DGIdb - LISURIDE Drug Record

LISURIDE chembl:CHEMBL157138 Approved

Alternate Names:

LISURIDE MALEATE
LISURIDE
LYSURIDE
REVANIL 200
(+)-LISURIDE
N'-((8ALPHA)-9,10-DIDEHYDRO-6-METHYLERGOLIN-8-YL)-N,N-DIETHYLUREA
DOPERGIN®
LISURIDA
LISURID
LISURIDUM
rxcui:6446
pubchem.compound:28864
chemidplus:18016-80-3
chembl:CHEMBL157138
drugbank:00589

Drug Info:

FDA Approval	not approved by the FDA
Drug Class	small molecule
Drug Indications	Antiparkinson Agents
Drug Class	antiparkinson agents
Year of Approval	not approved by the fda
Drug Groups	investigational
Drug Categories	agents that produce hypertension
Drug Categories	antidepressive agents
Drug Categories	central nervous system depressants
Drug Categories	cytochrome p-450 cyp3a substrates
Drug Categories	cytochrome p-450 substrates
Drug Categories	dopamine antagonists
Drug Categories	ergot alkaloids and derivatives
Drug Categories	ergot-derivative dopamine receptor agonists
Drug Categories	genito urinary system and sex hormones
Drug Categories	heterocyclic compounds, fused-ring
Drug Categories	prolactine inhibitors
Drug Categories	serotonergic drugs shown to increase risk of serotonin syndrome
Drug Categories	serotonin 5-ht2 receptor antagonists
Drug Categories	serotonin receptor antagonists

(2 More Sources)

Publications:

Kvernmo et al., 2008, Receptor-binding and pharmacokinetic properties of dopaminergic agonists., Curr Top Med Chem
Imming et al., 2006, Drugs, their targets and the nature and number of drug targets., Nat Rev Drug Discov
Overington et al., 2006, How many drug targets are there?, Nat Rev Drug Discov
Chen et al., 2002, TTD: Therapeutic Target Database., Nucleic Acids Res.
Egan et al., 1998, Agonist activity of LSD and lisuride at cloned 5HT2A and 5HT2C receptors., Psychopharmacology (Berl.)
Akai et al., 1991, [Anxiolytic effects of lisuride and its agonistic action to central 5-HT1A receptors]., Nippon Yakurigaku Zasshi
Cunningham et al., 1987, Discriminative stimulus properties of 8-hydroxy-2-(di-n-propylamino)tetralin (8-OHDPAT): implications for understanding the actions of novel anxiolytics., Eur. J. Pharmacol.
Kimura et al., 1991, Dual activation by lisuride of central serotonin 5-HT(1A) and dopamine D(2) receptor sites: drug discrimination and receptor binding studies., Behav Pharmacol
Marona-Lewicka et al., 2002, Re-evaluation of lisuride pharmacology: 5-hydroxytryptamine1A receptor-mediated behavioral effects overlap its other properties in rats., Psychopharmacology (Berl.)
Miyazawa et al., 1991, [Effect of lisuride on experimental cerebral infarction in rats]., Nippon Yakurigaku Zasshi
Toohey N et al., 2009, Human 5-HT7 receptor-induced inactivation of forskolin-stimulated adenylate cyclase by risperidone, 9-OH-risperidone and other "inactivating antagonists"., Mol Pharmacol
Knight et al., 2009, Pharmacological analysis of the novel, rapid, and potent inactivation of the human 5-Hydroxytryptamine7 receptor by risperidone, 9-OH-Risperidone, and other inactivating antagonists., Mol. Pharmacol.

LISURIDE DRD2

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Endogenous Drug? False

Specific Action of the Ligand Partial agonist

Trial Name -

Publications:

Kvernmo et al., 2008, Receptor-binding and pharmacokinetic properties of dopaminergic agonists., Curr Top Med Chem

Chen et al., 2002, TTD: Therapeutic Target Database., Nucleic Acids Res.

LISURIDE HTR6

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Specific Action of the Ligand Partial agonist

Endogenous Drug? False

Publications:
LISURIDE ADRA1A

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Specific Action of the Ligand Antagonist

Endogenous Drug? False

Publications:

LISURIDE DRD1

Interaction Types & Directionality:

antagonist (inhibitory)

agonist (activating)

Interaction Info:

Trial Name -

Novel drug target Established target

Specific Action of the Ligand Partial agonist

Publications:

Kvernmo et al., 2008, Receptor-binding and pharmacokinetic properties of dopaminergic agonists., Curr Top Med Chem

Imming et al., 2006, Drugs, their targets and the nature and number of drug targets., Nat Rev Drug Discov

Overington et al., 2006, How many drug targets are there?, Nat Rev Drug Discov

LISURIDE DRD3

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Specific Action of the Ligand Partial agonist

Endogenous Drug? False

Publications:

Kvernmo et al., 2008, Receptor-binding and pharmacokinetic properties of dopaminergic agonists., Curr Top Med Chem

LISURIDE HTR2A

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Specific Action of the Ligand Partial agonist

Endogenous Drug? False

Publications:

Egan et al., 1998, Agonist activity of LSD and lisuride at cloned 5HT2A and 5HT2C receptors., Psychopharmacology (Berl.)

Kvernmo et al., 2008, Receptor-binding and pharmacokinetic properties of dopaminergic agonists., Curr Top Med Chem

LISURIDE HTR1D

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Endogenous Drug? False

Specific Action of the Ligand Partial agonist

Publications:

Kvernmo et al., 2008, Receptor-binding and pharmacokinetic properties of dopaminergic agonists., Curr Top Med Chem
LISURIDE HTR2B

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Endogenous Drug? False

Specific Action of the Ligand Antagonist

Publications:

Kvernmo et al., 2008, Receptor-binding and pharmacokinetic properties of dopaminergic agonists., Curr Top Med Chem
LISURIDE ADRA2A

Interaction Types & Directionality:

antagonist (inhibitory)

other/unknown

Interaction Info:

Specific Action of the Ligand Antagonist

Endogenous Drug? False

Publications:

Kvernmo et al., 2008, Receptor-binding and pharmacokinetic properties of dopaminergic agonists., Curr Top Med Chem

LISURIDE HTR2C

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Endogenous Drug? False

Specific Action of the Ligand Partial agonist

Publications:

Egan et al., 1998, Agonist activity of LSD and lisuride at cloned 5HT2A and 5HT2C receptors., Psychopharmacology (Berl.)

Kvernmo et al., 2008, Receptor-binding and pharmacokinetic properties of dopaminergic agonists., Curr Top Med Chem

LISURIDE DRD5

Interaction Types & Directionality:

agonist (activating)

antagonist (inhibitory)

Interaction Info:

Endogenous Drug? False

Specific Action of the Ligand Partial agonist

Publications:

Kvernmo et al., 2008, Receptor-binding and pharmacokinetic properties of dopaminergic agonists., Curr Top Med Chem
LISURIDE ADRA2B

Interaction Types & Directionality:

antagonist (inhibitory)

other/unknown

Interaction Info:

Specific Action of the Ligand Antagonist

Endogenous Drug? False

Publications:

Kvernmo et al., 2008, Receptor-binding and pharmacokinetic properties of dopaminergic agonists., Curr Top Med Chem
LISURIDE DRD4

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Specific Action of the Ligand Partial agonist

Endogenous Drug? False

Publications:

Kvernmo et al., 2008, Receptor-binding and pharmacokinetic properties of dopaminergic agonists., Curr Top Med Chem

LISURIDE HTR1A

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Specific Action of the Ligand Full agonist

Endogenous Drug? False

Trial Name -

Publications:

Akai et al., 1991, [Anxiolytic effects of lisuride and its agonistic action to central 5-HT1A receptors]., Nippon Yakurigaku Zasshi

Cunningham et al., 1987, Discriminative stimulus properties of 8-hydroxy-2-(di-n-propylamino)tetralin (8-OHDPAT): implications for understanding the actions of novel anxiolytics., Eur. J. Pharmacol.

Kimura et al., 1991, Dual activation by lisuride of central serotonin 5-HT(1A) and dopamine D(2) receptor sites: drug discrimination and receptor binding studies., Behav Pharmacol

LISURIDE ADRA2C

Interaction Types & Directionality:

antagonist (inhibitory)

other/unknown

Interaction Info:

Specific Action of the Ligand Antagonist

Endogenous Drug? False

Publications:

Kvernmo et al., 2008, Receptor-binding and pharmacokinetic properties of dopaminergic agonists., Curr Top Med Chem
LISURIDE HTR1B

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Specific Action of the Ligand Partial agonist

Endogenous Drug? False

Publications:

Kvernmo et al., 2008, Receptor-binding and pharmacokinetic properties of dopaminergic agonists., Curr Top Med Chem

LISURIDE HTR7

Interaction Types & Directionality:

n/a

Interaction Info:

Publications:

Toohey N et al., 2009, Human 5-HT7 receptor-induced inactivation of forskolin-stimulated adenylate cyclase by risperidone, 9-OH-risperidone and other "inactivating antagonists"., Mol Pharmacol

Knight et al., 2009, Pharmacological analysis of the novel, rapid, and potent inactivation of the human 5-Hydroxytryptamine7 receptor by risperidone, 9-OH-Risperidone, and other inactivating antagonists., Mol. Pharmacol.

DrugBank: DB00589

Version: 5.1.7

Alternate Names:

LISURIDE DrugBank Drug Name

18016-80-3 CAS Number

Arolac Drug Brand

Drug Info:

Drug Type small molecule

Drug Groups approved

Drug Groups investigational

Publications:

Egan et al., 1998, Agonist activity of LSD and lisuride at cloned 5HT2A and 5HT2C receptors., Psychopharmacology (Berl.)

Kvernmo et al., 2008, Receptor-binding and pharmacokinetic properties of dopaminergic agonists., Curr Top Med Chem

Chen et al., 2002, TTD: Therapeutic Target Database., Nucleic Acids Res.

TEND: LISURIDE
- Version: 01-August-2011
Alternate Names:

LISURIDE Primary Drug Name

Drug Info:

Year of Approval not approved by the fda

Drug Class antiparkinson agents

Publications:
TdgClinicalTrial: LISURIDE
- Version: January-2014
Alternate Names:

Drug Info:

Drug Indications Antiparkinson Agents

Drug Class small molecule

FDA Approval not approved by the FDA

Publications:
TTD: Lisuride
- Version: 2020.06.01
Alternate Names:

D0X7KB TTD Drug ID

Drug Info:

Publications:
GuideToPharmacology: 135650525
- Version: 29-September-2020
Alternate Names:

LISURIDE GuideToPharmacology Ligand Name

Drug Info:

Publications:
ChemblDrugs: chembl:CHEMBL157138
- Version: ChEMBL_27
Alternate Names:

Drug Info:

Publications:

Endogenous Drug?	False
Specific Action of the Ligand	Partial agonist
Trial Name	-

Specific Action of the Ligand	Antagonist
Endogenous Drug?	False

Trial Name	-
Novel drug target	Established target
Specific Action of the Ligand	Partial agonist

Specific Action of the Ligand	Full agonist
Endogenous Drug?	False
Trial Name	-

LISURIDE	DrugBank Drug Name
18016-80-3	CAS Number
Arolac	Drug Brand

Drug Type	small molecule
Drug Groups	approved
Drug Groups	investigational

LISURIDE Drug Record

LISURIDE chembl:CHEMBL157138 Approved

Alternate Names:

Drug Info:

Publications:

Interaction Types & Directionality: agonist (activating)

Interaction Info: Endogenous Drug? False Specific Action of the Ligand Partial agonist Trial Name -

Publications: Kvernmo et al., 2008, Receptor-binding and pharmacokinetic properties of dopaminergic agonists., Curr Top Med Chem Chen et al., 2002, TTD: Therapeutic Target Database., Nucleic Acids Res.

Interaction Types & Directionality: agonist (activating)

Interaction Info: Specific Action of the Ligand Partial agonist Endogenous Drug? False

Publications:

Interaction Types & Directionality: antagonist (inhibitory)

Interaction Info: Specific Action of the Ligand Antagonist Endogenous Drug? False

Publications:

Interaction Types & Directionality: antagonist (inhibitory) agonist (activating)

Interaction Info: Trial Name - Novel drug target Established target Specific Action of the Ligand Partial agonist

Interaction Types & Directionality: agonist (activating)

Interaction Info: Specific Action of the Ligand Partial agonist Endogenous Drug? False

Publications: Kvernmo et al., 2008, Receptor-binding and pharmacokinetic properties of dopaminergic agonists., Curr Top Med Chem

Interaction Types & Directionality: agonist (activating)

Interaction Info: Specific Action of the Ligand Partial agonist Endogenous Drug? False

Publications: Egan et al., 1998, Agonist activity of LSD and lisuride at cloned 5HT2A and 5HT2C receptors., Psychopharmacology (Berl.) Kvernmo et al., 2008, Receptor-binding and pharmacokinetic properties of dopaminergic agonists., Curr Top Med Chem

Interaction Types & Directionality: agonist (activating)

Interaction Info: Endogenous Drug? False Specific Action of the Ligand Partial agonist

Publications: Kvernmo et al., 2008, Receptor-binding and pharmacokinetic properties of dopaminergic agonists., Curr Top Med Chem

Interaction Types & Directionality: antagonist (inhibitory)

Interaction Info: Endogenous Drug? False Specific Action of the Ligand Antagonist

Publications: Kvernmo et al., 2008, Receptor-binding and pharmacokinetic properties of dopaminergic agonists., Curr Top Med Chem

Interaction Types & Directionality: antagonist (inhibitory) other/unknown

Interaction Info: Specific Action of the Ligand Antagonist Endogenous Drug? False

Publications: Kvernmo et al., 2008, Receptor-binding and pharmacokinetic properties of dopaminergic agonists., Curr Top Med Chem

Interaction Types & Directionality: agonist (activating)

Interaction Info: Endogenous Drug? False Specific Action of the Ligand Partial agonist

Publications: Egan et al., 1998, Agonist activity of LSD and lisuride at cloned 5HT2A and 5HT2C receptors., Psychopharmacology (Berl.) Kvernmo et al., 2008, Receptor-binding and pharmacokinetic properties of dopaminergic agonists., Curr Top Med Chem

Interaction Types & Directionality: agonist (activating) antagonist (inhibitory)

Interaction Info: Endogenous Drug? False Specific Action of the Ligand Partial agonist

Publications: Kvernmo et al., 2008, Receptor-binding and pharmacokinetic properties of dopaminergic agonists., Curr Top Med Chem

Interaction Types & Directionality: antagonist (inhibitory) other/unknown

Interaction Info: Specific Action of the Ligand Antagonist Endogenous Drug? False

Publications: Kvernmo et al., 2008, Receptor-binding and pharmacokinetic properties of dopaminergic agonists., Curr Top Med Chem

Interaction Types & Directionality: agonist (activating)

Interaction Info: Specific Action of the Ligand Partial agonist Endogenous Drug? False

Publications: Kvernmo et al., 2008, Receptor-binding and pharmacokinetic properties of dopaminergic agonists., Curr Top Med Chem

Interaction Types & Directionality: agonist (activating)

Interaction Info: Specific Action of the Ligand Full agonist Endogenous Drug? False Trial Name -

Interaction Types & Directionality: antagonist (inhibitory) other/unknown

Interaction Info: Specific Action of the Ligand Antagonist Endogenous Drug? False

Publications: Kvernmo et al., 2008, Receptor-binding and pharmacokinetic properties of dopaminergic agonists., Curr Top Med Chem

Interaction Types & Directionality: agonist (activating)

Interaction Info: Specific Action of the Ligand Partial agonist Endogenous Drug? False

Publications: Kvernmo et al., 2008, Receptor-binding and pharmacokinetic properties of dopaminergic agonists., Curr Top Med Chem

Interaction Types & Directionality: n/a

Interaction Info:

DrugBank: DB00589

Alternate Names: LISURIDE DrugBank Drug Name 18016-80-3 CAS Number Arolac Drug Brand

Drug Info: Drug Type small molecule Drug Groups approved Drug Groups investigational

TEND: LISURIDE

Alternate Names: LISURIDE Primary Drug Name

Drug Info: Year of Approval not approved by the fda Drug Class antiparkinson agents

Publications:

TdgClinicalTrial: LISURIDE

Alternate Names:

Drug Info: Drug Indications Antiparkinson Agents Drug Class small molecule FDA Approval not approved by the FDA

Publications:

TTD: Lisuride

Alternate Names: D0X7KB TTD Drug ID

Drug Info:

Publications:

GuideToPharmacology: 135650525

Alternate Names: LISURIDE GuideToPharmacology Ligand Name

Drug Info:

Publications:

ChemblDrugs: chembl:CHEMBL157138

Alternate Names:

Drug Info:

Publications:

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Endogenous Drug? False

Specific Action of the Ligand Partial agonist

Trial Name -

Publications:

Kvernmo et al., 2008, Receptor-binding and pharmacokinetic properties of dopaminergic agonists., Curr Top Med Chem

Chen et al., 2002, TTD: Therapeutic Target Database., Nucleic Acids Res.

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Specific Action of the Ligand Partial agonist

Endogenous Drug? False

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Specific Action of the Ligand Antagonist

Endogenous Drug? False

Interaction Types & Directionality:

antagonist (inhibitory)

agonist (activating)

Interaction Info:

Trial Name -

Novel drug target Established target

Specific Action of the Ligand Partial agonist

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Specific Action of the Ligand Partial agonist

Endogenous Drug? False

Publications:

Kvernmo et al., 2008, Receptor-binding and pharmacokinetic properties of dopaminergic agonists., Curr Top Med Chem

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Specific Action of the Ligand Partial agonist

Endogenous Drug? False

Publications:

Egan et al., 1998, Agonist activity of LSD and lisuride at cloned 5HT2A and 5HT2C receptors., Psychopharmacology (Berl.)

Kvernmo et al., 2008, Receptor-binding and pharmacokinetic properties of dopaminergic agonists., Curr Top Med Chem

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Endogenous Drug? False

Specific Action of the Ligand Partial agonist

Publications:

Kvernmo et al., 2008, Receptor-binding and pharmacokinetic properties of dopaminergic agonists., Curr Top Med Chem

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Endogenous Drug? False

Specific Action of the Ligand Antagonist

Publications:

Kvernmo et al., 2008, Receptor-binding and pharmacokinetic properties of dopaminergic agonists., Curr Top Med Chem

Interaction Types & Directionality:

antagonist (inhibitory)

other/unknown

Interaction Info:

Specific Action of the Ligand Antagonist

Endogenous Drug? False

Publications:

Kvernmo et al., 2008, Receptor-binding and pharmacokinetic properties of dopaminergic agonists., Curr Top Med Chem

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Endogenous Drug? False

Specific Action of the Ligand Partial agonist

Publications:

Egan et al., 1998, Agonist activity of LSD and lisuride at cloned 5HT2A and 5HT2C receptors., Psychopharmacology (Berl.)

Kvernmo et al., 2008, Receptor-binding and pharmacokinetic properties of dopaminergic agonists., Curr Top Med Chem

Interaction Types & Directionality:

agonist (activating)

antagonist (inhibitory)

Interaction Info:

Endogenous Drug? False

Specific Action of the Ligand Partial agonist

Publications:

Kvernmo et al., 2008, Receptor-binding and pharmacokinetic properties of dopaminergic agonists., Curr Top Med Chem

Interaction Types & Directionality:

antagonist (inhibitory)

other/unknown

Interaction Info:

Specific Action of the Ligand Antagonist

Endogenous Drug? False

Publications:

Kvernmo et al., 2008, Receptor-binding and pharmacokinetic properties of dopaminergic agonists., Curr Top Med Chem

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Specific Action of the Ligand Partial agonist

Endogenous Drug? False

Publications:

Kvernmo et al., 2008, Receptor-binding and pharmacokinetic properties of dopaminergic agonists., Curr Top Med Chem

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Specific Action of the Ligand Full agonist

Endogenous Drug? False

Trial Name -

Interaction Types & Directionality:

antagonist (inhibitory)

other/unknown

Interaction Info:

Specific Action of the Ligand Antagonist

Endogenous Drug? False

Publications:

Kvernmo et al., 2008, Receptor-binding and pharmacokinetic properties of dopaminergic agonists., Curr Top Med Chem

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Specific Action of the Ligand Partial agonist

Endogenous Drug? False

Publications:

Kvernmo et al., 2008, Receptor-binding and pharmacokinetic properties of dopaminergic agonists., Curr Top Med Chem

Interaction Types & Directionality:

n/a

Alternate Names:

LISURIDE DrugBank Drug Name

18016-80-3 CAS Number

Arolac Drug Brand

Drug Info:

Drug Type small molecule

Drug Groups approved

Drug Groups investigational

Alternate Names:

LISURIDE Primary Drug Name

Drug Info:

Year of Approval not approved by the fda

Drug Class antiparkinson agents

Drug Info:

Drug Indications Antiparkinson Agents

Drug Class small molecule

FDA Approval not approved by the FDA

Alternate Names:

D0X7KB TTD Drug ID

Alternate Names:

LISURIDE GuideToPharmacology Ligand Name