• Search
      • Search Interactions Search Categories
    • Browse
      • Browse Categories Browse Sources
    • Information
      • About Publications Interaction Types & Directionalities Interaction Score & Query Score API Documentation FAQ Known Data Clients News Contact
    • Downloads
      • Data Source Code

LISURIDE Drug Record

  • Summary
  • Interactions
  • Claims
  • LISURIDE chembl:CHEMBL157138 Approved

    Alternate Names:

    LISURIDE MALEATE
    LISURIDE
    LYSURIDE
    REVANIL 200
    (+)-LISURIDE
    N'-((8ALPHA)-9,10-DIDEHYDRO-6-METHYLERGOLIN-8-YL)-N,N-DIETHYLUREA
    DOPERGIN®
    LISURIDA
    LISURID
    LISURIDUM
    rxcui:6446
    pubchem.compound:28864
    chemidplus:18016-80-3
    chembl:CHEMBL157138
    drugbank:00589

    Drug Info:

    FDA Approval not approved by the FDA
    Drug Class small molecule
    Drug Indications Antiparkinson Agents
    Drug Class antiparkinson agents
    Year of Approval not approved by the fda
    Drug Groups investigational
    Drug Categories agents that produce hypertension
    Drug Categories antidepressive agents
    Drug Categories central nervous system depressants
    Drug Categories cytochrome p-450 cyp3a substrates
    Drug Categories cytochrome p-450 substrates
    Drug Categories dopamine antagonists
    Drug Categories ergot alkaloids and derivatives
    Drug Categories ergot-derivative dopamine receptor agonists
    Drug Categories genito urinary system and sex hormones
    Drug Categories heterocyclic compounds, fused-ring
    Drug Categories prolactine inhibitors
    Drug Categories serotonergic drugs shown to increase risk of serotonin syndrome
    Drug Categories serotonin 5-ht2 receptor antagonists
    Drug Categories serotonin receptor antagonists
    (2 More Sources)

    Publications:

    Kvernmo et al., 2008, Receptor-binding and pharmacokinetic properties of dopaminergic agonists., Curr Top Med Chem
    Overington et al., 2006, How many drug targets are there?, Nat Rev Drug Discov
    Imming et al., 2006, Drugs, their targets and the nature and number of drug targets., Nat Rev Drug Discov
    Chen et al., 2002, TTD: Therapeutic Target Database., Nucleic Acids Res.
    Egan et al., 1998, Agonist activity of LSD and lisuride at cloned 5HT2A and 5HT2C receptors., Psychopharmacology (Berl.)
    Cunningham et al., 1987, Discriminative stimulus properties of 8-hydroxy-2-(di-n-propylamino)tetralin (8-OHDPAT): implications for understanding the actions of novel anxiolytics., Eur. J. Pharmacol.
    Miyazawa et al., 1991, [Effect of lisuride on experimental cerebral infarction in rats]., Nippon Yakurigaku Zasshi
    Kimura et al., 1991, Dual activation by lisuride of central serotonin 5-HT(1A) and dopamine D(2) receptor sites: drug discrimination and receptor binding studies., Behav Pharmacol
    Akai et al., 1991, [Anxiolytic effects of lisuride and its agonistic action to central 5-HT1A receptors]., Nippon Yakurigaku Zasshi
    Marona-Lewicka et al., 2002, Re-evaluation of lisuride pharmacology: 5-hydroxytryptamine1A receptor-mediated behavioral effects overlap its other properties in rats., Psychopharmacology (Berl.)
    Knight et al., 2009, Pharmacological analysis of the novel, rapid, and potent inactivation of the human 5-Hydroxytryptamine7 receptor by risperidone, 9-OH-Risperidone, and other inactivating antagonists., Mol. Pharmacol.
    Toohey N et al., 2009, Human 5-HT7 receptor-induced inactivation of forskolin-stimulated adenylate cyclase by risperidone, 9-OH-risperidone and other "inactivating antagonists"., Mol Pharmacol
  • LISURIDE   DRD5

    Interaction Score: 0.27

    Interaction Types & Directionality:
    agonist (activating)
    antagonist (inhibitory)

    Interaction Info:
    Endogenous Drug? False
    Specific Action of the Ligand Partial agonist

    PMIDs:
    18691132


    Sources:
    DrugBank GuideToPharmacology

  • LISURIDE   HTR1A

    Interaction Score: 0.22

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Specific Action of the Ligand Full agonist
    Endogenous Drug? False
    Trial Name -

    PMIDs:
    2887435 1783326 18691132 11224054 1678728 12373423


    Sources:
    TEND TdgClinicalTrial DrugBank GuideToPharmacology

  • LISURIDE   HTR7

    Interaction Score: 0.15

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    18996971 19509219


    Sources:
    DrugBank

  • LISURIDE   HTR1D

    Interaction Score: 0.15

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Endogenous Drug? False
    Specific Action of the Ligand Partial agonist

    PMIDs:
    18691132


    Sources:
    DrugBank GuideToPharmacology

  • LISURIDE   DRD4

    Interaction Score: 0.14

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Specific Action of the Ligand Partial agonist
    Endogenous Drug? False

    PMIDs:
    18691132


    Sources:
    DrugBank GuideToPharmacology

  • LISURIDE   HTR1B

    Interaction Score: 0.13

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Specific Action of the Ligand Partial agonist
    Endogenous Drug? False

    PMIDs:
    18691132


    Sources:
    DrugBank GuideToPharmacology

  • LISURIDE   DRD1

    Interaction Score: 0.13

    Interaction Types & Directionality:
    agonist (activating)
    antagonist (inhibitory)

    Interaction Info:
    Trial Name -
    Novel drug target Established target
    Specific Action of the Ligand Partial agonist

    PMIDs:
    18691132 17139284 17016423


    Sources:
    TEND TdgClinicalTrial DrugBank GuideToPharmacology

  • LISURIDE   HTR2B

    Interaction Score: 0.12

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Endogenous Drug? False
    Specific Action of the Ligand Antagonist

    PMIDs:
    18691132


    Sources:
    DrugBank GuideToPharmacology

  • LISURIDE   DRD2

    Interaction Score: 0.11

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Endogenous Drug? False
    Specific Action of the Ligand Partial agonist
    Trial Name -

    PMIDs:
    18691132 11752352


    Sources:
    TEND TdgClinicalTrial TTD DrugBank GuideToPharmacology

  • LISURIDE   ADRA2B

    Interaction Score: 0.11

    Interaction Types & Directionality:
    other/unknown
    antagonist (inhibitory)

    Interaction Info:
    Specific Action of the Ligand Antagonist
    Endogenous Drug? False

    PMIDs:
    18691132


    Sources:
    DrugBank GuideToPharmacology

  • LISURIDE   HTR2C

    Interaction Score: 0.1

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Endogenous Drug? False
    Specific Action of the Ligand Partial agonist

    PMIDs:
    18691132 9600588


    Sources:
    DrugBank GuideToPharmacology

  • LISURIDE   DRD3

    Interaction Score: 0.1

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Specific Action of the Ligand Partial agonist
    Endogenous Drug? False

    PMIDs:
    18691132


    Sources:
    DrugBank GuideToPharmacology

  • LISURIDE   ADRA2C

    Interaction Score: 0.1

    Interaction Types & Directionality:
    other/unknown
    antagonist (inhibitory)

    Interaction Info:
    Specific Action of the Ligand Antagonist
    Endogenous Drug? False

    PMIDs:
    18691132


    Sources:
    DrugBank GuideToPharmacology

  • LISURIDE   ADRA2A

    Interaction Score: 0.07

    Interaction Types & Directionality:
    other/unknown
    antagonist (inhibitory)

    Interaction Info:
    Specific Action of the Ligand Antagonist
    Endogenous Drug? False

    PMIDs:
    18691132


    Sources:
    DrugBank GuideToPharmacology

  • LISURIDE   HTR2A

    Interaction Score: 0.07

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Specific Action of the Ligand Partial agonist
    Endogenous Drug? False

    PMIDs:
    18691132 9600588


    Sources:
    DrugBank GuideToPharmacology

  • LISURIDE   HTR6

    Interaction Score: 0.07

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Specific Action of the Ligand Partial agonist
    Endogenous Drug? False

    PMIDs:
    None found


    Sources:
    GuideToPharmacology

  • LISURIDE   ADRA1A

    Interaction Score: 0.02

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Specific Action of the Ligand Antagonist
    Endogenous Drug? False

    PMIDs:
    None found


    Sources:
    GuideToPharmacology

  • DrugBank: DB00589

    • Version: 5.1.7

    Alternate Names:
    LISURIDE DrugBank Drug Name
    18016-80-3 CAS Number
    Arolac Drug Brand

    Drug Info:
    Drug Type small molecule
    Drug Groups approved
    Drug Groups investigational

    Publications:
    Kvernmo et al., 2008, Receptor-binding and pharmacokinetic properties of dopaminergic agonists., Curr Top Med Chem
    Egan et al., 1998, Agonist activity of LSD and lisuride at cloned 5HT2A and 5HT2C receptors., Psychopharmacology (Berl.)
    Chen et al., 2002, TTD: Therapeutic Target Database., Nucleic Acids Res.

  • TEND: LISURIDE

    • Version: 01-August-2011

    Alternate Names:
    LISURIDE Primary Drug Name

    Drug Info:
    Year of Approval not approved by the fda
    Drug Class antiparkinson agents

    Publications:

  • TdgClinicalTrial: LISURIDE

    • Version: January-2014

    Alternate Names:

    Drug Info:
    Drug Indications Antiparkinson Agents
    Drug Class small molecule
    FDA Approval not approved by the FDA

    Publications:

  • TTD: Lisuride

    • Version: 2020.06.01

    Alternate Names:
    D0X7KB TTD Drug ID

    Drug Info:

    Publications:

  • GuideToPharmacology: 135650525

    • Version: 29-September-2020

    Alternate Names:
    LISURIDE GuideToPharmacology Ligand Name

    Drug Info:

    Publications:

  • ChemblDrugs: chembl:CHEMBL157138

    • Version: ChEMBL_27

    Alternate Names:

    Drug Info:

    Publications:

Disclaimer: This resource is intended for purely research purposes. It should not be used for emergencies or medical or professional advice.

A finding of a drug-gene interaction or potentially druggable category does not necessarily indicate effectiveness (or lack thereof) of any drug or treatment regimen. A finding of no interaction or no potentially druggable category does not necessarily indicate lack of effectiveness of any drug or treatment regimen. Drug-gene interactions or potentially druggable categories are not presented in ranked order of potential or predicted efficacy.

The dgidb.org website does not provide any medical or healthcare products, services or advice, and is not for medical emergencies or urgent situations. IF YOU THINK YOU MAY HAVE A MEDICAL EMERGENCY, CALL YOUR DOCTOR OR 911 IMMEDIATELY. Information contained on this website is not a substitute for a doctor's medical judgment or advice. We recommend that you discuss your specific, individual health concerns with your doctor or health care professional.

DGIdb (v4.2.0 - sha1 afd9f30b) • Last updated 2020-10-21