DGIdb - LISURIDE Drug Record

LISURIDE chembl:CHEMBL157138 Approved

Alternate Names:

LISURIDE MALEATE
LISURIDE
LYSURIDE
REVANIL 200
(+)-LISURIDE
N'-((8ALPHA)-9,10-DIDEHYDRO-6-METHYLERGOLIN-8-YL)-N,N-DIETHYLUREA
DOPERGIN®
LISURIDA
LISURID
LISURIDUM
rxcui:6446
pubchem.compound:28864
chemidplus:18016-80-3
chembl:CHEMBL157138
drugbank:00589

Drug Info:

FDA Approval	not approved by the FDA
Drug Class	small molecule
Drug Indications	Antiparkinson Agents
Drug Class	antiparkinson agents
Year of Approval	not approved by the fda

(0 More Sources)

Publications:

Kvernmo et al., 2008, Receptor-binding and pharmacokinetic properties of dopaminergic agonists., Curr Top Med Chem
Imming et al., 2006, Drugs, their targets and the nature and number of drug targets., Nat Rev Drug Discov
Overington et al., 2006, How many drug targets are there?, Nat Rev Drug Discov
Chen et al., 2002, TTD: Therapeutic Target Database., Nucleic Acids Res.
Akai et al., 1991, [Anxiolytic effects of lisuride and its agonistic action to central 5-HT1A receptors]., Nippon Yakurigaku Zasshi
Cunningham et al., 1987, Discriminative stimulus properties of 8-hydroxy-2-(di-n-propylamino)tetralin (8-OHDPAT): implications for understanding the actions of novel anxiolytics., Eur. J. Pharmacol.
Kimura et al., 1991, Dual activation by lisuride of central serotonin 5-HT(1A) and dopamine D(2) receptor sites: drug discrimination and receptor binding studies., Behav Pharmacol
Marona-Lewicka et al., 2002, Re-evaluation of lisuride pharmacology: 5-hydroxytryptamine1A receptor-mediated behavioral effects overlap its other properties in rats., Psychopharmacology (Berl.)
Miyazawa et al., 1991, [Effect of lisuride on experimental cerebral infarction in rats]., Nippon Yakurigaku Zasshi

LISURIDE HTR1A

Interaction Score: 2.94

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
1678728 2887435 11224054 12373423 18691132 1783326

Sources:
TdgClinicalTrial TEND
LISURIDE DRD1

Interaction Score: 0.66

Interaction Types & Directionality:

agonist (activating)

antagonist (inhibitory)

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
18691132 17016423 17139284

Sources:
TdgClinicalTrial TEND
LISURIDE DRD2

Interaction Score: 0.62

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
18691132 11752352

Sources:
TdgClinicalTrial TEND TTD

TEND: LISURIDE
- Version: 01-August-2011
Alternate Names:

LISURIDE Primary Drug Name

Drug Info:

Year of Approval not approved by the fda

Drug Class antiparkinson agents

Publications:
TdgClinicalTrial: LISURIDE
- Version: January-2014
Alternate Names:

Drug Info:

Drug Indications Antiparkinson Agents

Drug Class small molecule

FDA Approval not approved by the FDA

Publications:
TTD: Lisuride
- Version: 2020.06.01
Alternate Names:

D0X7KB TTD Drug ID

Drug Info:

Publications:
ChemblDrugs: chembl:CHEMBL157138
- Version: ChEMBL_27
Alternate Names:

Drug Info:

Publications:

Trial Name	-
Novel drug target	Established target

agonist (activating)
antagonist (inhibitory)

Trial Name	-
Novel drug target	Established target

Trial Name	-
Novel drug target	Established target

LISURIDE Drug Record

LISURIDE chembl:CHEMBL157138 Approved

Alternate Names:

Drug Info:

Publications:

LISURIDE HTR1A

Interaction Types & Directionality: agonist (activating)

Interaction Info: Trial Name - Novel drug target Established target

PMIDs: 1678728 2887435 11224054 12373423 18691132 1783326

Sources: TdgClinicalTrial TEND

LISURIDE DRD1

Interaction Types & Directionality: agonist (activating) antagonist (inhibitory)

Interaction Info: Trial Name - Novel drug target Established target

PMIDs: 18691132 17016423 17139284

Sources: TdgClinicalTrial TEND

LISURIDE DRD2

Interaction Types & Directionality: agonist (activating)

Interaction Info: Trial Name - Novel drug target Established target

PMIDs: 18691132 11752352

Sources: TdgClinicalTrial TEND TTD

TEND: LISURIDE

Alternate Names: LISURIDE Primary Drug Name

Drug Info: Year of Approval not approved by the fda Drug Class antiparkinson agents

Publications:

TdgClinicalTrial: LISURIDE

Alternate Names:

Drug Info: Drug Indications Antiparkinson Agents Drug Class small molecule FDA Approval not approved by the FDA

Publications:

TTD: Lisuride

Alternate Names: D0X7KB TTD Drug ID

Drug Info:

Publications:

ChemblDrugs: chembl:CHEMBL157138

Alternate Names:

Drug Info:

Publications:

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
1678728 2887435 11224054 12373423 18691132 1783326

Sources:
TdgClinicalTrial TEND

Interaction Types & Directionality:

agonist (activating)

antagonist (inhibitory)

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
18691132 17016423 17139284

Sources:
TdgClinicalTrial TEND

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
18691132 11752352

Sources:
TdgClinicalTrial TEND TTD

Alternate Names:

LISURIDE Primary Drug Name

Drug Info:

Year of Approval not approved by the fda

Drug Class antiparkinson agents

Drug Info:

Drug Indications Antiparkinson Agents

Drug Class small molecule

FDA Approval not approved by the FDA

Alternate Names:

D0X7KB TTD Drug ID