)

Interaction Info: Specific Action of the Ligand Antagonist Endogenous Drug? False

PMIDs: None found

Sources: GuideToPharmacology

TEND: LISURIDE

Alternate Names: LISURIDE Primary Drug Name

Drug Info: Year of Approval not approved by the fda Drug Class antiparkinson agents

Publications:

TdgClinicalTrial: LISURIDE

Alternate Names:

Drug Info: Drug Indications Antiparkinson Agents Drug Class small molecule FDA Approval not approved by the FDA

Publications:

TTD: Lisuride

Alternate Names: D0X7KB TTD Drug ID

Drug Info:

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Specific Action of the Ligand Full agonist

Endogenous Drug? False

Trial Name -

PMIDs:
1678728 2887435 11224054 12373423 18691132 1783326

Sources:
TdgClinicalTrial TEND GuideToPharmacology

Interaction Types & Directionality:

agonist (activating)

antagonist (inhibitory)

Interaction Info:

Endogenous Drug? False

Specific Action of the Ligand Partial agonist

PMIDs:
18691132

Sources:
GuideToPharmacology

Interaction Types & Directionality:

agonist (activating)

antagonist (inhibitory)

Interaction Info:

Trial Name -

Novel drug target Established target

Specific Action of the Ligand Partial agonist

PMIDs:
18691132 17016423 17139284

Sources:
TdgClinicalTrial TEND GuideToPharmacology

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Endogenous Drug? False

Specific Action of the Ligand Partial agonist

Trial Name -

PMIDs:
18691132 11752352

Sources:
TdgClinicalTrial TEND GuideToPharmacology TTD

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Endogenous Drug? False

Specific Action of the Ligand Partial agonist

PMIDs:
18691132

Sources:
GuideToPharmacology

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Specific Action of the Ligand Partial agonist

Endogenous Drug? False

PMIDs:
18691132

Sources:
GuideToPharmacology

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Endogenous Drug? False

Specific Action of the Ligand Partial agonist

PMIDs:
9600588 18691132

Sources:
GuideToPharmacology

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Specific Action of the Ligand Partial agonist

Endogenous Drug? False

PMIDs:
18691132

Sources:
GuideToPharmacology

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Endogenous Drug? False

Specific Action of the Ligand Antagonist

PMIDs:
18691132

Sources:
GuideToPharmacology

Interaction Types & Directionality:

other/unknown

antagonist (inhibitory)

Interaction Info:

Specific Action of the Ligand Antagonist

Endogenous Drug? False

PMIDs:
18691132

Sources:
GuideToPharmacology

Interaction Types & Directionality:

other/unknown

antagonist (inhibitory)

Interaction Info:

Specific Action of the Ligand Antagonist

Endogenous Drug? False

PMIDs:
18691132

Sources:
GuideToPharmacology

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Specific Action of the Ligand Partial agonist

Endogenous Drug? False

PMIDs:
None found

Sources:
GuideToPharmacology

Interaction Types & Directionality:

other/unknown

antagonist (inhibitory)

Interaction Info:

Specific Action of the Ligand Antagonist

Endogenous Drug? False

PMIDs:
18691132

Sources:
GuideToPharmacology

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Specific Action of the Ligand Partial agonist

Endogenous Drug? False

PMIDs:
18691132

Sources:
GuideToPharmacology

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Specific Action of the Ligand Partial agonist

Endogenous Drug? False

PMIDs:
9600588 18691132

Sources:
GuideToPharmacology

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Specific Action of the Ligand Antagonist

Endogenous Drug? False

PMIDs:
None found

Sources:
GuideToPharmacology

Alternate Names:

LISURIDE Primary Drug Name

Drug Info:

Year of Approval not approved by the fda

Drug Class antiparkinson agents

Drug Info:

Drug Indications Antiparkinson Agents

Drug Class small molecule

FDA Approval not approved by the FDA

Alternate Names:

D0X7KB TTD Drug ID

Alternate Names:

LISURIDE GuideToPharmacology Ligand Name